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Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16).

Journal of biomolecular structure & dynamics

Kumar M, Roy A, Rawat RS, Alok A, Tetala KKR, Biswas NR, Kaur P, Kumar S.
PMID: 34766876
J Biomol Struct Dyn. 2021 Nov 12;1-11. doi: 10.1080/07391102.2021.1997821. Epub 2021 Nov 12.

Pathogenic RNA viruses are emerging as one of the major threats and posing challenges to human community. RNA viruses have an exceptionally shorter generation time and easy to adapt in host cells. The recent emergence of SARS-CoV-2, a long...

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Kumar M, Roy A, Rawat RS, et al. Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16). J Biomol Struct Dyn. 2021;1-11doi: 10.1080/07391102.2021.1997821.
Kumar, M., Roy, A., Rawat, R. S., Alok, A., Tetala, K. K. R., Biswas, N. R., Kaur, P., & Kumar, S. (2021). Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16). Journal of biomolecular structure & dynamics, 1-11. https://doi.org/10.1080/07391102.2021.1997821
Kumar, Mukesh, et al. "Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16)." Journal of biomolecular structure & dynamics vol. (2021): 1-11. doi: https://doi.org/10.1080/07391102.2021.1997821
Kumar M, Roy A, Rawat RS, Alok A, Tetala KKR, Biswas NR, Kaur P, Kumar S. Identification and structural studies of natural inhibitors against SARS-CoV-2 viral RNA methyltransferase (NSP16). J Biomol Struct Dyn. 2021 Nov 12;1-11. doi: 10.1080/07391102.2021.1997821. Epub 2021 Nov 12. PMID: 34766876.
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Evaluation to Differentiate between Tumor Lesions and the Parenchyma in Partial Nephrectomies for Renal Tumors Based on Quantitative Fluorescence Imaging Using Indocyanine Green Dye.

Current urology

Soga N, Inoko A, Furusawa J, Ogura Y.
PMID: 31768173
Curr Urol. 2019 Oct;13(2):74-81. doi: 10.1159/000499289. Epub 2019 Oct 01.

INTRODUCTION: Near-infrared fluorescence imaging with indocyanine green is a useful tool during partial nephrectomy. Because an accurate method for judging hasn't been established yet, the success rate may be slightly different and inconsistent.MATERIALS AND METHODS: A total of 21...

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Soga N, Inoko A, Furusawa J, et al. Evaluation to Differentiate between Tumor Lesions and the Parenchyma in Partial Nephrectomies for Renal Tumors Based on Quantitative Fluorescence Imaging Using Indocyanine Green Dye. Curr Urol. 2019;13(2):74-81doi: 10.1159/000499289.
Soga, N., Inoko, A., Furusawa, J., & Ogura, Y. (2019). Evaluation to Differentiate between Tumor Lesions and the Parenchyma in Partial Nephrectomies for Renal Tumors Based on Quantitative Fluorescence Imaging Using Indocyanine Green Dye. Current urology, 13(2), 74-81. https://doi.org/10.1159/000499289
Soga, Norihito, et al. "Evaluation to Differentiate between Tumor Lesions and the Parenchyma in Partial Nephrectomies for Renal Tumors Based on Quantitative Fluorescence Imaging Using Indocyanine Green Dye." Current urology vol. 13,2 (2019): 74-81. doi: https://doi.org/10.1159/000499289
Soga N, Inoko A, Furusawa J, Ogura Y. Evaluation to Differentiate between Tumor Lesions and the Parenchyma in Partial Nephrectomies for Renal Tumors Based on Quantitative Fluorescence Imaging Using Indocyanine Green Dye. Curr Urol. 2019 Oct;13(2):74-81. doi: 10.1159/000499289. Epub 2019 Oct 01. PMID: 31768173; PMCID: PMC6873096.
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Venous and Arterial Thromboembolism in Patients With Cancer: .

JACC. CardioOncology

Gervaso L, Dave H, Khorana AA.
PMID: 34396323
JACC CardioOncol. 2021 Apr 20;3(2):173-190. doi: 10.1016/j.jaccao.2021.03.001. eCollection 2021 Jun.

