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Showing 25 to 36 of 155 entries
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Effect of counselling during pulmonary rehabilitation on self-determined motivation to be physically active for people with chronic obstructive pulmonary disease: a pragmatic RCT.

BMC pulmonary medicine

Rausch Osthoff AK, Beyer S, Gisi D, Rezek S, Schwank A, Meichtry A, Sievi NA, Hess T, Wirz M.
PMID: 34641819
BMC Pulm Med. 2021 Oct 12;21(1):317. doi: 10.1186/s12890-021-01685-2.

BACKGROUND: Counselling is considered to be a promising approach to increasing physical activity (PA) in people with chronic obstructive pulmonary disease (COPD). The aim of the current study was to investigate whether a PA counselling program for people with...

Specialized pro-resolving mediators: biosynthesis and biological role in bacterial infections.

The FEBS journal

Jordan PM, Werz O.
PMID: 34741578
FEBS J. 2021 Nov 06; doi: 10.1111/febs.16266. Epub 2021 Nov 06.

Acute inflammation caused by bacterial infections is an essential biological defence mechanism of the host in order to neutralize and clear the invaders and to return to homeostasis. Despite its protective function, inflammation may become persistent and uncontrolled, resulting...

The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages.

International journal of molecular sciences

Wolfram T, Weidenbach LM, Adolf J, Schwarz M, Schädel P, Gollowitzer A, Werz O, Koeberle A, Kipp AP, Koeberle SC.
PMID: 34681720
Int J Mol Sci. 2021 Oct 14;22(20). doi: 10.3390/ijms222011060.

Physiological selenium (Se) levels counteract excessive inflammation, with selenoproteins shaping the immunoregulatory cytokine and lipid mediator profile. How exactly differentiation of monocytes into macrophages influences the expression of the selenoproteome in concert with the Se supply remains obscure. THP-1...

A method for designing a novel class of gold-containing molecules.

Chemical communications (Cambridge, England)

Celaya CA, Orozco-Ic M, Dimitrova M, Wirz LN, Sundholm D.
PMID: 32292960
Chem Commun (Camb). 2020 May 18;56(40):5433-5436. doi: 10.1039/d0cc01227k. Epub 2020 Apr 14.

We propose a novel class of gold-containing molecules, which have been designed using conjugated carbon structures as templates. The sp-hybridized carbons of C

Modified Bacterial Cellulose Dressings to Treat Inflammatory Wounds.

Nanomaterials (Basel, Switzerland)

Beekmann U, Zahel P, Karl B, Schmölz L, Börner F, Gerstmeier J, Werz O, Lorkowski S, Wiegand C, Fischer D, Kralisch D.
PMID: 33327519
Nanomaterials (Basel). 2020 Dec 14;10(12). doi: 10.3390/nano10122508.

Natural products suited for prophylaxis and therapy of inflammatory diseases have gained increasing importance. These compounds could be beneficially integrated into bacterial cellulose (BC), which is a natural hydropolymer applicable as a wound dressing and drug delivery system alike....

Diversity of Chromanol and Chromenol Structures and Functions: An Emerging Class of Anti-Inflammatory and Anti-Carcinogenic Agents.

Frontiers in pharmacology

Wallert M, Kluge S, Schubert M, Koeberle A, Werz O, Birringer M, Lorkowski S.
PMID: 32372948
Front Pharmacol. 2020 Apr 21;11:362. doi: 10.3389/fphar.2020.00362. eCollection 2020.

Natural chromanols and chromenols comprise a family of molecules with enormous structural diversity and biological activities of pharmacological interest. A recently published systematic review described more than 230 structures that are derived from a chromanol ortpd chromenol core. For...

The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

Publisher Correction: ChromID identifies the protein interactome at chromatin marks.

Nature biotechnology

Villaseñor R, Pfaendler R, Ambrosi C, Butz S, Giuliani S, Bryan E, Sheahan TW, Gable AL, Schmolka N, Manzo M, Wirz J, Feller C, von Mering C, Aebersold R, Voigt P, Baubec T.
PMID: 32518402
Nat Biotechnol. 2020 Jun;38(6):757. doi: 10.1038/s41587-020-0484-5.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Deference and decision-making in science and society: How deference to scientific authority goes beyond confidence in science and scientists to become authoritarianism.

Public understanding of science (Bristol, England)

Howell EL, Wirz CD, Scheufele DA, Brossard D, Xenos MA.
PMID: 33153407
Public Underst Sci. 2020 Nov;29(8):800-818. doi: 10.1177/0963662520962741. Epub 2020 Oct 08.

No abstract available.

The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia.

Cell host & microbe

Dashdorj NJ, Wirz OF, Röltgen K, Haraguchi E, Buzzanco AS, Sibai M, Wang H, Miller JA, Solis D, Sahoo MK, Arunachalam PS, Lee AS, Shah MM, Liu J, Byambabaatar S, Bat-Ulzii P, Enkhbat A, Batbold E, Zulkhuu D, Ochirsum B, Khurelsukh T, Dalantai G, Burged N, Baatarsuren U, Ariungerel N, Oidovsambuu O, Bungert AS, Genden Z, Yagaanbuyant D, Mordorj A, Pulendran B, Chinthrajah S, Nadeau KC, Jardetzky T, Wilbur JL, Wohlstadter JN, Sigal GB, Pinsky BA, Boyd SD, Dashdorj ND.
PMID: 34861167
Cell Host Microbe. 2021 Dec 08;29(12):1738-1743.e4. doi: 10.1016/j.chom.2021.11.004. Epub 2021 Nov 12.

Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19...

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.

Biochemical pharmacology

Kretzer C, Jordan PM, Meyer KPL, Hoff D, Werner M, Hofstetter RK, Koeberle A, Cala Peralta A, Viault G, Seraphin D, Richomme P, Helesbeux JJ, Stuppner H, Temml V, Schuster D, Werz O.
PMID: 34762841
Biochem Pharmacol. 2022 Jan;195:114825. doi: 10.1016/j.bcp.2021.114825. Epub 2021 Nov 08.

Specialized pro-resolving mediators (SPMs) comprise lipid mediators (LMs) produced from polyunsaturated fatty acids (PUFAs) via stereoselective oxygenation particularly involving 12/15-lipoxygenases (LOXs). In contrast to pro-inflammatory LMs such as leukotrienes formed by 5-LOX and prostaglandins formed by cyclooxygenases, the SPMs...

Showing 25 to 36 of 155 entries