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Showing 13 to 24 of 211 entries
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Framing the future of food: The contested promises of alternative proteins.

Environment and planning. E, Nature and space

Sexton AE, Garnett T, Lorimer J.
PMID: 32039343
Environ Plan E Nat Space. 2019 Mar;2(1):47-72. doi: 10.1177/2514848619827009. Epub 2019 Feb 06.

This paper offers a critical examination of the narrative landscape that has emerged with a new movement of alternative proteins intended as substitutes for conventional meat, milk and other animal-based food products. The alternative protein approaches analysed include edible...

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Sexton AE, Garnett T, Lorimer J. Framing the future of food: The contested promises of alternative proteins. Environ Plan E Nat Space. 2019;2(1):47-72doi: 10.1177/2514848619827009.
Sexton, A. E., Garnett, T., & Lorimer, J. (2019). Framing the future of food: The contested promises of alternative proteins. Environment and planning. E, Nature and space, 2(1), 47-72. https://doi.org/10.1177/2514848619827009
Sexton, Alexandra E, et al. "Framing the future of food: The contested promises of alternative proteins." Environment and planning. E, Nature and space vol. 2,1 (2019): 47-72. doi: https://doi.org/10.1177/2514848619827009
Sexton AE, Garnett T, Lorimer J. Framing the future of food: The contested promises of alternative proteins. Environ Plan E Nat Space. 2019 Mar;2(1):47-72. doi: 10.1177/2514848619827009. Epub 2019 Feb 06. PMID: 32039343; PMCID: PMC6989034.
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Successful kidney transplantation normalizes platelet function.

Clinical kidney journal

Kennedy C, Wong L, Sexton DJ, Cowman J, Oglesby I, Kenny M, Conlon PJ, Kenny D.
PMID: 30087773
Clin Kidney J. 2018 Aug;11(4):574-580. doi: 10.1093/ckj/sfx148. Epub 2018 Jan 17.

BACKGROUND: Uraemic platelet dysfunction is not completely understood, in part due to non-physiological platelet function assays. We have developed a physiological flow-based assay that quantifies platelet function in microlitre volumes of blood under arterial shear. The aim of this...

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Kennedy C, Wong L, Sexton DJ, et al. Successful kidney transplantation normalizes platelet function. Clin Kidney J. 2018;11(4):574-580doi: 10.1093/ckj/sfx148.
Kennedy, C., Wong, L., Sexton, D. J., Cowman, J., Oglesby, I., Kenny, M., Conlon, P. J., & Kenny, D. (2018). Successful kidney transplantation normalizes platelet function. Clinical kidney journal, 11(4), 574-580. https://doi.org/10.1093/ckj/sfx148
Kennedy, Claire, et al. "Successful kidney transplantation normalizes platelet function." Clinical kidney journal vol. 11,4 (2018): 574-580. doi: https://doi.org/10.1093/ckj/sfx148
Kennedy C, Wong L, Sexton DJ, Cowman J, Oglesby I, Kenny M, Conlon PJ, Kenny D. Successful kidney transplantation normalizes platelet function. Clin Kidney J. 2018 Aug;11(4):574-580. doi: 10.1093/ckj/sfx148. Epub 2018 Jan 17. PMID: 30087773; PMCID: PMC6070122.
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Coinfection of .

Case reports in infectious diseases

Awari DW, Shah AS, Sexton AM, Sexton MA.
PMID: 32774953
Case Rep Infect Dis. 2020 Jul 24;2020:8888270. doi: 10.1155/2020/8888270. eCollection 2020.

Management of infections in the immunocompromised patient requires unique considerations that are not typically seen in the immunocompetent. Immunocompromised hosts require a broad set of differential diagnoses when presenting with febrile illness involving a wide variety of microbiology. Moreover,...

