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Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin.

Cancers

Mauri G, Monfardini L, Garnero A, Zampino MG, Orsi F, Della Vigna P, Bonomo G, Varano GM, Busso M, Gazzera C, Fonio P, Veltri A, Calandri M.
PMID: 34073585
Cancers (Basel). 2021 May 26;13(11). doi: 10.3390/cancers13112617.

Colorectal cancer (CRC) is the third most common cancer worldwide and has a high rate of metastatic disease which is the main cause of CRC-related death. Oligometastatic disease is a clinical condition recently included in ESMO guidelines that can...

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Mauri G, Monfardini L, Garnero A, et al. Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin. Cancers (Basel). 2021;13(11)doi: 10.3390/cancers13112617.
Mauri, G., Monfardini, L., Garnero, A., Zampino, M. G., Orsi, F., Della Vigna, P., Bonomo, G., Varano, G. M., Busso, M., Gazzera, C., Fonio, P., Veltri, A., & Calandri, M. (2021). Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin. Cancers, 13(11), . https://doi.org/10.3390/cancers13112617
Mauri, Giovanni, et al. "Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin." Cancers vol. 13,11 (2021). doi: https://doi.org/10.3390/cancers13112617
Mauri G, Monfardini L, Garnero A, Zampino MG, Orsi F, Della Vigna P, Bonomo G, Varano GM, Busso M, Gazzera C, Fonio P, Veltri A, Calandri M. Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin. Cancers (Basel). 2021 May 26;13(11). doi: 10.3390/cancers13112617. PMID: 34073585; PMCID: PMC8198296.
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Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives.

Journal of clinical medicine

Venturini M, Piacentino F, Coppola A, Bettoni V, Macchi E, De Marchi G, Curti M, Ossola C, Marra P, Palmisano A, Cappelli A, Basile A, Golfieri R, Cobelli F, Piffaretti G, Tozzi M, Carcano G, Fontana F.
PMID: 34200171
J Clin Med. 2021 Jun 07;10(11). doi: 10.3390/jcm10112520.

Visceral artery aneurysms (VAAs) are rare, usually asymptomatic and incidentally discovered during a routine radiological examination. Shared guidelines suggest their treatment in the following conditions: VAAs with diameter larger than 2 cm, or 3 times exceeding the target artery;...

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Venturini M, Piacentino F, Coppola A, et al. Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives. J Clin Med. 2021;10(11)doi: 10.3390/jcm10112520.
Venturini, M., Piacentino, F., Coppola, A., Bettoni, V., Macchi, E., De Marchi, G., Curti, M., Ossola, C., Marra, P., Palmisano, A., Cappelli, A., Basile, A., Golfieri, R., Cobelli, F., Piffaretti, G., Tozzi, M., Carcano, G., & Fontana, F. (2021). Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives. Journal of clinical medicine, 10(11), . https://doi.org/10.3390/jcm10112520
Venturini, Massimo, et al. "Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives." Journal of clinical medicine vol. 10,11 (2021). doi: https://doi.org/10.3390/jcm10112520
Venturini M, Piacentino F, Coppola A, Bettoni V, Macchi E, De Marchi G, Curti M, Ossola C, Marra P, Palmisano A, Cappelli A, Basile A, Golfieri R, Cobelli F, Piffaretti G, Tozzi M, Carcano G, Fontana F. Visceral Artery Aneurysms Embolization and Other Interventional Options: State of the Art and New Perspectives. J Clin Med. 2021 Jun 07;10(11). doi: 10.3390/jcm10112520. PMID: 34200171; PMCID: PMC8201262.
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Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model.

British journal of anaesthesia

Wittenstein J, Huhle R, Leiderman M, Möbius M, Braune A, Tauer S, Herzog P, Barana G, de Ferrari A, Corona A, Bluth T, Kiss T, Güldner A, Schultz MJ, Rocco PRM, Pelosi P, Gama de Abreu M, Scharffenberg M.
PMID: 34895719
Br J Anaesth. 2021 Nov 10; doi: 10.1016/j.bja.2021.10.037. Epub 2021 Nov 10.

BACKGROUND: Patient-ventilator asynchrony during mechanical ventilation may exacerbate lung and diaphragm injury in spontaneously breathing subjects. We investigated whether subject-ventilator asynchrony increases lung or diaphragmatic injury in a porcine model of acute respiratory distress syndrome (ARDS).METHODS: ARDS was induced...

