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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.

RSC chemical biology

Seixas JD, Sousa BB, Marques MC, Guerreiro A, Traquete R, Rodrigues T, Albuquerque IS, Sousa MFQ, Lemos AR, Sousa PMF, Bandeiras TM, Wu D, Doyle SK, Robinson CV, Koehler AN, Corzana F, Matias PM, Bernardes GJL.
PMID: 34458764
RSC Chem Biol. 2020 Aug 28;1(4):251-262. doi: 10.1039/d0cb00033g. eCollection 2020 Oct 01.

The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with unexploited topological pharmacophore patterns. Importantly, we...

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Seixas JD, Sousa BB, Marques MC, et al. Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors. RSC Chem Biol. 2020;1(4):251-262doi: 10.1039/d0cb00033g.
Seixas, J. D., Sousa, B. B., Marques, M. C., Guerreiro, A., Traquete, R., Rodrigues, T., Albuquerque, I. S., Sousa, M. F. Q., Lemos, A. R., Sousa, P. M. F., Bandeiras, T. M., Wu, D., Doyle, S. K., Robinson, C. V., Koehler, A. N., Corzana, F., Matias, P. M., & Bernardes, G. J. L. (2020). Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors. RSC chemical biology, 1(4), 251-262. https://doi.org/10.1039/d0cb00033g
Seixas, João D, et al. "Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors." RSC chemical biology vol. 1,4 (2020): 251-262. doi: https://doi.org/10.1039/d0cb00033g
Seixas JD, Sousa BB, Marques MC, Guerreiro A, Traquete R, Rodrigues T, Albuquerque IS, Sousa MFQ, Lemos AR, Sousa PMF, Bandeiras TM, Wu D, Doyle SK, Robinson CV, Koehler AN, Corzana F, Matias PM, Bernardes GJL. Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors. RSC Chem Biol. 2020 Aug 28;1(4):251-262. doi: 10.1039/d0cb00033g. eCollection 2020 Oct 01. PMID: 34458764; PMCID: PMC8341910.
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Surface Passivation Using 2D Perovskites toward Efficient and Stable Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.)

Wu G, Liang R, Ge M, Sun G, Zhang Y, Xing G.
PMID: 34865245
Adv Mater. 2021 Dec 05;e2105635. doi: 10.1002/adma.202105635. Epub 2021 Dec 05.

3D perovskite solar cells (PSCs) have shown great promise for use in next-generation photovoltaic devices. However, some challenges need to be addressed before their commercial production, such as enormous defects formed on the surface, which result in severe SRH...

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Wu G, Liang R, Ge M, et al. Surface Passivation Using 2D Perovskites toward Efficient and Stable Perovskite Solar Cells. Adv Mater. 2021;e2105635doi: 10.1002/adma.202105635.
Wu, G., Liang, R., Ge, M., Sun, G., Zhang, Y., & Xing, G. (2021). Surface Passivation Using 2D Perovskites toward Efficient and Stable Perovskite Solar Cells. Advanced materials (Deerfield Beach, Fla.), e2105635. https://doi.org/10.1002/adma.202105635
Wu, Guangbao, et al. "Surface Passivation Using 2D Perovskites toward Efficient and Stable Perovskite Solar Cells." Advanced materials (Deerfield Beach, Fla.) vol. (2021): e2105635. doi: https://doi.org/10.1002/adma.202105635
Wu G, Liang R, Ge M, Sun G, Zhang Y, Xing G. Surface Passivation Using 2D Perovskites toward Efficient and Stable Perovskite Solar Cells. Adv Mater. 2021 Dec 05;e2105635. doi: 10.1002/adma.202105635. Epub 2021 Dec 05. PMID: 34865245.
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Chasing on the way of cancer immunotherapy.

Journal of thoracic disease

Wu L.
PMID: 24977024
J Thorac Dis. 2014 Jun;6(6):E137-8. doi: 10.3978/j.issn.2072-1439.2014.03.14.

No abstract available.

