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Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of alpha-Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids.

The Journal of organic chemistry

Okauchi T, Kakiuchi T, Kitamura N, Utsunomiya T, Ichikawa J, Minami T.
PMID: 11671980
J Org Chem. 1997 Nov 28;62(24):8419-8424. doi: 10.1021/jo971153g.

alpha-Ester-substituted 1,3-dienylphosphonates 7 and 8, prepared by the Knoevenagel condensation, underwent intramolecular [2 + 2] cycloaddition in the presence of Lewis acid to form bicyclo[4.2.0] (26-57% yield) and bicyclo[3.2.0]skeleton (14-38% yield), respectively. Similar treatment of homologous 1,3-dienylphosphonate 11 and...

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Okauchi T, Kakiuchi T, Kitamura N, et al. Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of alpha-Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids. J Org Chem. 1997;62(24):8419-8424doi: 10.1021/jo971153g.
Okauchi, T., Kakiuchi, T., Kitamura, N., Utsunomiya, T., Ichikawa, J., & Minami, T. (1997). Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of alpha-Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids. The Journal of organic chemistry, 62(24), 8419-8424. https://doi.org/10.1021/jo971153g
Okauchi, Tatsuo, et al. "Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of alpha-Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids." The Journal of organic chemistry vol. 62,24 (1997): 8419-8424. doi: https://doi.org/10.1021/jo971153g
Okauchi T, Kakiuchi T, Kitamura N, Utsunomiya T, Ichikawa J, Minami T. Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of alpha-Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids. J Org Chem. 1997 Nov 28;62(24):8419-8424. doi: 10.1021/jo971153g. PMID: 11671980.
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Clinical significance of disordered beta-catenin expression pattern in human gastric cancers.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Inoue M, Yasuda T, Fujiwara Y, Monden M.
PMID: 11984736
Gastric Cancer. 2000 Dec;3(4):193-201. doi: 10.1007/pl00011717.

BACKGROUND: Beta-catenin plays two distinct roles, in intercellular adhesion by E-cadherin, and in transcriptional activation via TCF/LEF. Theoretically, the former role is tumor-suppressive, while the latter is oncogenic. We investigated the involvement of beta-catenin in the histogenesis and clinical...

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Utsunomiya T, Doki Y, Takemoto H, et al. Clinical significance of disordered beta-catenin expression pattern in human gastric cancers. Gastric Cancer. 2000;3(4):193-201doi: 10.1007/pl00011717.
Utsunomiya, T., Doki, Y., Takemoto, H., Shiozaki, H., Yano, M., Inoue, M., Yasuda, T., Fujiwara, Y., & Monden, M. (2000). Clinical significance of disordered beta-catenin expression pattern in human gastric cancers. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 3(4), 193-201. https://doi.org/10.1007/pl00011717
Utsunomiya, Takehiro, et al. "Clinical significance of disordered beta-catenin expression pattern in human gastric cancers." Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association vol. 3,4 (2000): 193-201. doi: https://doi.org/10.1007/pl00011717
Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Inoue M, Yasuda T, Fujiwara Y, Monden M. Clinical significance of disordered beta-catenin expression pattern in human gastric cancers. Gastric Cancer. 2000 Dec;3(4):193-201. doi: 10.1007/pl00011717. PMID: 11984736.
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Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia.

The Journal of organic chemistry

Yasuda M, Kojima R, Tsutsui H, Utsunomiya D, Ishii K, Jinnouchi K, Shiragami T, Yamashita T.
PMID: 14510533
J Org Chem. 2003 Oct 03;68(20):7618-24. doi: 10.1021/jo030053+.

1,2,4-Triphenylbenzene and 2,2'-methylenedioxy-1,1'-binaphthalene successfully photosensitized the aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia and primary amines in the presence of m- or p-dicyanobenzene, which gave the 4-amino-1,2-benzocycloalkenes, 3-amino-1-arylpropanes, and 7-amino-5-(p-cyanophenyl)bicyclo[2.2.1]hept-2-ene, respectively. A key pathway for the photosensitized amination...

