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Showing 25 to 36 of 41 entries
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Contribution of chaperones to STAT pathway signaling.

JAK-STAT

Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ.
PMID: 26413421
JAKSTAT. 2014 Oct 30;3(3):e970459. doi: 10.4161/21623988.2014.970459. eCollection 2014.

Aberrant STAT signaling is associated with the development and progression of many cancers and immune related diseases. Recent findings demonstrate that proteostasis modulators under clinical investigation for cancer therapy have a significant impact on STAT signaling, which may be...

Impact of epidural analgesia on the systemic biomarker response after hepatic resection.

Oncotarget

Vicente D, Patino M, Marcus R, Lillmoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP.
PMID: 30728909
Oncotarget. 2019 Jan 15;10(5):584-594. doi: 10.18632/oncotarget.26549. eCollection 2019 Jan 15.

BACKGROUND: Perioperative inflammation is associated with poor oncologic outcomes. Regional analgesia has been shown mitigate some of these inflammatory changes and be associated with better oncologic outcomes in patients with hepatic malignancies. The mechanism for this effect, however, remains...

The Generalized NEQ and Detectability Index for Tomosynthesis and Cone-Beam CT: From Cascaded Systems Analysis to Human Observers.

Proceedings of SPIE--the International Society for Optical Engineering

Gang GJ, Lee J, Stayman JW, Tward DJ, Zbijewski W, Prince JL, Siewerdsen JH.
PMID: 24307930
Proc SPIE Int Soc Opt Eng. 2010 Mar 22;7622. doi: 10.1117/12.845462.

PURPOSE: In the early development of new imaging modalities - such as tomosynthesis and cone-beam CT (CBCT) - an accurate predictive model for imaging performance is particularly valuable in identifying the physical factors that govern image quality and guiding...

A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture.

Oncogenesis

Zheng M, Turton KB, Zhu F, Li Y, Grindle KM, Annis DS, Lu L, Drennan AC, Tweardy DJ, Bharadwaj U, Mosher DF, Rui L.
PMID: 26727576
Oncogenesis. 2016 Jan 04;4:e184. doi: 10.1038/oncsis.2015.44.

Activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL) is characterized by increased expression and activator of signal transducer and activator of transcription 3 (STAT3). ABC DLBCL cells require STAT3 for growth in culture. In ABC DLBCL cells, eosinophils and...

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Oncotarget

Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ.
PMID: 30899429
Oncotarget. 2019 Feb 22;10(16):1603. doi: 10.18632/oncotarget.26743. eCollection 2019 Feb 22.

[This corrects the article DOI: 10.18632/oncotarget.8368.].

Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data.

Annual review of biomedical engineering

Goergen CJ, Tweardy MJ, Steinhubl SR, Wegerich SW, Singh K, Mieloszyk RJ, Dunn J.
PMID: 34932906
Annu Rev Biomed Eng. 2021 Dec 21; doi: 10.1146/annurev-bioeng-103020-040136. Epub 2021 Dec 21.

Mounting clinical evidence suggests that viral infections can lead to detectable changes in an individual's normal physiologic and behavioral metrics, including heart and respiration rates, heart rate variability, temperature, activity, and sleep prior to symptom onset, potentially even in...

Corrigendum to "Robust Diffeomorphic Mapping via Geodesically Controlled Active Shapes".

International journal of biomedical imaging

Tward DJ, Ma J, Miller MI, Younes L.
PMID: 34135947
Int J Biomed Imaging. 2021 May 26;2021:9780202. doi: 10.1155/2021/9780202. eCollection 2021.

[This corrects the article DOI: 10.1155/2013/205494.].

Motion Artifact Reduction In Photoplethysmography For Reliable Signal Selection.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Mao R, Tweardy M, Wegerich SW, Goergen CJ, Wodicka GR, Zhu F.
PMID: 34892399
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5625-5630. doi: 10.1109/EMBC46164.2021.9630595.

Photoplethysmography (PPG) is a non-invasive and economical technique to extract vital signs of the human body. Although it has been widely used in consumer and research grade wrist devices to track a user's physiology, the PPG signal is very...

Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Biochemical pharmacology

Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ.
PMID: 34864607
Biochem Pharmacol. 2021 Dec 02;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02.

No abstract available.

PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.

Cell reports

Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J.
PMID: 27149849
Cell Rep. 2016 Apr 26;15(4):843-856. doi: 10.1016/j.celrep.2016.03.070. Epub 2016 Apr 14.

Upon growth factor stimulation or in some EGFR mutant cancer cells, PKM2 translocates into the nucleus to induce glycolysis and cell growth. Here, we report that nuclear PKM2 binds directly to poly-ADP ribose, and this PAR-binding capability is critical...

Robust Diffeomorphic Mapping via Geodesically Controlled Active Shapes.

International journal of biomedical imaging

Tward DJ, Ma J, Miller MI, Younes L.
PMID: 23690757
Int J Biomed Imaging. 2013;2013:205494. doi: 10.1155/2013/205494. Epub 2013 Apr 03.

This paper presents recent advances in the use of diffeomorphic active shapes which incorporate the conservation laws of large deformation diffeomorphic metric mapping. The equations of evolution satisfying the conservation law are geodesics under the diffeomorphism metric and therefore...

Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Biochemical pharmacology

Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ.
PMID: 34864607
Biochem Pharmacol. 2021 Dec 02;195:114860. doi: 10.1016/j.bcp.2021.114860. Epub 2021 Dec 02.

No abstract available.

Showing 25 to 36 of 41 entries