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Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response.

Biochemical and biophysical research communications

Konishi A, Suzuki J, Kuwahara M, Matsumoto A, Nomura S, Soga T, Yorozuya T, Yamashita M.
PMID: 34942532
Biochem Biophys Res Commun. 2021 Dec 17;588:34-40. doi: 10.1016/j.bbrc.2021.12.050. Epub 2021 Dec 17.

Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have various effects on T cells. However, the long-term influence of GCs on the T cell-mediated immune response remain to be elucidated. We demonstrated that the administration of GC during the TCR-mediated activation...

Showing 85 to 85 of 85 entries