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Using Drosophila models of neurodegenerative diseases for drug discovery.

Expert opinion on drug discovery

Newman T, Sinadinos C, Johnston A, Sealey M, Mudher A.
PMID: 22647132
Expert Opin Drug Discov. 2011 Feb;6(2):129-40. doi: 10.1517/17460441.2011.549124.

INTRODUCTION: Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease are increasing in prevalence as our aging population increases in size. Despite this, currently there are no disease-modifying drugs available for the treatment of these conditions. Drosophila...

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Newman T, Sinadinos C, Johnston A, et al. Using Drosophila models of neurodegenerative diseases for drug discovery. Expert Opin Drug Discov. 2011;6(2):129-40doi: 10.1517/17460441.2011.549124.
Newman, T., Sinadinos, C., Johnston, A., Sealey, M., & Mudher, A. (2011). Using Drosophila models of neurodegenerative diseases for drug discovery. Expert opinion on drug discovery, 6(2), 129-40. https://doi.org/10.1517/17460441.2011.549124
Newman, Tracey, et al. "Using Drosophila models of neurodegenerative diseases for drug discovery." Expert opinion on drug discovery vol. 6,2 (2011): 129-40. doi: https://doi.org/10.1517/17460441.2011.549124
Newman T, Sinadinos C, Johnston A, Sealey M, Mudher A. Using Drosophila models of neurodegenerative diseases for drug discovery. Expert Opin Drug Discov. 2011 Feb;6(2):129-40. doi: 10.1517/17460441.2011.549124. PMID: 22647132.
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The Case for Examining and Treating the Combined Effects of Parental Drug Use and Interparental Violence on Children in their Homes.

Aggression and violent behavior

Kelley ML, Klostermann K, Doane AN, Mignone T, Lam WK, Fals-Stewart W, Padilla MA.
PMID: 20161505
Aggress Violent Behav. 2010;15(1):76-82. doi: 10.1016/j.avb.2009.09.002.

This review examines what have been, to this point, generally two divergent lines of research: (a) effects of parental drug abuse on children, and (b) effects of children's exposure to interparental violence. A small, but growing body of literature...

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Kelley ML, Klostermann K, Doane AN, et al. The Case for Examining and Treating the Combined Effects of Parental Drug Use and Interparental Violence on Children in their Homes. Aggress Violent Behav. 2010;15(1):76-82doi: 10.1016/j.avb.2009.09.002.
Kelley, M. L., Klostermann, K., Doane, A. N., Mignone, T., Lam, W. K., Fals-Stewart, W., & Padilla, M. A. (2010). The Case for Examining and Treating the Combined Effects of Parental Drug Use and Interparental Violence on Children in their Homes. Aggression and violent behavior, 15(1), 76-82. https://doi.org/10.1016/j.avb.2009.09.002
Kelley, Michelle L, et al. "The Case for Examining and Treating the Combined Effects of Parental Drug Use and Interparental Violence on Children in their Homes." Aggression and violent behavior vol. 15,1 (2010): 76-82. doi: https://doi.org/10.1016/j.avb.2009.09.002
Kelley ML, Klostermann K, Doane AN, Mignone T, Lam WK, Fals-Stewart W, Padilla MA. The Case for Examining and Treating the Combined Effects of Parental Drug Use and Interparental Violence on Children in their Homes. Aggress Violent Behav. 2010;15(1):76-82. doi: 10.1016/j.avb.2009.09.002. PMID: 20161505; PMCID: PMC2796845.
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Contingency contracting with disadvantaged youths: Improving classroom performance.

Journal of applied behavior analysis

Kelley ML, Stokes TF.
PMID: 16795661
J Appl Behav Anal. 1982;15(3):447-54. doi: 10.1901/jaba.1982.15-447.

This study evaluated the effects of a student-teacher contracting procedure on adolescent students' academic productivity. Participants were 13 youths enrolled in a vocational training program for disadvantaged youth and their classroom teacher. During the baseline conditions students were paid...

