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Showing 9985 to 9996 of 67312 entries
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Ultrashort Peptides and Hyaluronic Acid-Based Injectable Composite Hydrogels for Sustained Drug Release and Chronic Diabetic Wound Healing.

ACS applied materials & interfaces

Wang L, Li J, Xiong Y, Wu Y, Yang F, Guo Y, Chen Z, Gao L, Deng W.
PMID: 34860513
ACS Appl Mater Interfaces. 2021 Dec 15;13(49):58329-58339. doi: 10.1021/acsami.1c16738. Epub 2021 Dec 03.

Peptide hydrogels are widely used for biomedical applications owing to their good biocompatibility and unique advantages in terms of amino acid-based structures and functions. However, the exploration of the peptide/saccharide composite hydrogels as potential biomaterials for chronic diabetic wound...

Development of a europium nanoparticles lateral flow immunoassay for NGAL detection in urine and diagnosis of acute kidney injury.

BMC nephrology

Yin M, Nie Y, Liu H, Liu L, Tang L, Dong Y, Hu C, Wang H.
PMID: 35031018
BMC Nephrol. 2022 Jan 14;23(1):30. doi: 10.1186/s12882-021-02493-w.

BACKGROUND: AKI is related to severe adverse outcomes and mortality with Coronavirus Disease 2019 (COVID-19) patients, that early diagnosed and intervened is imperative. Neutrophil gelatinase-associated lipocalin (NGAL) is one of the most promising biomarkers for detection of acute kidney...

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

Molecular cancer

Pan Z, Zhao R, Li B, Qi Y, Qiu W, Guo Q, Zhang S, Zhao S, Xu H, Li M, Gao Z, Fan Y, Xu J, Wang H, Wang S, Qiu J, Wang Q, Guo X, Deng L, Zhang P, Xue H, Li G.
PMID: 35031058
Mol Cancer. 2022 Jan 14;21(1):16. doi: 10.1186/s12943-021-01485-6.

BACKGROUND: Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), a newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been...

A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice.

Molecular biology and evolution

Szpak M, Collins SC, Li Y, Liu X, Ayub Q, Fischer MC, Vancollie VE, Lelliott CJ, Xue Y, Yalcin B, Yang H, Tyler-Smith C.
PMID: 34464968
Mol Biol Evol. 2021 Dec 09;38(12):5655-5663. doi: 10.1093/molbev/msab243.

A nonsense allele at rs1343879 in human MAGEE2 on chromosome X has previously been reported as a strong candidate for positive selection in East Asia. This premature stop codon causing ∼80% protein truncation is characterized by a striking geographical...

Safety, Tolerability, and Pharmacokinetics of Telacebec (Q203), a New Antituberculosis Agent, in Healthy Subjects.

Antimicrobial agents and chemotherapy

Kim J, Choi J, Kang H, Ahn J, Hutchings J, van Niekerk C, Park D, Kim J, Jeon Y, Nam K, Shin S, Shin BS.
PMID: 34694872
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0143621. doi: 10.1128/AAC.01436-21. Epub 2021 Oct 25.

Telacebec (Q203) is a potent drug candidate under clinical development for the treatment of drug-naïve and drug-resistant tuberculosis. The first-in-human randomized, placebo-controlled, double-blind, dose-escalation Phase 1A trial (Q203-TB-PI-US001) was conducted to evaluate the safety, tolerability, and pharmacokinetics of telacebec....

Aortic Root Replacement of Small Roots to Prepare for Transcatheter Aortic Valve Replacement.

The Annals of thoracic surgery

Clemence J, Yang B.
PMID: 35031288
Ann Thorac Surg. 2022 Jan 11; doi: 10.1016/j.athoracsur.2021.12.023. Epub 2022 Jan 11.

Small aortic root is a significant limitation of optimal hemodynamics for surgical aortic valve replacement due to a small annulus and application of transcatheter aortic valve replacement (TAVR) due to low coronary ostia and limited space at the root....

A stochastic model explains the periodicity phenomenon of influenza on network.

Scientific reports

Yang H, Jin Z.
PMID: 34697349
Sci Rep. 2021 Oct 25;11(1):20996. doi: 10.1038/s41598-021-00260-3.

Influenza is an infectious disease with obvious periodic changes over time. It is of great practical significance to explore the non-environment-related factors that cause this regularity for influenza control and individual protection. In this paper, based on the randomness...

The Role of .

Antimicrobial agents and chemotherapy

Jiang S, Zhuang H, Zhu F, Wei X, Zhang J, Sun L, Ji S, Wang H, Wu D, Zhao F, Yan R, Yu Y, Chen Y.
PMID: 34662187
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0129521. doi: 10.1128/AAC.01295-21. Epub 2021 Oct 18.

The emergence of daptomycin-resistant (DAP-R) Staphylococcus aureus strains has become a global problem. Point mutations in

Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol.

Antioxidants (Basel, Switzerland)

Bae H, Park S, Yang C, Song G, Lim W.
PMID: 33802602
Antioxidants (Basel). 2021 Mar 03;10(3). doi: 10.3390/antiox10030379.

Phytosterols, which are present in a variety of foods, exhibit various physiological functions and do not have any side effects. Here, we attempted to identify functional role of campesterol in regulation of oxidative stress by leading to cell death...

Routine Radiologic Assessment for Anastomotic Leak Is Not Necessary in Asymptomatic Patients After Esophagectomy for Esophageal Cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Kang H, Ben-David K, Sarosi GA, Thomas RM.
PMID: 35037179
J Gastrointest Surg. 2022 Jan 17; doi: 10.1007/s11605-021-05219-3. Epub 2022 Jan 17.

BACKGROUND: Anastomotic leaks (AL) are a major source of post-esophagectomy morbidity and patients are often initially asymptomatic. Debate exists on timing and utility of imaging to detect AL post-esophagectomy. We sought to evaluate the efficacy and timing of radiographic...

Iron-based biochar derived from waste-activated sludge enhances anaerobic digestion of synthetic salty organic wastewater for methane production.

Bioresource technology

Che L, Yang B, Tian Q, Xu H.
PMID: 34864176
Bioresour Technol. 2021 Dec 02;345:126465. doi: 10.1016/j.biortech.2021.126465. Epub 2021 Dec 02.

Herein, synthetic iron-based biochar was used in anaerobic digestion of synthetic salty organic wastewater for methane production. The iron-based biochar synthesized at different pyrolysis temperatures improved methane production. An optimal methane production of 551 ± 4.0 mL/L was achieved...

Genome-wide analysis reveals the spatiotemporal expression patterns of SOS3 genes in the maize B73 genome in response to salt stress.

BMC genomics

Cao Y, Shan T, Fang H, Sun K, Shi W, Tang B, Wu J, Wang K, Li P, Wang B.
PMID: 35034642
BMC Genomics. 2022 Jan 16;23(1):60. doi: 10.1186/s12864-021-08287-6.

BACKGROUND: Salt damage is an important abiotic stress that affects the growth and yield of maize worldwide. As an important member of the salt overly sensitive (SOS) signal transduction pathway, the SOS3 gene family participates in the transmission of...

Showing 9985 to 9996 of 67312 entries