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Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.

Science immunology

Askenase MH, Goods BA, Beatty HE, Steinschneider AF, Velazquez SE, Osherov A, Landreneau MJ, Carroll SL, Tran TB, Avram VS, Drake RS, Gatter GJ, Massey JA, Karuppagounder SS, Ratan RR, Matouk CC, Sheth KN, Ziai WC, Parry-Jones AR, Awad IA, Zuccarello M, Thompson RE, Dawson J, Hanley DF, Love JC, Shalek AK, Sansing LH.
PMID: 33891558
Sci Immunol. 2021 Feb 19;6(56). doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19.

Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral...

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Askenase MH, Goods BA, Beatty HE, et al. Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Sci Immunol. 2021;6(56)doi: 10.1126/sciimmunol.abd6279.
Askenase, M. H., Goods, B. A., Beatty, H. E., Steinschneider, A. F., Velazquez, S. E., Osherov, A., Landreneau, M. J., Carroll, S. L., Tran, T. B., Avram, V. S., Drake, R. S., Gatter, G. J., Massey, J. A., Karuppagounder, S. S., Ratan, R. R., Matouk, C. C., Sheth, K. N., Ziai, W. C., Parry-Jones, A. R., Awad, I. A., Zuccarello, M., Thompson, R. E., Dawson, J., Hanley, D. F., Love, J. C., Shalek, A. K., Sansing, L. H. (2021). Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Science immunology, 6(56), . https://doi.org/10.1126/sciimmunol.abd6279
Askenase, Michael H, et al. "Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage." Science immunology vol. 6,56 (2021). doi: https://doi.org/10.1126/sciimmunol.abd6279
Askenase MH, Goods BA, Beatty HE, Steinschneider AF, Velazquez SE, Osherov A, Landreneau MJ, Carroll SL, Tran TB, Avram VS, Drake RS, Gatter GJ, Massey JA, Karuppagounder SS, Ratan RR, Matouk CC, Sheth KN, Ziai WC, Parry-Jones AR, Awad IA, Zuccarello M, Thompson RE, Dawson J, Hanley DF, Love JC, Shalek AK, Sansing LH. Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Sci Immunol. 2021 Feb 19;6(56). doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19. PMID: 33891558; PMCID: PMC8252865.
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Dataset on the deposits of the semi-circular rampart around the former Viking settlement Hedeby and its vicinity.

Data in brief

Vasiullina A, Khamnueva-Wendt S, Wendt J, Bork HR.
PMID: 33225031
Data Brief. 2020 Nov 04;33:106493. doi: 10.1016/j.dib.2020.106493. eCollection 2020 Dec.

Soils and sediments are able to preserve traces of human activity in the form of morphological, geochemical and geophysical properties of materials. Thanks to that the study of these materials may provide valuable information about the formation and functioning...

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Vasiullina A, Khamnueva-Wendt S, Wendt J, et al. Dataset on the deposits of the semi-circular rampart around the former Viking settlement Hedeby and its vicinity. Data Brief. 2020;33:106493doi: 10.1016/j.dib.2020.106493.
Vasiullina, A., Khamnueva-Wendt, S., Wendt, J., & Bork, H. R. (2020). Dataset on the deposits of the semi-circular rampart around the former Viking settlement Hedeby and its vicinity. Data in brief, 33106493. https://doi.org/10.1016/j.dib.2020.106493
Vasiullina, Anastasiia, et al. "Dataset on the deposits of the semi-circular rampart around the former Viking settlement Hedeby and its vicinity." Data in brief vol. 33 (2020): 106493. doi: https://doi.org/10.1016/j.dib.2020.106493
Vasiullina A, Khamnueva-Wendt S, Wendt J, Bork HR. Dataset on the deposits of the semi-circular rampart around the former Viking settlement Hedeby and its vicinity. Data Brief. 2020 Nov 04;33:106493. doi: 10.1016/j.dib.2020.106493. eCollection 2020 Dec. PMID: 33225031; PMCID: PMC7666324.
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[On the Conceptual History of Myotonia Congenita: The Contributions of Julius Thomsen and Adolph Seeligmüller].

Fortschritte der Neurologie-Psychiatrie

Arendt C, Zierz S.
PMID: 34448176
Fortschr Neurol Psychiatr. 2021 Aug 26; doi: 10.1055/a-1552-3528. Epub 2021 Aug 26.