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Yasuda M, Kojima R, Tsutsui H, et al. Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia. J Org Chem. 2003;68(20):7618-24doi: 10.1021/jo030053+.
Yasuda, M., Kojima, R., Tsutsui, H., Utsunomiya, D., Ishii, K., Jinnouchi, K., Shiragami, T., & Yamashita, T. (2003). Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia. The Journal of organic chemistry, 68(20), 7618-24. https://doi.org/10.1021/jo030053+
Yasuda, Masahide, et al. "Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia." The Journal of organic chemistry vol. 68,20 (2003): 7618-24. doi: https://doi.org/10.1021/jo030053+
Yasuda M, Kojima R, Tsutsui H, Utsunomiya D, Ishii K, Jinnouchi K, Shiragami T, Yamashita T. Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia. J Org Chem. 2003 Oct 03;68(20):7618-24. doi: 10.1021/jo030053+. PMID: 14510533.
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Effect of caffeine on the multiplication of DNA and RNA viruses.

Molecular medicine reports

Murayama M, Tsujimoto K, Uozaki M, Katsuyama Y, Yamasaki H, Utsunomiya H, Koyama AH.
PMID: 21479405
Mol Med Rep. 2008 Mar-Apr;1(2):251-5.

The present study examined the effect of caffeine on RNA and DNA viruses, revealing that it inhibits the multiplication of both. In the presence of caffeine, the progeny virus yield of both herpes simplex virus type 1 (HSV-1) and...

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Murayama M, Tsujimoto K, Uozaki M, et al. Effect of caffeine on the multiplication of DNA and RNA viruses. Mol Med Rep. 2008;1(2):251-5
Murayama, M., Tsujimoto, K., Uozaki, M., Katsuyama, Y., Yamasaki, H., Utsunomiya, H., & Koyama, A. H. (2008). Effect of caffeine on the multiplication of DNA and RNA viruses. Molecular medicine reports, 1(2), 251-5.
Murayama, Masaki, et al. "Effect of caffeine on the multiplication of DNA and RNA viruses." Molecular medicine reports vol. 1,2 (2008): 251-5.
Murayama M, Tsujimoto K, Uozaki M, Katsuyama Y, Yamasaki H, Utsunomiya H, Koyama AH. Effect of caffeine on the multiplication of DNA and RNA viruses. Mol Med Rep. 2008 Mar-Apr;1(2):251-5. PMID: 21479405.
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The results of a new distal protection method in intervention for chronic total occlusion of the superficial femoral artery.

Cardiology research and practice

Kobayashi T, Funatsu A, Ejima E, Muranishi H, Utsunomiya M, Shibata K, Mizobuchi M, Enjoji Y, Nakamura S.
PMID: 19946634
Cardiol Res Pract. 2009;2009:687609. doi: 10.4061/2009/687609. Epub 2009 Sep 01.

Aims. To determine the efficacy of a new distal protection method in SFA CTO interventions. Methods and Results. From June 2003 to February 2009, ninety-two consecutive, chronic total occlusions of superficial femoral arteries were treated with catheter-based intervention using...

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Kobayashi T, Funatsu A, Ejima E, et al. The results of a new distal protection method in intervention for chronic total occlusion of the superficial femoral artery. Cardiol Res Pract. 2009;2009:687609doi: 10.4061/2009/687609.
Kobayashi, T., Funatsu, A., Ejima, E., Muranishi, H., Utsunomiya, M., Shibata, K., Mizobuchi, M., Enjoji, Y., & Nakamura, S. (2009). The results of a new distal protection method in intervention for chronic total occlusion of the superficial femoral artery. Cardiology research and practice, 2009687609. https://doi.org/10.4061/2009/687609
Kobayashi, Tomoko, et al. "The results of a new distal protection method in intervention for chronic total occlusion of the superficial femoral artery." Cardiology research and practice vol. 2009 (2009): 687609. doi: https://doi.org/10.4061/2009/687609
Kobayashi T, Funatsu A, Ejima E, Muranishi H, Utsunomiya M, Shibata K, Mizobuchi M, Enjoji Y, Nakamura S. The results of a new distal protection method in intervention for chronic total occlusion of the superficial femoral artery. Cardiol Res Pract. 2009;2009:687609. doi: 10.4061/2009/687609. Epub 2009 Sep 01. PMID: 19946634; PMCID: PMC2778189.
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Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy.

