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Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions.

Drug discovery today

Jin W, Tan H, Wu J, He G, Liu B.
PMID: 34438075
Drug Discov Today. 2021 Aug 23; doi: 10.1016/j.drudis.2021.08.007. Epub 2021 Aug 23.

Bromodomain-containing protein 4 (BRD4) is emerging as a therapeutic target that acts synergistically with other targets of small-molecule drugs in cancer. Therefore, the discovery of potential new dual-target inhibitors of BRD4 may be a promising strategy for cancer therapy....

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Jin W, Tan H, Wu J, et al. Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions. Drug Discov Today. 2021;doi: 10.1016/j.drudis.2021.08.007.
Jin, W., Tan, H., Wu, J., He, G., & Liu, B. (2021). Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions. Drug discovery today, . https://doi.org/10.1016/j.drudis.2021.08.007
Jin, Wenke, et al. "Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions." Drug discovery today vol. (2021). doi: https://doi.org/10.1016/j.drudis.2021.08.007
Jin W, Tan H, Wu J, He G, Liu B. Dual-target inhibitors of bromodomain-containing protein 4 (BRD4) in cancer therapy: Current situation and future directions. Drug Discov Today. 2021 Aug 23; doi: 10.1016/j.drudis.2021.08.007. Epub 2021 Aug 23. PMID: 34438075.
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PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation.

Chemistry, an Asian journal

Yang L, Wang Y, Feng H, Zeng H, Tan C, Yao J, Zhang J, Jiang L, Sun Y.
PMID: 33245210
Chem Asian J. 2021 Jan 04;16(1):34-38. doi: 10.1002/asia.202001253. Epub 2020 Dec 07.

Recently, direct formic acid fuel cells (DFAFCs) which possess superior advantages such as a low operating temperature, light environmental pollution and high energy density, have been considered as one of the power generation technologies with a bright prospect. Herein,...

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Yang L, Wang Y, Feng H, et al. PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation. Chem Asian J. 2020;16(1):34-38doi: 10.1002/asia.202001253.
Yang, L., Wang, Y., Feng, H., Zeng, H., Tan, C., Yao, J., Zhang, J., Jiang, L., & Sun, Y. (2021). PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation. Chemistry, an Asian journal, 16(1), 34-38. https://doi.org/10.1002/asia.202001253
Yang, Lei, et al. "PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation." Chemistry, an Asian journal vol. 16,1 (2021): 34-38. doi: https://doi.org/10.1002/asia.202001253
Yang L, Wang Y, Feng H, Zeng H, Tan C, Yao J, Zhang J, Jiang L, Sun Y. PdAg Nanoparticles with Different Sizes: Facile One-Step Synthesis and High Electrocatalytic Activity for Formic Acid Oxidation. Chem Asian J. 2021 Jan 04;16(1):34-38. doi: 10.1002/asia.202001253. Epub 2020 Dec 07. PMID: 33245210.
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Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling.

Journal of hepatology

Lan T, Hu Y, Hu F, Li H, Chen Y, Zhang J, Yu Y, Jiang S, Weng Q, Tian S, Ma T, Yang G, Luo D, Wang L, Li K, Piao S, Rong X, Guo J.
PMID: 34656650
J Hepatol. 2022 Feb;76(2):407-419. doi: 10.1016/j.jhep.2021.09.040. Epub 2021 Oct 15.

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. The advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), has been recognized as a leading cause of end-stage liver injury for which there...

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Lan T, Hu Y, Hu F, et al. Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. J Hepatol. 2021;76(2):407-419doi: 10.1016/j.jhep.2021.09.040.
Lan, T., Hu, Y., Hu, F., Li, H., Chen, Y., Zhang, J., Yu, Y., Jiang, S., Weng, Q., Tian, S., Ma, T., Yang, G., Luo, D., Wang, L., Li, K., Piao, S., Rong, X., & Guo, J. (2022). Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. Journal of hepatology, 76(2), 407-419. https://doi.org/10.1016/j.jhep.2021.09.040
Lan, Tian, et al. "Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling." Journal of hepatology vol. 76,2 (2022): 407-419. doi: https://doi.org/10.1016/j.jhep.2021.09.040
Lan T, Hu Y, Hu F, Li H, Chen Y, Zhang J, Yu Y, Jiang S, Weng Q, Tian S, Ma T, Yang G, Luo D, Wang L, Li K, Piao S, Rong X, Guo J. Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. J Hepatol. 2022 Feb;76(2):407-419. doi: 10.1016/j.jhep.2021.09.040. Epub 2021 Oct 15. PMID: 34656650.
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Plasma Concentrations of Pro-inflammatory Cytokine IL-6 and Antiinflammatory Cytokine IL-10 in Short- and Long-term Opioid Users with Noncancer Pain.

