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Showing 337 to 339 of 339 entries
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LC-MS Characterization and Biological Activities of Cuban Cultivars of .

Plants (Basel, Switzerland)

Rodríguez-Ferreiro AO, Ochoa-Pacheco A, Méndez-Rodriguez D, Ortiz-Beatón E, Font-Salmo O, Guisado-Bourzac F, Molina-Bertrán S, Monzote L, Cos P, Foubert K, Pieters L, Perez-Novo C, Vanden Berghe W, Escalona-Arranz JC, Setzer WN.
PMID: 35009137
Plants (Basel). 2022 Jan 04;11(1). doi: 10.3390/plants11010134.

No abstract available.

Canine Lafora Disease: An Unstable Repeat Expansion Disorder.

Life (Basel, Switzerland)

von Klopmann T, Ahonen S, Espadas-Santiuste I, Matiasek K, Sanchez-Masian D, Rupp S, Vandenberghe H, Rose J, Wang T, Wang P, Minassian BA, Rusbridge C.
PMID: 34357061
Life (Basel). 2021 Jul 14;11(7). doi: 10.3390/life11070689.

Canine Lafora disease is a recessively inherited, rapidly progressing neurodegenerative disease caused by the accumulation of abnormally constructed insoluble glycogen Lafora bodies in the brain and other tissues due to the loss of NHL repeat containing E3 ubiquitin protein...

ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia.

Molecular therapy. Methods & clinical development

Ilyinskii PO, Michaud AM, Rizzo GL, Roy CJ, Leung SS, Elkins SL, Capela T, Chowdhury A, Li L, Chandler RJ, Manoli I, Andres-Mateos E, Johnston LPM, Vandenberghe LH, Venditti CP, Kishimoto TK.
PMID: 34485611
Mol Ther Methods Clin Dev. 2021 Jul 16;22:279-292. doi: 10.1016/j.omtm.2021.06.015. eCollection 2021 Sep 10.

A major barrier to adeno-associated virus (AAV) gene therapy is the inability to re-dose patients due to formation of vector-induced neutralizing antibodies (Nabs). Tolerogenic nanoparticles encapsulating rapamycin (ImmTOR) provide long-term and specific suppression of adaptive immune responses, allowing for...

Showing 337 to 339 of 339 entries