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Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706-1713.

Diabetes care

Parente EB, Dahlström EH, Harjutsalo V, Inkeri J, Mutter S, Forsblom C, Sandholm N, Gordin D, Groop PH.
PMID: 34986261
Diabetes Care. 2022 Jan 01;45(1):e8-e9. doi: 10.2337/dci21-0045.

No abstract available.

Cite
Parente EB, Dahlström EH, Harjutsalo V, et al. Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706-1713. Diabetes Care. 2022;45(1):e8-e9doi: 10.2337/dci21-0045.
Parente, E. B., Dahlström, E. H., Harjutsalo, V., Inkeri, J., Mutter, S., Forsblom, C., Sandholm, N., Gordin, D., & Groop, P. H. (2022). Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706-1713. Diabetes care, 45(1), e8-e9. https://doi.org/10.2337/dci21-0045
Parente, Erika B, et al. "Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706-1713." Diabetes care vol. 45,1 (2022): e8-e9. doi: https://doi.org/10.2337/dci21-0045
Parente EB, Dahlström EH, Harjutsalo V, Inkeri J, Mutter S, Forsblom C, Sandholm N, Gordin D, Groop PH. Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706-1713. Diabetes Care. 2022 Jan 01;45(1):e8-e9. doi: 10.2337/dci21-0045. PMID: 34986261.
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Combination treatment optimization using a pan-cancer pathway model.

PLoS computational biology

Schmucker R, Farina G, Faeder J, Fröhlich F, Saglam AS, Sandholm T.
PMID: 34962919
PLoS Comput Biol. 2021 Dec 28;17(12):e1009689. doi: 10.1371/journal.pcbi.1009689. eCollection 2021 Dec.

The design of efficient combination therapies is a difficult key challenge in the treatment of complex diseases such as cancers. The large heterogeneity of cancers and the large number of available drugs renders exhaustive in vivo or even in...

Cite
Schmucker R, Farina G, Faeder J, et al. Combination treatment optimization using a pan-cancer pathway model. PLoS Comput Biol. 2021;17(12):e1009689doi: 10.1371/journal.pcbi.1009689.
Schmucker, R., Farina, G., Faeder, J., Fröhlich, F., Saglam, A. S., & Sandholm, T. (2021). Combination treatment optimization using a pan-cancer pathway model. PLoS computational biology, 17(12), e1009689. https://doi.org/10.1371/journal.pcbi.1009689
Schmucker, Robin, et al. "Combination treatment optimization using a pan-cancer pathway model." PLoS computational biology vol. 17,12 (2021): e1009689. doi: https://doi.org/10.1371/journal.pcbi.1009689
Schmucker R, Farina G, Faeder J, Fröhlich F, Saglam AS, Sandholm T. Combination treatment optimization using a pan-cancer pathway model. PLoS Comput Biol. 2021 Dec 28;17(12):e1009689. doi: 10.1371/journal.pcbi.1009689. eCollection 2021 Dec. PMID: 34962919; PMCID: PMC8747684.
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Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Journal of the American Heart Association

Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ.
PMID: 34668383
J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20.

Background Translocation of lipopolysaccharide from gram-negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods and Results We performed a genome-wide association...

Cite
Leskelä J, Toppila I, Härma MA, et al. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021;10(21):e022482doi: 10.1161/JAHA.121.022482.
Leskelä, J., Toppila, I., Härma, M. A., Palviainen, T., Salminen, A., Sandholm, N., Pietiäinen, M., Kopra, E., Pais de Barros, J. P., Lassenius, M. I., Kumar, A., Harjutsalo, V., Roslund, K., Forsblom, C., Loukola, A., Havulinna, A. S., Lagrost, L., Salomaa, V., Groop, P. H., Perola, M., Kaprio, J., Lehto, M., & Pussinen, P. J. (2021). Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. Journal of the American Heart Association, 10(21), e022482. https://doi.org/10.1161/JAHA.121.022482
Leskelä, Jaakko, et al. "Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke." Journal of the American Heart Association vol. 10,21 (2021): e022482. doi: https://doi.org/10.1161/JAHA.121.022482
Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20. PMID: 34668383; PMCID: PMC8751832.
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Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Journal of the American Heart Association

Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ.
PMID: 34668383
J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20.