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Wu L. Chasing on the way of cancer immunotherapy. J Thorac Dis. 2014;6(6):E137-8doi: 10.3978/j.issn.2072-1439.2014.03.14.
Wu, L. (2014). Chasing on the way of cancer immunotherapy. Journal of thoracic disease, 6(6), E137-8. https://doi.org/10.3978/j.issn.2072-1439.2014.03.14
Wu, Licun. "Chasing on the way of cancer immunotherapy." Journal of thoracic disease vol. 6,6 (2014): E137-8. doi: https://doi.org/10.3978/j.issn.2072-1439.2014.03.14
Wu L. Chasing on the way of cancer immunotherapy. J Thorac Dis. 2014 Jun;6(6):E137-8. doi: 10.3978/j.issn.2072-1439.2014.03.14. PMID: 24977024; PMCID: PMC4073415.
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Mutations in the RS1 gene in a Chinese family with X-linked juvenile retinoschisis.

Intractable & rare diseases research

Hou Q, Chu Y, Guo Q, Wu D, Liao S.
PMID: 25343070
Intractable Rare Dis Res. 2012 Feb;1(1):30-4. doi: 10.5582/irdr.2012.v1.1.30.

The purpose of our study was to identify the mutations in the retinoschisis 1 (RS1) gene, which was associated with X-linked retinoschisis (XLRS) in a four-generation Chinese family, and to provide the theoretical basis for gene diagnosis and gene...

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Hou Q, Chu Y, Guo Q, et al. Mutations in the RS1 gene in a Chinese family with X-linked juvenile retinoschisis. Intractable Rare Dis Res. 2012;1(1):30-4doi: 10.5582/irdr.2012.v1.1.30.
Hou, Q., Chu, Y., Guo, Q., Wu, D., & Liao, S. (2012). Mutations in the RS1 gene in a Chinese family with X-linked juvenile retinoschisis. Intractable & rare diseases research, 1(1), 30-4. https://doi.org/10.5582/irdr.2012.v1.1.30
Hou, Qiaofang, et al. "Mutations in the RS1 gene in a Chinese family with X-linked juvenile retinoschisis." Intractable & rare diseases research vol. 1,1 (2012): 30-4. doi: https://doi.org/10.5582/irdr.2012.v1.1.30
Hou Q, Chu Y, Guo Q, Wu D, Liao S. Mutations in the RS1 gene in a Chinese family with X-linked juvenile retinoschisis. Intractable Rare Dis Res. 2012 Feb;1(1):30-4. doi: 10.5582/irdr.2012.v1.1.30. PMID: 25343070; PMCID: PMC4204588.
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Integrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola.

Ecotoxicology and environmental safety

Zhu Y, Qiu W, He X, Wu L, Bi, Deng Z, He Z, Wu C, Zhuo R.
PMID: 34974361
Ecotoxicol Environ Saf. 2021 Dec 30;230:113149. doi: 10.1016/j.ecoenv.2021.113149. Epub 2021 Dec 30.

Sedum plumbizincicola, a cadmium (Cd) hyperaccumulating herbaceous plant, can accumulate large amounts of Cd in the above-ground tissues without being poisoned. However, the molecular mechanisms regulating the processes are not fully understood. In this study, Transcriptional and proteomic analyses...

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Zhu Y, Qiu W, He X, et al. Integrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola. Ecotoxicol Environ Saf. 2021;230:113149doi: 10.1016/j.ecoenv.2021.113149.
Zhu, Y., Qiu, W., He, X., Wu, L., Bi, Deng, Z., He, Z., Wu, C., & Zhuo, R. (2021). Integrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola. Ecotoxicology and environmental safety, 230113149. https://doi.org/10.1016/j.ecoenv.2021.113149
Zhu, Yue, et al. "Integrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola." Ecotoxicology and environmental safety vol. 230 (2021): 113149. doi: https://doi.org/10.1016/j.ecoenv.2021.113149
Zhu Y, Qiu W, He X, Wu L, Bi, Deng Z, He Z, Wu C, Zhuo R. Integrative analysis of transcriptome and proteome provides insights into adaptation to cadmium stress in Sedum plumbizincicola. Ecotoxicol Environ Saf. 2021 Dec 30;230:113149. doi: 10.1016/j.ecoenv.2021.113149. Epub 2021 Dec 30. PMID: 34974361.
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Transgenic insect-resistant Bt cotton expressing Cry1Ac/1Ab does not harm the insect predator Geocoris pallidipennis.

