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Showing 25 to 36 of 191 entries
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Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas.

Frontiers in neuroinformatics

Krepl J, Casalegno F, Delattre E, Erö C, Lu H, Keller D, Rodarie D, Markram H, Schürmann F.
PMID: 34393747
Front Neuroinform. 2021 Jul 28;15:691918. doi: 10.3389/fninf.2021.691918. eCollection 2021.

The acquisition of high quality maps of gene expression in the rodent brain is of fundamental importance to the neuroscience community. The generation of such datasets relies on registering individual gene expression images to a reference volume, a task...

Unlocking big data doubled the accuracy in predicting the grain yield in hybrid wheat.

Science advances

Zhao Y, Thorwarth P, Jiang Y, Philipp N, Schulthess AW, Gils M, Boeven PHG, Longin CFH, Schacht J, Ebmeyer E, Korzun V, Mirdita V, Dörnte J, Avenhaus U, Horbach R, Cöster H, Holzapfel J, Ramgraber L, Kühnle S, Varenne P, Starke A, Schürmann F, Beier S, Scholz U, Liu F, Schmidt RH, Reif JC.
PMID: 34117061
Sci Adv. 2021 Jun 11;7(24). doi: 10.1126/sciadv.abf9106. Print 2021 Jun.

The potential of big data to support businesses has been demonstrated in financial services, manufacturing, and telecommunications. Here, we report on efforts to enter a new data era in plant breeding by collecting genomic and phenotypic information from 12,858...

HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue.

Molecular metabolism

Hauffe R, Rath M, Schell M, Ritter K, Kappert K, Deubel S, Ott C, Jähnert M, Jonas W, Schürmann A, Kleinridders A.
PMID: 34153520
Mol Metab. 2021 Nov;53:101276. doi: 10.1016/j.molmet.2021.101276. Epub 2021 Jun 18.

OBJECTIVE: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. The aim of this investigation was to determine the effect...

Prediction of Educational Attainment and Occupational Functioning in Young Adults With a Childhood Diagnosis of ADHD: Results from the Cologne Adaptive Multimodal Treatment (CAMT) Study.

Journal of attention disorders

von Wirth E, Breuer D, Mandler J, Schürmann S, Döpfner M.
PMID: 34697953
J Atten Disord. 2021 Oct 26;10870547211045740. doi: 10.1177/10870547211045740. Epub 2021 Oct 26.

OBJECTIVE: This longitudinal study examined early predictors of educational attainment and occupational functioning in adults with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD).METHOD: Participants (RESULTS: Hierarchical regression analysis revealed that poor reading skill and externalizing behaviors in childhood were...

C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation.

Frontiers in cell and developmental biology

Manikowski D, Kastl P, Schürmann S, Ehring K, Steffes G, Jakobs P, Grobe K.
PMID: 33511123
Front Cell Dev Biol. 2021 Jan 12;8:615698. doi: 10.3389/fcell.2020.615698. eCollection 2020.

Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation during biosynthesis. The current hypothesis is...

Fabrication of ZnO Nanobrushes by H.

ACS applied materials & interfaces

Kohlmann N, Hansen L, Lupan C, Schürmann U, Reimers A, Schütt F, Adelung R, Kersten H, Kienle L.
PMID: 34907774
ACS Appl Mater Interfaces. 2021 Dec 15; doi: 10.1021/acsami.1c18679. Epub 2021 Dec 15.

Zinc oxide has widespread use in diverse applications due to its distinct properties. Many of these applications benefit from controlling the morphology on the nanoscale, where for example gas sensing is strongly enhanced for high surface-to-volume ratios. In this...

MALDI mass spectrometry imaging unravels organ and amyloid-type specific peptide signatures in pulmonary and gastrointestinal amyloidosis.

Proteomics. Clinical applications

Schürmann J, Gottwald J, Rottenaicher G, Tholey A, Röcken C.
PMID: 34061454
Proteomics Clin Appl. 2021 Nov;15(6):e2000079. doi: 10.1002/prca.202000079. Epub 2021 Jun 12.

PURPOSE: Amyloidosis is a disease group caused by pathological aggregation and deposition of peptides in diverse tissue sites. Recently, matrix-assisted laser desorption/ionization mass spectrometry imaging coupled with ion mobility separation (MALDI-IMS MSI) was introduced as a novel tool to...

Correction to: Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.

Infection

Stecher M, Schommers P, Kollan C, Stoll M, Kuhlendahl F, Stellbrink HJ, Wasmuth JC, Stephan C, Hamacher L, Lehmann C, Boesecke C, Bogner J, Esser S, Fritzsche C, Haberl A, Schürmann D, Degen O, Horst HA, Hoffmann C, Jensen B, Schwarze-Zander C, Platten M, Fätkenheuer G, Schmidt D, Gunsenheimer-Bartmeyer B, Vehreschild JJ.
PMID: 34346028
Infection. 2021 Dec;49(6):1365-1366. doi: 10.1007/s15010-021-01655-0.

No abstract available.

Editorial: Intermittent Fasting - Mechanisms and Clinical Usefulness.

Frontiers in endocrinology

Fritsche A, Szendrödi J, Schürmann A.
PMID: 34594306
Front Endocrinol (Lausanne). 2021 Sep 14;12:757539. doi: 10.3389/fendo.2021.757539. eCollection 2021.

No abstract available.

Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards.

The Lancet. Oncology

Bottomley A, Pe M, Sloan J, Basch E, Bonnetain F, Calvert M, Campbell A, Cleeland C, Cocks K, Collette L, Dueck AC, Devlin N, Flechtner HH, Gotay C, Greimel E, Griebsch I, Groenvold M, Hamel JF, King M, Kluetz PG, Koller M, Malone DC, Martinelli F, Mitchell SA, Moinpour CM, Musoro J, O'Connor D, Oliver K, Piault-Louis E, Piccart M, Pimentel FL, Quinten C, Reijneveld JC, Schürmann C, Smith AW, Soltys KM, Taphoorn MJB, Velikova G, Coens C.
PMID: 27769798
Lancet Oncol. 2016 Nov;17(11):e510-e514. doi: 10.1016/S1470-2045(16)30510-1. Epub 2016 Oct 18.

Measures of health-related quality of life (HRQOL) and other patient-reported outcomes generate important data in cancer randomised trials to assist in assessing the risks and benefits of cancer therapies and fostering patient-centred cancer care. However, the various ways these...

Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide.

Organic letters

Bold CP, Klaus C, Pfeiffer B, Schürmann J, Lombardi R, Lucena-Agell D, Díaz JF, Altmann KH.
PMID: 33635661
Org Lett. 2021 Mar 19;23(6):2238-2242. doi: 10.1021/acs.orglett.1c00378. Epub 2021 Feb 26.

Studies are described toward the synthesis of an oxazole-based analog of (-)-zampanolide (

Efficacy of Δ.

Frontiers in aging neuroscience

Nidadavolu P, Bilkei-Gorzo A, Krämer M, Schürmann B, Palmisano M, Beins EC, Madea B, Zimmer A.
PMID: 34526890
Front Aging Neurosci. 2021 Aug 30;13:718850. doi: 10.3389/fnagi.2021.718850. eCollection 2021.

Decline in cognitive performance, an aspect of the normal aging process, is influenced by the endocannabinoid system (ECS). Cannabinoid receptor 1 (CB1) signaling diminishes with advancing age in specific brain regions that regulate learning and memory and abolishing CB1...

Showing 25 to 36 of 191 entries