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Showing 25 to 36 of 207 entries
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Embracing complexity with systems thinking in general practitioners' clinical reasoning helps handling uncertainty.

Journal of evaluation in clinical practice

Stolper E, Van Royen P, Jack E, Uleman J, Olde Rikkert M.
PMID: 33592677
J Eval Clin Pract. 2021 Oct;27(5):1175-1181. doi: 10.1111/jep.13549. Epub 2021 Feb 16.

Clinical reasoning in general practice is increasingly challenging because of the rise in the number of patients with multimorbidity. This creates uncertainty because of unpredictable interactions between the symptoms from multiple medical problems and the patient's personality, psychosocial context...

Infarct-related chronic total coronary occlusion and the risk of ventricular tachyarrhythmic events in out-of-hospital cardiac arrest survivors.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

van der Graaf M, Jewbali LSD, Lemkes JS, Spoormans EM, van der Ent M, Meuwissen M, Blans MJ, van der Harst P, Henriques JP, Beishuizen A, Camaro C, Bleeker GB, van Royen N, Yap SC.
PMID: 34046780
Neth Heart J. 2021 Oct;29(10):500-505. doi: 10.1007/s12471-021-01578-3. Epub 2021 May 27.

INTRODUCTION: Chronic total coronary occlusion (CTO) has been identified as a risk factor for ventricular arrhythmias, especially a CTO in an infarct-related artery (IRA). This study aimed to evaluate the effect of an IRA-CTO on the occurrence of ventricular...

From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.

Journal of personalized medicine

Decaesteker B, Durinck K, Van Roy N, De Wilde B, Van Neste C, Van Haver S, Roberts S, De Preter K, Vermeirssen V, Speleman F.
PMID: 34945759
J Pers Med. 2021 Dec 03;11(12). doi: 10.3390/jpm11121286.

Neuroblastoma is a pediatric tumor arising from the sympatho-adrenal lineage and a worldwide leading cause of childhood cancer-related deaths. About half of high-risk patients die from the disease while survivors suffer from multiple therapy-related side-effects. While neuroblastomas present with...

Contribution of three-dimensional images in the planning of cementoblastoma resection.

BJR case reports

Van Hoe S, Shaheen E, de Faria Vasconcelos K, Schoenaers J, Politis C, Jacobs R.
PMID: 34131494
BJR Case Rep. 2021 Jan 08;7(3):20200156. doi: 10.1259/bjrcr.20200156. eCollection 2021 May 01.

Cementoblastomas are rare benign tumours that represent less than 1% of all odontogenic tumours. Complete resection is mandatory to avoid recurrence. This case report describes the contribution of three-dimensional imaging and three-dimensional printing in the pre-operative surgical planning of...

Association of unbalanced translocation der(1;7) with germline GATA2 mutations.

Blood

Kozyra EJ, Göhring G, Hickstein DD, Calvo KR, DiNardo CD, Dworzak M, de Haas V, Starý J, Hasle H, Shimamura A, Fleming MD, Inaba H, Lewis S, Hsu AP, Holland SM, Arnold DE, Mecucci C, Keel SB, Bertuch AA, Tawana K, Barzilai S, Hirabayashi S, Onozawa M, Lei S, Alaiz H, Andrikovics H, Betts D, Beverloo BH, Buechner J, Čermák M, Cervera J, Haus O, Jahnukainen K, Manola KN, Nebral K, Pasquali F, Tchinda J, Turkiewicz D, Van Roy N, Zemanova Z, Pastor VB, Strahm B, Noellke P, Niemeyer CM, Schlegelberger B, Yoshimi A, Wlodarski MW.
PMID: 34469508
Blood. 2021 Dec 09;138(23):2441-2445. doi: 10.1182/blood.2021012781.

No abstract available.

The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma.

The Journal of pathology

Ruh M, Stemmler MP, Frisch I, Fuchs K, van Roey R, Kleemann J, Roas M, Schuhwerk H, Eccles RL, Agaimy A, Baumhoer D, Berx G, Müller F, Brabletz T, Brabletz S.
PMID: 33675037
J Pathol. 2021 Jun;254(2):199-211. doi: 10.1002/path.5659. Epub 2021 May 06.

Osteosarcoma is an often-fatal mesenchyme-derived malignancy in children and young adults. Overexpression of EMT-transcription factors (EMT-TFs) has been associated with poor clinical outcome. Here, we demonstrated that the EMT-TF ZEB1 is able to block osteoblastic differentiation in normal bone...

Coronary Angiography After Cardiac Arrest Without ST Segment Elevation: One-Year Outcomes of the COACT Randomized Clinical Trial.