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Kelley ML, Stokes TF. Contingency contracting with disadvantaged youths: Improving classroom performance. J Appl Behav Anal. 1982;15(3):447-54doi: 10.1901/jaba.1982.15-447.
Kelley, M. L., & Stokes, T. F. (1982). Contingency contracting with disadvantaged youths: Improving classroom performance. Journal of applied behavior analysis, 15(3), 447-54. https://doi.org/10.1901/jaba.1982.15-447
Kelley, M L, and Stokes, T F. "Contingency contracting with disadvantaged youths: Improving classroom performance." Journal of applied behavior analysis vol. 15,3 (1982): 447-54. doi: https://doi.org/10.1901/jaba.1982.15-447
Kelley ML, Stokes TF. Contingency contracting with disadvantaged youths: Improving classroom performance. J Appl Behav Anal. 1982;15(3):447-54. doi: 10.1901/jaba.1982.15-447. PMID: 16795661; PMCID: PMC1308288.
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Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression.

Veterinary and comparative oncology

Mealey KL, Bentjen SA, Gay JM, Hosick HL.
PMID: 19379318
Vet Comp Oncol. 2003 Jun;1(2):67-75. doi: 10.1046/j.1476-5829.2003.00009.x.

Glucocorticoids are often used in veterinary cancer patients because of their anti-inflammatory actions, appetite-stimulating effects, ability to decrease nausea and vomiting associated with some chemotherapy agents, and, in some instances, for their cytotoxic actions on susceptible tumour cells. Veterinary...

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Mealey KL, Bentjen SA, Gay JM, et al. Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression. Vet Comp Oncol. 2003;1(2):67-75doi: 10.1046/j.1476-5829.2003.00009.x.
Mealey, K. L., Bentjen, S. A., Gay, J. M., & Hosick, H. L. (2003). Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression. Veterinary and comparative oncology, 1(2), 67-75. https://doi.org/10.1046/j.1476-5829.2003.00009.x
Mealey, K L, et al. "Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression." Veterinary and comparative oncology vol. 1,2 (2003): 67-75. doi: https://doi.org/10.1046/j.1476-5829.2003.00009.x
Mealey KL, Bentjen SA, Gay JM, Hosick HL. Dexamethasone treatment of a canine, but not human, tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression. Vet Comp Oncol. 2003 Jun;1(2):67-75. doi: 10.1046/j.1476-5829.2003.00009.x. PMID: 19379318.
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OA21 The power to choose: developing community capacity to provide palliative care in four first nations communities in canada.

BMJ supportive & palliative care

Kelley ML, Prince H, Monture L, Maki L, Crow M, Smith J.
PMID: 25960533
BMJ Support Palliat Care. 2015 Apr;5:A7. doi: 10.1136/bmjspcare-2015-000906.21.

BACKGROUND: First Nations people in Canada are ageing with a high burden of chronic, progressive, and life-limiting illness. The majority now die in urban hospitals or long term care homes far away from family and culture. Today, First Nations...

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Kelley ML, Prince H, Monture L, et al. OA21 The power to choose: developing community capacity to provide palliative care in four first nations communities in canada. BMJ Support Palliat Care. 2015;5:A7doi: 10.1136/bmjspcare-2015-000906.21.
Kelley, M. L., Prince, H., Monture, L., Maki, L., Crow, M., & Smith, J. (2015). OA21 The power to choose: developing community capacity to provide palliative care in four first nations communities in canada. BMJ supportive & palliative care, 5A7. https://doi.org/10.1136/bmjspcare-2015-000906.21
Kelley, Mary Lou, et al. "OA21 The power to choose: developing community capacity to provide palliative care in four first nations communities in canada." BMJ supportive & palliative care vol. 5 (2015): A7. doi: https://doi.org/10.1136/bmjspcare-2015-000906.21
Kelley ML, Prince H, Monture L, Maki L, Crow M, Smith J. OA21 The power to choose: developing community capacity to provide palliative care in four first nations communities in canada. BMJ Support Palliat Care. 2015 Apr;5:A7. doi: 10.1136/bmjspcare-2015-000906.21. PMID: 25960533.
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Death in Long-term Care: A Brief Report Examining Factors Associated with Death within 31 Days of Assessment.

Palliative care

Brink P, Kelley ML.
PMID: 25674000
Palliat Care. 2015 Feb 01;9:1-5. doi: 10.4137/PCRT.S20347. eCollection 2015.

INTRODUCTION: The ability to estimate prognosis using administrative data has already been established. Research indicates that residents newly admitted to long-term care are at a higher risk of mortality. Studies have also examined mortality within 90 days or a...