Journal of pharmacy & bioallied sciences

Mizher H, Zin CS, Helal Uddin AB, Mohamed AH, Ling TH, Izzat M.
PMID: 33828357
J Pharm Bioallied Sci. 2020 Nov;12:S663-S666. doi: 10.4103/jpbs.JPBS_13_20. Epub 2020 Nov 05.

INTRODUCTION: Little is known whether the duration of opioid use influences the concentrations of pro- and anti-inflammatory cytokines.OBJECTIVES: This study examined the plasma concentration of pro-inflammatory cytokine, interleukin 6 (IL-6), and anti-inflammatory cytokine, interleukin 10 (IL-10), in short-, and...

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Mizher H, Zin CS, Helal Uddin AB, et al. Plasma Concentrations of Pro-inflammatory Cytokine IL-6 and Antiinflammatory Cytokine IL-10 in Short- and Long-term Opioid Users with Noncancer Pain. J Pharm Bioallied Sci. 2020;12:S663-S666doi: 10.4103/jpbs.JPBS_13_20.
Mizher, H., Zin, C. S., Helal Uddin, A. B., Mohamed, A. H., Ling, T. H., & Izzat, M. (2020). Plasma Concentrations of Pro-inflammatory Cytokine IL-6 and Antiinflammatory Cytokine IL-10 in Short- and Long-term Opioid Users with Noncancer Pain. Journal of pharmacy & bioallied sciences, 12S663-S666. https://doi.org/10.4103/jpbs.JPBS_13_20
Mizher, Hussam, et al. "Plasma Concentrations of Pro-inflammatory Cytokine IL-6 and Antiinflammatory Cytokine IL-10 in Short- and Long-term Opioid Users with Noncancer Pain." Journal of pharmacy & bioallied sciences vol. 12 (2020): S663-S666. doi: https://doi.org/10.4103/jpbs.JPBS_13_20
Mizher H, Zin CS, Helal Uddin AB, Mohamed AH, Ling TH, Izzat M. Plasma Concentrations of Pro-inflammatory Cytokine IL-6 and Antiinflammatory Cytokine IL-10 in Short- and Long-term Opioid Users with Noncancer Pain. J Pharm Bioallied Sci. 2020 Nov;12:S663-S666. doi: 10.4103/jpbs.JPBS_13_20. Epub 2020 Nov 05. PMID: 33828357; PMCID: PMC8021053.
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Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations.

Neural computation

Zha W, Zhang W, Li D, Xing Y, He L, Tan J.
PMID: 34915572
Neural Comput. 2022 Jan 14;34(2):518-540. doi: 10.1162/neco_a_01462.

Neural networks are increasingly used widely in the solution of partial differential equations (PDEs). This letter proposes 3D-PDE-Net to solve the three-dimensional PDE. We give a mathematical derivation of a three-dimensional convolution kernel that can approximate any order differential...

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Zha W, Zhang W, Li D, et al. Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations. Neural Comput. 2022;34(2):518-540doi: 10.1162/neco_a_01462.
Zha, W., Zhang, W., Li, D., Xing, Y., He, L., & Tan, J. (2022). Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations. Neural computation, 34(2), 518-540. https://doi.org/10.1162/neco_a_01462
Zha, Wenshu, et al. "Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations." Neural computation vol. 34,2 (2022): 518-540. doi: https://doi.org/10.1162/neco_a_01462
Zha W, Zhang W, Li D, Xing Y, He L, Tan J. Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations. Neural Comput. 2022 Jan 14;34(2):518-540. doi: 10.1162/neco_a_01462. PMID: 34915572.
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An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury.