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, represents a major cause of morbidity and mortality in patients with cancer. Arterial thromboembolism, including myocardial infarction and stroke, is also prevalent. Risk differs in subgroups, with higher rates...

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Gervaso L, Dave H, Khorana AA. Venous and Arterial Thromboembolism in Patients With Cancer: . JACC CardioOncol. 2021;3(2):173-190doi: 10.1016/j.jaccao.2021.03.001.
Gervaso, L., Dave, H., & Khorana, A. A. (2021). Venous and Arterial Thromboembolism in Patients With Cancer: . JACC. CardioOncology, 3(2), 173-190. https://doi.org/10.1016/j.jaccao.2021.03.001
Gervaso, Lorenzo, et al. "Venous and Arterial Thromboembolism in Patients With Cancer: ." JACC. CardioOncology vol. 3,2 (2021): 173-190. doi: https://doi.org/10.1016/j.jaccao.2021.03.001
Gervaso L, Dave H, Khorana AA. Venous and Arterial Thromboembolism in Patients With Cancer: . JACC CardioOncol. 2021 Apr 20;3(2):173-190. doi: 10.1016/j.jaccao.2021.03.001. eCollection 2021 Jun. PMID: 34396323; PMCID: PMC8352228.
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Identification of pesticides exposure biomarkers for residents living close to vineyards in France.

Environment international

Dereumeaux C, Mercier F, Soulard P, Hulin M, Oleko A, Pecheux M, Fillol C, Denys S, Quenel P.
PMID: 34890902
Environ Int. 2021 Dec 07;159:107013. doi: 10.1016/j.envint.2021.107013. Epub 2021 Dec 07.

Biomonitoring can be relevant for assessing pesticides exposure of residents living close to vineyards (LCTV). However, because xenobiotics are generally present at low levels in human biological matrices and the sources of pesticide exposure are multiple, several challenges need...

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Dereumeaux C, Mercier F, Soulard P, et al. Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environ Int. 2021;159:107013doi: 10.1016/j.envint.2021.107013.
Dereumeaux, C., Mercier, F., Soulard, P., Hulin, M., Oleko, A., Pecheux, M., Fillol, C., Denys, S., & Quenel, P. (2021). Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environment international, 159107013. https://doi.org/10.1016/j.envint.2021.107013
Dereumeaux, Clémentine, et al. "Identification of pesticides exposure biomarkers for residents living close to vineyards in France." Environment international vol. 159 (2021): 107013. doi: https://doi.org/10.1016/j.envint.2021.107013
Dereumeaux C, Mercier F, Soulard P, Hulin M, Oleko A, Pecheux M, Fillol C, Denys S, Quenel P. Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environ Int. 2021 Dec 07;159:107013. doi: 10.1016/j.envint.2021.107013. Epub 2021 Dec 07. PMID: 34890902.
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Prevalence of enteric opportunistic pathogens and extended-spectrum cephalosporin- and carbapenem-resistant coliforms and genes in wastewater from municipal wastewater treatment plants in Croatia.

Journal of hazardous materials

Puljko A, Milaković M, Križanović S, Kosić-Vukšić J, Babić I, Petrić I, Maravić A, Jelić M, Udiković-Kolić N.
PMID: 34991006
J Hazard Mater. 2021 Dec 28;427:128155. doi: 10.1016/j.jhazmat.2021.128155. Epub 2021 Dec 28.

Extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacterales are a critical global health problem and wastewater treatment plants (WWTPs) can promote their spread into the environment; yet their efficacy is not well characterized. Here, we have used conventional culturing to monitor...