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Wittenstein J, Huhle R, Leiderman M, et al. Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model. Br J Anaesth. 2021;doi: 10.1016/j.bja.2021.10.037.
Wittenstein, J., Huhle, R., Leiderman, M., Möbius, M., Braune, A., Tauer, S., Herzog, P., Barana, G., de Ferrari, A., Corona, A., Bluth, T., Kiss, T., Güldner, A., Schultz, M. J., Rocco, P. R. M., Pelosi, P., Gama de Abreu, M., & Scharffenberg, M. (2021). Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model. British journal of anaesthesia, . https://doi.org/10.1016/j.bja.2021.10.037
Wittenstein, Jakob, et al. "Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model." British journal of anaesthesia vol. (2021). doi: https://doi.org/10.1016/j.bja.2021.10.037
Wittenstein J, Huhle R, Leiderman M, Möbius M, Braune A, Tauer S, Herzog P, Barana G, de Ferrari A, Corona A, Bluth T, Kiss T, Güldner A, Schultz MJ, Rocco PRM, Pelosi P, Gama de Abreu M, Scharffenberg M. Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model. Br J Anaesth. 2021 Nov 10; doi: 10.1016/j.bja.2021.10.037. Epub 2021 Nov 10. PMID: 34895719.
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Mucosal immune response in BNT162b2 COVID-19 vaccine recipients.

EBioMedicine

Azzi L, Dalla Gasperina D, Veronesi G, Shallak M, Ietto G, Iovino D, Baj A, Gianfagna F, Maurino V, Focosi D, Maggi F, Ferrario MM, Dentali F, Carcano G, Tagliabue A, Maffioli LS, Accolla RS, Forlani G.
PMID: 34954658
EBioMedicine. 2021 Dec 23;75:103788. doi: 10.1016/j.ebiom.2021.103788. Epub 2021 Dec 23.

BACKGROUND: Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing antibodies in serum protecting against COVID-19, it has not been studied in detail whether it could generate specific immunity at mucosal sites, which represent the primary route...

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Azzi L, Dalla Gasperina D, Veronesi G, et al. Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine. 2021;75:103788doi: 10.1016/j.ebiom.2021.103788.
Azzi, L., Dalla Gasperina, D., Veronesi, G., Shallak, M., Ietto, G., Iovino, D., Baj, A., Gianfagna, F., Maurino, V., Focosi, D., Maggi, F., Ferrario, M. M., Dentali, F., Carcano, G., Tagliabue, A., Maffioli, L. S., Accolla, R. S., & Forlani, G. (2021). Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine, 75103788. https://doi.org/10.1016/j.ebiom.2021.103788
Azzi, Lorenzo, et al. "Mucosal immune response in BNT162b2 COVID-19 vaccine recipients." EBioMedicine vol. 75 (2021): 103788. doi: https://doi.org/10.1016/j.ebiom.2021.103788
Azzi L, Dalla Gasperina D, Veronesi G, Shallak M, Ietto G, Iovino D, Baj A, Gianfagna F, Maurino V, Focosi D, Maggi F, Ferrario MM, Dentali F, Carcano G, Tagliabue A, Maffioli LS, Accolla RS, Forlani G. Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine. 2021 Dec 23;75:103788. doi: 10.1016/j.ebiom.2021.103788. Epub 2021 Dec 23. PMID: 34954658; PMCID: PMC8718969.
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Neonatal Lung Ultrasound and Surfactant Administration: A Pragmatic, Multicenter Study.

Chest

Raimondi F, Migliaro F, Corsini I, Meneghin F, Pierri L, Salomè S, Perri A, Aversa S, Nobile S, Lama S, Varano S, Savoia M, Gatto S, Leonardi V, Capasso L, Carnielli VP, Mosca F, Dani C, Vento G, Dolce P, Lista G.
PMID: 34293317
Chest. 2021 Dec;160(6):2178-2186. doi: 10.1016/j.chest.2021.06.076. Epub 2021 Jul 19.

BACKGROUND: Previous research shows that a lung ultrasound score (LUS) can anticipate CPAP failure in neonatal respiratory distress syndrome.RESEARCH QUESTION: Can LUS also predict the need for surfactant replacement?STUDY DESIGN AND METHODS: Multicenter, pragmatic study of preterm neonates who...