Bioactive materials

Luo Y, Fan L, Liu C, Wen H, Wang S, Guan P, Chen D, Ning C, Zhou L, Tan G.
PMID: 34466720
Bioact Mater. 2021 Jun 01;7:98-111. doi: 10.1016/j.bioactmat.2021.05.039. eCollection 2022 Jan.

Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury (SCI) by bridging cavity spaces. However, there are limited reports of injectable, electroconductive hydrogels with self-healing properties being employed for the treatment of...

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Luo Y, Fan L, Liu C, et al. An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury. Bioact Mater. 2021;7:98-111doi: 10.1016/j.bioactmat.2021.05.039.
Luo, Y., Fan, L., Liu, C., Wen, H., Wang, S., Guan, P., Chen, D., Ning, C., Zhou, L., & Tan, G. (2022). An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury. Bioactive materials, 798-111. https://doi.org/10.1016/j.bioactmat.2021.05.039
Luo, Yian, et al. "An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury." Bioactive materials vol. 7 (2022): 98-111. doi: https://doi.org/10.1016/j.bioactmat.2021.05.039
Luo Y, Fan L, Liu C, Wen H, Wang S, Guan P, Chen D, Ning C, Zhou L, Tan G. An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury. Bioact Mater. 2021 Jun 01;7:98-111. doi: 10.1016/j.bioactmat.2021.05.039. eCollection 2022 Jan. PMID: 34466720; PMCID: PMC8379448.
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Understanding the Effect of pH on the Solubility and Aggregation Extent of Humic Acid in Solution by Combining Simulation and the Experiment.

Environmental science & technology

Lan T, Wu P, Liu Z, Stroet M, Liao J, Chai Z, Mark AE, Liu N, Wang D.
PMID: 34981918
Environ Sci Technol. 2022 Jan 18;56(2):917-927. doi: 10.1021/acs.est.1c05938. Epub 2022 Jan 04.

Molecular dynamics (MD) simulations were performed to investigate the dynamics of humic acid (HA) in an aqueous solution and the influence of pH, temperature, and HA concentration. The HA model employed in MD simulations was chosen and validated using...

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Lan T, Wu P, Liu Z, et al. Understanding the Effect of pH on the Solubility and Aggregation Extent of Humic Acid in Solution by Combining Simulation and the Experiment. Environ Sci Technol. 2022;56(2):917-927doi: 10.1021/acs.est.1c05938.
Lan, T., Wu, P., Liu, Z., Stroet, M., Liao, J., Chai, Z., Mark, A. E., Liu, N., & Wang, D. (2022). Understanding the Effect of pH on the Solubility and Aggregation Extent of Humic Acid in Solution by Combining Simulation and the Experiment. Environmental science & technology, 56(2), 917-927. https://doi.org/10.1021/acs.est.1c05938
Lan, Tu, et al. "Understanding the Effect of pH on the Solubility and Aggregation Extent of Humic Acid in Solution by Combining Simulation and the Experiment." Environmental science & technology vol. 56,2 (2022): 917-927. doi: https://doi.org/10.1021/acs.est.1c05938
Lan T, Wu P, Liu Z, Stroet M, Liao J, Chai Z, Mark AE, Liu N, Wang D. Understanding the Effect of pH on the Solubility and Aggregation Extent of Humic Acid in Solution by Combining Simulation and the Experiment. Environ Sci Technol. 2022 Jan 18;56(2):917-927. doi: 10.1021/acs.est.1c05938. Epub 2022 Jan 04. PMID: 34981918.
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Examining the Attitudes of Non-Psychiatric Practicing Healthcare Workers Towards Patients With Alcohol Problems in General Hospital Setting.

Substance abuse : research and treatment

Tan HT, Lui YS, Peh LH, Winslow RM, Guo S.
PMID: 35035219
Subst Abuse. 2022 Jan 08;16:11782218211065755. doi: 10.1177/11782218211065755. eCollection 2022.

BACKGROUND AND OBJECTIVES: Problematic alcohol-use affect the physical and mental well-being of hospitalised individuals and may receive screening and brief-intervention during treatment. Non-psychiatric doctors and nurses might respond inadequately due to negative attitudes and beliefs. This study aimed to...

