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Showing 757 to 768 of 768 entries
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The role of the immunoescape in colorectal cancer liver metastasis.

PloS one

Takasu C, Yamashita S, Morine Y, Yoshikawa K, Tokunaga T, Nishi M, Kashihara H, Yoshimoto T, Shimada M.
PMID: 34797860
PLoS One. 2021 Nov 19;16(11):e0259940. doi: 10.1371/journal.pone.0259940. eCollection 2021.

The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study...

Single-loop bi-atrial tachycardia with presumed conduction block across an anteroseptal mitral ablation line: A case report: Bi-AT after septal mitral isthmus ablation.

Journal of cardiology cases

An Y, Ogawa H, Yanagisawa M, Marumiya C, Ikeda S, Akao M.
PMID: 34354785
J Cardiol Cases. 2021 Feb 27;24(2):89-93. doi: 10.1016/j.jccase.2021.02.004. eCollection 2021 Aug.

A 64-year-old man with no previous medical history underwent catheter ablation (CA) by right pulmonary vein isolation and creation of an anteroseptal mitral isthmus (MI) line for peri-mitral atrial flutter. Since atrial tachycardia (AT) recurred with palpitation 4 months...

Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach.

Bioorganic & medicinal chemistry

Yudi Utomo R, Asawa Y, Okada S, Ban HS, Yoshimori A, Bajorath J, Nakamura H.
PMID: 34391121
Bioorg Med Chem. 2021 Sep 15;46:116357. doi: 10.1016/j.bmc.2021.116357. Epub 2021 Aug 08.

Amyloid β (Aβ) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Aβ inhibitors from ChEMBL (data set 2487). Among the compounds predicted, compound B was found...

Therapeutic Potential of a Self-Assembling Peptide Hydrogel to Treat Colonic Injuries Associated with Inflammatory Bowel Disease.

Journal of Crohn's & colitis

Araki T, Mitsuyama K, Yamasaki H, Morita M, Tsuruta K, Mori A, Yoshimura T, Fukunaga S, Kuwaki K, Yoshioka S, Takedatsu H, Kakuma T, Akiba J, Torimura T.
PMID: 33596312
J Crohns Colitis. 2021 Sep 25;15(9):1517-1527. doi: 10.1093/ecco-jcc/jjab033.

BACKGROUND AND AIMS: The Self-assembling Peptide Hydrogel [SAPH, PuraMatrix], a fully synthetic peptide solution designed to replace collagen, has recently been used to promote mucosal regeneration in iatrogenic ulcers following endoscopic submucosal dissection. Herein, we evaluated its utility in...

Correction: ERdj8 governs the size of autophagosomes during the formation process.

The Journal of cell biology

Yamamoto YH, Kasai A, Omori H, Takino T, Sugihara M, Umemoto T, Hamasaki M, Hatta T, Natsume T, Morimoto RI, Arai R, Waguri S, Sato M, Sato K, Bar-Nun S, Yoshimori T, Noda T, Nagata K.
PMID: 34357389
J Cell Biol. 2020 Sep 06;220(9). doi: 10.1083/jcb.20190312707282021c. Epub 2021 Aug 06.

No abstract available.

Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.

Bone

Saito T, Terajima M, Taga Y, Hayashi F, Oshima S, Kasamatsu A, Okubo Y, Ito C, Toshimori K, Sunohara M, Tanzawa H, Uzawa K, Yamauchi M.
PMID: 34718219
Bone. 2022 Jan;154:116242. doi: 10.1016/j.bone.2021.116242. Epub 2021 Oct 27.

Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links. Though abnormal LH2 activities have been implicated in various diseases...

The role of the immunoescape in colorectal cancer liver metastasis.

PloS one

Takasu C, Yamashita S, Morine Y, Yoshikawa K, Tokunaga T, Nishi M, Kashihara H, Yoshimoto T, Shimada M.
PMID: 34797860
PLoS One. 2021 Nov 19;16(11):e0259940. doi: 10.1371/journal.pone.0259940. eCollection 2021.

The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study...

TT[over ¯]-Deformed Conformal Field Theories out of Equilibrium.

Physical review letters

Medenjak M, Policastro G, Yoshimura T.
PMID: 33834840
Phys Rev Lett. 2021 Mar 26;126(12):121601. doi: 10.1103/PhysRevLett.126.121601.

We consider the out-of-equilibrium transport in TT[over ¯]-deformed (1+1)-dimension conformal field theories (CFTs). The theories admit two disparate approaches, integrability and holography, which we make full use of in order to compute the transport quantities, such as the exact...

Usefulness of electron microscopy in the diagnosis of wild-type transthyretin cardiac amyloidosis.

Journal of cardiology cases

Sunayama I, Yoshimura T, Sonoura T, Nakamura Y, Morishita Y, Sekihara T, Ishimi M, Yamato M, Hoshida Y, Yasuoka Y.
PMID: 33841594
J Cardiol Cases. 2021 Jan 19;23(4):166-169. doi: 10.1016/j.jccase.2020.11.023. eCollection 2021 Apr.

Wild-type transthyretin cardiac amyloidosis (ATTRwt) has been recognized as an important cause of heart failure with preserved ejection fraction; thus, its accurate diagnosis is crucial. Herein, we describe the case of a 76-year-old man who presented with dyspnea and...

Characteristics of "chūnibyō" identified by a questionnaire.

PloS one

Shimoda M, Morimoto K, Tanaka Y, Yoshimori K, Ohta K.
PMID: 34818343
PLoS One. 2021 Nov 24;16(11):e0260375. doi: 10.1371/journal.pone.0260375. eCollection 2021.

BACKGROUND: "Chūnibyō" is a term that represents a distinctive, transient mental state during puberty in Japan, but its characteristics and precise definition have not been standardized. Increased awareness of chūnibyō could lead to a better environment for those who...

Effectiveness of fibreoptic endoscopic evaluation of swallowing and dietary intervention during home-visit dental care in older individuals.

Gerodontology

Tajitsu M, Ishihata K, Tezuka M, Yoshimura T, Ichiki M, Ohta H, Nohara K, Nakamura N.
PMID: 34240454
Gerodontology. 2021 Jul 08; doi: 10.1111/ger.12581. Epub 2021 Jul 08.

BACKGROUND: Currently, patients with dysphagia are receiving dietary management that deviates from their original swallowing function.OBJECTIVE: To evaluate the clinical significance of fibreoptic endoscopic evaluation of swallowing (FEES) and dietary intervention (DI) by multi-professional collaboration during visit care for...

Zwitterionic heterogemini surfactants containing ammonium and carboxylate headgroups 2: aggregation behavior studied by SANS, DLS, and cryo-TEM.

Journal of colloid and interface science

Nyuta K, Yoshimura T, Tsuchiya K, Sakai H, Abe M, Iwase H.
PMID: 22261272
J Colloid Interface Sci. 2012 Mar 15;370(1):80-5. doi: 10.1016/j.jcis.2011.12.027. Epub 2011 Dec 19.

The aggregation behavior in aqueous solution of zwitterionic heterogemini surfactants, N,N-dimethyl-N-[2-(N'-alkyl-N'-β-carboxypropanoylamino)ethyl]-1-alkylammonium bromides (2C(n)AmCa, in which n represents hydrocarbon chain lengths of 8, 10, 12, and 14), with nonidentical headgroups containing ammonium and carboxylate was investigated through small-angle neutron scattering...

Showing 757 to 768 of 768 entries