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Showing 13 to 24 of 33 entries
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Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis.

Pathology, research and practice

Wrede N, Hoffmann I, Vollbrecht C, Koch I, Wolkenstein P, Klauschen F, Capper D, von Laffert M, Jurmeister P.
PMID: 34844086
Pathol Res Pract. 2021 Nov 22;229:153689. doi: 10.1016/j.prp.2021.153689. Epub 2021 Nov 22.

Mucosal melanomas arise from the mucosal lining of various organs. Their etiology is currently unknown and there are no tissue-based methods to differentiate it from cutaneous melanomas. Furthermore, prognostic and predictive markers (e.g. for immune checkpoint inhibition) are lacking....

NeoRAS wild-type in metastatic colorectal cancer: Myth or truth?-Case series and review of the literature.

European journal of cancer (Oxford, England : 1990)

Osumi H, Vecchione L, Keilholz U, Vollbrecht C, Alig AHS, von Einem JC, Stahler A, Striefler JK, Kurreck A, Kind A, Modest DP, Stintzing S, Jelas I.
PMID: 34153718
Eur J Cancer. 2021 Aug;153:86-95. doi: 10.1016/j.ejca.2021.05.010. Epub 2021 Jun 18.

Upfront KRAS and NRAS gene testing ('RAS') is the standard of care for metastatic colorectal cancer (mCRC), to guide first-line treatment. The presence of RAS mutation (MT) is a negative predictor for the efficacy of anti-EGFR antibodies and the...

Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis.

Pathology, research and practice

Wrede N, Hoffmann I, Vollbrecht C, Koch I, Wolkenstein P, Klauschen F, Capper D, von Laffert M, Jurmeister P.
PMID: 34844086
Pathol Res Pract. 2021 Nov 22;229:153689. doi: 10.1016/j.prp.2021.153689. Epub 2021 Nov 22.

Mucosal melanomas arise from the mucosal lining of various organs. Their etiology is currently unknown and there are no tissue-based methods to differentiate it from cutaneous melanomas. Furthermore, prognostic and predictive markers (e.g. for immune checkpoint inhibition) are lacking....

Isothermal multiple displacement amplification: a methodical approach enhancing molecular routine diagnostics of microcarcinomas and small biopsies.

OncoTargets and therapy

Mairinger FD, Walter RF, Vollbrecht C, Hager T, Worm K, Ting S, Wohlschläger J, Zarogoulidis P, Zarogoulidis K, Schmid KW.
PMID: 25152625
Onco Targets Ther. 2014 Aug 13;7:1441-7. doi: 10.2147/OTT.S65144. eCollection 2014.

BACKGROUND AND METHODS: Isothermal multiple displacement amplification (IMDA) can be a powerful tool in molecular routine diagnostics for homogeneous and sequence-independent whole-genome amplification of notably small tumor samples, eg, microcarcinomas and biopsies containing a small amount of tumor. Currently,...

PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.

Brain pathology (Zurich, Switzerland)

Reimer L, Betzer C, Kofoed RH, Volbracht C, Fog K, Kurhade C, Nilsson E, Överby AK, Jensen PH.
PMID: 32716602
Brain Pathol. 2021 Jan;31(1):103-119. doi: 10.1111/bpa.12883. Epub 2020 Aug 06.

Deposition of extensively hyperphosphorylated tau in specific brain cells is a clear pathological hallmark in Alzheimer's disease and a number of other neurodegenerative disorders, collectively termed the tauopathies. Furthermore, hyperphosphorylation of tau prevents it from fulfilling its physiological role...

Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors.

Journal of Cancer

Walter RF, Vollbrecht C, Christoph D, Werner R, Schmeller J, Flom E, Trakada G, Rapti A, Adamidis V, Hohenforst-Schmidt W, Kollmeier J, Mairinger T, Wohlschlaeger J, Zarogoulidis P, Porpodis K, Schmidt KW, Mairinger FD.
PMID: 27994651
J Cancer. 2016 Oct 25;7(15):2165-2172. doi: 10.7150/jca.16925. eCollection 2016.

No abstract available.

Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.

Journal of Cancer

Walter RF, Vollbrecht C, Werner R, Mairinger T, Schmeller J, Flom E, Wohlschlaeger J, Barbetakis N, Paliouras D, Chatzinikolaou F, Adamidis V, Tsakiridis K, Zarogoulidis P, Trakada G, Christoph DC, Schmid KW, Mairinger FD.
PMID: 27698933
J Cancer. 2016 Sep 13;7(13):1915-1925. doi: 10.7150/jca.16390. eCollection 2016.

CONCLUSION: DNA-damage response plays a crucial role in response to platin-based chemotherapeutic regimes. In particular,

Dual strategy for reduced signal-suppression effects in matrix-assisted laser desorption/ionization mass spectrometry imaging.

Rapid communications in mass spectrometry : RCM

Bastrup J, Birkelund S, Asuni AA, Volbracht C, Stensballe A.
PMID: 31307118
Rapid Commun Mass Spectrom. 2019 Nov 30;33(22):1711-1721. doi: 10.1002/rcm.8521.

RATIONALE: The molecular complexity of tissue features several signal-suppression effects which reduce the ionization of analytes significantly and thereby weakens the quality of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) imaging (MALDI imaging). We report a novel approach in...

Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis.

Pathology, research and practice

Wrede N, Hoffmann I, Vollbrecht C, Koch I, Wolkenstein P, Klauschen F, Capper D, von Laffert M, Jurmeister P.
PMID: 34844086
Pathol Res Pract. 2021 Nov 22;229:153689. doi: 10.1016/j.prp.2021.153689. Epub 2021 Nov 22.

Mucosal melanomas arise from the mucosal lining of various organs. Their etiology is currently unknown and there are no tissue-based methods to differentiate it from cutaneous melanomas. Furthermore, prognostic and predictive markers (e.g. for immune checkpoint inhibition) are lacking....

Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis.

Pathology, research and practice

Wrede N, Hoffmann I, Vollbrecht C, Koch I, Wolkenstein P, Klauschen F, Capper D, von Laffert M, Jurmeister P.
PMID: 34844086
Pathol Res Pract. 2021 Nov 22;229:153689. doi: 10.1016/j.prp.2021.153689. Epub 2021 Nov 22.

Mucosal melanomas arise from the mucosal lining of various organs. Their etiology is currently unknown and there are no tissue-based methods to differentiate it from cutaneous melanomas. Furthermore, prognostic and predictive markers (e.g. for immune checkpoint inhibition) are lacking....

KRAS.

Translational lung cancer research

Frost N, Kollmeier J, Vollbrecht C, Grah C, Matthes B, Pultermann D, von Laffert M, Lüders H, Olive E, Raspe M, Mairinger T, Ochsenreither S, Blum T, Hummel M, Suttorp N, Witzenrath M, Grohé C.
PMID: 33718018
Transl Lung Cancer Res. 2021 Feb;10(2):737-752. doi: 10.21037/tlcr-20-958.

BACKGROUND: Pembrolizumab is a standard of care as first line palliative therapy in PD-L1 overexpressing (≥50%) non-small cell lung cancer (NSCLC). This study aimed at the identification of KRAS and TP53-defined mutational subgroups in the PD-L1 high population to...

EVA-Scalp: Evaluation of Patient Satisfaction with a Scalp Cooling Device to Prevent Chemotherapy-Induced Alopecia in Breast Cancer Patients.

Breast care (Basel, Switzerland)

Bitto FF, König A, Phan-Brehm T, Vallbracht T, Koch JG, Schinköthe T, Wolfgarten M, Mahner S, Harbeck N, Würstlein R.
PMID: 32398986
Breast Care (Basel). 2020 Apr;15(2):171-177. doi: 10.1159/000501393. Epub 2019 Jul 25.

PURPOSE: Scalp cooling (SC) offers a chance to reduce hair loss (HL), but patient satisfaction, the effect on well-being, as well as patient selection criteria have not been sufficiently assessed yet.METHODS: In the EVAScalp trial, SC was offered to...

Showing 13 to 24 of 33 entries