Ecotoxicology and environmental safety

Zhang M, Ma Y, Luo J, Ji J, Gao X, Wu C, Zhu X, Wang L, Zhang K, Li D, Wang L, Niu L, Cui J.
PMID: 34979310
Ecotoxicol Environ Saf. 2021 Dec 31;230:113129. doi: 10.1016/j.ecoenv.2021.113129. Epub 2021 Dec 31.

The large-scale commercial cultivation of genetically modified (GM) cotton has brought significant economic and environmental benefits. However, GM crops must undergo strict environmental monitoring and long-term observation. An important natural enemy insect in cotton fields, Geocoris pallidipennis, can ingest...

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Zhang M, Ma Y, Luo J, et al. Transgenic insect-resistant Bt cotton expressing Cry1Ac/1Ab does not harm the insect predator Geocoris pallidipennis. Ecotoxicol Environ Saf. 2021;230:113129doi: 10.1016/j.ecoenv.2021.113129.
Zhang, M., Ma, Y., Luo, J., Ji, J., Gao, X., Wu, C., Zhu, X., Wang, L., Zhang, K., Li, D., Wang, L., Niu, L., & Cui, J. (2021). Transgenic insect-resistant Bt cotton expressing Cry1Ac/1Ab does not harm the insect predator Geocoris pallidipennis. Ecotoxicology and environmental safety, 230113129. https://doi.org/10.1016/j.ecoenv.2021.113129
Zhang, Meng, et al. "Transgenic insect-resistant Bt cotton expressing Cry1Ac/1Ab does not harm the insect predator Geocoris pallidipennis." Ecotoxicology and environmental safety vol. 230 (2021): 113129. doi: https://doi.org/10.1016/j.ecoenv.2021.113129
Zhang M, Ma Y, Luo J, Ji J, Gao X, Wu C, Zhu X, Wang L, Zhang K, Li D, Wang L, Niu L, Cui J. Transgenic insect-resistant Bt cotton expressing Cry1Ac/1Ab does not harm the insect predator Geocoris pallidipennis. Ecotoxicol Environ Saf. 2021 Dec 31;230:113129. doi: 10.1016/j.ecoenv.2021.113129. Epub 2021 Dec 31. PMID: 34979310.
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Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis.

Angiology

Lin J, Chen J, Wu D, Li X, Guo X, Shi S, Lin K.
PMID: 34461746
Angiology. 2021 Aug 30;33197211039921. doi: 10.1177/00033197211039921. Epub 2021 Aug 30.

Contrast-induced nephropathy (CIN) is a complication of patients undergoing percutaneous coronary intervention (PCI). Promising biomarkers for the early prediction of CIN can significantly improve outcomes of these patients. We searched PubMed, EMBASE, Web of Science, and Cochrane Library for...

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Lin J, Chen J, Wu D, et al. Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis. Angiology. 2021;33197211039921doi: 10.1177/00033197211039921.
Lin, J., Chen, J., Wu, D., Li, X., Guo, X., Shi, S., & Lin, K. (2021). Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis. Angiology, 33197211039921. https://doi.org/10.1177/00033197211039921
Lin, Jing, et al. "Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis." Angiology vol. (2021): 33197211039921. doi: https://doi.org/10.1177/00033197211039921
Lin J, Chen J, Wu D, Li X, Guo X, Shi S, Lin K. Biomarkers for the early prediction of contrast-induced nephropathy after percutaneous coronary intervention in adults: A systematic review and meta-analysis. Angiology. 2021 Aug 30;33197211039921. doi: 10.1177/00033197211039921. Epub 2021 Aug 30. PMID: 34461746.
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Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal.

Frontiers in immunology

Zhang Z, Wu H, Peng Q, Xie Z, Chen F, Ma Y, Zhang Y, Zhou Y, Yang J, Chen C, Li S, Zhang Y, Tian W, Wang Y, Xu Y, Luo H, Zhu M, Kuang YQ, Yu J, Wang K.
PMID: 34489980
Front Immunol. 2021 Aug 19;12:730300. doi: 10.3389/fimmu.2021.730300. eCollection 2021.

Heroin addiction and withdrawal influence multiple physiological functions, including immune responses, but the mechanism remains largely elusive. The objective of this study was to investigate the molecular inflammatory interactome, particularly the cytokines and transcriptome regulatory network in heroin addicts...