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Awari DW, Shah AS, Sexton AM, et al. Coinfection of . Case Rep Infect Dis. 2020;2020:8888270doi: 10.1155/2020/8888270.
Awari, D. W., Shah, A. S., Sexton, A. M., & Sexton, M. A. (2020). Coinfection of . Case reports in infectious diseases, 20208888270. https://doi.org/10.1155/2020/8888270
Awari, Daniel W, et al. "Coinfection of ." Case reports in infectious diseases vol. 2020 (2020): 8888270. doi: https://doi.org/10.1155/2020/8888270
Awari DW, Shah AS, Sexton AM, Sexton MA. Coinfection of . Case Rep Infect Dis. 2020 Jul 24;2020:8888270. doi: 10.1155/2020/8888270. eCollection 2020. PMID: 32774953; PMCID: PMC7396101.
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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.

Frontiers in pharmacology

van der Westhuizen ET, Choy KHC, Valant C, McKenzie-Nickson S, Bradley SJ, Tobin AB, Sexton PM, Christopoulos A.
PMID: 33584282
Front Pharmacol. 2021 Jan 29;11:606656. doi: 10.3389/fphar.2020.606656. eCollection 2020.

The M

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van der Westhuizen ET, Choy KHC, Valant C, et al. Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Front Pharmacol. 2021;11:606656doi: 10.3389/fphar.2020.606656.
van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2020). Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Frontiers in pharmacology, 11606656. https://doi.org/10.3389/fphar.2020.606656
van der Westhuizen, Emma T, et al. "Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias." Frontiers in pharmacology vol. 11 (2020): 606656. doi: https://doi.org/10.3389/fphar.2020.606656
van der Westhuizen ET, Choy KHC, Valant C, McKenzie-Nickson S, Bradley SJ, Tobin AB, Sexton PM, Christopoulos A. Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Front Pharmacol. 2021 Jan 29;11:606656. doi: 10.3389/fphar.2020.606656. eCollection 2020. PMID: 33584282; PMCID: PMC7878563.
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Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection.

Open forum infectious diseases

Kanamori H, Rutala WA, Gergen MF, Sickbert-Bennett EE, Knelson LP, Anderson DJ, Sexton DJ, Weber DJ.
PMID: 33575427
Open Forum Infect Dis. 2021 Jan 04;8(2):ofab008. doi: 10.1093/ofid/ofab008. eCollection 2021 Feb.

We examined the microbial burden on hospital room environmental sites after standard (quaternary ammonium [Quat]) or enhanced disinfection (quat/ultraviolet light [UV-C], bleach, or bleach/UV-C). An enhanced terminal room disinfection reduced the microbial burden of epidemiologically important pathogens on high-touch...

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Kanamori H, Rutala WA, Gergen MF, et al. Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection. Open Forum Infect Dis. 2021;8(2):ofab008doi: 10.1093/ofid/ofab008.
Kanamori, H., Rutala, W. A., Gergen, M. F., Sickbert-Bennett, E. E., Knelson, L. P., Anderson, D. J., Sexton, D. J., & Weber, D. J. (2021). Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection. Open forum infectious diseases, 8(2), ofab008. https://doi.org/10.1093/ofid/ofab008
Kanamori, Hajime, et al. "Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection." Open forum infectious diseases vol. 8,2 (2021): ofab008. doi: https://doi.org/10.1093/ofid/ofab008
Kanamori H, Rutala WA, Gergen MF, Sickbert-Bennett EE, Knelson LP, Anderson DJ, Sexton DJ, Weber DJ. Microbial Assessment of Health Care-Associated Pathogens on Various Environmental Sites in Patient Rooms After Terminal Room Disinfection. Open Forum Infect Dis. 2021 Jan 04;8(2):ofab008. doi: 10.1093/ofid/ofab008. eCollection 2021 Feb. PMID: 33575427; PMCID: PMC7863860.
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A rare case of chronic otitis externa due to .

