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Showing 5713 to 5717 of 5717 entries
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A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury .

Acta pharmaceutica Sinica. B

He T, Shang J, Gao C, Guan X, Chen Y, Zhu L, Zhang L, Zhang C, Zhang J, Pang T.
PMID: 33777677
Acta Pharm Sin B. 2021 Mar;11(3):708-726. doi: 10.1016/j.apsb.2020.11.002. Epub 2020 Nov 07.

Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke, but how to control the overactive neuroinflammation is still a long-standing challenge. Here,...

Preliminary Assessment of the Resource and Exploitation Potential of Lower Permian Marine-Continent Transitional Facies Shale Gas in the Huainan Basin, Eastern China, Based on a Comprehensive Understanding of Geological Conditions.

ACS omega

Liu H, Yumina DD, Liu J, Hu B, Xu H, Wu H, Shang J, Zheng K, Wei Q, Zhang M, Fang H.
PMID: 33817512
ACS Omega. 2021 Mar 22;6(12):8502-8516. doi: 10.1021/acsomega.1c00290. eCollection 2021 Mar 30.

The Huainan Basin in eastern China contains abundant shale gas resources; the Lower Permian is an exploration horizon with a high potential for shale gas in marine-continent transitional facies. However, few detailed analyses have investigated shale gas in this...

Zeb2/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity.

Journal of molecular neuroscience : MN

Wei R, Zhang L, Hu W, Shang X, He Y, Zhang W.
PMID: 34401997
J Mol Neurosci. 2021 Aug 16; doi: 10.1007/s12031-021-01887-7. Epub 2021 Aug 16.

Exosomes harvested from bone marrow-derived mesenchymal stromal cells (BMSCs) have shown treatment potential in many diseases. In vitro, Zeb2/Axin2 stimulated endogenous neurogenesis, which induced functional recovery after stroke. Here, we investigated whether the Zeb2/Axin2-enriched exosomes harvested from BMSCs transfected...

Bepridil, a class IV antiarrhythmic agent, can block the TREK-1 potassium channel.

Annals of translational medicine

Wang Y, Fu Z, Ma Z, Li N, Shang H.
PMID: 34430564
Ann Transl Med. 2021 Jul;9(14):1123. doi: 10.21037/atm-20-7971.

BACKGROUND: The TWIK-related potassium channel (TREK-1) can be regulated by different stimuli. However, it is not clear whether some antiarrhythmics affect the activity of TREK-1. In the present study, the effect of bepridil on the TREK-1 currents is investigated.METHODS:...

Surface modification of the simvastatin factor-loaded silk fibroin promotes the healing of rotator cuff injury through β-catenin signaling.

Journal of biomaterials applications

Hao L, Chen J, Shang X, Chen S.
PMID: 33779364
J Biomater Appl. 2021 Aug;36(2):210-218. doi: 10.1177/0885328221995926. Epub 2021 Mar 28.

Rupture of the rotator cuff is a common injury of the shoulder joint in sports professionals. In addition, research on repair of the rotator cuff has gained popularity over the recent years. Given the high rate of re-tear after...

Showing 5713 to 5717 of 5717 entries