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Showing 133 to 139 of 139 entries
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Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons .

Frontiers in synaptic neuroscience

Wegrzyn D, Freund N, Faissner A, Juckel G.
PMID: 33708102
Front Synaptic Neurosci. 2021 Feb 23;13:637549. doi: 10.3389/fnsyn.2021.637549. eCollection 2021.

Perineuronal nets (PNNs) are specialized, reticular structures of the extracellular matrix (ECM) that can be found covering the soma and proximal dendrites of a neuronal subpopulation. Recent studies have shown that PNNs can highly influence synaptic plasticity and are...

Differences in gene expression patterns, revealed by RNA-seq analysis, between various Sanfilippo and Morquio disease subtypes.

Gene

Wiśniewska K, Gaffke L, Krzelowska K, Węgrzyn G, Pierzynowska K.
PMID: 34896230
Gene. 2022 Feb 20;812:146090. doi: 10.1016/j.gene.2021.146090. Epub 2021 Dec 08.

Mucopolysaccharidoses (MPS) are genetic disorders that affect up to 1 in 25,000 births. They are caused by dysfunctions of lysosomal hydrolases that degrade glycosaminoglycans (GAGs) which accumulate in cells, damaging their proper functioning. There are 7 types of MPS,...

The Dependence of Flue Pipe Airflow Parameters on the Proximity of an Obstacle to the Pipe's Mouth.

Sensors (Basel, Switzerland)

Węgrzyn D, Wrzeciono P, Wieczorkowska A.
PMID: 35009552
Sensors (Basel). 2021 Dec 21;22(1). doi: 10.3390/s22010010.

This paper describes the influence of the presence of an obstacle near the flue pipe's mouth on the air jet, which directly affects the parameters of the sound generated by the flue pipe. Labial pipes of the most common...

Polyethylene wear of dual mobility cups: a comparative analysis based on patient-specific finite element modeling.

International orthopaedics

Wegrzyn J, Antoniadis A, Sarshari E, Boubat M, Terrier A.
PMID: 35020024
Int Orthop. 2022 Jan 12; doi: 10.1007/s00264-022-05305-4. Epub 2022 Jan 12.

PURPOSE: Concerns remain about potential increased wear with dual mobility cups related to the multiple articulations involved in this specific design of implant. This finite element analysis study aimed to compare polyethylene (PE) wear between dual mobility cup and...

Viscoelastic Polyurethane Foams for Use as Auxiliary Materials in Orthopedics.

Materials (Basel, Switzerland)

Grzęda D, Węgrzyk G, Leszczyńska M, Szczepkowski L, Gloc M, Ryszkowska J.
PMID: 35009278
Materials (Basel). 2021 Dec 24;15(1). doi: 10.3390/ma15010133.

One of the essential factors in prostheses is their fitting. To assemble a prosthesis with the residual limb, so-called liners are used. Liners used currently are criticized by users for their lack of comfort, causing excessive sweating and skin...

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A.

International immunopharmacology

Dziedzic K, Węgrzyn P, Gałęzowski M, Bońkowska M, Grycuk K, Satała G, Wiatrowska K, Wiklik K, Brzózka K, Nowak M.
PMID: 33894488
Int Immunopharmacol. 2021 Jul;96:107645. doi: 10.1016/j.intimp.2021.107645. Epub 2021 Apr 21.

Immunosuppression is one of the main mechanisms facilitating tumor expansion. It may be driven by immune checkpoint protein expression, anti-inflammatory cytokine secretion or enhanced metabolic enzyme production, leading to the subsequent build-up of metabolites such as adenosine. Under physiological...

Co-Creating and Evaluating an App-Based Well-Being Intervention: The HOW (Healthier Outcomes at Work) Social Work Project.

International journal of environmental research and public health

Ravalier JM, Wainwright E, Smyth N, Clabburn O, Wegrzynek P, Loon M.
PMID: 33255460
Int J Environ Res Public Health. 2020 Nov 24;17(23). doi: 10.3390/ijerph17238730.

Stress and mental health at work are the leading causes of long-term sickness absence in the UK, with chronically poor working conditions impacting employee physiological and psychological health. Social workers play a significant part in the fabric of UK...

Showing 133 to 139 of 139 entries