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Showing 121 to 128 of 128 entries
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The attitudes towards, and beliefs about, physical activity in people with osteoarthritis and comorbidity: A qualitative investigation.

Musculoskeletal care

McKevitt S, Jinks C, Healey EL, Quicke JG.
PMID: 34245657
Musculoskeletal Care. 2021 Jul 10; doi: 10.1002/msc.1579. Epub 2021 Jul 10.

OBJECTIVE: To investigate the attitudes towards, and beliefs about, physical activity (PA) in older adults with osteoarthritis (OA) and comorbidity to understand experiences and seek ways to improve PA participation.METHODS: Semi-structured interviews with adults aged ≥45, with self-reported OA...

Objective biomarkers for clinical relapse in multiple sclerosis: a metabolomics approach.

Brain communications

Yeo T, Probert F, Sealey M, Saldana L, Geraldes R, Höeckner S, Schiffer E, Claridge TDW, Leppert D, DeLuca G, Kuhle J, Palace J, Anthony DC.
PMID: 34755110
Brain Commun. 2021 Oct 12;3(4):fcab240. doi: 10.1093/braincomms/fcab240. eCollection 2021.

Accurate determination of relapses in multiple sclerosis is important for diagnosis, classification of clinical course and therapeutic decision making. The identification of biofluid markers for multiple sclerosis relapses would add to our current diagnostic armamentarium and increase our understanding...

Glasdegib in newly diagnosed acute myeloid leukemia.

Expert review of anticancer therapy

Sarkaria SM, Heaney ML.
PMID: 33593233
Expert Rev Anticancer Ther. 2021 Jun;21(6):573-581. doi: 10.1080/14737140.2021.1891885. Epub 2021 Feb 25.

INTRODUCTION: Acute myeloid leukemia (AML) is an aggressive blood cancer that proves fatal for the majority of affected individuals. Older patients are particularly vulnerable due to more unfavorable disease biology and diminished ability to tolerate intensive induction chemotherapy (ICT)....

Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis.

Brain communications

Probert F, Yeo T, Zhou Y, Sealey M, Arora S, Palace J, Claridge TDW, Hillenbrand R, Oechtering J, Leppert D, Kuhle J, Anthony DC.
PMID: 33997784
Brain Commun. 2021 Apr 19;3(2):fcab084. doi: 10.1093/braincomms/fcab084. eCollection 2021.

Eighty-five percent of multiple sclerosis cases begin with a discrete attack termed clinically isolated syndrome, but 37% of clinically isolated syndrome patients do not experience a relapse within 20 years of onset. Thus, the identification of biomarkers able to...

Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia.

Blood

Warren JT, Cupo RR, Wattanasirakul P, Spencer D, Locke AE, Makaryan V, Bolyard AA, Kelley ML, Kingston NL, Shorter J, Bellanné-Chantelot C, Donadieu J, Dale DC, Link DC.
PMID: 34115842
Blood. 2021 Jun 11; doi: 10.1182/blood.2021010762. Epub 2021 Jun 11.

Severe congenital neutropenia (SCN) is an inborn disorder of granulopoiesis. Approximately one-third of cases do not have a known genetic cause. Exome sequencing of 104 persons with congenital neutropenia identified heterozygous missense variants of CLPB (caseinolytic peptidase B) in...

Comparison of reliability, construct validity and responsiveness of the IPAQ-SF and PASE in adults with osteoarthritis.

Musculoskeletal care

Smith RD, McHugh GA, Quicke JG, Dziedzic KS, Healey EL.
PMID: 33683799
Musculoskeletal Care. 2021 Dec;19(4):473-483. doi: 10.1002/msc.1540. Epub 2021 Mar 08.

BACKGROUND: This study assessed the measurement properties of two commonly used self-report physical activity (PA) measures: the International Physical Activity Questionnaire-Short Form (IPAQ-SF) and the Physical Activity Scale for the elderly (PASE) in adults with osteoarthritis.METHODS: Secondary analysis of...

Comparison of reliability, construct validity and responsiveness of the IPAQ-SF and PASE in adults with osteoarthritis.

Musculoskeletal care

Smith RD, McHugh GA, Quicke JG, Dziedzic KS, Healey EL.
PMID: 33683799
Musculoskeletal Care. 2021 Mar 08; doi: 10.1002/msc.1540. Epub 2021 Mar 08.

BACKGROUND: This study assessed the measurement properties of two commonly used self-report physical activity (PA) measures: the International Physical Activity Questionnaire-Short Form (IPAQ-SF) and the Physical Activity Scale for the elderly (PASE) in adults with osteoarthritis.METHODS: Secondary analysis of...

Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial.

Family practice

Healey EL, Mallen CD, Chew-Graham CA, Nicholls E, Lewis M, Lawton SA, Finney AG, Tan V, Cooper V, Dziedzic KS, Liddle J, Wathall S, Jinks C.
PMID: 34546341
Fam Pract. 2021 Sep 21; doi: 10.1093/fampra/cmab113. Epub 2021 Sep 21.

BACKGROUND: Multimorbidity is increasingly the norm; however, primary care remains focused on single diseases. Osteoarthritis, anxiety, and depression are frequently comorbid with other long-term conditions (LTCs), but rarely prioritized by clinicians.OBJECTIVES: To test the feasibility of a randomized controlled...

Showing 121 to 128 of 128 entries