Background Translocation of lipopolysaccharide from gram-negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods and Results We performed a genome-wide association...

Cite
Leskelä J, Toppila I, Härma MA, et al. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021;10(21):e022482doi: 10.1161/JAHA.121.022482.
Leskelä, J., Toppila, I., Härma, M. A., Palviainen, T., Salminen, A., Sandholm, N., Pietiäinen, M., Kopra, E., Pais de Barros, J. P., Lassenius, M. I., Kumar, A., Harjutsalo, V., Roslund, K., Forsblom, C., Loukola, A., Havulinna, A. S., Lagrost, L., Salomaa, V., Groop, P. H., Perola, M., Kaprio, J., Lehto, M., & Pussinen, P. J. (2021). Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. Journal of the American Heart Association, 10(21), e022482. https://doi.org/10.1161/JAHA.121.022482
Leskelä, Jaakko, et al. "Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke." Journal of the American Heart Association vol. 10,21 (2021): e022482. doi: https://doi.org/10.1161/JAHA.121.022482
Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20. PMID: 34668383.
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The Low-Expression Variant of .

Diabetes

Dahlström EH, Saksi J, Forsblom C, Uglebjerg N, Mars N, Thorn LM, Harjutsalo V, Rossing P, Ahluwalia TS, Lindsberg PJ, Sandholm N, Groop PH.
PMID: 34244239
Diabetes. 2021 Oct;70(10):2391-2401. doi: 10.2337/db21-0056. Epub 2021 Jul 09.

Fatty acid binding protein 4 (FABP4) is implicated in the pathogenesis of cardiometabolic disorders. Pharmacological inhibition or genetic deletion of FABP4 improves cardiometabolic health and protects against atherosclerosis in preclinical models. As cardiovascular disease (CVD) is common in type...

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Dahlström EH, Saksi J, Forsblom C, et al. The Low-Expression Variant of . Diabetes. 2021;70(10):2391-2401doi: 10.2337/db21-0056.
Dahlström, E. H., Saksi, J., Forsblom, C., Uglebjerg, N., Mars, N., Thorn, L. M., Harjutsalo, V., Rossing, P., Ahluwalia, T. S., Lindsberg, P. J., Sandholm, N., Groop, P. H. (2021). The Low-Expression Variant of . Diabetes, 70(10), 2391-2401. https://doi.org/10.2337/db21-0056
Dahlström, Emma H, et al. "The Low-Expression Variant of ." Diabetes vol. 70,10 (2021): 2391-2401. doi: https://doi.org/10.2337/db21-0056
Dahlström EH, Saksi J, Forsblom C, Uglebjerg N, Mars N, Thorn LM, Harjutsalo V, Rossing P, Ahluwalia TS, Lindsberg PJ, Sandholm N, Groop PH. The Low-Expression Variant of . Diabetes. 2021 Oct;70(10):2391-2401. doi: 10.2337/db21-0056. Epub 2021 Jul 09. PMID: 34244239.
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Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study.

Clinical epigenetics

Smyth LJ, Kilner J, Nair V, Liu H, Brennan E, Kerr K, Sandholm N, Cole J, Dahlström E, Syreeni A, Salem RM, Nelson RG, Looker HC, Wooster C, Anderson K, McKay GJ, Kee F, Young I, Andrews D, Forsblom C, Hirschhorn JN, Godson C, Groop PH, Maxwell AP, Susztak K, Kretzler M, Florez JC, McKnight AJ.
PMID: 33933144
Clin Epigenetics. 2021 May 01;13(1):99. doi: 10.1186/s13148-021-01081-x.