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Raimondi F, Migliaro F, Corsini I, et al. Neonatal Lung Ultrasound and Surfactant Administration: A Pragmatic, Multicenter Study. Chest. 2021;160(6):2178-2186doi: 10.1016/j.chest.2021.06.076.
Raimondi, F., Migliaro, F., Corsini, I., Meneghin, F., Pierri, L., Salomè, S., Perri, A., Aversa, S., Nobile, S., Lama, S., Varano, S., Savoia, M., Gatto, S., Leonardi, V., Capasso, L., Carnielli, V. P., Mosca, F., Dani, C., Vento, G., Dolce, P., & Lista, G. (2021). Neonatal Lung Ultrasound and Surfactant Administration: A Pragmatic, Multicenter Study. Chest, 160(6), 2178-2186. https://doi.org/10.1016/j.chest.2021.06.076
Raimondi, Francesco, et al. "Neonatal Lung Ultrasound and Surfactant Administration: A Pragmatic, Multicenter Study." Chest vol. 160,6 (2021): 2178-2186. doi: https://doi.org/10.1016/j.chest.2021.06.076
Raimondi F, Migliaro F, Corsini I, Meneghin F, Pierri L, Salomè S, Perri A, Aversa S, Nobile S, Lama S, Varano S, Savoia M, Gatto S, Leonardi V, Capasso L, Carnielli VP, Mosca F, Dani C, Vento G, Dolce P, Lista G. Neonatal Lung Ultrasound and Surfactant Administration: A Pragmatic, Multicenter Study. Chest. 2021 Dec;160(6):2178-2186. doi: 10.1016/j.chest.2021.06.076. Epub 2021 Jul 19. PMID: 34293317.
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Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR.

Advances in therapy

Frankel J, Staskin D, Varano S, Kennelly M, Newman DK, Rosenberg MT, Jankowich RA, Shortino D, Mudd PN, Girman CJ.
PMID: 34921665
Adv Ther. 2021 Dec 18; doi: 10.1007/s12325-021-01972-8. Epub 2021 Dec 18.

INTRODUCTION: Reductions in bothersome symptoms of overactive bladder (OAB) demonstrate improvement in clinical trials, but patient perception of meaningfulness of such improvement is lacking. In the 12-week phase 3 EMPOWUR trial, vibegron significantly reduced average daily number of micturitions,...

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Frankel J, Staskin D, Varano S, et al. Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR. Adv Ther. 2021;doi: 10.1007/s12325-021-01972-8.
Frankel, J., Staskin, D., Varano, S., Kennelly, M., Newman, D. K., Rosenberg, M. T., Jankowich, R. A., Shortino, D., Mudd, P. N., & Girman, C. J. (2021). Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR. Advances in therapy, . https://doi.org/10.1007/s12325-021-01972-8
Frankel, Jeffrey, et al. "Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR." Advances in therapy vol. (2021). doi: https://doi.org/10.1007/s12325-021-01972-8
Frankel J, Staskin D, Varano S, Kennelly M, Newman DK, Rosenberg MT, Jankowich RA, Shortino D, Mudd PN, Girman CJ. Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR. Adv Ther. 2021 Dec 18; doi: 10.1007/s12325-021-01972-8. Epub 2021 Dec 18. PMID: 34921665.
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Transcatheter Arterial Embolization in Acute Non-Variceal Gastrointestinal Bleedings: A Ten-Year Single-Center Experience in 91 Patients and Review of the Literature.

Journal of clinical medicine

Fontana F, Piacentino F, Ossola C, Coppola A, Curti M, Macchi E, De Marchi G, Floridi C, Ierardi AM, Carrafiello G, Segato S, Carcano G, Venturini M.
PMID: 34768505
J Clin Med. 2021 Oct 27;10(21). doi: 10.3390/jcm10214979.

OBJECTIVE: To report the safety and efficacy of trans-arterial embolization (TAE) for upper gastrointestinal bleeding (UGIB) and lower gastrointestinal bleeding (LGIB) due to different etiologies in 91 patients for ten years.METHODS: A retrospective analysis of GIB treated between January...

