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Showing 1189 to 1193 of 1193 entries
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Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR.

Nature communications

Shiraishi Y, Kofuku Y, Ueda T, Pandey S, Dwivedi-Agnihotri H, Shukla AK, Shimada I.
PMID: 34887409
Nat Commun. 2021 Dec 09;12(1):7158. doi: 10.1038/s41467-021-27482-3.

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with phosphorylated C-terminal tail (C tail) and transmembrane core (TM core) of GPCRs. However, the effects of the C tail- and TM core-mediated...

Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection.

Translational research : the journal of laboratory and clinical medicine

Latif MB, Shukla S, Estrada PMDR, Ribeiro SP, Sekaly RP, Sharma AA.
PMID: 34871809
Transl Res. 2021 Dec 03; doi: 10.1016/j.trsl.2021.12.001. Epub 2021 Dec 03.

Patients with cancers have been severely affected by the COVID-19 pandemic. This is highlighted by the adverse outcomes in cancer patients with COVID-19 as well as by the impact of the COVID-19 pandemic on cancer care. Patients with cancer...

Kirsten rat sarcoma virus protein overexpression in adenocarcinoma lung: Association with clinicopathological and histomorphological features.

Journal of carcinogenesis

Pandey RK, Shukla S, Hadi R, Husain N, Islam MH, Singhal A, Tripathi SK, Garg R.
PMID: 33679239
J Carcinog. 2020 Oct 08;19:9. doi: 10.4103/jcar.JCar_11_20. eCollection 2020.

CONTEXT: Lung cancer is the leading cause of cancer-related deaths worldwide. The constitutive activation of multiple signaling pathways is the major cause of carcinogenesis.AIMS: The study evaluates the frequency of Kirsten rat sarcoma virus (KRAS) protein overexpression and correlates...

Evaluation of decontamination efficacy of electrolytically generated hypochlorous acid for vesicating agent: A multimodel Study.

Current pharmaceutical biotechnology

Sharma AK, Shukla SK, Kalonia A, Shaw P, Khanna K, Gupta R, Yashavarddhan MH, Bhatnagar A.
PMID: 33719970
Curr Pharm Biotechnol. 2021 Mar 11; doi: 10.2174/1389201022666210311140922. Epub 2021 Mar 11.

BACKGROUND: Sulfur Mustard is a strong vesicant and chemical warfare agent that imposes toxicity to the lungs, eyes, and skin after accidental or intended exposure.OBJECTIVES: The current study was intended to explore in vitro and in vivo decontamination properties...

Assessment of front-line healthcare workers' Knowledge, Attitude and Practice after several months of COVID-19 pandemic.

Journal of healthcare quality research

Maurya VK, Upadhyay V, Dubey P, Shukla S, Chaturvedi A.
PMID: 34419379
J Healthc Qual Res. 2022 Jan-Feb;37(1):20-27. doi: 10.1016/j.jhqr.2021.07.004. Epub 2021 Jul 22.

BACKGROUND: Frontline healthcare workers (F-HCWs) are at the forefront of medical care providers against the novel coronavirus 2019 (COVID-19) pandemic which has life-threatening potentials. Inadequate knowledge and incorrect attitudes among HCWs can directly influence practices and lead to delayed...

Showing 1189 to 1193 of 1193 entries