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Estimating the natural indirect effect and the mediation proportion via the product method.

BMC medical research methodology

Cheng C, Spiegelman D, Li F.
PMID: 34800985
BMC Med Res Methodol. 2021 Nov 20;21(1):253. doi: 10.1186/s12874-021-01425-4.

BACKGROUND: The natural indirect effect (NIE) and mediation proportion (MP) are two measures of primary interest in mediation analysis. The standard approach for mediation analysis is through the product method, which involves a model for the outcome conditional on...

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Cheng C, Spiegelman D, Li F. Estimating the natural indirect effect and the mediation proportion via the product method. BMC Med Res Methodol. 2021;21(1):253doi: 10.1186/s12874-021-01425-4.
Cheng, C., Spiegelman, D., & Li, F. (2021). Estimating the natural indirect effect and the mediation proportion via the product method. BMC medical research methodology, 21(1), 253. https://doi.org/10.1186/s12874-021-01425-4
Cheng, Chao, et al. "Estimating the natural indirect effect and the mediation proportion via the product method." BMC medical research methodology vol. 21,1 (2021): 253. doi: https://doi.org/10.1186/s12874-021-01425-4
Cheng C, Spiegelman D, Li F. Estimating the natural indirect effect and the mediation proportion via the product method. BMC Med Res Methodol. 2021 Nov 20;21(1):253. doi: 10.1186/s12874-021-01425-4. PMID: 34800985; PMCID: PMC8606099.
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.

Cell metabolism

Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET.
PMID: 34861155
Cell Metab. 2022 Jan 04;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 02.

Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss-of-function model has recently been shown to have a severe deficiency in the entire electron transport...

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Mills EL, Harmon C, Jedrychowski MP, et al. Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metab. 2021;34(1):140-157.e8doi: 10.1016/j.cmet.2021.11.003.
Mills, E. L., Harmon, C., Jedrychowski, M. P., Xiao, H., Gruszczyk, A. V., Bradshaw, G. A., Tran, N., Garrity, R., Laznik-Bogoslavski, D., Szpyt, J., Prendeville, H., Lynch, L., Murphy, M. P., Gygi, S. P., Spiegelman, B. M., & Chouchani, E. T. (2022). Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell metabolism, 34(1), 140-157.e8. https://doi.org/10.1016/j.cmet.2021.11.003
Mills, Evanna L, et al. "Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation." Cell metabolism vol. 34,1 (2022): 140-157.e8. doi: https://doi.org/10.1016/j.cmet.2021.11.003
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metab. 2022 Jan 04;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 02. PMID: 34861155.
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Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.

Genes & cancer

Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS.
PMID: 21779431
Genes Cancer. 2010 Oct;1(10):1074-82. doi: 10.1177/1947601910395581.

The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts...

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Noubissi FK, Nikiforov MA, Colburn N, et al. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer. 2010;1(10):1074-82doi: 10.1177/1947601910395581.
Noubissi, F. K., Nikiforov, M. A., Colburn, N., & Spiegelman, V. S. (2010). Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes & cancer, 1(10), 1074-82. https://doi.org/10.1177/1947601910395581
Noubissi, Felicite K, et al. "Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions." Genes & cancer vol. 1,10 (2010): 1074-82. doi: https://doi.org/10.1177/1947601910395581
Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer. 2010 Oct;1(10):1074-82. doi: 10.1177/1947601910395581. PMID: 21779431; PMCID: PMC3092266.
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Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study.

Sleep medicine

Agrawal R, Jones MB, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A.
PMID: 34906781
Sleep Med. 2021 Nov 12;89:60-64. doi: 10.1016/j.sleep.2021.10.034. Epub 2021 Nov 12.

BACKGROUND: Hospital readmissions and outpatient visits contribute to the significant burden on healthcare systems. Obstructive sleep apnea (OSA) is a chronic medical condition that is associated with cardiovascular comorbidities and other chronic conditions. Inpatient and outpatient healthcare utilization rates...

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Agrawal R, Jones MB, Spiegelman AM, et al. Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep Med. 2021;89:60-64doi: 10.1016/j.sleep.2021.10.034.
Agrawal, R., Jones, M. B., Spiegelman, A. M., Bandi, V. D., Hirshkowitz, M., & Sharafkhaneh, A. (2021). Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep medicine, 8960-64. https://doi.org/10.1016/j.sleep.2021.10.034
Agrawal, Ritwick, et al. "Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study." Sleep medicine vol. 89 (2021): 60-64. doi: https://doi.org/10.1016/j.sleep.2021.10.034
Agrawal R, Jones MB, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A. Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep Med. 2021 Nov 12;89:60-64. doi: 10.1016/j.sleep.2021.10.034. Epub 2021 Nov 12. PMID: 34906781.
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Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells.