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Fontana F, Piacentino F, Ossola C, et al. Transcatheter Arterial Embolization in Acute Non-Variceal Gastrointestinal Bleedings: A Ten-Year Single-Center Experience in 91 Patients and Review of the Literature. J Clin Med. 2021;10(21)doi: 10.3390/jcm10214979.
Fontana, F., Piacentino, F., Ossola, C., Coppola, A., Curti, M., Macchi, E., De Marchi, G., Floridi, C., Ierardi, A. M., Carrafiello, G., Segato, S., Carcano, G., & Venturini, M. (2021). Transcatheter Arterial Embolization in Acute Non-Variceal Gastrointestinal Bleedings: A Ten-Year Single-Center Experience in 91 Patients and Review of the Literature. Journal of clinical medicine, 10(21), . https://doi.org/10.3390/jcm10214979
Fontana, Federico, et al. "Transcatheter Arterial Embolization in Acute Non-Variceal Gastrointestinal Bleedings: A Ten-Year Single-Center Experience in 91 Patients and Review of the Literature." Journal of clinical medicine vol. 10,21 (2021). doi: https://doi.org/10.3390/jcm10214979
Fontana F, Piacentino F, Ossola C, Coppola A, Curti M, Macchi E, De Marchi G, Floridi C, Ierardi AM, Carrafiello G, Segato S, Carcano G, Venturini M. Transcatheter Arterial Embolization in Acute Non-Variceal Gastrointestinal Bleedings: A Ten-Year Single-Center Experience in 91 Patients and Review of the Literature. J Clin Med. 2021 Oct 27;10(21). doi: 10.3390/jcm10214979. PMID: 34768505; PMCID: PMC8584454.
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Mucosal immune response in BNT162b2 COVID-19 vaccine recipients.

EBioMedicine

Azzi L, Dalla Gasperina D, Veronesi G, Shallak M, Ietto G, Iovino D, Baj A, Gianfagna F, Maurino V, Focosi D, Maggi F, Ferrario MM, Dentali F, Carcano G, Tagliabue A, Maffioli LS, Accolla RS, Forlani G.
PMID: 34954658
EBioMedicine. 2021 Dec 23;75:103788. doi: 10.1016/j.ebiom.2021.103788. Epub 2021 Dec 23.

BACKGROUND: Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing antibodies in serum protecting against COVID-19, it has not been studied in detail whether it could generate specific immunity at mucosal sites, which represent the primary route...

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Azzi L, Dalla Gasperina D, Veronesi G, et al. Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine. 2021;75:103788doi: 10.1016/j.ebiom.2021.103788.
Azzi, L., Dalla Gasperina, D., Veronesi, G., Shallak, M., Ietto, G., Iovino, D., Baj, A., Gianfagna, F., Maurino, V., Focosi, D., Maggi, F., Ferrario, M. M., Dentali, F., Carcano, G., Tagliabue, A., Maffioli, L. S., Accolla, R. S., & Forlani, G. (2021). Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine, 75103788. https://doi.org/10.1016/j.ebiom.2021.103788
Azzi, Lorenzo, et al. "Mucosal immune response in BNT162b2 COVID-19 vaccine recipients." EBioMedicine vol. 75 (2021): 103788. doi: https://doi.org/10.1016/j.ebiom.2021.103788
Azzi L, Dalla Gasperina D, Veronesi G, Shallak M, Ietto G, Iovino D, Baj A, Gianfagna F, Maurino V, Focosi D, Maggi F, Ferrario MM, Dentali F, Carcano G, Tagliabue A, Maffioli LS, Accolla RS, Forlani G. Mucosal immune response in BNT162b2 COVID-19 vaccine recipients. EBioMedicine. 2021 Dec 23;75:103788. doi: 10.1016/j.ebiom.2021.103788. Epub 2021 Dec 23. PMID: 34954658.
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Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers.

Proceedings (Baylor University. Medical Center)

Safder T, McCullough PA, Wheelan KR, Rahimi G, Zurawski S, Zurawski G, Gu J, Wang X, Balaji U, Berhe M, Clariday L, Baker R, Chionh K, Carino G, Sandkovsky US.
PMID: 34219921
Proc (Bayl Univ Med Cent). 2021 Mar 30;34(4):437-441. doi: 10.1080/08998280.2021.1895959.

The prevalence and seroconversion rate of SARS-CoV-2 infection among asymptomatic health care workers in the US is unclear. Our study utilized real-time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing and serological evaluation to detect IgG antibodies specific to SARS-CoV-2 antigens...