BACKGROUND: A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), the most common cause globally of end-stage kidney disease (ESKD). Emerging evidence suggests epigenetic changes in DNA methylation may have...

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Smyth LJ, Kilner J, Nair V, et al. Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study. Clin Epigenetics. 2021;13(1):99doi: 10.1186/s13148-021-01081-x.
Smyth, L. J., Kilner, J., Nair, V., Liu, H., Brennan, E., Kerr, K., Sandholm, N., Cole, J., Dahlström, E., Syreeni, A., Salem, R. M., Nelson, R. G., Looker, H. C., Wooster, C., Anderson, K., McKay, G. J., Kee, F., Young, I., Andrews, D., Forsblom, C., Hirschhorn, J. N., Godson, C., Groop, P. H., Maxwell, A. P., Susztak, K., Kretzler, M., Florez, J. C., & McKnight, A. J. (2021). Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study. Clinical epigenetics, 13(1), 99. https://doi.org/10.1186/s13148-021-01081-x
Smyth, L J, et al. "Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study." Clinical epigenetics vol. 13,1 (2021): 99. doi: https://doi.org/10.1186/s13148-021-01081-x
Smyth LJ, Kilner J, Nair V, Liu H, Brennan E, Kerr K, Sandholm N, Cole J, Dahlström E, Syreeni A, Salem RM, Nelson RG, Looker HC, Wooster C, Anderson K, McKay GJ, Kee F, Young I, Andrews D, Forsblom C, Hirschhorn JN, Godson C, Groop PH, Maxwell AP, Susztak K, Kretzler M, Florez JC, McKnight AJ. Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study. Clin Epigenetics. 2021 May 01;13(1):99. doi: 10.1186/s13148-021-01081-x. PMID: 33933144; PMCID: PMC8088646.
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Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.

Journal of the American Heart Association

Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ.
PMID: 34668383
J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20.

Background Translocation of lipopolysaccharide from gram-negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods and Results We performed a genome-wide association...

Cite
Leskelä J, Toppila I, Härma MA, et al. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021;10(21):e022482doi: 10.1161/JAHA.121.022482.
Leskelä, J., Toppila, I., Härma, M. A., Palviainen, T., Salminen, A., Sandholm, N., Pietiäinen, M., Kopra, E., Pais de Barros, J. P., Lassenius, M. I., Kumar, A., Harjutsalo, V., Roslund, K., Forsblom, C., Loukola, A., Havulinna, A. S., Lagrost, L., Salomaa, V., Groop, P. H., Perola, M., Kaprio, J., Lehto, M., & Pussinen, P. J. (2021). Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. Journal of the American Heart Association, 10(21), e022482. https://doi.org/10.1161/JAHA.121.022482
Leskelä, Jaakko, et al. "Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke." Journal of the American Heart Association vol. 10,21 (2021): e022482. doi: https://doi.org/10.1161/JAHA.121.022482
Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP, Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ. Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. J Am Heart Assoc. 2021 Nov 02;10(21):e022482. doi: 10.1161/JAHA.121.022482. Epub 2021 Oct 20. PMID: 34668383; PMCID: PMC8751832.
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Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer.

Oncology letters

Tuomela J, Sandholm J, Kauppila JH, Lehenkari P, Harris KW, Selander KS.
PMID: 24273604
Oncol Lett. 2013 Dec;6(6):1665-1672. doi: 10.3892/ol.2013.1602. Epub 2013 Oct 04.

Toll-like receptor-9 (TLR9) is an intracellular DNA receptor that is widely expressed in breast and other cancers. We previously demonstrated that low tumor TLR9 expression upon diagnosis is associated with significantly shortened disease-specific survival times in patients with triple-negative...

