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Showing 13 to 24 of 155 entries
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Development of A Low-Cost FPGA-Based Measurement System for Real-Time Processing of Acoustic Emission Data: Proof of Concept Using Control of Pulsed Laser Ablation in Liquids.

Sensors (Basel, Switzerland)

Wirtz SF, Cunha APA, Labusch M, Marzun G, Barcikowski S, Söffker D.
PMID: 29865158
Sensors (Basel). 2018 Jun 01;18(6). doi: 10.3390/s18061775.

Today, the demand for continuous monitoring of valuable or safety critical equipment is increasing in many industrial applications due to safety and economical requirements. Therefore, reliable in-situ measurement techniques are required for instance in Structural Health Monitoring (SHM) as...

Photo-Wolff Rearrangement of 2-Diazo-1,2-naphthoquinone: Stern-Volmer Analysis of the Stepwise Reaction Pathway.

Photochemistry and photobiology

Ladinig M, Ramseier M, Wirz J.
PMID: 25196741
Photochem Photobiol. 2015 May-Jun;91(3):678-83. doi: 10.1111/php.12341. Epub 2014 Sep 30.

2-Diazo-1,2-naphthoquinone (1) and its derivatives are the photoactive components in Novolak photoresists. A femtosecond infrared study has established that the photoreaction of 1 proceeds largely by a concerted Wolff rearrangement yielding the ketene 1H-inden-1-ylidene-methanone (3) within 300 fs after...

2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases.

Angewandte Chemie (International ed. in English)

Peng L, Nachon F, Wirz J, Goeldner M.
PMID: 29711614
Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2691-2693. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7.

As heavy-atom analogues of caged cholinergic ligands, the arsonium compounds 1-3 were synthesized for potential time-resolved crystallographic studies on cholinesterases. Compounds 1 and 3 possess the desired properties for dynamic studies on the catalytic mechanism of cholinesterases: structural similarity...

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor.

Chemical science

Rodrigues T, Werner M, Roth J, da Cruz EHG, Marques MC, Akkapeddi P, Lobo SA, Koeberle A, Corzana F, da Silva Júnior EN, Werz O, Bernardes GJL.
PMID: 30310622
Chem Sci. 2018 Jul 17;9(34):6899-6903. doi: 10.1039/c8sc02634c. eCollection 2018 Sep 14.

Using machine learning, targets were identified for β-lapachone. Resorting to biochemical assays, β-lapachone was validated as a potent, ligand efficient, allosteric and reversible modulator of 5-lipoxygenase (5-LO). Moreover, we provide a rationale for 5-LO modulation and show that inhibition...

Promises and perils of gene drives: Navigating the communication of complex, post-normal science.

Proceedings of the National Academy of Sciences of the United States of America

Brossard D, Belluck P, Gould F, Wirz CD.
PMID: 30642954
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7692-7697. doi: 10.1073/pnas.1805874115. Epub 2019 Jan 14.

In November of 2017, an interdisciplinary panel discussed the complexities of gene drive applications as part of the third Sackler Colloquium on "The Science of Science Communication." The panel brought together a social scientist, life scientist, and journalist to...

Superficial Parotidectomy: Impact of Postoperative Drainage.

Ear, nose, & throat journal

Nielsen CF, Riis CBS, Christensen ALB, Mirz F, Reinholdt KB, Ovesen T, Fjaeldstad AW.
PMID: 32744902
Ear Nose Throat J. 2020 Aug 03;145561320942380. doi: 10.1177/0145561320942380. Epub 2020 Aug 03.

BACKGROUND: Use of suction drain after superficial parotidectomy (SP) is based on national consensus considered best practice, but there is no evidence on the effect of the treatment. The aim of the present study is to evaluate the effectiveness...

The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2022 Jan;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.

European journal of medicinal chemistry

Potenza M, Sciarretta M, Chini MG, Saviano A, Maione F, D'Auria MV, De Marino S, Giordano A, Hofstetter RK, Festa C, Werz O, Bifulco G.
PMID: 34315041
Eur J Med Chem. 2021 Nov 15;224:113693. doi: 10.1016/j.ejmech.2021.113693. Epub 2021 Jul 13.

The multiple inhibition of biological targets involved in pro-inflammatory eicosanoid biosynthesis represents an innovative strategy for treating inflammatory disorders in light of higher efficacy and safety. Herein, following a multidisciplinary protocol involving virtual combinatorial screening, chemical synthesis, and in...

Physiotherapists' use and perceptions of digital remote physiotherapy during COVID-19 lockdown in Switzerland: an online cross-sectional survey.

Archives of physiotherapy

Rausch AK, Baur H, Reicherzer L, Wirz M, Keller F, Opsommer E, Schoeb V, Vercelli S, Barbero M.
PMID: 34233763
Arch Physiother. 2021 Jul 07;11(1):18. doi: 10.1186/s40945-021-00112-3.

BACKGROUND: The Swiss containment strategy for the COVID-19 pandemic during the first wave in spring 2020 resulted in a moratorium on non-urgent physiotherapy via regular direct patient contact. Consequently, such physiotherapy sessions declined by 84%. This study investigates the...

Persistent Sputtering Yield Reduction in Plasma-Infused Foams.

Physical review letters

Li GZ, Wirz RE.
PMID: 33543949
Phys Rev Lett. 2021 Jan 22;126(3):035001. doi: 10.1103/PhysRevLett.126.035001.

Aluminum microfoams are found to exhibit persistent sputtering yield reductions of 40%-80% compared to a flat aluminum surface under 100 to 300 eV argon plasma bombardment. An analytical model reveals a strong dependency of the yield on the foam...

Drug delivery of 6-bromoindirubin-3'-glycerol-oxime ether employing poly(D,L-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents.

Journal of nanobiotechnology

Czapka A, Grune C, Schädel P, Bachmann V, Scheuer K, Dirauf M, Weber C, Skaltsounis AL, Jandt KD, Schubert US, Fischer D, Werz O.
PMID: 34983538
J Nanobiotechnology. 2022 Jan 04;20(1):5. doi: 10.1186/s12951-021-01179-7.

BACKGROUND: Insufficient solubility and stability of bioactive small molecules as well as poor biocompatibility may cause low bioavailability and are common obstacles in drug development. One example of such problematic molecules is 6-bromoindirubin-3'-glycerol-oxime ether (6BIGOE), a hydrophobic indirubin derivative....

Showing 13 to 24 of 155 entries