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Tan HT, Lui YS, Peh LH, et al. Examining the Attitudes of Non-Psychiatric Practicing Healthcare Workers Towards Patients With Alcohol Problems in General Hospital Setting. Subst Abuse. 2022;16:11782218211065755doi: 10.1177/11782218211065755.
Tan, H. T., Lui, Y. S., Peh, L. H., Winslow, R. M., & Guo, S. (2022). Examining the Attitudes of Non-Psychiatric Practicing Healthcare Workers Towards Patients With Alcohol Problems in General Hospital Setting. Substance abuse : research and treatment, 1611782218211065755. https://doi.org/10.1177/11782218211065755
Tan, Ho Teck, et al. "Examining the Attitudes of Non-Psychiatric Practicing Healthcare Workers Towards Patients With Alcohol Problems in General Hospital Setting." Substance abuse : research and treatment vol. 16 (2022): 11782218211065755. doi: https://doi.org/10.1177/11782218211065755
Tan HT, Lui YS, Peh LH, Winslow RM, Guo S. Examining the Attitudes of Non-Psychiatric Practicing Healthcare Workers Towards Patients With Alcohol Problems in General Hospital Setting. Subst Abuse. 2022 Jan 08;16:11782218211065755. doi: 10.1177/11782218211065755. eCollection 2022. PMID: 35035219; PMCID: PMC8753239.
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Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice.

Journal of healthcare engineering

Tan C, Liu Y, Zhang H, Di C, Xu D, Liang C, Zhang N, Han B, Lang W.
PMID: 35035837
J Healthc Eng. 2022 Jan 05;2022:4602428. doi: 10.1155/2022/4602428. eCollection 2022.

Alzheimer's disease (AD) is recognized as one of the most common types of senile dementia. AD patients first suffer memory loss for recent events (short-term memory impairment). As the disease progresses, they are deprived of self-awareness. This study aims...

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Tan C, Liu Y, Zhang H, et al. Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice. J Healthc Eng. 2022;2022:4602428doi: 10.1155/2022/4602428.
Tan, C., Liu, Y., Zhang, H., Di, C., Xu, D., Liang, C., Zhang, N., Han, B., & Lang, W. (2022). Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice. Journal of healthcare engineering, 20224602428. https://doi.org/10.1155/2022/4602428
Tan, Chenxi, et al. "Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice." Journal of healthcare engineering vol. 2022 (2022): 4602428. doi: https://doi.org/10.1155/2022/4602428
Tan C, Liu Y, Zhang H, Di C, Xu D, Liang C, Zhang N, Han B, Lang W. Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice. J Healthc Eng. 2022 Jan 05;2022:4602428. doi: 10.1155/2022/4602428. eCollection 2022. PMID: 35035837; PMCID: PMC8754595.
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Counter-Current Fractionation-Assisted Bioassay-Guided Separation of Active Compound from Blueberry and the Interaction between the Active Compound and α-Glucosidase.

Foods (Basel, Switzerland)

Xue H, Zhu X, Tan J, Fan L, Li Q, Tang J, Cai X.
PMID: 33804322
Foods. 2021 Mar 01;10(3). doi: 10.3390/foods10030509.

An efficient strategy for the selection of active compounds from blueberry based on counter-current fractionation and bioassay-guided separation was established in this study. Blueberry extract showed potential α-glucosidase inhibitory activity. After extraction by different solvents, the active components were...

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Xue H, Zhu X, Tan J, et al. Counter-Current Fractionation-Assisted Bioassay-Guided Separation of Active Compound from Blueberry and the Interaction between the Active Compound and α-Glucosidase. Foods. 2021;10(3)doi: 10.3390/foods10030509.
Xue, H., Zhu, X., Tan, J., Fan, L., Li, Q., Tang, J., & Cai, X. (2021). Counter-Current Fractionation-Assisted Bioassay-Guided Separation of Active Compound from Blueberry and the Interaction between the Active Compound and α-Glucosidase. Foods (Basel, Switzerland), 10(3), . https://doi.org/10.3390/foods10030509
Xue, Hongkun, et al. "Counter-Current Fractionation-Assisted Bioassay-Guided Separation of Active Compound from Blueberry and the Interaction between the Active Compound and α-Glucosidase." Foods (Basel, Switzerland) vol. 10,3 (2021). doi: https://doi.org/10.3390/foods10030509
Xue H, Zhu X, Tan J, Fan L, Li Q, Tang J, Cai X. Counter-Current Fractionation-Assisted Bioassay-Guided Separation of Active Compound from Blueberry and the Interaction between the Active Compound and α-Glucosidase. Foods. 2021 Mar 01;10(3). doi: 10.3390/foods10030509. PMID: 33804322; PMCID: PMC7998573.
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Narrow linewidth VCSEL based on resonant optical feedback from an on-chip microring add-drop filter.

