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Showing 13 to 24 of 38 entries
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Inhibition of the Arp2/3 complex represses human lung myofibroblast differentiation and attenuates bleomycin-induced pulmonary fibrosis.

British journal of pharmacology

Mergault C, Lisée F, Tiroille V, Magnien M, Parent C, Lenga Mabonda W, Sizaret D, Jaillet M, Crestani B, Marchand-Adam S, Plantier L.
PMID: 34453744
Br J Pharmacol. 2022 Jan;179(1):125-140. doi: 10.1111/bph.15675. Epub 2021 Nov 15.

BACKGROUND AND PURPOSE: The Arp2/3 multiprotein complex regulates branched polymerisation of the actin cytoskeleton and may contribute to collagen synthesis and fibrogenesis in the lung.EXPERIMENTAL APPROACH: Expression of Arp2/3 components was assessed in human lung fibroblasts and in the...

Nasal mucosa and blood cell transcriptome profiles do not reflect respiratory symptoms associated with moisture damage.

Indoor air

Ndika J, Suojalehto H, Täubel M, Lehto M, Karvala K, Pallasaho P, Sund J, Auvinen P, Järvi K, Pekkanen J, Kinaret P, Greco D, Hyvärinen A, Alenius H.
PMID: 29729044
Indoor Air. 2018 May 04; doi: 10.1111/ina.12472. Epub 2018 May 04.

Upper and lower respiratory symptoms and asthma are adverse health effects associated with moisture-damaged buildings. Quantitative measures to detect adverse health effects related to exposure to dampness and mold are needed. Here, we investigate differences in gene expression between...

Multi-omics analysis of ten carbon nanomaterials effects highlights cell type specific patterns of molecular regulation and adaptation.

NanoImpact

Scala G, Kinaret P, Marwah V, Sund J, Fortino V, Greco D.
PMID: 32140619
NanoImpact. 2018 Jul;11:99-108. doi: 10.1016/j.impact.2018.05.003.

New strategies to characterize the effects of engineered nanomaterials (ENMs) based on omics technologies are emerging. However, given the intricate interplay of multiple regulatory layers, the study of a single molecular species in exposed biological systems might not allow...

Integration of genome-wide mRNA and miRNA expression, and DNA methylation data of three cell lines exposed to ten carbon nanomaterials.

Data in brief

Scala G, Marwah V, Kinaret P, Sund J, Fortino V, Greco D.
PMID: 30228994
Data Brief. 2018 May 25;19:1046-1057. doi: 10.1016/j.dib.2018.05.107. eCollection 2018 Aug.

We present data derived from an exposure experiment in which three cell-lines representative of cell types of the respiratory tissue (epithelial type-I A549, epithelial type-II BEAS-2B, and macrophage THP-1) have been exposed to ten different carbon-based nanomaterials for 48...

Ferromagnetic ground state for a hypothetical iron-based extended metal atom chain.

Journal of molecular modeling

Szarek P, Wegner W, Grochala W.
PMID: 26910724
J Mol Model. 2016 Mar;22(3):63. doi: 10.1007/s00894-016-2928-x. Epub 2016 Feb 24.

Theoretical calculations for the first tri-iron-based extended metal atom chain (EMAC) molecule are reported. The studied triple-high-spin (S = 6) complex exhibits ferromagnetic ordering (according to Ising and spin-projection approximations), which renders it unique among all previously prepared and...

Reactivity patterns of imidazole, oxazole, and thiazole as reflected by the polarization justified Fukui functions.

The journal of physical chemistry. A

Beker W, Szarek P, Komorowski L, Lipiński J.
PMID: 23327161
J Phys Chem A. 2013 Feb 21;117(7):1596-600. doi: 10.1021/jp309390j. Epub 2013 Jan 31.

The concept of the polarization justified Fukui functions has been tested for the set of model molecules: imidazole, oxazole, and thiazole. Calculations of the Fukui functions have been based on the molecular polarizability analysis, which makes them a potentially...

Beyond Oxides: Nitride as a Ligand in a Neutral Ir.

Chemistry (Weinheim an der Bergstrasse, Germany)

Wolański Ł, Domański M, Grochala W, Szarek P.
PMID: 31119805
Chemistry. 2019 Aug 06;25(44):10290-10293. doi: 10.1002/chem.201902142. Epub 2019 Jul 01.

Theoretical calculations utilizing relativistic ZORA Hamiltonian point to the conceivable existence of an IrNO

Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells.

Cytotechnology

Kowalczyk T, Sitarek P, Skała E, Toma M, Wielanek M, Pytel D, Wieczfińska J, Szemraj J, Śliwiński T.
PMID: 30610508
Cytotechnology. 2019 Feb;71(1):165-180. doi: 10.1007/s10616-018-0274-9. Epub 2019 Jan 04.

Menyanthes trifoliata L. has been used in traditional medicine for centuries. It exists in Asia, Europe, North America and in Morocco and is exploited as a remedy for anemia and lack of appetite. This plant shows many pharmacological properties,...

Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor.

Biological chemistry

Lavergne M, Guillon-Munos A, Lenga Ma Bonda W, Attucci S, Kryza T, Barascu A, Moreau T, Petit-Courty A, Sizaret D, Courty Y, Iochmann S, Reverdiau P.
PMID: 33977679
Biol Chem. 2021 May 12;402(10):1257-1268. doi: 10.1515/hsz-2020-0389. Print 2021 Sep 27.

The protease activities are tightly regulated by inhibitors and dysregulation contribute to pathological processes such as cancer and inflammatory disorders. Tissue factor pathway inhibitor 2 (TFPI-2) is a serine proteases inhibitor, that mainly inhibits plasmin. This protease activated matrix...

Atomic/Ionic Radius as Mathematical Limit of System Energy Evolution.

The journal of physical chemistry. A

Szarek P, Chlebicki A, Grochala W.
PMID: 30632754
J Phys Chem A. 2019 Jan 24;123(3):682-692. doi: 10.1021/acs.jpca.8b08813. Epub 2019 Jan 11.

The classical, in its nature, concept of atomic or ionic radii, although profitable in many fields, is represented by an ambiguous choice of formulations. In this work, we propose a definition of atomic and ionic radii rooted in chemical...

Sante publique (Vandoeuvre-les-Nancy, France)

Sizaret A, Laurent A, Ferron C.
PMID: 30990264
Sante Publique. 2018 November December;30(6):765-766. doi: 10.3917/spub.187.0765.

No abstract available.

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines.

Cancers

Sitarek P, Merecz-Sadowska A, Śliwiński T, Zajdel R, Kowalczyk T.
PMID: 33066157
Cancers (Basel). 2020 Oct 13;12(10). doi: 10.3390/cancers12102957.

It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer...

Showing 13 to 24 of 38 entries