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Showing 121 to 124 of 124 entries
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Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant .

JCO precision oncology

Keshinro A, Vanderbilt C, Kim JK, Firat C, Chen CT, Yaeger R, Ganesh K, Segal NH, Gonen M, Shia J, Stadler Z, Weiser MR.
PMID: 34250404
JCO Precis Oncol. 2021 May 12;5. doi: 10.1200/PO.20.00456. eCollection 2021.

To characterize the relationship between tumor-infiltrating lymphocytes (TIL), tumor mutational burden (TMB), and genetic alterations in microsatellite stable (MSS), microsatellite instability (MSI), or mutant POLE/POLD1 colon cancer.MATERIALS AND METHODS: Four hundred ninety-nine resected stage I-III colon tumors treated between...

Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells.

Human molecular genetics

Adhikari A, Copping NA, Beegle J, Cameron DL, Deng P, O'Geen H, Segal DJ, Fink KD, Silverman JL, Anderson JS.
PMID: 33856035
Hum Mol Genet. 2021 Jun 09;30(12):1067-1083. doi: 10.1093/hmg/ddab104.

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by impaired communication skills, ataxia, motor and balance deficits, intellectual disabilities, and seizures. The genetic cause of AS is the neuronal loss of UBE3A expression in the brain. A novel...

Association Between Cervical Artery Dissection and Aortic Dissection.

Circulation

Witsch J, Mir SA, Parikh NS, Murthy SB, Kamel H, Navi BB, Segal AZ, Fink ME, Rutrick SB, Safford MM, Narula N, Goyal P, Gaudino M, Girardi LN, Devereux RB, Roman MJ, Zhang C, Merkler AE.
PMID: 34491775
Circulation. 2021 Sep 07;144(10):840-842. doi: 10.1161/CIRCULATIONAHA.121.055274. Epub 2021 Sep 07.

No abstract available.

Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Latham A, Shia J, Patel Z, Reidy-Lagunes DL, Segal NH, Yaeger R, Ganesh K, Connell L, Kemeny NE, Kelsen DP, Hechtman JF, Nash GM, Paty PB, Zehir A, Tkachuk KA, Sheikh R, Markowitz AJ, Mandelker D, Offit K, Berger MF, Cercek A, Garcia-Aguilar J, Saltz LB, Weiser MR, Stadler ZK.
PMID: 33199489
Clin Cancer Res. 2021 Mar 01;27(5):1429-1437. doi: 10.1158/1078-0432.CCR-20-2892. Epub 2020 Nov 16.

PURPOSE: The prevalence and clinical characteristics of small bowel adenocarcinomas (SBA) in the setting of Lynch syndrome have not been well studied. We characterized SBA according to DNA mismatch repair and/or microsatellite instability (MMR/MSI) and germline mutation status and...

Showing 121 to 124 of 124 entries