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Brink P, Kelley ML. Death in Long-term Care: A Brief Report Examining Factors Associated with Death within 31 Days of Assessment. Palliat Care. 2015;9:1-5doi: 10.4137/PCRT.S20347.
Brink, P., & Kelley, M. L. (2015). Death in Long-term Care: A Brief Report Examining Factors Associated with Death within 31 Days of Assessment. Palliative care, 91-5. https://doi.org/10.4137/PCRT.S20347
Brink, Peter, and Kelley, Mary Lou. "Death in Long-term Care: A Brief Report Examining Factors Associated with Death within 31 Days of Assessment." Palliative care vol. 9 (2015): 1-5. doi: https://doi.org/10.4137/PCRT.S20347
Brink P, Kelley ML. Death in Long-term Care: A Brief Report Examining Factors Associated with Death within 31 Days of Assessment. Palliat Care. 2015 Feb 01;9:1-5. doi: 10.4137/PCRT.S20347. eCollection 2015. PMID: 25674000; PMCID: PMC4315121.
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Genetic mapping of principal components of canine pelvic morphology.

Canine genetics and epidemiology

Fealey MJ, Li J, Todhunter RJE, Krotscheck U, Hayashi K, McConkey MJ, Boyko AR, Hayward JJ, Todhunter RJ.
PMID: 28352471
Canine Genet Epidemiol. 2017 Mar 24;4:4. doi: 10.1186/s40575-017-0043-7. eCollection 2017.

No abstract available.

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Fealey MJ, Li J, Todhunter RJE, et al. Genetic mapping of principal components of canine pelvic morphology. Canine Genet Epidemiol. 2017;4:4doi: 10.1186/s40575-017-0043-7.
Fealey, M. J., Li, J., Todhunter, R. J. E., Krotscheck, U., Hayashi, K., McConkey, M. J., Boyko, A. R., Hayward, J. J., & Todhunter, R. J. (2017). Genetic mapping of principal components of canine pelvic morphology. Canine genetics and epidemiology, 44. https://doi.org/10.1186/s40575-017-0043-7
Fealey, Mark J, et al. "Genetic mapping of principal components of canine pelvic morphology." Canine genetics and epidemiology vol. 4 (2017): 4. doi: https://doi.org/10.1186/s40575-017-0043-7
Fealey MJ, Li J, Todhunter RJE, Krotscheck U, Hayashi K, McConkey MJ, Boyko AR, Hayward JJ, Todhunter RJ. Genetic mapping of principal components of canine pelvic morphology. Canine Genet Epidemiol. 2017 Mar 24;4:4. doi: 10.1186/s40575-017-0043-7. eCollection 2017. PMID: 28352471; PMCID: PMC5364603.
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Evaluation of healing at molar extraction sites with ridge preservation using a non-resorbable dense polytetrafluoroethylene membrane: A four-arm cohort prospective study.

Clinical and experimental dental research

Al Hugail AM, Mealey BL, Walker C, Al Harthi S, Duong M, Noujeim M, Lasho DJ, Prihoda TJ, Huynh-Ba G.
PMID: 34096195
Clin Exp Dent Res. 2021 Dec;7(6):1103-1111. doi: 10.1002/cre2.459. Epub 2021 Jun 06.

OBJECTIVES: To examine ridge dimensional changes and histologic parameters of healing when ridge preservation (RP) was performed at molar sites using dense polytetrafluoroethylene (dPTFE) membrane alone, without a bone graft.MATERIAL AND METHODS: Eighteen patients had molar extraction and RP...

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Al Hugail AM, Mealey BL, Walker C, et al. Evaluation of healing at molar extraction sites with ridge preservation using a non-resorbable dense polytetrafluoroethylene membrane: A four-arm cohort prospective study. Clin Exp Dent Res. 2021;7(6):1103-1111doi: 10.1002/cre2.459.
Al Hugail, A. M., Mealey, B. L., Walker, C., Al Harthi, S., Duong, M., Noujeim, M., Lasho, D. J., Prihoda, T. J., & Huynh-Ba, G. (2021). Evaluation of healing at molar extraction sites with ridge preservation using a non-resorbable dense polytetrafluoroethylene membrane: A four-arm cohort prospective study. Clinical and experimental dental research, 7(6), 1103-1111. https://doi.org/10.1002/cre2.459
Al Hugail, Arwa M, et al. "Evaluation of healing at molar extraction sites with ridge preservation using a non-resorbable dense polytetrafluoroethylene membrane: A four-arm cohort prospective study." Clinical and experimental dental research vol. 7,6 (2021): 1103-1111. doi: https://doi.org/10.1002/cre2.459
Al Hugail AM, Mealey BL, Walker C, Al Harthi S, Duong M, Noujeim M, Lasho DJ, Prihoda TJ, Huynh-Ba G. Evaluation of healing at molar extraction sites with ridge preservation using a non-resorbable dense polytetrafluoroethylene membrane: A four-arm cohort prospective study. Clin Exp Dent Res. 2021 Dec;7(6):1103-1111. doi: 10.1002/cre2.459. Epub 2021 Jun 06. PMID: 34096195; PMCID: PMC8638281.
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Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats.

