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Showing 973 to 983 of 983 entries
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Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis.

European journal of cancer (Oxford, England : 1990)

Goldinger SM, Buder-Bakhaya K, Lo SN, Forschner A, McKean M, Zimmer L, Khoo C, Dummer R, Eroglu Z, Buchbinder EI, Ascierto PA, Gutzmer R, Rozeman EA, Hoeller C, Johnson DB, Gesierich A, Kölblinger P, Bennannoune N, Cohen JV, Kähler KC, Wilson MA, Cebon J, Atkinson V, Smith JL, Michielin O, Long GV, Hassel JC, Weide B, Haydu LE, Schadendorf D, McArthur G, Ott PA, Blank C, Robert C, Sullivan R, Hauschild A, Carlino MS, Garbe C, Davies MA, Menzies AM.
PMID: 34952480
Eur J Cancer. 2021 Dec 21;162:22-33. doi: 10.1016/j.ejca.2021.11.022. Epub 2021 Dec 21.

INTRODUCTION: Despite remarkably improved outcomes with immune checkpoint inhibition, many patients with metastatic melanoma will eventually require further therapy. Chemotherapy has limited activity when used first-line but can alter the tumour microenvironment and does improve efficacy when used in...

"What will we do if we get infected?" a qualitative interview-based study of the COVID-19 pandemic and its effects on the health and safety of sex workers in the United States.

SSM. Qualitative research in health

Callander D, Thilani Singham Goodwin A, Duncan DT, Grov C, El-Sadr W, Grant M, Thompson RJ, Simmons M, Oshiro-Brantley JL, Bhatt K, Meunier É.
PMID: 34901921
SSM Qual Res Health. 2021 Dec 08;100027. doi: 10.1016/j.ssmqr.2021.100027. Epub 2021 Dec 08.

Emerging evidence suggests that sex workers face unique and profound risks arising from the COVID-19 pandemic. To illuminate the pandemic's effects on sex worker health and safety and identify intervention opportunities, from May-August 2018 in-depth interviews were conducted with...

GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.

iScience

Selyutina A, Hu P, Miller S, Simons LM, Yu HJ, Hultquist JF, Lee K, KewalRamani VN, Diaz-Griffero F.
PMID: 35005542
iScience. 2021 Dec 09;25(1):103593. doi: 10.1016/j.isci.2021.103593. eCollection 2022 Jan 21.

The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection. HIV-1 inhibition by GS-CA1 did not require CPSF6 in CD4

Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure.

medRxiv : the preprint server for health sciences

Demonbreun AR, McDade TW, Pesce L, Vaught LA, Reiser NL, Bogdanovic E, Velez MP, Hsieh RR, Simons LM, Saber R, Ryan DT, Ison MG, Hultquist JF, Wilkins JT, D'Aquila RT, Mustanski B, McNally EM.
PMID: 33236031
medRxiv. 2021 Mar 16; doi: 10.1101/2020.11.17.20233452.

BACKGROUND: Estimates of seroprevalence to SARS-CoV-2 vary widely and may influence vaccination response. We ascertained IgG levels across a single US metropolitan site, Chicago, from June 2020 through December 2020.METHODS: Participants (n=7935) were recruited through electronic advertising and received...

A critical review of the definition of 'wellbeing' for doctors and their patients in a post Covid-19 era.

The International journal of social psychiatry

Simons G, Baldwin DS.
PMID: 34240644
Int J Soc Psychiatry. 2021 Dec;67(8):984-991. doi: 10.1177/00207640211032259. Epub 2021 Jul 09.

BACKGROUND: There is no international consensus definition of 'wellbeing'. This has led to wellbeing being captured in many different ways.AIMS: To construct an inclusive, global operational definition of wellbeing.METHODS: The differences between wellbeing components and determinants and the terms...

High Health-Related Quality of Life During Dendritic Cell Vaccination Therapy in Patients With Castration-Resistant Prostate Cancer.

Frontiers in oncology

Westdorp H, Creemers JHA, van Oort IM, Mehra N, Hins-de Bree SM, Figdor CG, Witjes JA, Schreibelt G, de Vries IJM, Gerritsen WR, Ottevanger PB.
PMID: 33194595
Front Oncol. 2020 Oct 26;10:536700. doi: 10.3389/fonc.2020.536700. eCollection 2020.

