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Showing 193 to 204 of 204 entries
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An efficient implementation of the NEVPT2 and CASPT2 methods avoiding higher-order density matrices.

The Journal of chemical physics

Kollmar C, Sivalingam K, Guo Y, Neese F.
PMID: 34937355
J Chem Phys. 2021 Dec 21;155(23):234104. doi: 10.1063/5.0072129.

A factorization of the matrix elements of the Dyall Hamiltonian in N-electron valence state perturbation theory allowing their evaluation with a computational effort comparable to the one needed for the construction of the third-order reduced density matrix at the...

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model.

PloS one

Weegh N, Zentrich E, Zechner D, Struve B, Wassermann L, Talbot SR, Kumstel S, Heider M, Vollmar B, Bleich A, Häger C.
PMID: 34941923
PLoS One. 2021 Dec 23;16(12):e0261662. doi: 10.1371/journal.pone.0261662. eCollection 2021.

Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality. In the present study, we, therefore, performed an evidence-based severity...

Clinical Nurse Specialist: A Critical Member of the ICU Team.

AACN advanced critical care

Gabbard ER, Klein D, Vollman K, Chamblee TB, Soltis LM, Zellinger M.
PMID: 34879134
AACN Adv Crit Care. 2021 Dec 15;32(4):413-420. doi: 10.4037/aacnacc2021511.

OBJECTIVES: To describe the role of the clinical nurse specialist, an advanced practice registered nurse in the intensive care setting. The value and impact of the clinical nurse specialist role as a member of the ICU is presented along...

Calicheamicin Antibody-Drug Conjugates with Improved Properties.

Molecular cancer therapeutics

Vollmar BS, Frantz C, Schutten MM, Zhong F, Del Rosario G, Go MAT, Yu SF, Leipold DD, Kamath AV, Ng C, Xu K, Dela Cruz-Chuh J, Kozak KR, Chen J, Xu Z, Wai J, Adhikari P, Erickson HK, Dragovich PS, Polson AG, Pillow TH.
PMID: 33722856
Mol Cancer Ther. 2021 Jun;20(6):1112-1120. doi: 10.1158/1535-7163.MCT-20-0035. Epub 2021 Mar 15.

Calicheamicin antibody-drug conjugates (ADCs) are effective therapeutics for leukemias with two recently approved in the United States: Mylotarg (gemtuzumab ozogamicin) targeting CD33 for acute myeloid leukemia and Besponsa (inotuzumab ozogamicin) targeting CD22 for acute lymphocytic leukemia. Both of these...

Functional inhibition of Oct leads to HNF4α upregulation.

Experimental and therapeutic medicine

Vollmar J, Kim YO, Marquardt JU, Galle PR, Schuppan D, Zimmermann T.
PMID: 33732322
Exp Ther Med. 2021 Apr;21(4):349. doi: 10.3892/etm.2021.9780. Epub 2021 Feb 11.

Organic cation transporters (human, OCT; mouse, Oct) are responsible for the intracellular uptake and detoxification of a broad spectrum of endogenous and exogenous substrates. The OCT1 gene SLC22A1 (human; mouse, Scl22a1) is transactivated by hepatocyte nuclear factor 4α (human,...

Antenatal counselling for prospective parents whose fetus has a neurological anomaly: part 1, experiences and recommendations for service design.

Developmental medicine and child neurology

Hart AR, Vollmer B, Howe D, Boxall S, Foulds N, de Lacy P, Vasudevan C, Griffiths PD, Piercy H.
PMID: 34423423
Dev Med Child Neurol. 2022 Jan;64(1):14-22. doi: 10.1111/dmcn.15022. Epub 2021 Aug 22.

Prospective parents whose fetus is diagnosed with a neurological anomaly go through a complex range of emotions. They describe their discussions of antenatal counselling from health care professionals as focusing too much on the nature of the anomaly involving...

Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members.