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Puljko A, Milaković M, Križanović S, et al. Prevalence of enteric opportunistic pathogens and extended-spectrum cephalosporin- and carbapenem-resistant coliforms and genes in wastewater from municipal wastewater treatment plants in Croatia. J Hazard Mater. 2021;427:128155doi: 10.1016/j.jhazmat.2021.128155.
Puljko, A., Milaković, M., Križanović, S., Kosić-Vukšić, J., Babić, I., Petrić, I., Maravić, A., Jelić, M., & Udiković-Kolić, N. (2021). Prevalence of enteric opportunistic pathogens and extended-spectrum cephalosporin- and carbapenem-resistant coliforms and genes in wastewater from municipal wastewater treatment plants in Croatia. Journal of hazardous materials, 427128155. https://doi.org/10.1016/j.jhazmat.2021.128155
Puljko, Ana, et al. "Prevalence of enteric opportunistic pathogens and extended-spectrum cephalosporin- and carbapenem-resistant coliforms and genes in wastewater from municipal wastewater treatment plants in Croatia." Journal of hazardous materials vol. 427 (2021): 128155. doi: https://doi.org/10.1016/j.jhazmat.2021.128155
Puljko A, Milaković M, Križanović S, Kosić-Vukšić J, Babić I, Petrić I, Maravić A, Jelić M, Udiković-Kolić N. Prevalence of enteric opportunistic pathogens and extended-spectrum cephalosporin- and carbapenem-resistant coliforms and genes in wastewater from municipal wastewater treatment plants in Croatia. J Hazard Mater. 2021 Dec 28;427:128155. doi: 10.1016/j.jhazmat.2021.128155. Epub 2021 Dec 28. PMID: 34991006.
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Reversible cerebral vasoconstriction syndrome developing after an erenumab injection for migraine prevention.

Cephalalgia : an international journal of headache

Rozen TD, Bhatt AA.
PMID: 34405713
Cephalalgia. 2021 Aug 18;3331024211037277. doi: 10.1177/03331024211037277. Epub 2021 Aug 18.

BACKGROUND: Reversible cerebral vasoconstriction syndrome is normally triggered by vasoactive compounds or illicit drugs. A new type of migraine preventive medication blocks calcitonin gene-related peptide utilizing monoclonal antibodies. Calcitonin gene-related peptide is a potent vasodilator for the cerebrovascular system....

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Rozen TD, Bhatt AA. Reversible cerebral vasoconstriction syndrome developing after an erenumab injection for migraine prevention. Cephalalgia. 2021;3331024211037277doi: 10.1177/03331024211037277.
Rozen, T. D., & Bhatt, A. A. (2021). Reversible cerebral vasoconstriction syndrome developing after an erenumab injection for migraine prevention. Cephalalgia : an international journal of headache, 3331024211037277. https://doi.org/10.1177/03331024211037277
Rozen, Todd D, and Bhatt, Alok A. "Reversible cerebral vasoconstriction syndrome developing after an erenumab injection for migraine prevention." Cephalalgia : an international journal of headache vol. (2021): 3331024211037277. doi: https://doi.org/10.1177/03331024211037277
Rozen TD, Bhatt AA. Reversible cerebral vasoconstriction syndrome developing after an erenumab injection for migraine prevention. Cephalalgia. 2021 Aug 18;3331024211037277. doi: 10.1177/03331024211037277. Epub 2021 Aug 18. PMID: 34405713.
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Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status.

Cancer medicine

Kamath SD, Torrejon N, Wei W, Tullio K, Nair KG, Liska D, Krishnamurthi SS, Khorana AA.
PMID: 34647438
Cancer Med. 2021 Nov;10(21):7542-7550. doi: 10.1002/cam4.4276. Epub 2021 Oct 14.

BACKGROUND: The incidence of colorectal cancer (CRC) in patients under age 50 is rising for unclear reasons. We examined the effects of socioeconomic factors on outcomes for patients with early-onset CRC compared to late-onset CRC.METHODS: Patients with CRC from...

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Kamath SD, Torrejon N, Wei W, et al. Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status. Cancer Med. 2021;10(21):7542-7550doi: 10.1002/cam4.4276.
Kamath, S. D., Torrejon, N., Wei, W., Tullio, K., Nair, K. G., Liska, D., Krishnamurthi, S. S., & Khorana, A. A. (2021). Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status. Cancer medicine, 10(21), 7542-7550. https://doi.org/10.1002/cam4.4276
Kamath, Suneel D, et al. "Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status." Cancer medicine vol. 10,21 (2021): 7542-7550. doi: https://doi.org/10.1002/cam4.4276
Kamath SD, Torrejon N, Wei W, Tullio K, Nair KG, Liska D, Krishnamurthi SS, Khorana AA. Racial disparities negatively impact outcomes in early-onset colorectal cancer independent of socioeconomic status. Cancer Med. 2021 Nov;10(21):7542-7550. doi: 10.1002/cam4.4276. Epub 2021 Oct 14. PMID: 34647438; PMCID: PMC8559495.
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Association of tuberculosis treatment with pregnancy complications: A protocol for systematic review and meta-analysis.

