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Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Biochemical pharmacology

Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ.
PMID: 34864607
Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02.

No abstract available.

Cite
Kasembeli MM, Singhmar P, Ma J, et al. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2021;195:114860doi: 10.1016/j.bcp.2021.114860.
Kasembeli, M. M., Singhmar, P., Ma, J., Edralin, J., Tang, Y., Adams, C., Heijnen, C. J., Kavelaars, A., & Tweardy, D. J. (2022). Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochemical pharmacology, 195114860. https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli, Moses M, et al. "Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]." Biochemical pharmacology vol. 195 (2022): 114860. doi: https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02. PMID: 34864607.
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Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease.

Frontiers in neuroscience

Kulason S, Xu E, Tward DJ, Bakker A, Albert M, Younes L, Miller MI.
PMID: 32973425
Front Neurosci. 2020 Aug 21;14:804. doi: 10.3389/fnins.2020.00804. eCollection 2020.

This study examines the atrophy patterns in the entorhinal and transentorhinal cortices of subjects that converted from normal cognition to mild cognitive impairment. The regions were manually segmented from 3T MRI, then corrected for variability in boundary definition over...

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Kulason S, Xu E, Tward DJ, et al. Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease. Front Neurosci. 2020;14:804doi: 10.3389/fnins.2020.00804.
Kulason, S., Xu, E., Tward, D. J., Bakker, A., Albert, M., Younes, L., & Miller, M. I. (2020). Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease. Frontiers in neuroscience, 14804. https://doi.org/10.3389/fnins.2020.00804
Kulason, Sue, et al. "Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease." Frontiers in neuroscience vol. 14 (2020): 804. doi: https://doi.org/10.3389/fnins.2020.00804
Kulason S, Xu E, Tward DJ, Bakker A, Albert M, Younes L, Miller MI. Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease. Front Neurosci. 2020 Aug 21;14:804. doi: 10.3389/fnins.2020.00804. eCollection 2020. PMID: 32973425; PMCID: PMC7472871.
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Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry.

Frontiers in neuroinformatics

Athey TL, Teneggi J, Vogelstein JT, Tward DJ, Mueller U, Miller MI.
PMID: 34456702
Front Neuroinform. 2021 Aug 11;15:704627. doi: 10.3389/fninf.2021.704627. eCollection 2021.

Neuromorphology is crucial to identifying neuronal subtypes and understanding learning. It is also implicated in neurological disease. However, standard morphological analysis focuses on macroscopic features such as branching frequency and connectivity between regions, and often neglects the internal geometry...

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Athey TL, Teneggi J, Vogelstein JT, et al. Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry. Front Neuroinform. 2021;15:704627doi: 10.3389/fninf.2021.704627.
Athey, T. L., Teneggi, J., Vogelstein, J. T., Tward, D. J., Mueller, U., & Miller, M. I. (2021). Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry. Frontiers in neuroinformatics, 15704627. https://doi.org/10.3389/fninf.2021.704627
Athey, Thomas L, et al. "Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry." Frontiers in neuroinformatics vol. 15 (2021): 704627. doi: https://doi.org/10.3389/fninf.2021.704627
Athey TL, Teneggi J, Vogelstein JT, Tward DJ, Mueller U, Miller MI. Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry. Front Neuroinform. 2021 Aug 11;15:704627. doi: 10.3389/fninf.2021.704627. eCollection 2021. PMID: 34456702; PMCID: PMC8385655.
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Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Biochemical pharmacology

Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ.
PMID: 34864607
Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02.

No abstract available.

Cite
Kasembeli MM, Singhmar P, Ma J, et al. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2021;195:114860doi: 10.1016/j.bcp.2021.114860.
Kasembeli, M. M., Singhmar, P., Ma, J., Edralin, J., Tang, Y., Adams, C., Heijnen, C. J., Kavelaars, A., & Tweardy, D. J. (2022). Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochemical pharmacology, 195114860. https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli, Moses M, et al. "Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]." Biochemical pharmacology vol. 195 (2022): 114860. doi: https://doi.org/10.1016/j.bcp.2021.114860
Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2022 Jan;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02. PMID: 34864607; PMCID: PMC8718107.
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Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients.

NPJ digital medicine

Richards DM, Tweardy MJ, Steinhubl SR, Chestek DW, Hoek TLV, Larimer KA, Wegerich SW.
PMID: 34750499
NPJ Digit Med. 2021 Nov 08;4(1):155. doi: 10.1038/s41746-021-00527-z.

The COVID-19 pandemic has accelerated the adoption of innovative healthcare methods, including remote patient monitoring. In the setting of limited healthcare resources, outpatient management of individuals newly diagnosed with COVID-19 was commonly implemented, some taking advantage of various personal...