Hepatology communications

Coto-Llerena M, Tosti N, Taha-Mehlitz S, Kancherla V, Paradiso V, Gallon J, Bianco G, Garofoli A, Ghosh S, Tang F, Ercan C, Christofori GM, Matter MS, Droeser RA, Zavolan M, Soysal SD, von Flüe M, Kollmar O, Terracciano LM, Ng CKY, Piscuoglio S.
PMID: 33860124
Hepatol Commun. 2021 Jan 20;5(4):661-674. doi: 10.1002/hep4.1656. eCollection 2021 Apr.

Transcriptional enhancer factor domain family member 4 (TEAD4) is a downstream effector of the conserved Hippo signaling pathway, regulating the expression of genes involved in cell proliferation and differentiation. It is up-regulated in several cancer types and is associated...

Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis.

General hospital psychiatry

Grigoroglou C, van der Feltz-Cornelis C, Hodkinson A, Coventry PA, Zghebi SS, Kontopantelis E, Bower P, Lovell K, Gilbody S, Waheed W, Dickens C, Archer J, Blakemore A, Adler DA, Aragones E, Björkelund C, Bruce ML, Buszewicz M, Carney RM, Cole MG, Davidson KW, Gensichen J, Grote NK, Russo J, Huijbregts K, Huffman JC, Menchetti M, Patel V, Richards DA, Rollman B, Smit A, Zijlstra-Vlasveld MC, Wells KB, Zimmermann T, Unutzer J, Panagioti M.
PMID: 33915444
Gen Hosp Psychiatry. 2021 Jul-Aug;71:27-35. doi: 10.1016/j.genhosppsych.2021.04.004. Epub 2021 Apr 21.

To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects.METHOD: We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to...

Distress Analysis of Mice with Cervical Arteriovenous Fistulas.

Animals : an open access journal from MDPI

Xie W, Palme R, Schafmayer C, Zechner D, Vollmar B, Grambow E.
PMID: 34827783
Animals (Basel). 2021 Oct 26;11(11). doi: 10.3390/ani11113051.

The welfare of laboratory animals is a consistent concern for researchers. Its evaluation not only fosters ethical responsibility and addresses legal requirements, but also provides a solid basis for a high quality of research. Recently, a new cervical arteriovenous...

'That's okay for me.' 'But it's not okay for me.' Tension and balance between patient's will and surgeon's motivation.

Patient education and counseling

Klasen JM, Würth K, Kollmar O.
PMID: 33573917
Patient Educ Couns. 2021 Sep;104(9):2179-2180. doi: 10.1016/j.pec.2021.01.037. Epub 2021 Feb 02.

This Reflective Practice describes the potential tension between the patient's will and surgeon's motivation. I, as the care given surgeon, learned a couple of intensive lessons trough the presented case, which I would like to share with colleagues to...

Antenatal counselling for prospective parents whose fetus has a neurological anomaly: part 2, risks of adverse outcome in common anomalies.

Developmental medicine and child neurology

Hart AR, Vasudevan C, Griffiths PD, Foulds N, Piercy H, de Lacy P, Boxall S, Howe D, Vollmer B.
PMID: 34482539
Dev Med Child Neurol. 2022 Jan;64(1):23-39. doi: 10.1111/dmcn.15043. Epub 2021 Sep 05.

After diagnosis of a fetal neurological anomaly, prospective parents want to know the best and worst-case scenarios and an estimation of the risk to their infant of having an atypical developmental outcome. The literature on developmental outcomes for fetal...

Predictive validity of a qualitative and quantitative Prechtl's General Movements Assessment at term age: Comparison between preterm infants and term infants with HIE.

Early human development

Robinson H, Hart D, Vollmer B.
PMID: 34481188
Early Hum Dev. 2021 Oct;161:105449. doi: 10.1016/j.earlhumdev.2021.105449. Epub 2021 Aug 17.

AIM: To determine (1) if the General Movement Optimality Score (GMOS) at term age enhances prediction of motor impairment at 12 and 24 months of age in high-risk infants, when compared to a global General Movement Assessment (GMA), and...

Showing 193 to 204 of 204 entries