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Showing 13 to 24 of 144 entries
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Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain.

Biomaterials

Zhang X, Chai Z, Lee Dobbins A, Itano MS, Askew C, Miao Z, Niu H, Samulski RJ, Li C.
PMID: 34998171
Biomaterials. 2021 Dec 31;281:121340. doi: 10.1016/j.biomaterials.2021.121340. Epub 2021 Dec 31.

Recombinant adeno-associated virus (rAAV) vectors have been widely used as favored delivery vehicles for the treatment of inherited diseases in clinical trials, including neurological diseases. However, the noninvasive systemic delivery of rAAV to the central nervous system is severely...

Low-energy electron beam has severe impact on seedling development compared to cold atmospheric pressure plasma.

Scientific reports

Waskow A, Butscher D, Oberbossel G, Klöti D, Rudolf von Rohr P, Büttner-Mainik A, Drissner D, Schuppler M.
PMID: 34385534
Sci Rep. 2021 Aug 12;11(1):16373. doi: 10.1038/s41598-021-95767-0.

Sprouts are germinated seeds that are often consumed due to their high nutritional content and health benefits. However, the conditions for germination strongly support the proliferation of present bacteria, including foodborne pathogens. Since sprouts are consumed raw or minimally...

Applicability and information value of biocalorimetry for the monitoring of fungal solid-state fermentation of lignocellulosic agricultural by-products.

New biotechnology

Duong HL, Paufler S, Harms H, Maskow T, Schlosser D.
PMID: 34767975
N Biotechnol. 2021 Nov 09;66:97-106. doi: 10.1016/j.nbt.2021.11.001. Epub 2021 Nov 09.

The applicability of biocalorimetry for monitoring fungal conversion of lignocellulosic agricultural by-products during solid-state fermentation (SSF) was substantiated through linking the non-invasive measurement of metabolic heat fluxes to conventional invasive determination of fungal activity (growth, substrate degradation, enzyme activity)...

Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation.

Cell reports

Huang X, Roet KCD, Zhang L, Brault A, Berg AP, Jefferson AB, Klug-McLeod J, Leach KL, Vincent F, Yang H, Coyle AJ, Jones LH, Frost D, Wiskow O, Chen K, Maeda R, Grantham A, Dornon MK, Klim JR, Siekmann MT, Zhao D, Lee S, Eggan K, Woolf CJ.
PMID: 34107252
Cell Rep. 2021 Jun 08;35(10):109224. doi: 10.1016/j.celrep.2021.109224.

Drug development is hampered by poor target selection. Phenotypic screens using neurons differentiated from patient stem cells offer the possibility to validate known and discover novel disease targets in an unbiased fashion. To identify targets for managing hyperexcitability, a...

Increases in temperature do not translate to increased flooding.

Nature communications

Wasko C, Sharma A, Lettenmaier DP.
PMID: 31831731
Nat Commun. 2019 Dec 12;10(1):5676. doi: 10.1038/s41467-019-13612-5.

No abstract available.

Characterization of Efficiency and Mechanisms of Cold Atmospheric Pressure Plasma Decontamination of Seeds for Sprout Production.

Frontiers in microbiology

Waskow A, Betschart J, Butscher D, Oberbossel G, Klöti D, Büttner-Mainik A, Adamcik J, von Rohr PR, Schuppler M.
PMID: 30619223
Front Microbiol. 2018 Dec 19;9:3164. doi: 10.3389/fmicb.2018.03164. eCollection 2018.

The consumption of fresh fruit and vegetable products has strongly increased during the past few decades. However, inherent to all minimally processed products is the short shelf life, and the risk of foodborne diseases, which have been increasingly related...

Narrative Interventions in the Palliative Care Setting: A Scoping Review.

Journal of pain and symptom management

Laskow T, Small L, Wu DS.
PMID: 31216430
J Pain Symptom Manage. 2019 Oct;58(4):696-706. doi: 10.1016/j.jpainsymman.2019.06.009. Epub 2019 Jun 16.

CONTEXT: This scoping review maps the existing literature on narrative interventions within a palliative care and end-of-life context.OBJECTIVES: A scoping review was performed to address the following research question: What observational or randomized controlled trials have been performed to...

Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain.

Biomaterials

Zhang X, Chai Z, Lee Dobbins A, Itano MS, Askew C, Miao Z, Niu H, Samulski RJ, Li C.
PMID: 34998171
Biomaterials. 2021 Dec 31;281:121340. doi: 10.1016/j.biomaterials.2021.121340. Epub 2021 Dec 31.

Recombinant adeno-associated virus (rAAV) vectors have been widely used as favored delivery vehicles for the treatment of inherited diseases in clinical trials, including neurological diseases. However, the noninvasive systemic delivery of rAAV to the central nervous system is severely...

Inertial Sensors as a Tool for Diagnosing Discopathy Lumbosacral Pathologic Gait: A Preliminary Research.

Diagnostics (Basel, Switzerland)

Glowinski S, Łosiński K, Kowiański P, Waśkow M, Bryndal A, Grochulska A.
PMID: 32466525
Diagnostics (Basel). 2020 May 26;10(6). doi: 10.3390/diagnostics10060342.

BACKGROUND: the goal of the study is to ascertain the influence of discopathy in the lumbosacral (L-S) segment on the gait parameters. The inertial sensors are used to determine the pathologic parameters of gait.METHODS: the study involved four patients...

Event-based surveillance at health facility and community level in low-income and middle-income countries: a systematic review.

BMJ global health

Kuehne A, Keating P, Polonsky J, Haskew C, Schenkel K, Le Polain de Waroux O, Ratnayake R.
PMID: 31908863
BMJ Glob Health. 2019 Dec 10;4(6):e001878. doi: 10.1136/bmjgh-2019-001878. eCollection 2019.

BACKGROUND: The International Health Regulations require member states to establish "capacity to detect, assess, notify and report events". Event-based surveillance (EBS) can contribute to rapid detection of acute public health events. This is particularly relevant in low-income and middle-income...

Preventing and reducing fear using positive modelling: A systematic review of experimental research with children.

Behaviour research and therapy

Krause L, Askew C.
PMID: 34837839
Behav Res Ther. 2022 Jan;148:103992. doi: 10.1016/j.brat.2021.103992. Epub 2021 Oct 28.

Fear of specific stimuli is thought to develop through associative learning mechanisms and research indicates that a form of observational (vicarious) learning known as positive modelling can counter these effects. This systematic review examined and synthesised the experimental positive...

Guided Growth in Leg Length Discrepancy in Beckwith-Wiedemann Syndrome: A Consecutive Case Series.

Children (Basel, Switzerland)

De Pellegrin M, Brogioni L, Laskow G, Barera G, Pajno R, Osimani S, Russo S, Marcucci L.
PMID: 34943348
Children (Basel). 2021 Dec 07;8(12). doi: 10.3390/children8121152.

Beckwith-Wiedemann Syndrome (BWS) is a rare genetic disorder characterized by overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycemia, predisposition to embryonal tumor, lateralized overgrowth, and leg length discrepancy (LLD), which can affect normal posture and gait. Aim of this study...

Showing 13 to 24 of 144 entries