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Tuomela J, Sandholm J, Kauppila JH, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013;6(6):1665-1672doi: 10.3892/ol.2013.1602.
Tuomela, J., Sandholm, J., Kauppila, J. H., Lehenkari, P., Harris, K. W., & Selander, K. S. (2013). Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncology letters, 6(6), 1665-1672. https://doi.org/10.3892/ol.2013.1602
Tuomela, Johanna, et al. "Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer." Oncology letters vol. 6,6 (2013): 1665-1672. doi: https://doi.org/10.3892/ol.2013.1602
Tuomela J, Sandholm J, Kauppila JH, Lehenkari P, Harris KW, Selander KS. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. doi: 10.3892/ol.2013.1602. Epub 2013 Oct 04. PMID: 24273604; PMCID: PMC3835157.
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Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus.

Cardiovascular research

Antikainen AAV, Sandholm N, Trégouët DA, Charmet R, McKnight AJ, Ahluwalia TS, Syreeni A, Valo E, Forsblom C, Gordin D, Harjutsalo V, Hadjadj S, Maxwell AP, Rossing P, Groop PH.
PMID: 32077919
Cardiovasc Res. 2021 Jan 21;117(2):600-612. doi: 10.1093/cvr/cvaa045.

AIMS: Diabetes is a known risk factor for coronary artery disease (CAD). There is accumulating evidence that CAD pathogenesis differs for individuals with type 1 diabetes (T1D). However, the genetic background has not been extensively studied. We aimed to...

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Antikainen AAV, Sandholm N, Trégouët DA, et al. Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus. Cardiovasc Res. 2021;117(2):600-612doi: 10.1093/cvr/cvaa045.
Antikainen, A. A. V., Sandholm, N., Trégouët, D. A., Charmet, R., McKnight, A. J., Ahluwalia, T. S., Syreeni, A., Valo, E., Forsblom, C., Gordin, D., Harjutsalo, V., Hadjadj, S., Maxwell, A. P., Rossing, P., & Groop, P. H. (2021). Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus. Cardiovascular research, 117(2), 600-612. https://doi.org/10.1093/cvr/cvaa045
Antikainen, Anni A V, et al. "Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus." Cardiovascular research vol. 117,2 (2021): 600-612. doi: https://doi.org/10.1093/cvr/cvaa045
Antikainen AAV, Sandholm N, Trégouët DA, Charmet R, McKnight AJ, Ahluwalia TS, Syreeni A, Valo E, Forsblom C, Gordin D, Harjutsalo V, Hadjadj S, Maxwell AP, Rossing P, Groop PH. Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus. Cardiovasc Res. 2021 Jan 21;117(2):600-612. doi: 10.1093/cvr/cvaa045. PMID: 32077919; PMCID: PMC8453280.
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The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes.

Diabetes care

Parente EB, Dahlström EH, Harjutsalo V, Inkeri J, Mutter S, Forsblom C, Sandholm N, Gordin D, Groop PH.
PMID: 34031143
Diabetes Care. 2021 Jul;44(7):1706-1713. doi: 10.2337/dc20-3175. Epub 2021 May 24.

OBJECTIVE: Obesity, which is associated with nonalcoholic fatty liver (NAFL), has increased among people with type 1 diabetes. Therefore, we explored the associations between body fat distribution and NAFL in this population.RESEARCH DESIGN AND METHODS: This study included 121...

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Parente EB, Dahlström EH, Harjutsalo V, et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care. 2021;44(7):1706-1713doi: 10.2337/dc20-3175.
Parente, E. B., Dahlström, E. H., Harjutsalo, V., Inkeri, J., Mutter, S., Forsblom, C., Sandholm, N., Gordin, D., Groop, P. H. (2021). The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes care, 44(7), 1706-1713. https://doi.org/10.2337/dc20-3175
Parente, Erika B, et al. "The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes." Diabetes care vol. 44,7 (2021): 1706-1713. doi: https://doi.org/10.2337/dc20-3175
Parente EB, Dahlström EH, Harjutsalo V, Inkeri J, Mutter S, Forsblom C, Sandholm N, Gordin D, Groop PH. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care. 2021 Jul;44(7):1706-1713. doi: 10.2337/dc20-3175. Epub 2021 May 24. PMID: 34031143.
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The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies.