Gastroenterology research and practice

Tsurumaru D, Utsunomiya T, Matsuura S, Komori M, Kawanami S, Ishibashi T, Honda H.
PMID: 20396664
Gastroenterol Res Pract. 2010;2010:494195. doi: 10.1155/2010/494195. Epub 2010 Apr 12.

AIM: To clarify the endoscopic mucosal change of the stomach caused by Lugol's iodine solution spray on screening esophagogastroduodenoscopy (EGD).METHODS: Sixty-four consecutive patients who underwent EGD for esophageal squamous cell carcinoma screening were included in this study. The records...

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Tsurumaru D, Utsunomiya T, Matsuura S, et al. Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy. Gastroenterol Res Pract. 2010;2010:494195doi: 10.1155/2010/494195.
Tsurumaru, D., Utsunomiya, T., Matsuura, S., Komori, M., Kawanami, S., Ishibashi, T., & Honda, H. (2010). Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy. Gastroenterology research and practice, 2010494195. https://doi.org/10.1155/2010/494195
Tsurumaru, Daisuke, et al. "Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy." Gastroenterology research and practice vol. 2010 (2010): 494195. doi: https://doi.org/10.1155/2010/494195
Tsurumaru D, Utsunomiya T, Matsuura S, Komori M, Kawanami S, Ishibashi T, Honda H. Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy. Gastroenterol Res Pract. 2010;2010:494195. doi: 10.1155/2010/494195. Epub 2010 Apr 12. PMID: 20396664; PMCID: PMC2853081.
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Selection of endovascular approach of vein of galen aneurysmal malformation.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Ito O, Goto K, Ogata N, Utsunomiya H, Sato S, Fukumura A.
PMID: 20663400
Interv Neuroradiol. 2001 Dec 22;7:187-92. doi: 10.1177/15910199010070S129. Epub 2002 Jan 10.

SUMMARY: Vein of Galen aneurysmal malformation (VGAM) is one of the most difficult intracranial vascular lesions because this disease consists of extremely high flow shunts and affects infants and small children. Thanks to the development of various diagnostic modalities,...

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Ito O, Goto K, Ogata N, et al. Selection of endovascular approach of vein of galen aneurysmal malformation. Interv Neuroradiol. 2002;7:187-92doi: 10.1177/15910199010070S129.
Ito, O., Goto, K., Ogata, N., Utsunomiya, H., Sato, S., & Fukumura, A. (2001). Selection of endovascular approach of vein of galen aneurysmal malformation. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 7187-92. https://doi.org/10.1177/15910199010070S129
Ito, O, et al. "Selection of endovascular approach of vein of galen aneurysmal malformation." Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences vol. 7 (2001): 187-92. doi: https://doi.org/10.1177/15910199010070S129
Ito O, Goto K, Ogata N, Utsunomiya H, Sato S, Fukumura A. Selection of endovascular approach of vein of galen aneurysmal malformation. Interv Neuroradiol. 2001 Dec 22;7:187-92. doi: 10.1177/15910199010070S129. Epub 2002 Jan 10. PMID: 20663400; PMCID: PMC3627241.
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Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology

Enkhbold C, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, Ishikawa D, Shimada M.
PMID: 24552289
Hepatol Res. 2014 Dec;44(14):E346-52. doi: 10.1111/hepr.12314. Epub 2014 Mar 18.