Medicine

Kgathi MA, Phoswa WN.
PMID: 34797321
Medicine (Baltimore). 2021 Nov 19;100(46):e27849. doi: 10.1097/MD.0000000000027849.

BACKGROUND: The increasing burden of tuberculosis (TB) remains a very serious concern around the world, and account for a decreased quantity and quality of life. However, there is a limited epidemiology of the association of TB treatment with pregnancy....

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Kgathi MA, Phoswa WN. Association of tuberculosis treatment with pregnancy complications: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021;100(46):e27849doi: 10.1097/MD.0000000000027849.
Kgathi, M. A., & Phoswa, W. N. (2021). Association of tuberculosis treatment with pregnancy complications: A protocol for systematic review and meta-analysis. Medicine, 100(46), e27849. https://doi.org/10.1097/MD.0000000000027849
Kgathi, Moloko A, and Phoswa, Wendy N. "Association of tuberculosis treatment with pregnancy complications: A protocol for systematic review and meta-analysis." Medicine vol. 100,46 (2021): e27849. doi: https://doi.org/10.1097/MD.0000000000027849
Kgathi MA, Phoswa WN. Association of tuberculosis treatment with pregnancy complications: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021 Nov 19;100(46):e27849. doi: 10.1097/MD.0000000000027849. PMID: 34797321; PMCID: PMC8601312.
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Thrombotic Complications Associated with Immune Checkpoint Inhibitors.

Cancers

Wang TF, Khorana AA, Carrier M.
PMID: 34572833
Cancers (Basel). 2021 Sep 14;13(18). doi: 10.3390/cancers13184606.

Thromboembolism is a common complication in patients with cancer and is associated with significant morbidity and mortality. Anticancer treatment is a known risk factor of cancer-associated thrombosis. Immune checkpoint inhibitors have become a mainstay of treatment in various cancers....

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Wang TF, Khorana AA, Carrier M. Thrombotic Complications Associated with Immune Checkpoint Inhibitors. Cancers (Basel). 2021;13(18)doi: 10.3390/cancers13184606.
Wang, T. F., Khorana, A. A., & Carrier, M. (2021). Thrombotic Complications Associated with Immune Checkpoint Inhibitors. Cancers, 13(18), . https://doi.org/10.3390/cancers13184606
Wang, Tzu-Fei, et al. "Thrombotic Complications Associated with Immune Checkpoint Inhibitors." Cancers vol. 13,18 (2021). doi: https://doi.org/10.3390/cancers13184606
Wang TF, Khorana AA, Carrier M. Thrombotic Complications Associated with Immune Checkpoint Inhibitors. Cancers (Basel). 2021 Sep 14;13(18). doi: 10.3390/cancers13184606. PMID: 34572833; PMCID: PMC8469452.
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Identification of pesticides exposure biomarkers for residents living close to vineyards in France.

Environment international

Dereumeaux C, Mercier F, Soulard P, Hulin M, Oleko A, Pecheux M, Fillol C, Denys S, Quenel P.
PMID: 34890902
Environ Int. 2021 Dec 07;159:107013. doi: 10.1016/j.envint.2021.107013. Epub 2021 Dec 07.

Biomonitoring can be relevant for assessing pesticides exposure of residents living close to vineyards (LCTV). However, because xenobiotics are generally present at low levels in human biological matrices and the sources of pesticide exposure are multiple, several challenges need...