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Richards DM, Tweardy MJ, Steinhubl SR, et al. Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients. NPJ Digit Med. 2021;4(1):155doi: 10.1038/s41746-021-00527-z.
Richards, D. M., Tweardy, M. J., Steinhubl, S. R., Chestek, D. W., Hoek, T. L. V., Larimer, K. A., & Wegerich, S. W. (2021). Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients. NPJ digital medicine, 4(1), 155. https://doi.org/10.1038/s41746-021-00527-z
Richards, Dylan M, et al. "Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients." NPJ digital medicine vol. 4,1 (2021): 155. doi: https://doi.org/10.1038/s41746-021-00527-z
Richards DM, Tweardy MJ, Steinhubl SR, Chestek DW, Hoek TLV, Larimer KA, Wegerich SW. Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients. NPJ Digit Med. 2021 Nov 08;4(1):155. doi: 10.1038/s41746-021-00527-z. PMID: 34750499; PMCID: PMC8576003.
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Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility.

Pharmacological research

Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ.
PMID: 33932608
Pharmacol Res. 2021 Jul;169:105637. doi: 10.1016/j.phrs.2021.105637. Epub 2021 Apr 29.

Efforts to develop STAT3 inhibitors have focused on its SH2 domain starting with short phosphotyrosylated peptides based on STAT3 binding motifs, e.g. pY

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Kong R, Bharadwaj U, Eckols TK, et al. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res. 2021;169:105637doi: 10.1016/j.phrs.2021.105637.
Kong, R., Bharadwaj, U., Eckols, T. K., Kolosov, M., Wu, H., Cruz-Pavlovich, F. J. S., Shaw, A., Ifelayo, O. I., Zhao, H., Kasembeli, M. M., Wong, S. T. C., & Tweardy, D. J. (2021). Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacological research, 169105637. https://doi.org/10.1016/j.phrs.2021.105637
Kong, Ren, et al. "Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility." Pharmacological research vol. 169 (2021): 105637. doi: https://doi.org/10.1016/j.phrs.2021.105637
Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res. 2021 Jul;169:105637. doi: 10.1016/j.phrs.2021.105637. Epub 2021 Apr 29. PMID: 33932608; PMCID: PMC8217378.
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Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis".

BioMed research international

Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P.
PMID: 26078968
Biomed Res Int. 2015;2015:869648. doi: 10.1155/2015/869648. Epub 2015 May 18.

No abstract available.

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Khumbatta M, Firozgary B, Tweardy DJ, et al. Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". Biomed Res Int. 2015;2015:869648doi: 10.1155/2015/869648.
Khumbatta, M., Firozgary, B., Tweardy, D. J., Weinstock, J., Firozgary, G., Bhatena, Z., Bulsara, T., Siller, R., & Robinson, P. (2015). Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". BioMed research international, 2015869648. https://doi.org/10.1155/2015/869648
Khumbatta, Mitra, et al. "Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis"." BioMed research international vol. 2015 (2015): 869648. doi: https://doi.org/10.1155/2015/869648
Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". Biomed Res Int. 2015;2015:869648. doi: 10.1155/2015/869648. Epub 2015 May 18. PMID: 26078968; PMCID: PMC4452501.
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On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale.

Frontiers in neuroscience

Tward DJ, Miller MI.
PMID: 29093658
Front Neurosci. 2017 Oct 18;11:577. doi: 10.3389/fnins.2017.00577. eCollection 2017.

In this work we devise a strategy for discrete coding of anatomical form as described by a Bayesian prior model, quantifying the entropy of this representation as a function of code rate (number of bits), and its relationship geometric...

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Tward DJ, Miller MI. On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale. Front Neurosci. 2017;11:577doi: 10.3389/fnins.2017.00577.
Tward, D. J., & Miller, M. I. (2017). On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale. Frontiers in neuroscience, 11577. https://doi.org/10.3389/fnins.2017.00577
Tward, Daniel J, and Miller, Michael I. "On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale." Frontiers in neuroscience vol. 11 (2017): 577. doi: https://doi.org/10.3389/fnins.2017.00577
Tward DJ, Miller MI. On the Complexity of Human Neuroanatomy at the Millimeter Morphome Scale: Developing Codes and Characterizing Entropy Indexed to Spatial Scale. Front Neurosci. 2017 Oct 18;11:577. doi: 10.3389/fnins.2017.00577. eCollection 2017. PMID: 29093658; PMCID: PMC5651257.
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ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM.

Quarterly of applied mathematics

Tward DJ, Mitra PP, Miller MI.
PMID: 31866695
Q Appl Math. 2019;77:467-488. doi: 10.1090/qam/1527. Epub 2018 Nov 20.

Anatomy is undergoing a renaissance driven by the availability of large digital data sets generated by light microscopy. A central computational task is to map individual data volumes to standardized templates. This is accomplished by regularized estimation of a...

