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Showing 289 to 294 of 294 entries
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Can Recent Health Crises Create Opportunities for Deprescribing?.

The Senior care pharmacist

Turner JP.
PMID: 34452650
Sr Care Pharm. 2021 Sep 01;36(9):422-425. doi: 10.4140/TCP.n.2021.422.

No abstract available.

Variability in reporting of key outcome predictors in acute myocardial infarction cardiogenic shock trials.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Tyler JM, Brown C, Jentzer JC, Baran DA, van Diepen S, Kapur NK, Garberich RF, Garcia S, Sharkey SW, Henry TD.
PMID: 33871159
Catheter Cardiovasc Interv. 2022 Jan 01;99(1):19-26. doi: 10.1002/ccd.29710. Epub 2021 Apr 19.

BACKGROUND: Among acute myocardial infarction patients with cardiogenic shock (AMICS), a number of key variables predict mortality, including cardiac arrest (CA) and shock classification as proposed by Society for Cardiovascular Angiography and Intervention (SCAI). Given this prognostic importance, we...

Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft.

JCI insight

Le DT, Huynh TR, Burt B, Van Buren G, Abeynaike SA, Zalfa C, Nikzad R, Kheradmand F, Tyner JJ, Paust S.
PMID: 34081628
JCI Insight. 2021 Jul 08;6(13). doi: 10.1172/jci.insight.140116.

Existing patient-derived xenograft (PDX) mouse models of solid tumors lack a fully tumor donor-matched, syngeneic, and functional immune system. We developed a model that overcomes these limitations by engrafting lymphopenic recipient mice with a fresh, undisrupted piece of solid...

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing.

JAMA neurology

Sechi E, Buciuc M, Pittock SJ, Chen JJ, Fryer JP, Jenkins SM, Budhram A, Weinshenker BG, Lopez-Chiriboga AS, Tillema JM, McKeon A, Mills JR, Tobin WO, Flanagan EP.
PMID: 33900394
JAMA Neurol. 2021 Jun 01;78(6):741-746. doi: 10.1001/jamaneurol.2021.0912.

IMPORTANCE: Myelin oligodendrocyte glycoprotein-IgG1-associated disorder (MOGAD) is a distinct central nervous system-demyelinating disease. Positive results on MOG-IgG1 testing by live cell-based assays can confirm a MOGAD diagnosis, but false-positive results may occur.OBJECTIVE: To determine the positive predictive value (PPV)...

Neurofascin-155 Immunoglobulin Subtypes: Clinicopathologic Associations and Neurologic Outcomes.

Neurology

Shelly S, Klein CJ, Dyck PJB, Paul P, Mauermann ML, Berini SE, Howe B, Fryer JP, Basal E, Bakri HM, Laughlin RS, McKeon A, Pittock SJ, Mills J, Dubey D.
PMID: 34635556
Neurology. 2021 Dec 14;97(24):e2392-e2403. doi: 10.1212/WNL.0000000000012932. Epub 2021 Oct 11.

BACKGROUND AND OBJECTIVE: Multiple studies highlighting the diagnostic utility of neurofascin-155 (NF155)-immunoglobulin G4 (IgG4) in chronic demyelinating inflammatory polyradiculoneuropathy (CIDP) have been published. However, few studies comprehensively address the long-term outcomes or clinical utility of NF155-immunoglobulin M (IgM) or...

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia.

NPJ precision oncology

White BS, Khan SA, Mason MJ, Ammad-Ud-Din M, Potdar S, Malani D, Kuusanmäki H, Druker BJ, Heckman C, Kallioniemi O, Kurtz SE, Porkka K, Tognon CE, Tyner JW, Aittokallio T, Wennerberg K, Guinney J.
PMID: 34302041
NPJ Precis Oncol. 2021 Jul 23;5(1):71. doi: 10.1038/s41698-021-00209-9.

The FDA recently approved eight targeted therapies for acute myeloid leukemia (AML), including the BCL-2 inhibitor venetoclax. Maximizing efficacy of these treatments requires refining patient selection. To this end, we analyzed two recent AML studies profiling the gene expression...

Showing 289 to 294 of 294 entries