Optics letters

Jiang L, Shi L, Luo J, Gao Q, Lan T, Huang L, Zhu T.
PMID: 33988573
Opt Lett. 2021 May 15;46(10):2320-2323. doi: 10.1364/OL.424496.

We demonstrate a narrow linewidth vertical-cavity surface-emitting laser (VCSEL) by injecting resonant optical feedback into the lasing cavity. A single longitudinal mode VCSEL with a Lorentzian linewidth of 32.6 kHz and a purified optical spectrum is experimentally achieved by...

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Jiang L, Shi L, Luo J, et al. Narrow linewidth VCSEL based on resonant optical feedback from an on-chip microring add-drop filter. Opt Lett. 2021;46(10):2320-2323doi: 10.1364/OL.424496.
Jiang, L., Shi, L., Luo, J., Gao, Q., Lan, T., Huang, L., & Zhu, T. (2021). Narrow linewidth VCSEL based on resonant optical feedback from an on-chip microring add-drop filter. Optics letters, 46(10), 2320-2323. https://doi.org/10.1364/OL.424496
Jiang, Lidan, et al. "Narrow linewidth VCSEL based on resonant optical feedback from an on-chip microring add-drop filter." Optics letters vol. 46,10 (2021): 2320-2323. doi: https://doi.org/10.1364/OL.424496
Jiang L, Shi L, Luo J, Gao Q, Lan T, Huang L, Zhu T. Narrow linewidth VCSEL based on resonant optical feedback from an on-chip microring add-drop filter. Opt Lett. 2021 May 15;46(10):2320-2323. doi: 10.1364/OL.424496. PMID: 33988573.
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Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of esophageal squamous cell carcinoma: a propensity score-matched study from the National Cancer Center in China.

Journal of cancer research and clinical oncology

Zhang G, Zhang C, Sun N, Xue L, Yang Z, Fang L, Zhang Z, Luo Y, Gao S, Xue Q, Mu J, Gao Y, Tan F, He J.
PMID: 34013382
J Cancer Res Clin Oncol. 2021 May 19; doi: 10.1007/s00432-021-03659-7. Epub 2021 May 19.

PURPOSE: The optimal mode of neoadjuvant treatment for esophageal squamous cell carcinoma (ESCC) has not been well characterized. Our study compared neoadjuvant chemotherapy (NCT) with neoadjuvant chemoradiotherapy (NCRT) for patients with ESCC.METHODS: Data from ESCC patients receiving NCRT or...

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Zhang G, Zhang C, Sun N, et al. Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of esophageal squamous cell carcinoma: a propensity score-matched study from the National Cancer Center in China. J Cancer Res Clin Oncol. 2021;doi: 10.1007/s00432-021-03659-7.
Zhang, G., Zhang, C., Sun, N., Xue, L., Yang, Z., Fang, L., Zhang, Z., Luo, Y., Gao, S., Xue, Q., Mu, J., Gao, Y., Tan, F., & He, J. (2021). Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of esophageal squamous cell carcinoma: a propensity score-matched study from the National Cancer Center in China. Journal of cancer research and clinical oncology, . https://doi.org/10.1007/s00432-021-03659-7
Zhang, Guochao, et al. "Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of esophageal squamous cell carcinoma: a propensity score-matched study from the National Cancer Center in China." Journal of cancer research and clinical oncology vol. (2021). doi: https://doi.org/10.1007/s00432-021-03659-7
Zhang G, Zhang C, Sun N, Xue L, Yang Z, Fang L, Zhang Z, Luo Y, Gao S, Xue Q, Mu J, Gao Y, Tan F, He J. Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for the treatment of esophageal squamous cell carcinoma: a propensity score-matched study from the National Cancer Center in China. J Cancer Res Clin Oncol. 2021 May 19; doi: 10.1007/s00432-021-03659-7. Epub 2021 May 19. PMID: 34013382.
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Showing 9985 to 9996 of 10358 entries