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Showing 625 to 629 of 629 entries
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Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.

Nucleic acids research

Li Y, Li J, Wang J, Lynch DR, Shen X, Corey DR, Parekh D, Bhat B, Woo C, Cherry JJ, Napierala JS, Napierala M.
PMID: 34718736
Nucleic Acids Res. 2021 Nov 18;49(20):11560-11574. doi: 10.1093/nar/gkab954.

Friedreich's ataxia (FRDA) is a severe multisystem disease caused by transcriptional repression induced by expanded GAA repeats located in intron 1 of the Frataxin (FXN) gene encoding frataxin. FRDA results from decreased levels of frataxin; thus, stabilization of the...

Effect of Dexmedetomidine on Biochemical Recurrence in Patients after Robot-Assisted Laparoscopic Radical Prostatectomy: A Retrospective Study.

Journal of personalized medicine

Yoo YC, Jang WS, Kim KJ, Hong JH, Yang S, Kim NY.
PMID: 34575688
J Pers Med. 2021 Sep 13;11(9). doi: 10.3390/jpm11090912.

The usage of dexmedetomidine during cancer surgery in current clinical practice is debatable, largely owing to the differing reports of its efficacy based on cancer type. This study aimed to investigate the effects of dexmedetomidine on biochemical recurrence (BCR)...

Ionic Salts@Metal-Organic Frameworks: Remarkable Component to Improve Performance of Fabric Filters to Remove Particulate Matters from Air.

ACS applied materials & interfaces

Yoo DK, Woo HC, Jhung SH.
PMID: 33970607
ACS Appl Mater Interfaces. 2021 May 19;13(19):23092-23102. doi: 10.1021/acsami.1c02290. Epub 2021 May 10.

The elimination of particulate matters (PMs) from the air is very important for our sustainability. In this study, highly porous metal-organic frameworks (MOFs) like MIL-101 and UiO-67 were first modified, coated onto cotton, and applied in PM removal via...

Photosynthetic symbiotic therapeutics - An innovative, effective treatment for ischemic cardiovascular diseases.

Journal of molecular and cellular cardiology

Zhu Y, Woo YJ.
PMID: 34813842
J Mol Cell Cardiol. 2021 Nov 20;164:51-57. doi: 10.1016/j.yjmcc.2021.11.007. Epub 2021 Nov 20.

Ischemic heart disease is a major cause of global morbidity and mortality, affecting over 15 million patients in the United States. Recent advances in research and innovation have greatly broadened clinicians' ability to treatment ischemic heart disease and associated...

A comprehensive preclinical study supporting clinical trial of oncolytic chimeric poxvirus CF33-hNIS-anti-PD-L1 to treat breast cancer.

Molecular therapy. Methods & clinical development

Chaurasiya S, Yang A, Zhang Z, Lu J, Valencia H, Kim SI, Woo Y, Warner SG, Olafsen T, Zhao Y, Wu X, Fein S, Cheng L, Cheng M, Ede N, Fong Y.
PMID: 35024377
Mol Ther Methods Clin Dev. 2021 Dec 06;24:102-116. doi: 10.1016/j.omtm.2021.12.002. eCollection 2022 Mar 10.

CF33-hNIS-anti-PD-L1 is an oncolytic chimeric poxvirus encoding two transgenes: human sodium iodide symporter and a single-chain variable fragment against PD-L1. Comprehensive preclinical pharmacology studies encompassing primary and secondary pharmacodynamics and biodistribution and safety studies were performed to support the...

Showing 625 to 629 of 629 entries