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Safder T, McCullough PA, Wheelan KR, et al. Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers. Proc (Bayl Univ Med Cent). 2021;34(4):437-441doi: 10.1080/08998280.2021.1895959.
Safder, T., McCullough, P. A., Wheelan, K. R., Rahimi, G., Zurawski, S., Zurawski, G., Gu, J., Wang, X., Balaji, U., Berhe, M., Clariday, L., Baker, R., Chionh, K., Carino, G., & Sandkovsky, U. S. (2021). Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers. Proceedings (Baylor University. Medical Center), 34(4), 437-441. https://doi.org/10.1080/08998280.2021.1895959
Safder, Taimur, et al. "Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers." Proceedings (Baylor University. Medical Center) vol. 34,4 (2021): 437-441. doi: https://doi.org/10.1080/08998280.2021.1895959
Safder T, McCullough PA, Wheelan KR, Rahimi G, Zurawski S, Zurawski G, Gu J, Wang X, Balaji U, Berhe M, Clariday L, Baker R, Chionh K, Carino G, Sandkovsky US. Screening for SARS-CoV-2 via PCR and serological testing in asymptomatic healthcare workers. Proc (Bayl Univ Med Cent). 2021 Mar 30;34(4):437-441. doi: 10.1080/08998280.2021.1895959. PMID: 34219921; PMCID: PMC8224198.
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Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation.

Frontiers in cell and developmental biology

Vassalli QA, Colantuono C, Nittoli V, Ferraioli A, Fasano G, Berruto F, Chiusano ML, Kelsh RN, Sordino P, Locascio A.
PMID: 33816460
Front Cell Dev Biol. 2021 Mar 18;9:602450. doi: 10.3389/fcell.2021.602450. eCollection 2021.

Photoreceptor cells (PRC) are neurons highly specialized for sensing light stimuli and have considerably diversified during evolution. The genetic mechanisms that underlie photoreceptor differentiation and accompanied the progressive increase in complexity and diversification of this sensory cell type are...

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Vassalli QA, Colantuono C, Nittoli V, et al. Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation. Front Cell Dev Biol. 2021;9:602450doi: 10.3389/fcell.2021.602450.
Vassalli, Q. A., Colantuono, C., Nittoli, V., Ferraioli, A., Fasano, G., Berruto, F., Chiusano, M. L., Kelsh, R. N., Sordino, P., & Locascio, A. (2021). Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation. Frontiers in cell and developmental biology, 9602450. https://doi.org/10.3389/fcell.2021.602450
Vassalli, Quirino Attilio, et al. "Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation." Frontiers in cell and developmental biology vol. 9 (2021): 602450. doi: https://doi.org/10.3389/fcell.2021.602450
Vassalli QA, Colantuono C, Nittoli V, Ferraioli A, Fasano G, Berruto F, Chiusano ML, Kelsh RN, Sordino P, Locascio A. Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation. Front Cell Dev Biol. 2021 Mar 18;9:602450. doi: 10.3389/fcell.2021.602450. eCollection 2021. PMID: 33816460; PMCID: PMC8012850.
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Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions.

Journal of medicinal chemistry

Bobone S, Pannone L, Biondi B, Solman M, Flex E, Canale VC, Calligari P, De Faveri C, Gandini T, Quercioli A, Torini G, Venditti M, Lauri A, Fasano G, Hoeksma J, Santucci V, Cattani G, Bocedi A, Carpentieri G, Tirelli V, Sanchez M, Peggion C, Formaggio F, den Hertog J, Martinelli S, Bocchinfuso G, Tartaglia M, Stella L.
PMID: 34714648
J Med Chem. 2021 Nov 11;64(21):15973-15990. doi: 10.1021/acs.jmedchem.1c01371. Epub 2021 Oct 29.

We developed a new class of inhibitors of protein-protein interactions of the SHP2 phosphatase, which is pivotal in cell signaling and represents a central target in the therapy of cancer and rare diseases. Currently available SHP2 inhibitors target the...

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Bobone S, Pannone L, Biondi B, et al. Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions. J Med Chem. 2021;64(21):15973-15990doi: 10.1021/acs.jmedchem.1c01371.
Bobone, S., Pannone, L., Biondi, B., Solman, M., Flex, E., Canale, V. C., Calligari, P., De Faveri, C., Gandini, T., Quercioli, A., Torini, G., Venditti, M., Lauri, A., Fasano, G., Hoeksma, J., Santucci, V., Cattani, G., Bocedi, A., Carpentieri, G., Tirelli, V., Sanchez, M., Peggion, C., Formaggio, F., den Hertog, J., Martinelli, S., Bocchinfuso, G., Tartaglia, M., & Stella, L. (2021). Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions. Journal of medicinal chemistry, 64(21), 15973-15990. https://doi.org/10.1021/acs.jmedchem.1c01371
Bobone, Sara, et al. "Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions." Journal of medicinal chemistry vol. 64,21 (2021): 15973-15990. doi: https://doi.org/10.1021/acs.jmedchem.1c01371
Bobone S, Pannone L, Biondi B, Solman M, Flex E, Canale VC, Calligari P, De Faveri C, Gandini T, Quercioli A, Torini G, Venditti M, Lauri A, Fasano G, Hoeksma J, Santucci V, Cattani G, Bocedi A, Carpentieri G, Tirelli V, Sanchez M, Peggion C, Formaggio F, den Hertog J, Martinelli S, Bocchinfuso G, Tartaglia M, Stella L. Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions. J Med Chem. 2021 Nov 11;64(21):15973-15990. doi: 10.1021/acs.jmedchem.1c01371. Epub 2021 Oct 29. PMID: 34714648; PMCID: PMC8591604.
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Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial.