Alcohol (Fayetteville, N.Y.)

Healey KL, Kibble SA, Bell A, Kramer G, Maldonado-Devincci A, Swartzwelder HS.
PMID: 34808302
Alcohol. 2022 Feb;98:43-50. doi: 10.1016/j.alcohol.2021.11.002. Epub 2021 Nov 19.

Adolescent intermittent ethanol (AIE) exposure in rodents has been shown to alter adult behavior in several domains, including learning and memory, social interaction, affective behavior, and ethanol self-administration. AIE has also been shown to produce non-specific behavioral changes that...

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Healey KL, Kibble SA, Bell A, et al. Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats. Alcohol. 2021;98:43-50doi: 10.1016/j.alcohol.2021.11.002.
Healey, K. L., Kibble, S. A., Bell, A., Kramer, G., Maldonado-Devincci, A., & Swartzwelder, H. S. (2022). Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats. Alcohol (Fayetteville, N.Y.), 9843-50. https://doi.org/10.1016/j.alcohol.2021.11.002
Healey, Kati L, et al. "Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats." Alcohol (Fayetteville, N.Y.) vol. 98 (2022): 43-50. doi: https://doi.org/10.1016/j.alcohol.2021.11.002
Healey KL, Kibble SA, Bell A, Kramer G, Maldonado-Devincci A, Swartzwelder HS. Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats. Alcohol. 2022 Feb;98:43-50. doi: 10.1016/j.alcohol.2021.11.002. Epub 2021 Nov 19. PMID: 34808302.
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Rationale and Design of a Remote Web-Based Daily Diary Study Examining Sexual Minority Stress, Relationship Factors, and Alcohol Use in Same-Sex Female Couples Across the United States: Study Protocol of Project Relate.

JMIR research protocols

Heron KE, Lewis RJ, Shappie AT, Dawson CA, Amerson R, Braitman AL, Winstead BA, Kelley ML.
PMID: 30714946
JMIR Res Protoc. 2019 Feb 04;8(2):e11718. doi: 10.2196/11718.

BACKGROUND: The Healthy People 2020 initiative aims to reduce health disparities, including alcohol use, among sexual minority women (SMW; eg, lesbian, bisexual, queer, and pansexual). Compared with heterosexual women, SMW engage in more hazardous drinking and report more alcohol-related...

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Heron KE, Lewis RJ, Shappie AT, et al. Rationale and Design of a Remote Web-Based Daily Diary Study Examining Sexual Minority Stress, Relationship Factors, and Alcohol Use in Same-Sex Female Couples Across the United States: Study Protocol of Project Relate. JMIR Res Protoc. 2019;8(2):e11718doi: 10.2196/11718.
Heron, K. E., Lewis, R. J., Shappie, A. T., Dawson, C. A., Amerson, R., Braitman, A. L., Winstead, B. A., & Kelley, M. L. (2019). Rationale and Design of a Remote Web-Based Daily Diary Study Examining Sexual Minority Stress, Relationship Factors, and Alcohol Use in Same-Sex Female Couples Across the United States: Study Protocol of Project Relate. JMIR research protocols, 8(2), e11718. https://doi.org/10.2196/11718
Heron, Kristin E, et al. "Rationale and Design of a Remote Web-Based Daily Diary Study Examining Sexual Minority Stress, Relationship Factors, and Alcohol Use in Same-Sex Female Couples Across the United States: Study Protocol of Project Relate." JMIR research protocols vol. 8,2 (2019): e11718. doi: https://doi.org/10.2196/11718
Heron KE, Lewis RJ, Shappie AT, Dawson CA, Amerson R, Braitman AL, Winstead BA, Kelley ML. Rationale and Design of a Remote Web-Based Daily Diary Study Examining Sexual Minority Stress, Relationship Factors, and Alcohol Use in Same-Sex Female Couples Across the United States: Study Protocol of Project Relate. JMIR Res Protoc. 2019 Feb 04;8(2):e11718. doi: 10.2196/11718. PMID: 30714946; PMCID: PMC6378553.
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Prevalence of Mental Health Problems and Willingness to Participate in a Mindfulness Treatment: An Examination among Veterans Injured in Combat.