Thrombosis and haemostasis

Grosso G, Sandholm K, Antovic A, Gunnarsson I, Zickert A, Vikerfors A, Truedsson L, Bruzelius M, Nilsson B, Nilsson-Ekdahl K, Svenungsson E.
PMID: 33412597
Thromb Haemost. 2021 Oct;121(10):1299-1309. doi: 10.1055/a-1347-5655. Epub 2021 Jan 07.

BACKGROUND:  Low levels of total C4b-binding protein (C4BPt), a circulating inhibitor of the classical/lectin complement pathways, were observed in patients with antiphospholipid antibodies (aPLs) and during warfarin treatment.OBJECTIVES:  To investigate the associations between aPL and C4BPt in patients with...

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Grosso G, Sandholm K, Antovic A, et al. The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies. Thromb Haemost. 2021;121(10):1299-1309doi: 10.1055/a-1347-5655.
Grosso, G., Sandholm, K., Antovic, A., Gunnarsson, I., Zickert, A., Vikerfors, A., Truedsson, L., Bruzelius, M., Nilsson, B., Nilsson-Ekdahl, K., & Svenungsson, E. (2021). The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies. Thrombosis and haemostasis, 121(10), 1299-1309. https://doi.org/10.1055/a-1347-5655
Grosso, Giorgia, et al. "The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies." Thrombosis and haemostasis vol. 121,10 (2021): 1299-1309. doi: https://doi.org/10.1055/a-1347-5655
Grosso G, Sandholm K, Antovic A, Gunnarsson I, Zickert A, Vikerfors A, Truedsson L, Bruzelius M, Nilsson B, Nilsson-Ekdahl K, Svenungsson E. The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies. Thromb Haemost. 2021 Oct;121(10):1299-1309. doi: 10.1055/a-1347-5655. Epub 2021 Jan 07. PMID: 33412597.
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Combination treatment optimization using a pan-cancer pathway model.

PLoS computational biology

Schmucker R, Farina G, Faeder J, Fröhlich F, Saglam AS, Sandholm T.
PMID: 34962919
PLoS Comput Biol. 2021 Dec 28;17(12):e1009689. doi: 10.1371/journal.pcbi.1009689. Epub 2021 Dec 28.

The design of efficient combination therapies is a difficult key challenge in the treatment of complex diseases such as cancers. The large heterogeneity of cancers and the large number of available drugs renders exhaustive in vivo or even in...

Cite
Schmucker R, Farina G, Faeder J, et al. Combination treatment optimization using a pan-cancer pathway model. PLoS Comput Biol. 2021;17(12):e1009689doi: 10.1371/journal.pcbi.1009689.
Schmucker, R., Farina, G., Faeder, J., Fröhlich, F., Saglam, A. S., & Sandholm, T. (2021). Combination treatment optimization using a pan-cancer pathway model. PLoS computational biology, 17(12), e1009689. https://doi.org/10.1371/journal.pcbi.1009689
Schmucker, Robin, et al. "Combination treatment optimization using a pan-cancer pathway model." PLoS computational biology vol. 17,12 (2021): e1009689. doi: https://doi.org/10.1371/journal.pcbi.1009689
Schmucker R, Farina G, Faeder J, Fröhlich F, Saglam AS, Sandholm T. Combination treatment optimization using a pan-cancer pathway model. PLoS Comput Biol. 2021 Dec 28;17(12):e1009689. doi: 10.1371/journal.pcbi.1009689. Epub 2021 Dec 28. PMID: 34962919.
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Showing 13 to 24 of 30 entries