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Zhang Z, Wu H, Peng Q, et al. Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal. Front Immunol. 2021;12:730300doi: 10.3389/fimmu.2021.730300.
Zhang, Z., Wu, H., Peng, Q., Xie, Z., Chen, F., Ma, Y., Zhang, Y., Zhou, Y., Yang, J., Chen, C., Li, S., Zhang, Y., Tian, W., Wang, Y., Xu, Y., Luo, H., Zhu, M., Kuang, Y. Q., Yu, J., & Wang, K. (2021). Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal. Frontiers in immunology, 12730300. https://doi.org/10.3389/fimmu.2021.730300
Zhang, Zunyue, et al. "Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal." Frontiers in immunology vol. 12 (2021): 730300. doi: https://doi.org/10.3389/fimmu.2021.730300
Zhang Z, Wu H, Peng Q, Xie Z, Chen F, Ma Y, Zhang Y, Zhou Y, Yang J, Chen C, Li S, Zhang Y, Tian W, Wang Y, Xu Y, Luo H, Zhu M, Kuang YQ, Yu J, Wang K. Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal. Front Immunol. 2021 Aug 19;12:730300. doi: 10.3389/fimmu.2021.730300. eCollection 2021. PMID: 34489980; PMCID: PMC8416766.
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Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei.

Fish & shellfish immunology

Wu J, Tian S, Luo K, Zhang Y, Pan H, Zhang W, Mai K.
PMID: 34983003
Fish Shellfish Immunol. 2022 Jan 01;121:39-52. doi: 10.1016/j.fsi.2021.12.052. Epub 2022 Jan 01.

The present study was conducted to investigate the effects of dietary recombinant human lysozyme (RHL) on the growth, immune response, anti-oxidative activity, intestinal morphology, intestinal microflora and disease resistance of shrimp Litopenaeus vannamei. Shrimps with an initial body weight...

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Wu J, Tian S, Luo K, et al. Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2022;121:39-52doi: 10.1016/j.fsi.2021.12.052.
Wu, J., Tian, S., Luo, K., Zhang, Y., Pan, H., Zhang, W., & Mai, K. (2022). Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei. Fish & shellfish immunology, 12139-52. https://doi.org/10.1016/j.fsi.2021.12.052
Wu, Jing, et al. "Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei." Fish & shellfish immunology vol. 121 (2022): 39-52. doi: https://doi.org/10.1016/j.fsi.2021.12.052
Wu J, Tian S, Luo K, Zhang Y, Pan H, Zhang W, Mai K. Dietary recombinant human lysozyme improves the growth, intestinal health, immunity and disease resistance of Pacific white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2022 Jan 01;121:39-52. doi: 10.1016/j.fsi.2021.12.052. Epub 2022 Jan 01. PMID: 34983003.
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Bisphenol S exposure induces cytotoxicity in mouse Leydig cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Zhang W, Huang T, Sun Z, Kuang H, Yuan Y, Zou W, Liu F, Zhang F, Yang B, Wu L, Zhang D.
PMID: 34990787
Food Chem Toxicol. 2022 Jan 04;160:112805. doi: 10.1016/j.fct.2021.112805. Epub 2022 Jan 04.

Bisphenol S (BPS), an increasingly used alternative to bisphenol A, has been linked to testosterone deficiency and male reproductive dysfunction in laboratory animals. This study aimed to examine the cytotoxicity of BPS exposure to Leydig cells and to investigate...

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Zhang W, Huang T, Sun Z, et al. Bisphenol S exposure induces cytotoxicity in mouse Leydig cells. Food Chem Toxicol. 2022;160:112805doi: 10.1016/j.fct.2021.112805.
Zhang, W., Huang, T., Sun, Z., Kuang, H., Yuan, Y., Zou, W., Liu, F., Zhang, F., Yang, B., Wu, L., & Zhang, D. (2022). Bisphenol S exposure induces cytotoxicity in mouse Leydig cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 160112805. https://doi.org/10.1016/j.fct.2021.112805
Zhang, Wenjuan, et al. "Bisphenol S exposure induces cytotoxicity in mouse Leydig cells." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 160 (2022): 112805. doi: https://doi.org/10.1016/j.fct.2021.112805
Zhang W, Huang T, Sun Z, Kuang H, Yuan Y, Zou W, Liu F, Zhang F, Yang B, Wu L, Zhang D. Bisphenol S exposure induces cytotoxicity in mouse Leydig cells. Food Chem Toxicol. 2022 Jan 04;160:112805. doi: 10.1016/j.fct.2021.112805. Epub 2022 Jan 04. PMID: 34990787.
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Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report.

