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Showing 13 to 24 of 55 entries
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Treating obesity like a tumor.

Cell metabolism

Seeley RJ.
PMID: 22225867
Cell Metab. 2012 Jan 04;15(1):1-2. doi: 10.1016/j.cmet.2011.12.007.

Expanding adipose tissue in obesity requires a great deal of angiogenesis to support increasing volumes of tissue. A growing body of evidence indicates that inhibiting these blood vessels can result in substantial weight loss, and now this has been...

Ghrelin.

Molecular metabolism

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.
PMID: 26042199
Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun.

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy...

Computer mouse movement patterns: A potential marker of mild cognitive impairment.

Alzheimer's & dementia (Amsterdam, Netherlands)

Seelye A, Hagler S, Mattek N, Howieson DB, Wild K, Dodge HH, Kaye JA.
PMID: 26878035
Alzheimers Dement (Amst). 2015 Dec 01;1(4):472-480. doi: 10.1016/j.dadm.2015.09.006. Epub 2015 Oct 19.

INTRODUCTION: Subtle changes in cognitively demanding activities occur in MCI but are difficult to assess with conventional methods. In an exploratory study, we examined whether patterns of computer mouse movements obtained from routine home computer use discriminated between older...

CNS GNPDA2 Does Not Control Appetite, but Regulates Glucose Homeostasis.

Frontiers in nutrition

Gutierrez-Aguilar R, Grayson BE, Kim DH, Yalamanchili S, Calcagno ML, Woods SC, Seeley RJ.
PMID: 34912841
Front Nutr. 2021 Nov 29;8:787470. doi: 10.3389/fnut.2021.787470. eCollection 2021.

No abstract available.

Vascular reactivity contributes to adipose tissue remodeling in obesity.

The Journal of endocrinology

Lee HJ, Shi H, Brönneke HS, Jin BY, Choi SH, Seeley RJ, Kim DH.
PMID: 34612845
J Endocrinol. 2021 Nov 08;251(3):195-206. doi: 10.1530/JOE-21-0187.

Vascular reactivity of adipose tissue (AT) is hypothesized to play an important role in the development of obesity. However, the exact role of vascular reactivity in the development of obesity remains unclear. In this study, we investigated the chronological...

Hospital-specific Template Matching for Benchmarking Performance in a Diverse Multihospital System.

Medical care

Vincent BM, Molling D, Escobar GJ, Hofer TP, Iwashyna TJ, Liu VX, Rosen AK, Ryan AM, Seelye S, Wiitala WL, Prescott HC.
PMID: 34629424
Med Care. 2021 Dec 01;59(12):1090-1098. doi: 10.1097/MLR.0000000000001645.

BACKGROUND: Hospital-specific template matching is a newer method of hospital performance measurement that may be fairer than regression-based benchmarking. However, it has been tested in only limited research settings.OBJECTIVE: The objective of this study was to test the feasibility...

High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.

Nature communications

Dreyfuss JM, Yuchi Y, Dong X, Efthymiou V, Pan H, Simonson DC, Vernon A, Halperin F, Aryal P, Konkar A, Sebastian Y, Higgs BW, Grimsby J, Rondinone CM, Kasif S, Kahn BB, Foster K, Seeley R, Goldfine A, Djordjilović V, Patti ME.
PMID: 34845204
Nat Commun. 2021 Nov 29;12(1):6951. doi: 10.1038/s41467-021-27289-2.

To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of mediation and applies empirical Bayesian linear modeling. We apply Hitman in a retrospective, exploratory analysis of the SLIMM-T2D...

Modifying Carbohydrate Supply to Fruit during Development Changes the Composition and Flavour of .

Plants (Basel, Switzerland)

Lievre DL, Anderson R, Boldingh H, Cooney J, Seelye R, Gould N, Hunter D, Jensen D, Pereira T, Wohlers M, Clearwater M, Richardson A.
PMID: 34209861
Plants (Basel). 2021 Jun 29;10(7). doi: 10.3390/plants10071328.

Consumer acceptance of fruit is determined by size, flavour and ripeness. In this study we investigated how altering the carbohydrate supply to

Dietary induction and reversal of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice.

The Journal of nutritional biochemistry

Geißler C, Krause C, Neumann AM, Britsemmer JH, Taege N, Grohs M, Keahler M, Cascorbi I, Lewis AG, Seeley RJ, Oster H, Kirchner H.
PMID: 34801693
J Nutr Biochem. 2021 Nov 18;108907. doi: 10.1016/j.jnutbio.2021.108907. Epub 2021 Nov 18.

BACKGROUND: DNA methylation is dynamically regulated in metabolic diseases, but it remains unclear whether the changes are causal or consequential. Therefore, we used a longitudinal approach to refine the onset of metabolic and DNA methylation changes at high temporal...

Variation in US Hospital Practices for Bronchoscopy in the ICU.

Annals of the American Thoracic Society

Wayne MT, Seelye S, Molling D, Hogan CK, Valley TS, Arenberg DA, De Cardenas J, Prescott HC.
PMID: 34847332
Ann Am Thorac Soc. 2021 Nov 30; doi: 10.1513/AnnalsATS.202110-1141RL. Epub 2021 Nov 30.

No abstract available.

Assessing changes to N95 respirator filtration efficiency, qualitative and quantitative fit, and seal check with repeated vaporized hydrogen peroxide (VHP) decontamination.

American journal of infection control

Yen CF, Seeley R, Gordon P, Parameswaran L, Wright SB, Pepe DE, Mehrotra P.
PMID: 35000800
Am J Infect Control. 2021 Dec 07; doi: 10.1016/j.ajic.2021.11.005. Epub 2021 Dec 07.

N95 respirators were reprocessed using vaporized hydrogen peroxide to supplement limited supplies during the COVID-19 pandemic. In this study, we found no statistically significant differences in qualitative and quantitative fit or filtration efficiency with reprocessing. Filtration efficiency remained above...

Dietary induction of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice.

The Journal of nutritional biochemistry

Geißler C, Krause C, Neumann AM, Britsemmer JH, Taege N, Grohs M, Kaehler M, Cascorbi I, Lewis AG, Seeley RJ, Oster H, Kirchner H.
PMID: 34801693
J Nutr Biochem. 2021 Nov 18;100:108907. doi: 10.1016/j.jnutbio.2021.108907. Epub 2021 Nov 18.

DNA methylation is dynamically regulated in metabolic diseases, but it remains unclear whether the changes are causal or consequential. Therefore, we used a longitudinal approach to refine the onset of metabolic and DNA methylation changes at high temporal resolution....

Showing 13 to 24 of 55 entries