AIM: FBXW7 acts as a tumor suppressor gene by targeting several oncogenic regulators of proliferation, growth and apoptosis for proteasomal degradation. However, the significance of this protein is not yet well understood in intrahepatic cholangiocarcinoma (IHCC). In this study,...

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Enkhbold C, Utsunomiya T, Morine Y, et al. Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma. Hepatol Res. 2014;44(14):E346-52doi: 10.1111/hepr.12314.
Enkhbold, C., Utsunomiya, T., Morine, Y., Imura, S., Ikemoto, T., Arakawa, Y., Kanamoto, M., Iwahashi, S., Saito, Y., Ishikawa, D., & Shimada, M. (2014). Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma. Hepatology research : the official journal of the Japan Society of Hepatology, 44(14), E346-52. https://doi.org/10.1111/hepr.12314
Enkhbold, Chinbold, et al. "Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma." Hepatology research : the official journal of the Japan Society of Hepatology vol. 44,14 (2014): E346-52. doi: https://doi.org/10.1111/hepr.12314
Enkhbold C, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, Ishikawa D, Shimada M. Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma. Hepatol Res. 2014 Dec;44(14):E346-52. doi: 10.1111/hepr.12314. Epub 2014 Mar 18. PMID: 24552289.
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Pre- and postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation.

Hepatology research : the official journal of the Japan Society of Hepatology

Urano E, Yamanaka-Okumura H, Teramoto A, Sugihara K, Morine Y, Imura S, Utsunomiya T, Shimada M, Takeda E.
PMID: 24164744
Hepatol Res. 2014 Oct;44(11):1102-9. doi: 10.1111/hepr.12263. Epub 2013 Nov 26.

AIM: The nutritional state of living donor liver transplantation (LDLT) recipients is one of the most important factors affecting postoperative outcome. Although the assessment of health-related quality of life (HRQOL) is of increasing importance, few studies have examined this...

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Urano E, Yamanaka-Okumura H, Teramoto A, et al. Pre- and postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation. Hepatol Res. 2013;44(11):1102-9doi: 10.1111/hepr.12263.
Urano, E., Yamanaka-Okumura, H., Teramoto, A., Sugihara, K., Morine, Y., Imura, S., Utsunomiya, T., Shimada, M., & Takeda, E. (2014). Pre- and postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation. Hepatology research : the official journal of the Japan Society of Hepatology, 44(11), 1102-9. https://doi.org/10.1111/hepr.12263
Urano, Eri, et al. "Pre- and postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation." Hepatology research : the official journal of the Japan Society of Hepatology vol. 44,11 (2014): 1102-9. doi: https://doi.org/10.1111/hepr.12263
Urano E, Yamanaka-Okumura H, Teramoto A, Sugihara K, Morine Y, Imura S, Utsunomiya T, Shimada M, Takeda E. Pre- and postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation. Hepatol Res. 2014 Oct;44(11):1102-9. doi: 10.1111/hepr.12263. Epub 2013 Nov 26. PMID: 24164744.
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Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab.

Hepatology research : the official journal of the Japan Society of Hepatology

Nakano N, Kusumoto S, Tanaka Y, Ishida T, Takeuchi S, Takatsuka Y, Akinaga S, Mizokami M, Ueda R, Utsunomiya A.
PMID: 23601025
Hepatol Res. 2014 Mar;44(3):354-7. doi: 10.1111/hepr.12117. Epub 2013 Apr 18.

The introduction of molecularly targeted drugs has increased the risk of reactivation of hepatitis B virus (HBV), which is a potentially fatal complication following anticancer chemotherapy even in patients who have previously resolved their HBV infection. CC chemokine receptor...