Journal of clinical tuberculosis and other mycobacterial diseases

DeSimone DC, Heaton PR, Neff BA, Dao LN, Wengenack NL, Fadel HJ.
PMID: 31723705
J Clin Tuberc Other Mycobact Dis. 2017 May 16;8:13-15. doi: 10.1016/j.jctube.2017.05.001. eCollection 2017 Aug.

Chronic otitis externa due to

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DeSimone DC, Heaton PR, Neff BA, et al. A rare case of chronic otitis externa due to . J Clin Tuberc Other Mycobact Dis. 2017;8:13-15doi: 10.1016/j.jctube.2017.05.001.
DeSimone, D. C., Heaton, P. R., Neff, B. A., Dao, L. N., Wengenack, N. L., & Fadel, H. J. (2017). A rare case of chronic otitis externa due to . Journal of clinical tuberculosis and other mycobacterial diseases, 813-15. https://doi.org/10.1016/j.jctube.2017.05.001
DeSimone, Daniel C, et al. "A rare case of chronic otitis externa due to ." Journal of clinical tuberculosis and other mycobacterial diseases vol. 8 (2017): 13-15. doi: https://doi.org/10.1016/j.jctube.2017.05.001
DeSimone DC, Heaton PR, Neff BA, Dao LN, Wengenack NL, Fadel HJ. A rare case of chronic otitis externa due to . J Clin Tuberc Other Mycobact Dis. 2017 May 16;8:13-15. doi: 10.1016/j.jctube.2017.05.001. eCollection 2017 Aug. PMID: 31723705; PMCID: PMC6850261.
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The essential but enigmatic regulatory role of HERVH in pluripotency.

Trends in genetics : TIG

Sexton CE, Tillett RL, Han MV.
PMID: 34340871
Trends Genet. 2021 Jul 30; doi: 10.1016/j.tig.2021.07.007. Epub 2021 Jul 30.

Human specific endogenous retrovirus H (HERVH) is highly expressed in both naive and primed stem cells and is essential for pluripotency. Despite the proven relationship between HERVH expression and pluripotency, there is no single definitive model for the function...

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Sexton CE, Tillett RL, Han MV. The essential but enigmatic regulatory role of HERVH in pluripotency. Trends Genet. 2021;doi: 10.1016/j.tig.2021.07.007.
Sexton, C. E., Tillett, R. L., & Han, M. V. (2021). The essential but enigmatic regulatory role of HERVH in pluripotency. Trends in genetics : TIG, . https://doi.org/10.1016/j.tig.2021.07.007
Sexton, Corinne E, et al. "The essential but enigmatic regulatory role of HERVH in pluripotency." Trends in genetics : TIG vol. (2021). doi: https://doi.org/10.1016/j.tig.2021.07.007
Sexton CE, Tillett RL, Han MV. The essential but enigmatic regulatory role of HERVH in pluripotency. Trends Genet. 2021 Jul 30; doi: 10.1016/j.tig.2021.07.007. Epub 2021 Jul 30. PMID: 34340871.
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Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation.

Frontiers in microbiology

Beskrovnaya P, Sexton DL, Golmohammadzadeh M, Hashimi A, Tocheva EI.
PMID: 33767680
Front Microbiol. 2021 Mar 09;12:630573. doi: 10.3389/fmicb.2021.630573. eCollection 2021.

Sporulation is a specialized developmental program employed by a diverse set of bacteria which culminates in the formation of dormant cells displaying increased resilience to stressors. This represents a major survival strategy for bacteria facing harsh environmental conditions, including...

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Beskrovnaya P, Sexton DL, Golmohammadzadeh M, et al. Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation. Front Microbiol. 2021;12:630573doi: 10.3389/fmicb.2021.630573.
Beskrovnaya, P., Sexton, D. L., Golmohammadzadeh, M., Hashimi, A., & Tocheva, E. I. (2021). Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation. Frontiers in microbiology, 12630573. https://doi.org/10.3389/fmicb.2021.630573
Beskrovnaya, Polina, et al. "Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation." Frontiers in microbiology vol. 12 (2021): 630573. doi: https://doi.org/10.3389/fmicb.2021.630573
Beskrovnaya P, Sexton DL, Golmohammadzadeh M, Hashimi A, Tocheva EI. Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation. Front Microbiol. 2021 Mar 09;12:630573. doi: 10.3389/fmicb.2021.630573. eCollection 2021. PMID: 33767680; PMCID: PMC7985256.
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Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA.

