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Showing 397 to 404 of 404 entries
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Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H.

Archiv der Pharmazie

Corona A, Seibt S, Schaller D, Schobert R, Volkamer A, Biersack B, Tramontano E.
PMID: 34008218
Arch Pharm (Weinheim). 2021 Sep;354(9):e2100123. doi: 10.1002/ardp.202100123. Epub 2021 May 18.

The bioactive components of Garcinia indica, garcinol (camboginol), and isogarcinol (cambogin), are suitable drug candidates for the treatment of various human diseases. HIV-1-RNase H assay was used to study the RNase H inhibition by garcinol and isogarcinol. Docking of...

Protective T cell receptor identification for orthotopic reprogramming of immunity in refractory virus infections.

Molecular therapy : the journal of the American Society of Gene Therapy

Stief TA, Kaeuferle T, Müller TR, Döring M, Jablonowski LM, Schober K, Feucht J, Dennehy KM, Willier S, Blaeschke F, Handgretinger R, Lang P, Busch DH, Feuchtinger T.
PMID: 34058386
Mol Ther. 2022 Jan 05;30(1):198-208. doi: 10.1016/j.ymthe.2021.05.021. Epub 2021 May 29.

Viral infections cause life-threatening disease in immunocompromised patients and especially following transplantation. T cell receptor (TCR) engineering redirects specificity and can bring significant progress to emerging adoptive T cell transfer (ACT) approaches. T cell epitopes are well described, although...

Heart failure with recovered ejection fraction (HFrecEF): A new entity with improved cardiac outcome.

Pacing and clinical electrophysiology : PACE

Zeller J, Hubauer U, Schober A, Schober A, Keyser A, Fredersdorf S, Uecer E, Maier LS, Jungbauer C.
PMID: 34687476
Pacing Clin Electrophysiol. 2021 Dec;44(12):2015-2023. doi: 10.1111/pace.14391. Epub 2021 Nov 04.

BACKGROUND: Aim of the study was a better characterization of heart failure (HF) with recovered ejection fraction (HFrecEF) and undulating EF (HFuEF) with regard to re-hospitalization due to congestive HF (CHF), adequate electric therapies (AETs) and mortality compared to...

Regioselectivity of Cobalamin-Dependent Methyltransferase Can Be Tuned by Reaction Conditions and Substrate.

ChemCatChem

Pompei S, Grimm C, Farnberger JE, Schober L, Kroutil W.
PMID: 33442427
ChemCatChem. 2020 Dec 04;12(23):5977-5983. doi: 10.1002/cctc.202001296. Epub 2020 Oct 01.

Regioselective reactions represent a significant challenge for organic chemistry. Here the regioselective methylation of a single hydroxy group of 4-substituted catechols was investigated employing the cobalamin-dependent methyltransferase from

Paternal Leave and Father-Infant Bonding: Findings From the Population-Based Cohort Study DREAM.

Frontiers in psychology

Schaber R, Kopp M, Zähringer A, Mack JT, Kress V, Garthus-Niegel S.
PMID: 34149562
Front Psychol. 2021 Jun 04;12:668028. doi: 10.3389/fpsyg.2021.668028. eCollection 2021.

No abstract available.

Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity.

Cancers

Yusenko MV, Biyanee A, Frank D, Köhler LHF, Andersson MK, Khandanpour C, Schobert R, Stenman G, Biersack B, Klempnauer KH.
PMID: 35008207
Cancers (Basel). 2021 Dec 23;14(1). doi: 10.3390/cancers14010043.

Studies of the role of MYB in human malignancies have highlighted MYB as a potential drug target for acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). Here, we present the initial characterization of 2-amino-4-(3,4,5-trimethoxyphenyl)-4

COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma.

HemaSphere

Gaitzsch E, Passerini V, Khatamzas E, Strobl CD, Muenchhoff M, Scherer C, Osterman A, Heide M, Reischer A, Subklewe M, Leutbecher A, Tast B, Ruhle A, Weiglein T, Stecher SS, Stemmler HJ, Dreyling M, Girl P, Georgi E, Wölfel R, Mateyka L, D'Ippolito E, Schober K, Busch DH, Kager J, Spinner CD, Treiber M, Rasch S, Lahmer T, Iakoubov R, Schneider J, Protzer U, Winter C, Ruland J, Quante M, Keppler OT, von Bergwelt-Baildon M, Hellmuth J, Weigert O.
PMID: 34235400
Hemasphere. 2021 Jun 28;5(7):e603. doi: 10.1097/HS9.0000000000000603. eCollection 2021 Jul.

The clinical and immunological impact of B-cell depletion in the context of coronavirus disease 2019 (COVID-19) is unclear. We conducted a prospectively planned analysis of COVID-19 in patients who received B-cell depleting anti-CD20 antibodies and chemotherapy for B-cell lymphomas....

MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions.

Circulation

Schober A, Blay RM, Saboor Maleki S, Zahedi F, Winklmaier AE, Kakar MY, Baatsch IM, Zhu M, Geißler C, Fusco AE, Eberlein A, Li N, Megens RTA, Banafsche R, Kumbrink J, Weber C, Nazari-Jahantigh M.
PMID: 34233454
Circulation. 2021 Sep 28;144(13):1059-1073. doi: 10.1161/CIRCULATIONAHA.120.051614. Epub 2021 Jul 08.

BACKGROUND: The necrotic core partly formed by ineffective efferocytosis increases the risk of an atherosclerotic plaque rupture. Microribonucleic acids contribute to necrotic core formation by regulating efferocytosis and macrophage apoptosis. Atherosclerotic plaque rupture occurs at increased frequency in the...

Showing 397 to 404 of 404 entries