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Showing 145 to 156 of 156 entries
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Pneumococcal Extracellular Vesicles Modulate Host Immunity.

mBio

Yerneni SS, Werner S, Azambuja JH, Ludwig N, Eutsey R, Aggarwal SD, Lucas PC, Bailey N, Whiteside TL, Campbell PG, Hiller NL.
PMID: 34253061
mBio. 2021 Aug 31;12(4):e0165721. doi: 10.1128/mBio.01657-21. Epub 2021 Jul 13.

Extracellular vesicles (EVs) have recently garnered attention for their participation in host-microbe interactions in pneumococcal infections. However, the effect of EVs on the host immune system remain poorly understood. Our studies focus on EVs produced by

Chemotherapy Promotes Release of Exosomes Which Upregulate Cholesterol Synthesis and Chemoresistance in AML Blasts.

Journal of clinical haematology

Hong CS, Boyiadzis M, Whiteside TL.
PMID: 34296216
J Clin Haematol. 2021;2(2):36-39. doi: 10.33696/haematology.2.026.

No abstract available.

Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients.

British journal of cancer

Theodoraki MN, Laban S, Jackson EK, Lotfi R, Schuler PJ, Brunner C, Hoffmann TK, Whiteside TL, Hofmann L.
PMID: 34642463
Br J Cancer. 2021 Dec;125(12):1677-1686. doi: 10.1038/s41416-021-01567-8. Epub 2021 Oct 12.

BACKGROUND: Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their cargo correlates with clinical parameters. Here, we evaluated the exosomal molecular profile for early detection of treatment failure in locally...

Leveraging a health information exchange to examine the accuracy of self-report emergency department utilization data among hospitalized injury survivors.

Trauma surgery & acute care open

Whiteside LK, Vrablik MC, Russo J, Bulger EM, Nehra D, Moloney K, Zatzick DF.
PMID: 33553651
Trauma Surg Acute Care Open. 2021 Jan 28;6(1):e000550. doi: 10.1136/tsaco-2020-000550. eCollection 2021.

BACKGROUND: Accurate acute care medical utilization history is an important outcome for clinicians and investigators concerned with improving trauma center care. The objective of this study was to examine the accuracy of self-report emergency department (ED) utilization compared with...

Evaluation of the enteric microflora of captive whooping cranes (Grus americana) and sandhill cranes (Grus canadensis).

Zoo biology

Hoar BM, Whiteside DP, Ward L, Douglas Inglis G, Morck DW.
PMID: 19360567
Zoo Biol. 2007 Mar;26(2):141-53. doi: 10.1002/zoo.20125.

The enteric flora of captive whooping cranes (Grus americana) and sandhill cranes (Grus canadensis) has not been well described, despite its potential importance in the understanding of both the normal condition of the intestinal physiology of these animals and...

Proteomic profile of melanoma cell-derived small extracellular vesicles in patients' plasma: a potential correlate of melanoma progression.

Journal of extracellular vesicles

Pietrowska M, Zebrowska A, Gawin M, Marczak L, Sharma P, Mondal S, Mika J, Polańska J, Ferrone S, Kirkwood JM, Widlak P, Whiteside TL.
PMID: 33613873
J Extracell Vesicles. 2021 Feb;10(4):e12063. doi: 10.1002/jev2.12063. Epub 2021 Feb 11.

Molecular profiling of small extracellular vesicles (sEV) isolated from plasma of cancer patients emerges as promising strategy for biomarkers discovery. We investigated the proteomic profiles of sEV immunoselected using anti-CSPG4 antibodies from 15 melanoma patients' plasma. The proteomes of...

Stepped Collaborative Care Targeting Posttraumatic Stress Disorder Symptoms and Comorbidity for US Trauma Care Systems: A Randomized Clinical Trial.

JAMA surgery

Zatzick D, Jurkovich G, Heagerty P, Russo J, Darnell D, Parker L, Roberts MK, Moodliar R, Engstrom A, Wang J, Bulger E, Whiteside L, Nehra D, Palinkas LA, Moloney K, Maier R.
PMID: 33688908
JAMA Surg. 2021 May 01;156(5):430-474. doi: 10.1001/jamasurg.2021.0131.

IMPORTANCE: To date, few multisite investigations have evaluated early interventions for injured patients with posttraumatic stress disorder (PTSD) symptoms.OBJECTIVE: To simultaneously assess the effectiveness and implementation of a brief stepped collaborative care intervention targeting PTSD and comorbidity.DESIGN, SETTING, AND...

Characterizing robotic surgical expertise: An exploratory study of neural activation during mental imagery of robotic suturing.

American journal of surgery

Anton NE, Whiteside JA, Cha J, Perkins LA, Martin M, Stefanidis D.
PMID: 33589243
Am J Surg. 2021 Dec;222(6):1131-1138. doi: 10.1016/j.amjsurg.2021.02.002. Epub 2021 Feb 09.

BACKGROUND: Mental imagery (MI) aids skill acquisition, however, it is unclear to what extend MI is used by experienced surgeons. The purpose of this study was to assess differences in MI of participants with varying surgical expertise in robotic...

Breast Cancer Cell-Derived Adenosine Enhances Generation and Suppressor Function of Human Adaptive Regulatory T Cells.

Journal of personalized medicine

Mandapathil M, Szczepanski MJ, Jackson EK, Lang S, Whiteside TL.
PMID: 34442398
J Pers Med. 2021 Jul 30;11(8). doi: 10.3390/jpm11080754.

INTRODUCTION: Adaptive regulatory T cells (Tr1) are induced in the periphery by environmental stimuli. CD73 expression and adenosine (ADO) production by tumor cells may influence Tr1 generation and their immunosuppressive activity.MATERIAL AND METHODS: Tr1 were generated in co-cultures of...

Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients.

British journal of cancer

Theodoraki MN, Laban S, Jackson EK, Lotfi R, Schuler PJ, Brunner C, Hoffmann TK, Whiteside TL, Hofmann L.
PMID: 34642463
Br J Cancer. 2021 Dec;125(12):1677-1686. doi: 10.1038/s41416-021-01567-8. Epub 2021 Oct 12.

BACKGROUND: Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their cargo correlates with clinical parameters. Here, we evaluated the exosomal molecular profile for early detection of treatment failure in locally...

Molecular and isotopic evidence reveals the end-Triassic carbon isotope excursion is not from massive exogenous light carbon.

Proceedings of the National Academy of Sciences of the United States of America

Fox CP, Cui X, Whiteside JH, Olsen PE, Summons RE, Grice K.
PMID: 33199627
Proc Natl Acad Sci U S A. 2020 Dec 01;117(48):30171-30178. doi: 10.1073/pnas.1917661117. Epub 2020 Nov 16.

The negative organic carbon isotope excursion (CIE) associated with the end-Triassic mass extinction (ETE) is conventionally interpreted as the result of a massive flux of isotopically light carbon from exogenous sources into the atmosphere (e.g., thermogenic methane and/or methane...

Characterizing robotic surgical expertise: An exploratory study of neural activation during mental imagery of robotic suturing.

American journal of surgery

Anton NE, Whiteside JA, Cha J, Perkins LA, Martin M, Stefanidis D.
PMID: 33589243
Am J Surg. 2021 Dec;222(6):1131-1138. doi: 10.1016/j.amjsurg.2021.02.002. Epub 2021 Feb 09.

BACKGROUND: Mental imagery (MI) aids skill acquisition, however, it is unclear to what extend MI is used by experienced surgeons. The purpose of this study was to assess differences in MI of participants with varying surgical expertise in robotic...

Showing 145 to 156 of 156 entries