Genome research

Vaisvila R, Ponnaluri VKC, Sun Z, Langhorst BW, Saleh L, Guan S, Dai N, Campbell MA, Sexton BS, Marks K, Samaranayake M, Samuelson JC, Church HE, Tamanaha E, Corrêa IR, Pradhan S, Dimalanta ET, Evans TC, Williams L, Davis TB.
PMID: 34140313
Genome Res. 2021 Jun 17; doi: 10.1101/gr.266551.120. Epub 2021 Jun 17.

Bisulfite sequencing detects 5mC and 5hmC at single-base resolution. However, bisulfite treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing data. To overcome these problems, enzymatic methyl-seq (EM-seq) was developed. This method detects 5mC and 5hmC...

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Vaisvila R, Ponnaluri VKC, Sun Z, et al. Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA. Genome Res. 2021;doi: 10.1101/gr.266551.120.
Vaisvila, R., Ponnaluri, V. K. C., Sun, Z., Langhorst, B. W., Saleh, L., Guan, S., Dai, N., Campbell, M. A., Sexton, B. S., Marks, K., Samaranayake, M., Samuelson, J. C., Church, H. E., Tamanaha, E., Corrêa, I. R., Pradhan, S., Dimalanta, E. T., Evans, T. C., Williams, L., & Davis, T. B. (2021). Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA. Genome research, . https://doi.org/10.1101/gr.266551.120
Vaisvila, Romualdas, et al. "Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA." Genome research vol. (2021). doi: https://doi.org/10.1101/gr.266551.120
Vaisvila R, Ponnaluri VKC, Sun Z, Langhorst BW, Saleh L, Guan S, Dai N, Campbell MA, Sexton BS, Marks K, Samaranayake M, Samuelson JC, Church HE, Tamanaha E, Corrêa IR, Pradhan S, Dimalanta ET, Evans TC, Williams L, Davis TB. Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA. Genome Res. 2021 Jun 17; doi: 10.1101/gr.266551.120. Epub 2021 Jun 17. PMID: 34140313; PMCID: PMC8256858.
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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

Cell

Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB.
PMID: 34822784
Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001.

Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative approach is to directly activate cholinergic receptors responsible for...

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Brown AJH, Bradley SJ, Marshall FH, et al. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. 2021;184(24):5886-5901.e22doi: 10.1016/j.cell.2021.11.001.
Brown, A. J. H., Bradley, S. J., Marshall, F. H., Brown, G. A., Bennett, K. A., Brown, J., Cansfield, J. E., Cross, D. M., de Graaf, C., Hudson, B. D., Dwomoh, L., Dias, J. M., Errey, J. C., Hurrell, E., Liptrot, J., Mattedi, G., Molloy, C., Nathan, P. J., Okrasa, K., Osborne, G., Patel, J. C., Pickworth, M., Robertson, N., Shahabi, S., Bundgaard, C., Phillips, K., Broad, L. M., Goonawardena, A. V., Morairty, S. R., Browning, M., Perini, F., Dawson, G. R., Deakin, J. F. W., Smith, R. T., Sexton, P. M., Warneck, J., Vinson, M., Tasker, T., Tehan, B. G., Teobald, B., Christopoulos, A., Langmead, C. J., Jazayeri, A., Cooke, R. M., Rucktooa, P., Congreve, M. S., Weir, M., & Tobin, A. B. (2021). From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell, 184(24), 5886-5901.e22. https://doi.org/10.1016/j.cell.2021.11.001
Brown, Alastair J H, et al. "From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease." Cell vol. 184,24 (2021): 5886-5901.e22. doi: https://doi.org/10.1016/j.cell.2021.11.001
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. PMID: 34822784.
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Ultrastructure of organohalide-respiring .