Cite
Dereumeaux C, Mercier F, Soulard P, et al. Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environ Int. 2021;159:107013doi: 10.1016/j.envint.2021.107013.
Dereumeaux, C., Mercier, F., Soulard, P., Hulin, M., Oleko, A., Pecheux, M., Fillol, C., Denys, S., & Quenel, P. (2021). Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environment international, 159107013. https://doi.org/10.1016/j.envint.2021.107013
Dereumeaux, Clémentine, et al. "Identification of pesticides exposure biomarkers for residents living close to vineyards in France." Environment international vol. 159 (2021): 107013. doi: https://doi.org/10.1016/j.envint.2021.107013
Dereumeaux C, Mercier F, Soulard P, Hulin M, Oleko A, Pecheux M, Fillol C, Denys S, Quenel P. Identification of pesticides exposure biomarkers for residents living close to vineyards in France. Environ Int. 2021 Dec 07;159:107013. doi: 10.1016/j.envint.2021.107013. Epub 2021 Dec 07. PMID: 34890902.
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Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Goyal L, Sirard C, Schrag M, Kagey MH, Eads JR, Stein S, El-Khoueiry AB, Manji GA, Abrams TA, Khorana AA, Miksad R, Mahalingam D, Zhu AX, Duda DG.
PMID: 32878766
Clin Cancer Res. 2020 Dec 01;26(23):6158-6167. doi: 10.1158/1078-0432.CCR-20-1310. Epub 2020 Sep 02.

PURPOSE: Dickkopf-1 (DKK1) modulates Wnt signaling, promoting tumor growth, metastasis, and immunosuppression. High DKK1 expression has been detected in various tumor types-including biliary tract cancer (BTC)-and is associated with poor prognosis. DKN-01-a humanized mAb targeting DKK1-was evaluated in a...

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Goyal L, Sirard C, Schrag M, et al. Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer. Clin Cancer Res. 2020;26(23):6158-6167doi: 10.1158/1078-0432.CCR-20-1310.
Goyal, L., Sirard, C., Schrag, M., Kagey, M. H., Eads, J. R., Stein, S., El-Khoueiry, A. B., Manji, G. A., Abrams, T. A., Khorana, A. A., Miksad, R., Mahalingam, D., Zhu, A. X., & Duda, D. G. (2020). Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 26(23), 6158-6167. https://doi.org/10.1158/1078-0432.CCR-20-1310
Goyal, Lipika, et al. "Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 26,23 (2020): 6158-6167. doi: https://doi.org/10.1158/1078-0432.CCR-20-1310
Goyal L, Sirard C, Schrag M, Kagey MH, Eads JR, Stein S, El-Khoueiry AB, Manji GA, Abrams TA, Khorana AA, Miksad R, Mahalingam D, Zhu AX, Duda DG. Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer. Clin Cancer Res. 2020 Dec 01;26(23):6158-6167. doi: 10.1158/1078-0432.CCR-20-1310. Epub 2020 Sep 02. PMID: 32878766.
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Can Diffusion-Weighted Imaging Serve as an Imaging Biomarker for Acute Bacterial Rhinosinusitis?.

Cureus

Bhatt AA, Donaldson AM, Olomu OU, Gupta V, Sandhu SJS.
PMID: 32968559
Cureus. 2020 Aug 20;12(8):e9893. doi: 10.7759/cureus.9893.

Acute rhinosinusitis is defined as symptomatic inflammation of the mucosal lining of the nasal cavity and paranasal sinuses lasting less than four weeks. It is most commonly secondary to viral infection but is often challenging to distinguish from bacterial...

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Bhatt AA, Donaldson AM, Olomu OU, et al. Can Diffusion-Weighted Imaging Serve as an Imaging Biomarker for Acute Bacterial Rhinosinusitis?. Cureus. 2020;12(8):e9893doi: 10.7759/cureus.9893.
Bhatt, A. A., Donaldson, A. M., Olomu, O. U., Gupta, V., & Sandhu, S. J. S. (2020). Can Diffusion-Weighted Imaging Serve as an Imaging Biomarker for Acute Bacterial Rhinosinusitis?. Cureus, 12(8), e9893. https://doi.org/10.7759/cureus.9893
Bhatt, Alok A, et al. "Can Diffusion-Weighted Imaging Serve as an Imaging Biomarker for Acute Bacterial Rhinosinusitis?." Cureus vol. 12,8 (2020): e9893. doi: https://doi.org/10.7759/cureus.9893
Bhatt AA, Donaldson AM, Olomu OU, Gupta V, Sandhu SJS. Can Diffusion-Weighted Imaging Serve as an Imaging Biomarker for Acute Bacterial Rhinosinusitis?. Cureus. 2020 Aug 20;12(8):e9893. doi: 10.7759/cureus.9893. PMID: 32968559; PMCID: PMC7502418.
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