JAMA cardiology

Lemkes JS, Janssens GN, van der Hoeven NW, Jewbali LSD, Dubois EA, Meuwissen MM, Rijpstra TA, Bosker HA, Blans MJ, Bleeker GB, Baak RR, Vlachojannis GJ, Eikemans BJW, van der Harst P, van der Horst ICC, Voskuil M, van der Heijden JJ, Beishuizen A, Stoel M, Camaro C, van der Hoeven H, Henriques JP, Vlaar APJ, Vink MA, van den Bogaard B, Heestermans TACM, de Ruijter W, Delnoij TSR, Crijns HJGM, Jessurun GAJ, Oemrawsingh PV, Gosselink MTM, Plomp K, Magro M, Elbers PWG, Spoormans EM, van de Ven PM, Oudemans-van Straaten HM, van Royen N.
PMID: 32876654
JAMA Cardiol. 2020 Dec 01;5(12):1358-1365. doi: 10.1001/jamacardio.2020.3670.

IMPORTANCE: Ischemic heart disease is a common cause of cardiac arrest. However, randomized data on long-term clinical outcomes of immediate coronary angiography and percutaneous coronary intervention (PCI) in patients successfully resuscitated from cardiac arrest in the absence of ST...

Waveguide-based absorption measurement system for visible wavelength applications.

Biomedical optics express

Neutens P, Jansen R, Woronoff G, Rutowska M, Hosseini N, Buja F, Humbert A, Colle F, Stakenborg T, Van Roy W.
PMID: 33996215
Biomed Opt Express. 2021 Mar 15;12(4):2041-2053. doi: 10.1364/BOE.418264. eCollection 2021 Apr 01.

We present a miniaturized waveguide-based absorption measurement system operating at a wavelength of 635 nm, based on a silicon nitride integrated photonic platform, suitable for lab-on-chip applications. We experimentally demonstrate a high correlation between the bulk dye concentration and...

From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.

Journal of personalized medicine

Decaesteker B, Durinck K, Van Roy N, De Wilde B, Van Neste C, Van Haver S, Roberts S, De Preter K, Vermeirssen V, Speleman F.
PMID: 34945759
J Pers Med. 2021 Dec 03;11(12). doi: 10.3390/jpm11121286.

Neuroblastoma is a pediatric tumor arising from the sympatho-adrenal lineage and a worldwide leading cause of childhood cancer-related deaths. About half of high-risk patients die from the disease while survivors suffer from multiple therapy-related side-effects. While neuroblastomas present with...

The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma.

The Journal of pathology

Ruh M, Stemmler MP, Frisch I, Fuchs K, van Roey R, Kleemann J, Roas M, Schuhwerk H, Eccles RL, Agaimy A, Baumhoer D, Berx G, Müller F, Brabletz T, Brabletz S.
PMID: 33675037
J Pathol. 2021 Jun;254(2):199-211. doi: 10.1002/path.5659. Epub 2021 May 06.

Osteosarcoma is an often-fatal mesenchyme-derived malignancy in children and young adults. Overexpression of EMT-transcription factors (EMT-TFs) has been associated with poor clinical outcome. Here, we demonstrated that the EMT-TF ZEB1 is able to block osteoblastic differentiation in normal bone...

Outcome Indicators on Interprofessional Collaboration Interventions for Elderly.

International journal of integrated care

Tsakitzidis G, Timmermans O, Callewaert N, Verhoeven V, Lopez-Hartmann M, Truijen S, Meulemans H, Van Royen P.
PMID: 27616961
Int J Integr Care. 2016 May 16;16(2):5. doi: 10.5334/ijic.2017.

BACKGROUND: Geriatric care increasingly needs more multidisciplinary health care services to deliver the necessary complex and continuous care. The aim of this study is to summarize indicators of effective interprofessional outcomes for this population.METHOD: A systematic review is performed...

Electrocardiographic recording direction impacts ventricular fibrillation waveform measurements: A potential pitfall for VF-waveform guided defibrillation protocols.

Resuscitation plus

Thannhauser J, Nas J, Vart P, Smeets JLRM, de Boer MJ, van Royen N, Bonnes JL, Brouwer MA.
PMID: 34223374
Resusc Plus. 2021 Apr 02;6:100114. doi: 10.1016/j.resplu.2021.100114. eCollection 2021 Jun.

AIM: In cardiac arrest, ventricular fibrillation (VF) waveform analysis has identified the amplitude spectrum area (AMSA) as a key predictor of defibrillation success and favorable neurologic survival. New resuscitation protocols are under investigation, where prompt defibrillation is restricted to...

Showing 25 to 36 of 207 entries