Applied and environmental microbiology

Sexton DL, Chen G, Kara Murdoch F, Hashimi A, Löffler FE, Tocheva EI.
PMID: 34788060
Appl Environ Microbiol. 2021 Nov 17;AEM0190621. doi: 10.1128/AEM.01906-21. Epub 2021 Nov 17.

No abstract available.

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Sexton DL, Chen G, Kara Murdoch F, et al. Ultrastructure of organohalide-respiring . Appl Environ Microbiol. 2021;AEM0190621doi: 10.1128/AEM.01906-21.
Sexton, D. L., Chen, G., Kara Murdoch, F., Hashimi, A., Löffler, F. E., & Tocheva, E. I. (2021). Ultrastructure of organohalide-respiring . Applied and environmental microbiology, AEM0190621. https://doi.org/10.1128/AEM.01906-21
Sexton, Danielle L, et al. "Ultrastructure of organohalide-respiring ." Applied and environmental microbiology vol. (2021): AEM0190621. doi: https://doi.org/10.1128/AEM.01906-21
Sexton DL, Chen G, Kara Murdoch F, Hashimi A, Löffler FE, Tocheva EI. Ultrastructure of organohalide-respiring . Appl Environ Microbiol. 2021 Nov 17;AEM0190621. doi: 10.1128/AEM.01906-21. Epub 2021 Nov 17. PMID: 34788060.
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Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.

BMJ open diabetes research & care

Riddy DM, Kammoun HL, Murphy AJ, Bosnyak-Gladovic S, De la Fuente Gonzalez R, Merlin J, Ziemann M, Fabb S, Pierce TL, Diepenhorst N, Rueda P, El-Osta A, Gautier JF, Venteclef N, Charman WN, Christopoulos A, Sexton PM, Summers RJ, Febbraio MA, Delerive P, Langmead CJ.
PMID: 34782333
BMJ Open Diabetes Res Care. 2021 Nov;9(2). doi: 10.1136/bmjdrc-2021-002285.

INTRODUCTION: A potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice are complicated by non-selective deletion of RESEARCH DESIGN AND...

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Riddy DM, Kammoun HL, Murphy AJ, et al. Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms. BMJ Open Diabetes Res Care. 2021;9(2)doi: 10.1136/bmjdrc-2021-002285.
Riddy, D. M., Kammoun, H. L., Murphy, A. J., Bosnyak-Gladovic, S., De la Fuente Gonzalez, R., Merlin, J., Ziemann, M., Fabb, S., Pierce, T. L., Diepenhorst, N., Rueda, P., El-Osta, A., Gautier, J. F., Venteclef, N., Charman, W. N., Christopoulos, A., Sexton, P. M., Summers, R. J., Febbraio, M. A., Delerive, P., & Langmead, C. J. (2021). Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms. BMJ open diabetes research & care, 9(2), . https://doi.org/10.1136/bmjdrc-2021-002285
Riddy, Darren M, et al. "Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms." BMJ open diabetes research & care vol. 9,2 (2021). doi: https://doi.org/10.1136/bmjdrc-2021-002285
Riddy DM, Kammoun HL, Murphy AJ, Bosnyak-Gladovic S, De la Fuente Gonzalez R, Merlin J, Ziemann M, Fabb S, Pierce TL, Diepenhorst N, Rueda P, El-Osta A, Gautier JF, Venteclef N, Charman WN, Christopoulos A, Sexton PM, Summers RJ, Febbraio MA, Delerive P, Langmead CJ. Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms. BMJ Open Diabetes Res Care. 2021 Nov;9(2). doi: 10.1136/bmjdrc-2021-002285. PMID: 34782333; PMCID: PMC8593704.
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Showing 13 to 24 of 211 entries