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Showing 613 to 613 of 613 entries
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Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.

Human molecular genetics

Argyrofthalmidou M, Spathis AD, Maniati M, Poula A, Katsianou MA, Sotiriou E, Manousaki M, Perier C, Papapanagiotou I, Papadopoulou-Daifoti Z, Pitychoutis PM, Alexakos P, Vila M, Stefanis L, Vassilatis DK.
PMID: 33902111
Hum Mol Genet. 2021 Jul 28;30(16):1469-1483. doi: 10.1093/hmg/ddab118.

Duplication/triplication mutations of the SNCA locus, encoding alpha-synuclein (ASYN), and loss of function mutations in Nurr1, a nuclear receptor guiding midbrain dopaminergic neuron development, are associated with familial Parkinson's disease (PD). As we age, the expression levels of these...

Showing 613 to 613 of 613 entries