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Showing 241 to 242 of 242 entries
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The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics.

Autophagy

Mercer TJ, Tooze SA.
PMID: 34520329
Autophagy. 2021 Dec;17(12):4491-4493. doi: 10.1080/15548627.2021.1968615. Epub 2021 Sep 14.

The mammalian ULK kinase complex is the most upstream component in the macroautophagy/autophagy signaling pathway. ULK1 and homolog ULK2, the sole serine/threonine kinases in autophagy, transduce an array of autophagy-inducing stimuli to downstream autophagic machinery, regulating autophagy from autophagosome...

Validation of Optical Genome Mapping for the Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy.

The Journal of molecular diagnostics : JMD

Stence AA, Thomason JG, Pruessner JA, Sompallae RR, Snow AN, Ma D, Moore SA, Bossler AD.
PMID: 34384893
J Mol Diagn. 2021 Nov;23(11):1506-1514. doi: 10.1016/j.jmoldx.2021.07.021. Epub 2021 Aug 09.

The molecular diagnosis of facioscapulohumeral muscular dystrophy (FSHD) relies on detecting contractions of the unique D4Z4 repeat array at the chromosome 4q35 locus in the presence of a permissive 4q35A haplotype. Long, intact DNA molecules are required for accurate...

Showing 241 to 242 of 242 entries