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Showing 25 to 36 of 190 entries
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Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

Nature biotechnology

Arnaud M, Chiffelle J, Genolet R, Navarro Rodrigo B, Perez MAS, Huber F, Magnin M, Nguyen-Ngoc T, Guillaume P, Baumgaertner P, Chong C, Stevenson BJ, Gfeller D, Irving M, Speiser DE, Schmidt J, Zoete V, Kandalaft LE, Bassani-Sternberg M, Bobisse S, Coukos G, Harari A.
PMID: 34782741
Nat Biotechnol. 2021 Nov 15; doi: 10.1038/s41587-021-01072-6. Epub 2021 Nov 15.

The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T...

Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature - The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11).

World journal for pediatric & congenital heart surgery

Jacobs JP, Franklin RCG, Béland MJ, Spicer DE, Colan SD, Walters HL, Bailliard F, Houyel L, St Louis JD, Lopez L, Aiello VD, Gaynor JW, Krogmann ON, Kurosawa H, Maruszewski BJ, Stellin G, Weinberg PM, Jacobs ML, Boris JR, Cohen MS, Everett AD, Giroud JM, Guleserian KJ, Hughes ML, Juraszek AL, Seslar SP, Shepard CW, Srivastava S, Cook AC, Crucean A, Hernandez LE, Loomba RS, Rogers LS, Sanders SP, Savla JJ, Tierney ESS, Tretter JT, Wang L, Elliott MJ, Mavroudis C, Tchervenkov CI.
PMID: 34304616
World J Pediatr Congenit Heart Surg. 2021 Sep;12(5):E1-E18. doi: 10.1177/21501351211032919. Epub 2021 Jul 26.

Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The...

Congenital adrenal hyperplasia - current insights in pathophysiology, diagnostics and management.

Endocrine reviews

Claahsen-van der Grinten HL, Speiser PW, Ahmed SF, Arlt W, Auchus RJ, Falhammar H, Flück CE, Guasti L, Huebner A, Kortmann BBM, Krone N, Merke DP, Miller WL, Nordenström A, Reisch N, Sandberg DE, Stikkelbroeck NMML, Touraine P, Utari A, Wudy SA, White PC.
PMID: 33961029
Endocr Rev. 2021 May 07; doi: 10.1210/endrev/bnab016. Epub 2021 May 07.

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to chronic overstimulation of the adrenal cortex and accumulation of precursors proximal to the blocked...

Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.

Allergy

Vogel M, Augusto G, Chang X, Liu X, Speiser D, Mohsen MO, Bachmann MF.
PMID: 34240429
Allergy. 2022 Jan;77(1):143-149. doi: 10.1111/all.15002. Epub 2021 Jul 27.

BACKGROUND: Several new variants of SARS-CoV-2 have emerged since fall 2020 which have multiple mutations in the receptor-binding domain (RBD) of the spike protein. It is unclear which mutations affect receptor affinity versus immune recognition.METHODS: We produced wild type...

Vibration-Driven Self-Doping of Dangling-Bond Wires on Si(553)-Au Surfaces.

Physical review letters

Braun C, Neufeld S, Gerstmann U, Sanna S, Plaickner J, Speiser E, Esser N, Schmidt WG.
PMID: 32338960
Phys Rev Lett. 2020 Apr 10;124(14):146802. doi: 10.1103/PhysRevLett.124.146802.

Density-functional theory is used to explore the Si(553)-Au surface dynamics. Our study (i) reveals a complex two-stage order-disorder phase transition where with rising temperature first the ×3 order along the Si step edges and, subsequently, the ×2 order of...

A paclitaxel-induced variant of hand-foot syndrome affecting dorsal surfaces.

Journal of cutaneous pathology

Zelman B, Lee K, Reserva J, Speiser J.
PMID: 33938036
J Cutan Pathol. 2021 Oct;48(10):1320-1323. doi: 10.1111/cup.14040. Epub 2021 May 16.

No abstract available.

BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid.

Frontiers in cell and developmental biology

Eslami M, Meinl E, Eibel H, Willen L, Donzé O, Distl O, Schneider H, Speiser DE, Tsiantoulas D, Yalkinoglu Ö, Samy E, Schneider P.
PMID: 33240880
Front Cell Dev Biol. 2020 Nov 06;8:577662. doi: 10.3389/fcell.2020.577662. eCollection 2020.

B cell activation factor of the TNF family (BAFF/BLyS), an essential B cell survival factor of which circulating levels are elevated in several autoimmune disorders, is targeted in the clinic for the treatment of systemic lupus erythematosus (SLE). The...

Endovascular Treatment of Intracerebral Giant Cell Arteritis.

Frontiers in neurology

Simonsen CZ, Speiser L, Hansen IT, Jayne D, von Weitzel-Mudersbach P.
PMID: 32373053
Front Neurol. 2020 Apr 16;11:287. doi: 10.3389/fneur.2020.00287. eCollection 2020.

No abstract available.

Evaluation of Myocardial Strain Using Cardiac Magnetic Resonance in Patients with Wilson's Disease.

Journal of clinical medicine

Zhang K, Reuner U, Hempel C, Speiser U, Ibrahim K, Heinzel FR, Pieske B, Christoph M, Heidrich FM, Quick S.
PMID: 33477453
J Clin Med. 2021 Jan 18;10(2). doi: 10.3390/jcm10020335.

(1) Background: Wilson's disease (WD) is an inherited autosomal recessive disorder with the excessive deposition of copper into different organs, including the heart. Previous studies showed structural cardiac changes even in patients with no signs of heart failure. The...

Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.

Allergy

Vogel M, Augusto G, Chang X, Liu X, Speiser D, Mohsen MO, Bachmann MF.
PMID: 34240429
Allergy. 2022 Jan;77(1):143-149. doi: 10.1111/all.15002. Epub 2021 Jul 27.

BACKGROUND: Several new variants of SARS-CoV-2 have emerged since fall 2020 which have multiple mutations in the receptor-binding domain (RBD) of the spike protein. It is unclear which mutations affect receptor affinity versus immune recognition.METHODS: We produced wild type...

Skin cancer discovery during total body skin examinations.

International journal of women's dermatology

Jiang A, Jefferson IS, Robinson SK, Griffin D, Adams W, Speiser J, Winterfield L, Peterson A, Tung-Hahn E, Lee K, Surprenant D, Coakley A, Tung R, Alam M.
PMID: 34621952
Int J Womens Dermatol. 2021 May 30;7(4):411-414. doi: 10.1016/j.ijwd.2021.05.005. eCollection 2021 Sep.

BACKGROUND: Patients presenting with a site-specific skin complaint may receive a total body skin examination (TBSE) or a more focused examination. A TBSE may be time-consuming but can potentially detect unsuspected or early stage skin cancers. The purpose of...

Predicting Future Mobility Limitation in Older Adults: A Machine Learning Analysis of Health ABC Study Data.

The journals of gerontology. Series A, Biological sciences and medical sciences

Speiser JL, Callahan KE, Ip EH, Miller ME, Tooze JA, Kritchevsky SB, Houston DK.
PMID: 34529794
J Gerontol A Biol Sci Med Sci. 2021 Sep 16; doi: 10.1093/gerona/glab269. Epub 2021 Sep 16.

BACKGROUND: Mobility limitation in older adults is common and associated with poor health outcomes and loss of independence. Identification of at-risk individuals remains challenging because of time-consuming clinical assessments and limitations of statistical models for dynamic outcomes over time....

Showing 25 to 36 of 190 entries