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Showing 13 to 14 of 14 entries
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The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.

Cell death and differentiation

Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E, Vakifahmetoglu-Norberg H, Norberg E.
PMID: 33082514
Cell Death Differ. 2021 Mar;28(3):1091-1109. doi: 10.1038/s41418-020-00639-1. Epub 2020 Oct 20.

Cancer cells undergo complex metabolic alterations. The mechanisms underlying the tuning of cancer metabolism are under active investigation. Here, we identify the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by displaying comprehensive effects on glucose...

CRISPR-Cas9 Gene Editing to Generate Isoform-Specific LAMP-2A Knockout in Human Cancer Cells.

Methods in molecular biology (Clifton, N.J.)

Yu TT, Zhou X, Vakifahmetoglu-Norberg H.
PMID: 34972984
Methods Mol Biol. 2022;2445:39-50. doi: 10.1007/978-1-0716-2071-7_3.

Chaperone-mediated autophagy (CMA) is a highly specific lysosomal-dependent protein degradation pathway. A critical molecular component of CMA is the lysosome-associated membrane protein (LAMP) type 2A, which is required for substrate uptake by the lysosome. Defects in the CMA pathway...

Showing 13 to 14 of 14 entries