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Showing 1321 to 1330 of 1330 entries
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Neurocircuitry basis of the opioid use disorder-post-traumatic stress disorder comorbid state: conceptual analyses using a dimensional framework.

The lancet. Psychiatry

Upadhyay J, Verrico CD, Cay M, Kodele S, Yammine L, Koob GF, Schreiber R.
PMID: 34774203
Lancet Psychiatry. 2022 Jan;9(1):84-96. doi: 10.1016/S2215-0366(21)00008-0. Epub 2021 Nov 11.

Understanding the interface between opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) is challenging. By use of a dimensional framework, such as research domain criteria, convergent and targetable neurobiological processes in OUD-PTSD comorbidity can be identified. We hypothesise...

Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation.

Molecular cell

Schreiber A, Collins BC, Davis C, Enchev RI, Sedra A, D'Antuono R, Aebersold R, Peter M.
PMID: 34798055
Mol Cell. 2021 Dec 16;81(24):5066-5081.e10. doi: 10.1016/j.molcel.2021.10.024. Epub 2021 Nov 18.

Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by using de novo double-membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar/lysosomal degradation. The Atg1 kinase is one of its...

White Matter Microstructure Underlies the Effects of Sleep Quality and Life Stress on Depression Symptomatology in Older Adults.

Frontiers in aging neuroscience

Li C, Schreiber J, Bittner N, Li S, Huang R, Moebus S, Bauer A, Caspers S, Elmenhorst D.
PMID: 33281597
Front Aging Neurosci. 2020 Nov 13;12:578037. doi: 10.3389/fnagi.2020.578037. eCollection 2020.

Sleep complaints are the most prevalent syndromes in older adults, particularly in women. Moreover, they are frequently accompanied with a high level of depression and stress. Although several diffusion tensor imaging (DTI) studies reported associations between sleep quality and...

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.

Frontiers in pharmacology

Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Bärenz F, Bender E, Digles D, Dürrenberger F, Heitman LH, IJzerman AP, Kell DB, Kickinger S, Körzö D, Leippe P, Licher T, Manolova V, Rizzetto R, Sassone F, Scarabottolo L, Schlessinger A, Schneider V, Sijben HJ, Steck AL, Sundström H, Tremolada S, Wilhelm M, Wright Muelas M, Zindel D, Steppan CM, Superti-Furga G.
PMID: 34447313
Front Pharmacol. 2021 Aug 10;12:722889. doi: 10.3389/fphar.2021.722889. eCollection 2021.

The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the...

Childhood acute myeloid leukemia shows a high level of germline predisposition.

Blood

Samaraweera SE, Wang PPS, Li KL, Casolari DA, Feng J, Pinese M, Maung KZY, Leo P, Cowley M, Perkins K, Smith AM, Ellis J, Wee A, Hiwase DK, Scott HS, Schreiber AW, Brown AL, Deans AJ, Ross DM, Moore AS, Gonda TJ, Hahn CN, D'Andrea RJ.
PMID: 34521114
Blood. 2021 Dec 02;138(22):2293-2298. doi: 10.1182/blood.2021012666.

No abstract available.

Transient knockout of photosynthesis mediated by electrical signals.

The New phytologist

Koziolek C, Grams TEE, Schreiber U, Matyssek R, Fromm J.
PMID: 33873726
New Phytol. 2004 Mar;161(3):715-722. doi: 10.1111/j.1469-8137.2004.00985.x.

•  In the sensitive species Mimosa pudica electric signals arise when the leaves are stimulated by touching or wounding. Experiments reported here provide information about a photosynthetic response that results from heat-induced electrical signalling in leaves. •  Electric potential...

Step-by-Step Cadaver Dissection and Surgical Technique for Compartmental Tongue and Floor of Mouth Resection.

Frontiers in oncology

Grammatica A, Piazza C, Ferrari M, Verzeletti V, Paderno A, Mattavelli D, Schreiber A, Lombardi D, Fazio E, Gazzini L, Giorgetti G, Buffoli B, Rodella LF, Nicolai P, Calabrese L.
PMID: 33968719
Front Oncol. 2021 Apr 23;11:613945. doi: 10.3389/fonc.2021.613945. eCollection 2021.

BACKGROUND: The aim of oral cancer surgery is tumor removal within clear margins of healthy tissue: the latter definition in the literature, however, may vary between 1 and 2 cm, and should be intended in the three dimensions, which...

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Schreiber M, Ahmad T, Scott M, Imrie K, Razack S.
PMID: 34860696
CMAJ. 2021 Jun 14;193(24):E937-E941. doi: 10.1503/cmaj.202642-f.

No abstract available.

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.

PLoS pathogens

Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.
PMID: 35007292
PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan.

A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator PrfA controls expression of key virulence...

Alemtuzumab treatment in Denmark: A national study based on the Danish Multiple Sclerosis Registry.

Multiple sclerosis (Houndmills, Basingstoke, England)

Theodorsdottir A, Debrabant B, Magyari M, Kant M, Rasmussen PV, Malmberg CF, Norberg IA, Hansen V, Bech D, Schmidt MF, Schreiber K, Frederiksen JL, Sellebjerg F, Illes Z.
PMID: 33779361
Mult Scler. 2021 Dec;27(14):2254-2266. doi: 10.1177/13524585211003291. Epub 2021 Mar 29.

OBJECTIVE: To investigate clinical outcomes in a real-world setting in the complete population-based cohort of alemtuzumab-treated MS patients in Denmark.METHODS: Data were retrieved from The Danish Multiple Sclerosis Registry between 2009 and 2019. Demographic and disease-specific patient parameters related...

Showing 1321 to 1330 of 1330 entries