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Tward DJ, Mitra PP, Miller MI. ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM. Q Appl Math. 2018;77:467-488doi: 10.1090/qam/1527.
Tward, D. J., Mitra, P. P., & Miller, M. I. (2019). ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM. Quarterly of applied mathematics, 77467-488. https://doi.org/10.1090/qam/1527
Tward, Daniel J, et al. "ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM." Quarterly of applied mathematics vol. 77 (2019): 467-488. doi: https://doi.org/10.1090/qam/1527
Tward DJ, Mitra PP, Miller MI. ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM. Q Appl Math. 2019;77:467-488. doi: 10.1090/qam/1527. Epub 2018 Nov 20. PMID: 31866695; PMCID: PMC6924927.
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Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors.

eLife

Graves AR, Roth RH, Tan HL, Zhu Q, Bygrave AM, Lopez-Ortega E, Hong I, Spiegel AC, Johnson RC, Vogelstein JT, Tward DJ, Miller MI, Huganir RL.
PMID: 34658338
Elife. 2021 Oct 18;10. doi: 10.7554/eLife.66809.

Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition and disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have...

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Graves AR, Roth RH, Tan HL, et al. Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. Elife. 2021;10doi: 10.7554/eLife.66809.
Graves, A. R., Roth, R. H., Tan, H. L., Zhu, Q., Bygrave, A. M., Lopez-Ortega, E., Hong, I., Spiegel, A. C., Johnson, R. C., Vogelstein, J. T., Tward, D. J., Miller, M. I., & Huganir, R. L. (2021). Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. eLife, 10. https://doi.org/10.7554/eLife.66809
Graves, Austin R, et al. "Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.66809
Graves AR, Roth RH, Tan HL, Zhu Q, Bygrave AM, Lopez-Ortega E, Hong I, Spiegel AC, Johnson RC, Vogelstein JT, Tward DJ, Miller MI, Huganir RL. Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. Elife. 2021 Oct 18;10. doi: 10.7554/eLife.66809. PMID: 34658338; PMCID: PMC8616579.
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Vestibular function and cortical and sub-cortical alterations in an aging population.

Heliyon

Jacob A, Tward DJ, Resnick S, Smith PF, Lopez C, Rebello E, Wei EX, Tilak Ratnanather J, Agrawal Y.
PMID: 32904672
Heliyon. 2020 Aug 18;6(8):e04728. doi: 10.1016/j.heliyon.2020.e04728. eCollection 2020 Aug.

While it is well known that the vestibular system is responsible for maintaining balance, posture and coordination, there is increasing evidence that it also plays an important role in cognition. Moreover, a growing number of epidemiological studies are demonstrating...

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Jacob A, Tward DJ, Resnick S, et al. Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon. 2020;6(8):e04728doi: 10.1016/j.heliyon.2020.e04728.
Jacob, A., Tward, D. J., Resnick, S., Smith, P. F., Lopez, C., Rebello, E., Wei, E. X., Tilak Ratnanather, J., & Agrawal, Y. (2020). Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon, 6(8), e04728. https://doi.org/10.1016/j.heliyon.2020.e04728
Jacob, Athira, et al. "Vestibular function and cortical and sub-cortical alterations in an aging population." Heliyon vol. 6,8 (2020): e04728. doi: https://doi.org/10.1016/j.heliyon.2020.e04728
Jacob A, Tward DJ, Resnick S, Smith PF, Lopez C, Rebello E, Wei EX, Tilak Ratnanather J, Agrawal Y. Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon. 2020 Aug 18;6(8):e04728. doi: 10.1016/j.heliyon.2020.e04728. eCollection 2020 Aug. PMID: 32904672; PMCID: PMC7457317.
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First Description of Oral .

Clinical microbiology & case reports

DiNardo AR, Schmidt D, Mitchell A, Kaufman Y, Tweardy DJ.
PMID: 27227123
Clin Microbiol Case Rep. 2015;1(3).

The majority of disseminated cryptococcal infections occur in patients with acquired immunodeficiency syndrome (AIDS), with only 11-14% of cases occurring in patients without AIDS. Most non-AIDS related cases (75%) occur in patients with another immune deficiency. Here, we present...

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DiNardo AR, Schmidt D, Mitchell A, et al. First Description of Oral . Clin Microbiol Case Rep. 2015;1(3)
DiNardo, A. R., Schmidt, D., Mitchell, A., Kaufman, Y., & Tweardy, D. J. (2015). First Description of Oral . Clinical microbiology & case reports, 1(3), .
DiNardo, Andrew R, et al. "First Description of Oral ." Clinical microbiology & case reports vol. 1,3 (2015).
DiNardo AR, Schmidt D, Mitchell A, Kaufman Y, Tweardy DJ. First Description of Oral . Clin Microbiol Case Rep. 2015;1(3). PMID: 27227123; PMCID: PMC4876986.
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Showing 13 to 24 of 41 entries