Mindfulness

Bravo AJ, Witkiewitz K, Kelley ML, Redman JC.
PMID: 31131067
Mindfulness (N Y). 2019 May;10(5):953-963. doi: 10.1007/s12671-018-1047-4. Epub 2018 Nov 10.

Numerous studies have demonstrated that combat-exposed military veterans are at risk for numerous psychiatric disorders and rates of comorbid mental health and substance use disorders are high. Veterans wounded in combat are a particularly high-risk group of military veterans,...

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Bravo AJ, Witkiewitz K, Kelley ML, et al. Prevalence of Mental Health Problems and Willingness to Participate in a Mindfulness Treatment: An Examination among Veterans Injured in Combat. Mindfulness (N Y). 2018;10(5):953-963doi: 10.1007/s12671-018-1047-4.
Bravo, A. J., Witkiewitz, K., Kelley, M. L., & Redman, J. C. (2019). Prevalence of Mental Health Problems and Willingness to Participate in a Mindfulness Treatment: An Examination among Veterans Injured in Combat. Mindfulness, 10(5), 953-963. https://doi.org/10.1007/s12671-018-1047-4
Bravo, Adrian J, et al. "Prevalence of Mental Health Problems and Willingness to Participate in a Mindfulness Treatment: An Examination among Veterans Injured in Combat." Mindfulness vol. 10,5 (2019): 953-963. doi: https://doi.org/10.1007/s12671-018-1047-4
Bravo AJ, Witkiewitz K, Kelley ML, Redman JC. Prevalence of Mental Health Problems and Willingness to Participate in a Mindfulness Treatment: An Examination among Veterans Injured in Combat. Mindfulness (N Y). 2019 May;10(5):953-963. doi: 10.1007/s12671-018-1047-4. Epub 2018 Nov 10. PMID: 31131067; PMCID: PMC6532979.
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Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial.

Nature medicine

Gotlib J, Reiter A, Radia DH, Deininger MW, George TI, Panse J, Vannucchi AM, Platzbecker U, Alvarez-Twose I, Mital A, Hermine O, Dybedal I, Hexner EO, Hicks LK, Span L, Mesa R, Bose P, Pettit KM, Heaney ML, Oh ST, Sen J, Lin HM, Mar BG, DeAngelo DJ.
PMID: 34873345
Nat Med. 2021 Dec;27(12):2192-2199. doi: 10.1038/s41591-021-01539-8. Epub 2021 Dec 06.

Advanced systemic mastocytosis (AdvSM) is a rare, KIT D816V-driven hematologic neoplasm characterized by mast cell infiltration and shortened survival. We report the results of a prespecified interim analysis of an ongoing pivotal single-arm phase 2 trial (no. NCT03580655 )...

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Gotlib J, Reiter A, Radia DH, et al. Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nat Med. 2021;27(12):2192-2199doi: 10.1038/s41591-021-01539-8.
Gotlib, J., Reiter, A., Radia, D. H., Deininger, M. W., George, T. I., Panse, J., Vannucchi, A. M., Platzbecker, U., Alvarez-Twose, I., Mital, A., Hermine, O., Dybedal, I., Hexner, E. O., Hicks, L. K., Span, L., Mesa, R., Bose, P., Pettit, K. M., Heaney, M. L., Oh, S. T., Sen, J., Lin, H. M., Mar, B. G., & DeAngelo, D. J. (2021). Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nature medicine, 27(12), 2192-2199. https://doi.org/10.1038/s41591-021-01539-8
Gotlib, Jason, et al. "Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial." Nature medicine vol. 27,12 (2021): 2192-2199. doi: https://doi.org/10.1038/s41591-021-01539-8
Gotlib J, Reiter A, Radia DH, Deininger MW, George TI, Panse J, Vannucchi AM, Platzbecker U, Alvarez-Twose I, Mital A, Hermine O, Dybedal I, Hexner EO, Hicks LK, Span L, Mesa R, Bose P, Pettit KM, Heaney ML, Oh ST, Sen J, Lin HM, Mar BG, DeAngelo DJ. Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nat Med. 2021 Dec;27(12):2192-2199. doi: 10.1038/s41591-021-01539-8. Epub 2021 Dec 06. PMID: 34873345.
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Showing 25 to 36 of 128 entries