Myotonia congenita was first described as an entity in 1876 by Julius Thomsen. Shortly later in the same year it was criticized by Adolph Seeligmüller who extended the clinical findings. Charles Bell, Moritz Benedict and Ernst von Leyden had...

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Arendt C, Zierz S. Zur Konzeptgeschichte der Myotonia congenita: Die Beiträge von Julius Thomsen und Adolph Seeligmüller. [On the Conceptual History of Myotonia Congenita: The Contributions of Julius Thomsen and Adolph Seeligmüller]. Fortschr Neurol Psychiatr. 2021;doi: 10.1055/a-1552-3528.
Arendt, C., & Zierz, S. (2021). Zur Konzeptgeschichte der Myotonia congenita: Die Beiträge von Julius Thomsen und Adolph Seeligmüller. [On the Conceptual History of Myotonia Congenita: The Contributions of Julius Thomsen and Adolph Seeligmüller]. Fortschritte der Neurologie-Psychiatrie, . https://doi.org/10.1055/a-1552-3528
Arendt, Carolin, and Zierz, Stephan. "Zur Konzeptgeschichte der Myotonia congenita: Die Beiträge von Julius Thomsen und Adolph Seeligmüller." [On the Conceptual History of Myotonia Congenita: The Contributions of Julius Thomsen and Adolph Seeligmüller]. Fortschritte der Neurologie-Psychiatrie vol. (2021). doi: https://doi.org/10.1055/a-1552-3528
Arendt C, Zierz S. Zur Konzeptgeschichte der Myotonia congenita: Die Beiträge von Julius Thomsen und Adolph Seeligmüller. [On the Conceptual History of Myotonia Congenita: The Contributions of Julius Thomsen and Adolph Seeligmüller]. Fortschr Neurol Psychiatr. 2021 Aug 26; doi: 10.1055/a-1552-3528. Epub 2021 Aug 26. German. PMID: 34448176.
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Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery.

Cell biology and toxicology

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E.
PMID: 33969458
Cell Biol Toxicol. 2021 May 10; doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10.

Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated diphenyl ethers are banned from the market and replaced by alternative FRs, like organophosphorus FRs, that have mostly unknown toxicological profiles. To study their neurodevelopmental toxicity, we evaluated the...

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Klose J, Pahl M, Bartmann K, et al. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2021;doi: 10.1007/s10565-021-09603-2.
Klose, J., Pahl, M., Bartmann, K., Bendt, F., Blum, J., Dolde, X., Förster, N., Holzer, A. K., Hübenthal, U., Keßel, H. E., Koch, K., Masjosthusmann, S., Schneider, S., Stürzl, L. C., Woeste, S., Rossi, A., Covaci, A., Behl, M., Leist, M., Tigges, J., & Fritsche, E. (2021). Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell biology and toxicology, . https://doi.org/10.1007/s10565-021-09603-2
Klose, Jördis, et al. "Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery." Cell biology and toxicology vol. (2021). doi: https://doi.org/10.1007/s10565-021-09603-2
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2021 May 10; doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458.
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Characterization of SSBP1-related optic atrophy and foveopathy.

Scientific reports

Meunier I, Bocquet B, Defoort-Dhellemmes S, Smirnov V, Arndt C, Picot MC, Dollfus H, Charif M, Audo I, Huguet H, Zanlonghi X, Lenaers G.
PMID: 34548540
Sci Rep. 2021 Sep 21;11(1):18703. doi: 10.1038/s41598-021-98150-1.

Dominant optic atrophy (DOA) is genetically heterogeneous and most commonly caused by mutations in OPA1. To distinguish between the classical OPA1-related and the recently identified SSBP1-related DOAs, the retina and fovea of 27 patients carrying the SSBP1 p.Arg38Gln variant...