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Nakano N, Kusumoto S, Tanaka Y, et al. Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. Hepatol Res. 2013;44(3):354-7doi: 10.1111/hepr.12117.
Nakano, N., Kusumoto, S., Tanaka, Y., Ishida, T., Takeuchi, S., Takatsuka, Y., Akinaga, S., Mizokami, M., Ueda, R., & Utsunomiya, A. (2014). Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. Hepatology research : the official journal of the Japan Society of Hepatology, 44(3), 354-7. https://doi.org/10.1111/hepr.12117
Nakano, Nobuaki, et al. "Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab." Hepatology research : the official journal of the Japan Society of Hepatology vol. 44,3 (2014): 354-7. doi: https://doi.org/10.1111/hepr.12117
Nakano N, Kusumoto S, Tanaka Y, Ishida T, Takeuchi S, Takatsuka Y, Akinaga S, Mizokami M, Ueda R, Utsunomiya A. Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. Hepatol Res. 2014 Mar;44(3):354-7. doi: 10.1111/hepr.12117. Epub 2013 Apr 18. PMID: 23601025.
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Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology

Hanaoka J, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H.
PMID: 22686861
Hepatol Res. 2012 Jul;42(7):727-31. doi: 10.1111/j.1872-034X.2012.00974.x.

We present a 43-year-old man with huge focal nodular hyperplasia (FNH) that was difficult to distinguish from well-differentiated hepatocellular carcinoma (HCC). He previously had abnormal portal vein circulation due to hypoplasia of the intrahepatic portal vein, which was treated...

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Hanaoka J, Shimada M, Utsunomiya T, et al. Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma. Hepatol Res. 2012;42(7):727-31doi: 10.1111/j.1872-034X.2012.00974.x.
Hanaoka, J., Shimada, M., Utsunomiya, T., Imura, S., Morine, Y., Ikemoto, T., & Mori, H. (2012). Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma. Hepatology research : the official journal of the Japan Society of Hepatology, 42(7), 727-31. https://doi.org/10.1111/j.1872-034X.2012.00974.x
Hanaoka, Jun, et al. "Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma." Hepatology research : the official journal of the Japan Society of Hepatology vol. 42,7 (2012): 727-31. doi: https://doi.org/10.1111/j.1872-034X.2012.00974.x
Hanaoka J, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H. Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma. Hepatol Res. 2012 Jul;42(7):727-31. doi: 10.1111/j.1872-034X.2012.00974.x. PMID: 22686861.
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Direct effects of CPT-11 and SN38 on ovarian granulosa cells.

Molecular medicine reports

Utsunomiya T, Tanaka T, Utsunomiya H, Umesaki N.
PMID: 21475811
Mol Med Rep. 2009 Mar-Apr;2(2):189-92. doi: 10.3892/mmr_00000082.

This study aimed to clarify the mechanism by which apoptosis and Fas ligand (FasL) expression are induced in the ovarian granulosa cells of mice injected with irinotecan HCl (CPT-11). To this end, the direct effects of CPT-11 and its...

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Utsunomiya T, Tanaka T, Utsunomiya H, et al. Direct effects of CPT-11 and SN38 on ovarian granulosa cells. Mol Med Rep. 2009;2(2):189-92doi: 10.3892/mmr_00000082.
Utsunomiya, T., Tanaka, T., Utsunomiya, H., & Umesaki, N. (2009). Direct effects of CPT-11 and SN38 on ovarian granulosa cells. Molecular medicine reports, 2(2), 189-92. https://doi.org/10.3892/mmr_00000082
Utsunomiya, Tomoko, et al. "Direct effects of CPT-11 and SN38 on ovarian granulosa cells." Molecular medicine reports vol. 2,2 (2009): 189-92. doi: https://doi.org/10.3892/mmr_00000082
Utsunomiya T, Tanaka T, Utsunomiya H, Umesaki N. Direct effects of CPT-11 and SN38 on ovarian granulosa cells. Mol Med Rep. 2009 Mar-Apr;2(2):189-92. doi: 10.3892/mmr_00000082. PMID: 21475811.
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