Journal of diabetes investigation

Zhang X, Chen Y, Tong N, Shao Q, Zhou Y, Mu T, Yang X, Zhang Y.
PMID: 34460997
J Diabetes Investig. 2021 Aug 30; doi: 10.1111/jdi.13651. Epub 2021 Aug 30.

Maternally inherited diabetes and deafness is a rare genetic disease mainly caused by a point mutation in mitochondrial deoxyribonucleic acid. Lipoprotein lipase gene mutations are associated with familial dyslipidemias, which are difficult to manage. We reported for the first...

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Zhang X, Chen Y, Tong N, et al. Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report. J Diabetes Investig. 2021;doi: 10.1111/jdi.13651.
Zhang, X., Chen, Y., Tong, N., Shao, Q., Zhou, Y., Mu, T., Yang, X., & Zhang, Y. (2021). Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report. Journal of diabetes investigation, . https://doi.org/10.1111/jdi.13651
Zhang, Xiaojuan, et al. "Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report." Journal of diabetes investigation vol. (2021). doi: https://doi.org/10.1111/jdi.13651
Zhang X, Chen Y, Tong N, Shao Q, Zhou Y, Mu T, Yang X, Zhang Y. Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report. J Diabetes Investig. 2021 Aug 30; doi: 10.1111/jdi.13651. Epub 2021 Aug 30. PMID: 34460997.
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Prostate-specific antigen nadir and testosterone level at prostate-specific antigen failure following radiation and androgen suppression therapy for unfavorable-risk prostate cancer and the risk of all-cause and prostate cancer-specific mortality.

Cancer

Bitterman DS, Chen MH, Wu J, Renshaw AA, Loffredo M, Kantoff PW, Small EJ, D'Amico AV.
PMID: 33823065
Cancer. 2021 Aug 01;127(15):2623-2630. doi: 10.1002/cncr.33543. Epub 2021 Apr 06.

BACKGROUND: Although both PSA nadir (PSAn) and testosterone levels at PSA failure are known prognostic factors in men undergoing radiation therapy (RT) and androgen deprivation therapy (ADT) for unfavorable-risk prostate cancer (PC), it is unclear whether their prognostic significance...

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Bitterman DS, Chen MH, Wu J, et al. Prostate-specific antigen nadir and testosterone level at prostate-specific antigen failure following radiation and androgen suppression therapy for unfavorable-risk prostate cancer and the risk of all-cause and prostate cancer-specific mortality. Cancer. 2021;127(15):2623-2630doi: 10.1002/cncr.33543.
Bitterman, D. S., Chen, M. H., Wu, J., Renshaw, A. A., Loffredo, M., Kantoff, P. W., Small, E. J., & D'Amico, A. V. (2021). Prostate-specific antigen nadir and testosterone level at prostate-specific antigen failure following radiation and androgen suppression therapy for unfavorable-risk prostate cancer and the risk of all-cause and prostate cancer-specific mortality. Cancer, 127(15), 2623-2630. https://doi.org/10.1002/cncr.33543
Bitterman, Danielle S, et al. "Prostate-specific antigen nadir and testosterone level at prostate-specific antigen failure following radiation and androgen suppression therapy for unfavorable-risk prostate cancer and the risk of all-cause and prostate cancer-specific mortality." Cancer vol. 127,15 (2021): 2623-2630. doi: https://doi.org/10.1002/cncr.33543
Bitterman DS, Chen MH, Wu J, Renshaw AA, Loffredo M, Kantoff PW, Small EJ, D'Amico AV. Prostate-specific antigen nadir and testosterone level at prostate-specific antigen failure following radiation and androgen suppression therapy for unfavorable-risk prostate cancer and the risk of all-cause and prostate cancer-specific mortality. Cancer. 2021 Aug 01;127(15):2623-2630. doi: 10.1002/cncr.33543. Epub 2021 Apr 06. PMID: 33823065.
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