RNA biology

Wallis N, Oberman F, Shurrush K, Germain N, Greenwald G, Gershon T, Pearl T, Abis G, Singh V, Singh A, Sharma AK, Barr HM, Ramos A, Spiegelman VS, Yisraeli JK.
PMID: 34895045
RNA Biol. 2021 Dec 11;1-18. doi: 10.1080/15476286.2021.2010983. Epub 2021 Dec 11.

Igf2bp1 is an oncofetal RNA binding protein whose expression in numerous types of cancers is associated with upregulation of key pro-oncogenic RNAs, poor prognosis, and reduced survival. Importantly, Igf2bp1 synergizes with mutations in Kras to enhance signalling and oncogenic...

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Wallis N, Oberman F, Shurrush K, et al. Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells. RNA Biol. 2021;1-18doi: 10.1080/15476286.2021.2010983.
Wallis, N., Oberman, F., Shurrush, K., Germain, N., Greenwald, G., Gershon, T., Pearl, T., Abis, G., Singh, V., Singh, A., Sharma, A. K., Barr, H. M., Ramos, A., Spiegelman, V. S., & Yisraeli, J. K. (2021). Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells. RNA biology, 1-18. https://doi.org/10.1080/15476286.2021.2010983
Wallis, Nadav, et al. "Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells." RNA biology vol. (2021): 1-18. doi: https://doi.org/10.1080/15476286.2021.2010983
Wallis N, Oberman F, Shurrush K, Germain N, Greenwald G, Gershon T, Pearl T, Abis G, Singh V, Singh A, Sharma AK, Barr HM, Ramos A, Spiegelman VS, Yisraeli JK. Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells. RNA Biol. 2021 Dec 11;1-18. doi: 10.1080/15476286.2021.2010983. Epub 2021 Dec 11. PMID: 34895045.
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Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study.

Sleep medicine

Agrawal R, Jones MB, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A.
PMID: 34906781
Sleep Med. 2021 Nov 12;89:60-64. doi: 10.1016/j.sleep.2021.10.034. Epub 2021 Nov 12.

BACKGROUND: Hospital readmissions and outpatient visits contribute to the significant burden on healthcare systems. Obstructive sleep apnea (OSA) is a chronic medical condition that is associated with cardiovascular comorbidities and other chronic conditions. Inpatient and outpatient healthcare utilization rates...

Cite
Agrawal R, Jones MB, Spiegelman AM, et al. Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep Med. 2021;89:60-64doi: 10.1016/j.sleep.2021.10.034.
Agrawal, R., Jones, M. B., Spiegelman, A. M., Bandi, V. D., Hirshkowitz, M., & Sharafkhaneh, A. (2021). Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep medicine, 8960-64. https://doi.org/10.1016/j.sleep.2021.10.034
Agrawal, Ritwick, et al. "Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study." Sleep medicine vol. 89 (2021): 60-64. doi: https://doi.org/10.1016/j.sleep.2021.10.034
Agrawal R, Jones MB, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A. Presence of obstructive sleep apnea is associated with higher future readmissions and outpatient visits-a nationwide administrative dataset study. Sleep Med. 2021 Nov 12;89:60-64. doi: 10.1016/j.sleep.2021.10.034. Epub 2021 Nov 12. PMID: 34906781.
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Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents.

Frontiers in oncology

Biegel JM, Dhamdhere M, Gao S, Gowda CP, Kawasawa YI, Spiegelman VS.
PMID: 33796454
Front Oncol. 2021 Mar 16;11:608816. doi: 10.3389/fonc.2021.608816. eCollection 2021.

Gain at chromosome 17q21 in neuroblastoma is associated with a poor prognosis, independent of MYCN amplification status. Several potential proto-oncogenes have been identified in this region, one of them-insulin-like growth-factor-2 mRNA binding protein (IGF2BP1)-is expressed at high levels in...

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Biegel JM, Dhamdhere M, Gao S, et al. Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents. Front Oncol. 2021;11:608816doi: 10.3389/fonc.2021.608816.
Biegel, J. M., Dhamdhere, M., Gao, S., Gowda, C. P., Kawasawa, Y. I., & Spiegelman, V. S. (2021). Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents. Frontiers in oncology, 11608816. https://doi.org/10.3389/fonc.2021.608816
Biegel, Jason M, et al. "Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents." Frontiers in oncology vol. 11 (2021): 608816. doi: https://doi.org/10.3389/fonc.2021.608816
Biegel JM, Dhamdhere M, Gao S, Gowda CP, Kawasawa YI, Spiegelman VS. Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents. Front Oncol. 2021 Mar 16;11:608816. doi: 10.3389/fonc.2021.608816. eCollection 2021. PMID: 33796454; PMCID: PMC8008117.
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Showing 253 to 259 of 259 entries