BACKGROUND: Maintaining health-related quality of life (HRQoL) is highly desirable during systemic therapies for patients with castration-resistant prostate cancer (CRPC). Patient-reported outcome measures (PROs) were studied in our phase IIa trial on cellular-based immunotherapy with dendritic cells (DC).METHODS: We...

Patients', carers' and clinicians' attitudes towards alternative terms to describe the at-risk for psychosis state.

Schizophrenia research

Polari A, Street R, Conus P, Finkelstein A, Hartmann JA, Kim SW, McGorry P, Schley C, Simmons M, Stratford J, Thompson A, Yung A, Nelson B, Lavoie S.
PMID: 34507056
Schizophr Res. 2021 Nov;237:69-75. doi: 10.1016/j.schres.2021.08.031. Epub 2021 Sep 08.

OBJECTIVE: Language used in psychiatry is important because it provides an understandable and accurate way of describing clinical and theoretical concepts. The use of labels in psychiatry has often been associated with stigma and reduced engagement with clinical services....

Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.

Molecular and cellular endocrinology

Limoncella S, Lazzaretti C, Paradiso E, D'Alessandro S, Barbagallo F, Pacifico S, Guerrini R, Tagliavini S, Trenti T, Santi D, Simoni M, Sola M, Di Rocco G, Casarini L.
PMID: 34875337
Mol Cell Endocrinol. 2021 Dec 04;542:111527. doi: 10.1016/j.mce.2021.111527. Epub 2021 Dec 04.

Type 5 phosphodiesterase (PDE5) blockade by inhibitors (PDE5i) results in intracellular cyclic guanosine monophosphate (cGMP) increase and smooth muscle relaxation and are used for the treatment of men erectile dysfunction. Although they have high specificity for PDE5, these inhibitors...

Improved Radium-223 Therapy with Combination Epithelial Sodium Channel Blockade.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Abou DS, Fears A, Summer L, Longtine M, Benabdallah N, Riddle RC, Ulmert D, Michalski J, Wahl RL, Chesner D, Doucet M, Zachos N, Simons B, Thorek DL.
PMID: 33837069
J Nucl Med. 2021 Apr 09; doi: 10.2967/jnumed.121.261977. Epub 2021 Apr 09.

No abstract available.

Anatomical Study of Sinus Tarsi-Based Lateral Lengthening Calcaneal Osteotomy.

Foot & ankle international

Aurich M, Lenz M, Hofmann GO, Schubert W, Knobe M, Roth KE, Simons P, Klos K.
PMID: 34490796
Foot Ankle Int. 2022 Jan;43(1):101-104. doi: 10.1177/10711007211041345. Epub 2021 Sep 07.

BACKGROUND: Lateral lengthening calcaneal osteotomy (LL-CO) is commonly performed as a treatment for an abducted midfoot in pes planovalgus deformity. The purpose of this study is to investigate potential damage to medial structures with a sinus tarsi LL-CO.METHODS: Sixteen...

Durability of SARS-CoV-2-Specific T-Cell Responses at 12 Months Postinfection.

The Journal of infectious diseases

Lu Z, Laing ED, Pena DaMata J, Pohida K, Tso MS, Samuels EC, Epsi NJ, Dorjbal B, Lake C, Richard SA, Maves RC, Lindholm DA, Rozman JS, English C, Huprikar N, Mende K, Colombo RE, Colombo CJ, Broder CC, Ganesan A, Lanteri CA, Agan BK, Tribble D, Simons MP, Dalgard CL, Blair PW, Chenoweth J, Pollett SD, Snow AL, Burgess TH, Malloy AMW.
PMID: 34673956
J Infect Dis. 2021 Dec 15;224(12):2010-2019. doi: 10.1093/infdis/jiab543.

BACKGROUND: Characterizing the longevity and quality of cellular immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of coronavirus disease 2019 (COVID-19) immunity that influences clinical outcomes. Prior studies suggest SARS-CoV-2-specific T cells are present in...

Showing 973 to 983 of 983 entries