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Meunier I, Bocquet B, Defoort-Dhellemmes S, et al. Characterization of SSBP1-related optic atrophy and foveopathy. Sci Rep. 2021;11(1):18703doi: 10.1038/s41598-021-98150-1.
Meunier, I., Bocquet, B., Defoort-Dhellemmes, S., Smirnov, V., Arndt, C., Picot, M. C., Dollfus, H., Charif, M., Audo, I., Huguet, H., Zanlonghi, X., & Lenaers, G. (2021). Characterization of SSBP1-related optic atrophy and foveopathy. Scientific reports, 11(1), 18703. https://doi.org/10.1038/s41598-021-98150-1
Meunier, Isabelle, et al. "Characterization of SSBP1-related optic atrophy and foveopathy." Scientific reports vol. 11,1 (2021): 18703. doi: https://doi.org/10.1038/s41598-021-98150-1
Meunier I, Bocquet B, Defoort-Dhellemmes S, Smirnov V, Arndt C, Picot MC, Dollfus H, Charif M, Audo I, Huguet H, Zanlonghi X, Lenaers G. Characterization of SSBP1-related optic atrophy and foveopathy. Sci Rep. 2021 Sep 21;11(1):18703. doi: 10.1038/s41598-021-98150-1. PMID: 34548540; PMCID: PMC8455542.
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Reply.

Hepatology (Baltimore, Md.)

Ghany MG, King WC, Lisker-Melman M, Lok ASF, Terrault N, Janssen HLA, Khalili M, Chung RT, Lee WM, Lau DTY, Cloherty GA, Sterling RK.
PMID: 34800047
Hepatology. 2021 Nov 20; doi: 10.1002/hep.32251. Epub 2021 Nov 20.

No abstract available.

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Ghany MG, King WC, Lisker-Melman M, et al. Reply. Hepatology. 2021;doi: 10.1002/hep.32251.
Ghany, M. G., King, W. C., Lisker-Melman, M., Lok, A. S. F., Terrault, N., Janssen, H. L. A., Khalili, M., Chung, R. T., Lee, W. M., Lau, D. T. Y., Cloherty, G. A., & Sterling, R. K. (2021). Reply. Hepatology (Baltimore, Md.), . https://doi.org/10.1002/hep.32251
Ghany, Marc G, et al. "Reply." Hepatology (Baltimore, Md.) vol. (2021). doi: https://doi.org/10.1002/hep.32251
Ghany MG, King WC, Lisker-Melman M, Lok ASF, Terrault N, Janssen HLA, Khalili M, Chung RT, Lee WM, Lau DTY, Cloherty GA, Sterling RK. Reply. Hepatology. 2021 Nov 20; doi: 10.1002/hep.32251. Epub 2021 Nov 20. PMID: 34800047.
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Phenibut, a GABAB Agonist, Detected in a Fatality.

Journal of analytical toxicology

Arndt C, Gray TR.
PMID: 34520515
J Anal Toxicol. 2021 Sep 14; doi: 10.1093/jat/bkab099. Epub 2021 Sep 14.

Phenibut, a GABAB agonist structurally similar to baclofen, is not approved for medical use in the United States, but is available through internet suppliers for recreational use. Calls to poison control centers for phenibut have increased over the last...

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Arndt C, Gray TR. Phenibut, a GABAB Agonist, Detected in a Fatality. J Anal Toxicol. 2021;doi: 10.1093/jat/bkab099.
Arndt, C., & Gray, T. R. (2021). Phenibut, a GABAB Agonist, Detected in a Fatality. Journal of analytical toxicology, . https://doi.org/10.1093/jat/bkab099
Arndt, Crystal, and Gray, Teresa R. "Phenibut, a GABAB Agonist, Detected in a Fatality." Journal of analytical toxicology vol. (2021). doi: https://doi.org/10.1093/jat/bkab099
Arndt C, Gray TR. Phenibut, a GABAB Agonist, Detected in a Fatality. J Anal Toxicol. 2021 Sep 14; doi: 10.1093/jat/bkab099. Epub 2021 Sep 14. PMID: 34520515.
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[No title available]

International journal of molecular sciences

Mairot K, Smirnov V, Bocquet B, Labesse G, Arndt C, Defoort-Dhellemmes S, Zanlonghi X, Hamroun D, Denis D, Picot MC, David T, Grunewald O, Pégart M, Huguet H, Roux AF, Kalatzis V, Dhaenens CM, Meunier I.
PMID: 34884448
Int J Mol Sci. 2021 Nov 23;22(23). doi: 10.3390/ijms222312642.

