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Showing 133 to 142 of 142 entries
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Boosting autophagy in the diabetic heart: a translational perspective.

Cardiovascular diagnosis and therapy

Sciarretta S, Boppana VS, Umapathi M, Frati G, Sadoshima J.
PMID: 26543826
Cardiovasc Diagn Ther. 2015 Oct;5(5):394-402. doi: 10.3978/j.issn.2223-3652.2015.07.02.

Diabetes, obesity, and dyslipidemia are main risk factors that promote the development of cardiovascular diseases. These metabolic abnormalities are frequently found to be associated together in a highly morbid clinical condition called metabolic syndrome. Metabolic derangements promote endothelial dysfunction,...

Anisotropy of Co.

Chemical science

Garlatti E, Guidi T, Chiesa A, Ansbro S, Baker ML, Ollivier J, Mutka H, Timco GA, Vitorica-Yrezabal I, Pavarini E, Santini P, Amoretti G, Winpenny REP, Carretta S.
PMID: 29780487
Chem Sci. 2018 Mar 07;9(14):3555-3562. doi: 10.1039/c8sc00163d. eCollection 2018 Apr 14.

The Cr

Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart.

JACC. Basic to translational science

Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J.
PMID: 31768477
JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep.

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and...

An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation.

Cell death & disease

Forte M, Bianchi F, Cotugno M, Marchitti S, Stanzione R, Maglione V, Sciarretta S, Valenti V, Carnevale R, Versaci F, Frati G, Volpe M, Rubattu S.
PMID: 34625529
Cell Death Dis. 2021 Oct 08;12(10):919. doi: 10.1038/s41419-021-04188-4.

The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors vascular dysfunction in knock-out mice, and accelerates cerebrovascular and renal damage in the...

User-Centered Design and Development of the Modular TWIN Lower Limb Exoskeleton.

Frontiers in neurorobotics

Laffranchi M, D'Angella S, Vassallo C, Piezzo C, Canepa M, De Giuseppe S, Di Salvo M, Succi A, Cappa S, Cerruti G, Scarpetta S, Cavallaro L, Boccardo N, D'Angelo M, Marchese C, Saglia JA, Guanziroli E, Barresi G, Semprini M, Traverso S, Maludrottu S, Molteni F, Sacchetti R, Gruppioni E, De Michieli L.
PMID: 34690732
Front Neurorobot. 2021 Oct 07;15:709731. doi: 10.3389/fnbot.2021.709731. eCollection 2021.

For decades, powered exoskeletons have been considered for possible employment in rehabilitation and personal use. Yet, these devices are still far from addressing the needs of users. Here, we introduce TWIN, a novel modular lower limb exoskeleton for personal...

Assessing the Nature of Chiral-Induced Spin Selectivity by Magnetic Resonance.

The journal of physical chemistry letters

Chiesa A, Chizzini M, Garlatti E, Salvadori E, Tacchino F, Santini P, Tavernelli I, Bittl R, Chiesa M, Sessoli R, Carretta S.
PMID: 34228926
J Phys Chem Lett. 2021 Jul 15;12(27):6341-6347. doi: 10.1021/acs.jpclett.1c01447. Epub 2021 Jul 06.

Understanding chiral-induced spin selectivity (CISS), resulting from charge transport through helical systems, has recently inspired many experimental and theoretical efforts but is still the object of intense debate. In order to assess the nature of CISS, we propose to...

Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.

Scientific reports

Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D, Sadoshima J.
PMID: 34873220
Sci Rep. 2021 Dec 06;11(1):23469. doi: 10.1038/s41598-021-02846-3.

The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and, in turn, phosphorylates YAP, causing inactivation of YAP. Lats2 stimulates apoptosis...

No difference in return to amateur sports after medial and lateral unicompartmental knee arthroplasty in patients younger than 65 years.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

D'Ambrosi R, Ursino C, Mariani I, Corona K, Dahmen J, Sciarretta FV, Valli F, Ursino N.
PMID: 33751156
Knee Surg Sports Traumatol Arthrosc. 2021 Mar 09; doi: 10.1007/s00167-021-06526-7. Epub 2021 Mar 09.

PURPOSE: The aim of this study was to assess the return to amateur sports of patients under 65 years, following medial unicompartmental knee arthroplasty (mUKA) versus lateral unicompartmental knee arthroplasty (lUKA). It was hypothesized that patients younger than 65...

Trehalose, a natural disaccharide, reduces stroke occurrence in the stroke-prone spontaneously hypertensive rat.

Pharmacological research

Forte M, Marchitti S, Cotugno M, Di Nonno F, Stanzione R, Bianchi F, Schirone L, Schiavon S, Vecchio D, Sarto G, Scioli M, Raffa S, Tocci G, Relucenti M, Torrisi MR, Valenti V, Versaci F, Vecchione C, Volpe M, Frati G, Rubattu S, Sciarretta S.
PMID: 34500062
Pharmacol Res. 2021 Nov;173:105875. doi: 10.1016/j.phrs.2021.105875. Epub 2021 Sep 07.

Cerebrovascular disease, a frequent complication of hypertension, is a major public health issue for which novel therapeutic and preventive approaches are needed. Autophagy activation is emerging as a potential therapeutic and preventive strategy toward stroke. Among usual activators of...

Photophobia and allodynia in persistent post-traumatic headache are associated with higher disease burden.

Cephalalgia : an international journal of headache

Cortez MM, Millsap L, Rea NA, Sciarretta C, Brennan KC.
PMID: 33910382
Cephalalgia. 2021 Sep;41(10):1089-1099. doi: 10.1177/03331024211010304. Epub 2021 Apr 28.

OBJECTIVE: To assess photophobia and allodynia in subjects with post-traumatic headache and examine how these sensory hypersensitivities associate with clinical measures of disease burden.BACKGROUND: Post-traumatic headache is the most frequent and disabling long-term consequence of mild traumatic brain injury....

Showing 133 to 142 of 142 entries