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Showing 8953 to 8963 of 8963 entries
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Recent Developments in Microbe-Plant-Based Bioremediation for Tackling Heavy Metal-Polluted Soils.

Frontiers in microbiology

Saha L, Tiwari J, Bauddh K, Ma Y.
PMID: 35002995
Front Microbiol. 2021 Dec 23;12:731723. doi: 10.3389/fmicb.2021.731723. eCollection 2021.

Soil contamination with heavy metals (HMs) is a serious concern for the developing world due to its non-biodegradability and significant potential to damage the ecosystem and associated services. Rapid industrialization and activities such as mining, manufacturing, and construction are...

Efficacy and safety of pulsed dye laser for the treatment of surgical scars: a systematic review and meta-analysis.

Lasers in medical science

Cai Y, Zeng X, Ying J, Zhu Y, Qiu Y, Xiang W.
PMID: 34351564
Lasers Med Sci. 2021 Aug 05; doi: 10.1007/s10103-021-03385-z. Epub 2021 Aug 05.

Various clinical trials have explored whether the pulsed dye laser (PDL) method is safe to treat scars, especially surgical scars. However, comprehensive evidence confirming the exact outcomes of PDL for treating surgical scars is lacking. The efficacy and safety...

A manualised weight management programme for adults with mild-moderate intellectual disabilities affected by excess weight: A randomised controlled feasibility trial (Shape Up-LD).

Journal of applied research in intellectual disabilities : JARID

Lally P, Beeken RJ, Wilson R, Omar R, Hunter R, Fovargue S, Anderson D, King M, Hassiotis A, Croker H.
PMID: 34297441
J Appl Res Intellect Disabil. 2021 Jul 23; doi: 10.1111/jar.12922. Epub 2021 Jul 23.

BACKGROUND: The aim was to pilot an adapted manualised weight management programme for persons with mild-moderate intellectual disabilities affected by overweight or obesity ('Shape Up-LD').METHOD: Adults with intellectual disabilities were enrolled in a 6-month trial (3-month active intervention and...

Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis.

Molecular cancer research : MCR

Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS.
PMID: 34810213
Mol Cancer Res. 2021 Nov 22; doi: 10.1158/1541-7786.MCR-21-0479. Epub 2021 Nov 22.

The Ras/Erk and NF-κB pathways play critical roles in cell proliferation and are known to drive oncogenesis when overactivated. Herein we report a gatekeeper function of the two pathways by working in synergy to suppress liver tumorigenesis. Hepatocyte-specific deletion...

Novel genetic characteristics in low-grade fetal adenocarcinoma of the lung.

Thoracic cancer

Zhang S, Yin H, Zhang J, Yang L, Yang G, Jia J, Jiao Y, Ying J, Wang Y.
PMID: 34464028
Thorac Cancer. 2021 Oct;12(20):2789-2795. doi: 10.1111/1759-7714.14126. Epub 2021 Aug 31.

BACKGROUND: Low-grade fetal adenocarcinoma of the lung (L-FLAC) is a rare subtype of lung adenocarcinoma with undetermined histological features and genetic abnormalities. In this study, we attempted to investigate the pathological characteristics and genomic profiles of L-FLAC.METHODS: Among 9839...

Effect of pH on the Catalytic Degradation of Rhodamine B by Synthesized CDs/g-C.

ACS omega

Guo Y, Zhou C, Fang L, Liu Z, Li W, Yang M.
PMID: 33817471
ACS Omega. 2021 Mar 15;6(12):8119-8130. doi: 10.1021/acsomega.0c05915. eCollection 2021 Mar 30.

The narrow pH range of Fenton oxidation restricts its applicability in water pollution treatment. In this work, a CDs/g-C

Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.

Molecular neurodegeneration

Li Q, Feng Y, Xue Y, Zhan X, Fu Y, Gui G, Zhou W, Richard JP, Taga A, Li P, Mao X, Maragakis NJ, Ying M.
PMID: 35012575
Mol Neurodegener. 2022 Jan 10;17(1):8. doi: 10.1186/s13024-021-00510-y.

BACKGROUND: Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenerative diseases. We need highly efficient MN differentiation strategies for generating...

Coordination of m.

Rice (New York, N.Y.)

Cheng Q, Wang P, Wu G, Wang Y, Tan J, Li C, Zhang X, Liu S, Huang S, Huang T, Yang M, He H, Bian J.
PMID: 34224034
Rice (N Y). 2021 Jul 05;14(1):62. doi: 10.1186/s12284-021-00502-y.

N

Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice.

Molecular therapy. Methods & clinical development

Freyn AW, Pine M, Rosado VC, Benz M, Muramatsu H, Beattie M, Tam YK, Krammer F, Palese P, Nachbagauer R, McMahon M, Pardi N.
PMID: 34485597
Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95. doi: 10.1016/j.omtm.2021.06.003. eCollection 2021 Sep 10.

Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization. mRNA vaccines allow for easy antigen modification, enabling rapid...

Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells.

Molecular therapy. Nucleic acids

Nai J, Zhang J, Li J, Li H, Yang Y, Yang M, Wang Y, Gong W, Li Z, Li L, Gao C.
PMID: 35024246
Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362. doi: 10.1016/j.omtn.2021.12.016. eCollection 2022 Mar 08.

Despite the success of small interfering RNAs (siRNAs) in clinical settings, their fast clearance and poor delivery efficiency to target cells still hinder their therapeutic effect. Herein, a new treatment system was constructed by combining thermosensitive liposomes with the...

Identification of a novel EXT2 frameshift mutation in a family with hereditary multiple exostoses by whole-exome sequencing.

Journal of clinical laboratory analysis

Yang M, Xie H, Xu B, Xiang Q, Wang H, Hu T, Liu S.
PMID: 34403521
J Clin Lab Anal. 2021 Sep;35(9):e23968. doi: 10.1002/jcla.23968. Epub 2021 Aug 17.

BACKGROUND: Hereditary multiple exostoses (HME), also referred to as multiple osteochondromas, is an autosomal dominant skeletal disease characterized by the development of multiple overgrown benign bony tumors capped by cartilage and is associated with bone deformity, joint limitation, and...

Showing 8953 to 8963 of 8963 entries