Pathogenic variants in

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Mairot K, Smirnov V, Bocquet B, et al. . Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312642.
Mairot, K., Smirnov, V., Bocquet, B., Labesse, G., Arndt, C., Defoort-Dhellemmes, S., Zanlonghi, X., Hamroun, D., Denis, D., Picot, M. C., David, T., Grunewald, O., Pégart, M., Huguet, H., Roux, A. F., Kalatzis, V., Dhaenens, C. M., & Meunier, I. (2021). . International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312642
Mairot, Kévin, et al. "." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312642
Mairot K, Smirnov V, Bocquet B, Labesse G, Arndt C, Defoort-Dhellemmes S, Zanlonghi X, Hamroun D, Denis D, Picot MC, David T, Grunewald O, Pégart M, Huguet H, Roux AF, Kalatzis V, Dhaenens CM, Meunier I. . Int J Mol Sci. 2021 Nov 23;22(23). doi: 10.3390/ijms222312642. PMID: 34884448.
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A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study.

AIDS research and human retroviruses

MacDonald DM, Collins G, Wendt CH, Wolfson J, Tracy RP, Rhame F, Deeks S, Rizza SA, Temesgen Z, Morse C, Liappis AP, Sereti I, Baker JV, Kunisaki KM.
PMID: 33749317
AIDS Res Hum Retroviruses. 2021 Apr 30; doi: 10.1089/AID.2020.0285. Epub 2021 Apr 30.

HIV is an independent risk factor for lung disease, including chronic obstructive pulmonary disease (COPD) and emphysema. Angiotensin receptor blockers may be beneficial in COPD and emphysema through pathways that have been implicated in HIV-related lung disease. We performed...

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MacDonald DM, Collins G, Wendt CH, et al. A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study. AIDS Res Hum Retroviruses. 2021;doi: 10.1089/AID.2020.0285.
MacDonald, D. M., Collins, G., Wendt, C. H., Wolfson, J., Tracy, R. P., Rhame, F., Deeks, S., Rizza, S. A., Temesgen, Z., Morse, C., Liappis, A. P., Sereti, I., Baker, J. V., & Kunisaki, K. M. (2021). A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study. AIDS research and human retroviruses, . https://doi.org/10.1089/AID.2020.0285
MacDonald, David M, et al. "A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study." AIDS research and human retroviruses vol. (2021). doi: https://doi.org/10.1089/AID.2020.0285
MacDonald DM, Collins G, Wendt CH, Wolfson J, Tracy RP, Rhame F, Deeks S, Rizza SA, Temesgen Z, Morse C, Liappis AP, Sereti I, Baker JV, Kunisaki KM. A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study. AIDS Res Hum Retroviruses. 2021 Apr 30; doi: 10.1089/AID.2020.0285. Epub 2021 Apr 30. PMID: 33749317.
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Physiologically informed neuromodulation.

Journal of the neurological sciences

Wendt K, Denison T, Foster G, Krinke L, Thomson A, Wilson S, Widge AS.
PMID: 34998239
J Neurol Sci. 2021 Dec 28;434:120121. doi: 10.1016/j.jns.2021.120121. Epub 2021 Dec 28.

The rapid evolution of neuromodulation techniques includes an increasing amount of research into stimulation paradigms that are guided by patients' neurophysiology, to increase efficacy and responder rates. Treatment personalisation and target engagement have shown to be effective in fields...

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Wendt K, Denison T, Foster G, et al. Physiologically informed neuromodulation. J Neurol Sci. 2021;434:120121doi: 10.1016/j.jns.2021.120121.
Wendt, K., Denison, T., Foster, G., Krinke, L., Thomson, A., Wilson, S., & Widge, A. S. (2021). Physiologically informed neuromodulation. Journal of the neurological sciences, 434120121. https://doi.org/10.1016/j.jns.2021.120121
Wendt, Karen, et al. "Physiologically informed neuromodulation." Journal of the neurological sciences vol. 434 (2021): 120121. doi: https://doi.org/10.1016/j.jns.2021.120121
Wendt K, Denison T, Foster G, Krinke L, Thomson A, Wilson S, Widge AS. Physiologically informed neuromodulation. J Neurol Sci. 2021 Dec 28;434:120121. doi: 10.1016/j.jns.2021.120121. Epub 2021 Dec 28. PMID: 34998239.
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