JAMA network open

Menichetti F, Popoli P, Puopolo M, Spila Alegiani S, Tiseo G, Bartoloni A, De Socio GV, Luchi S, Blanc P, Puoti M, Toschi E, Massari M, Palmisano L, Marano G, Chiamenti M, Martinelli L, Franchi S, Pallotto C, Suardi LR, Luciani Pasqua B, Merli M, Fabiani P, Bertolucci L, Borchi B, Modica S, Moneta S, Marchetti G, d'Arminio Monforte A, Stoppini L, Ferracchiato N, Piconi S, Fabbri C, Beccastrini E, Saccardi R, Giacometti A, Esperti S, Pierotti P, Bernini L, Bianco C, Benedetti S, Lanzi A, Bonfanti P, Massari M, Sani S, Saracino A, Castagna A, Trabace L, Lanza M, Focosi D, Mazzoni A, Pistello M, Falcone M.
PMID: 34842924
JAMA Netw Open. 2021 Nov 01;4(11):e2136246. doi: 10.1001/jamanetworkopen.2021.36246.

IMPORTANCE: Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death in hospitalized patients with COVID-19 pneumonia.OBJECTIVE: To evaluate the efficacy of CP plus standard therapy (ST) vs ST alone in preventing worsening respiratory...

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Menichetti F, Popoli P, Puopolo M, et al. Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial. JAMA Netw Open. 2021;4(11):e2136246doi: 10.1001/jamanetworkopen.2021.36246.
Menichetti, F., Popoli, P., Puopolo, M., Spila Alegiani, S., Tiseo, G., Bartoloni, A., De Socio, G. V., Luchi, S., Blanc, P., Puoti, M., Toschi, E., Massari, M., Palmisano, L., Marano, G., Chiamenti, M., Martinelli, L., Franchi, S., Pallotto, C., Suardi, L. R., Luciani Pasqua, B., Merli, M., Fabiani, P., Bertolucci, L., Borchi, B., Modica, S., Moneta, S., Marchetti, G., d'Arminio Monforte, A., Stoppini, L., Ferracchiato, N., Piconi, S., Fabbri, C., Beccastrini, E., Saccardi, R., Giacometti, A., Esperti, S., Pierotti, P., Bernini, L., Bianco, C., Benedetti, S., Lanzi, A., Bonfanti, P., Massari, M., Sani, S., Saracino, A., Castagna, A., Trabace, L., Lanza, M., Focosi, D., Mazzoni, A., Pistello, M., Falcone, M. (2021). Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial. JAMA network open, 4(11), e2136246. https://doi.org/10.1001/jamanetworkopen.2021.36246
Menichetti, Francesco, et al. "Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial." JAMA network open vol. 4,11 (2021): e2136246. doi: https://doi.org/10.1001/jamanetworkopen.2021.36246
Menichetti F, Popoli P, Puopolo M, Spila Alegiani S, Tiseo G, Bartoloni A, De Socio GV, Luchi S, Blanc P, Puoti M, Toschi E, Massari M, Palmisano L, Marano G, Chiamenti M, Martinelli L, Franchi S, Pallotto C, Suardi LR, Luciani Pasqua B, Merli M, Fabiani P, Bertolucci L, Borchi B, Modica S, Moneta S, Marchetti G, d'Arminio Monforte A, Stoppini L, Ferracchiato N, Piconi S, Fabbri C, Beccastrini E, Saccardi R, Giacometti A, Esperti S, Pierotti P, Bernini L, Bianco C, Benedetti S, Lanzi A, Bonfanti P, Massari M, Sani S, Saracino A, Castagna A, Trabace L, Lanza M, Focosi D, Mazzoni A, Pistello M, Falcone M. Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial. JAMA Netw Open. 2021 Nov 01;4(11):e2136246. doi: 10.1001/jamanetworkopen.2021.36246. PMID: 34842924; PMCID: PMC8630572.
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