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The pruritogenic role of the type 2 immune response in diseases associated with chronic itch.

Experimental dermatology

Ingrasci G, Lipman ZM, Hawash AA, Girolomoni G, Yosipovitch G.
PMID: 34033148
Exp Dermatol. 2021 Sep;30(9):1208-1217. doi: 10.1111/exd.14401. Epub 2021 Jun 05.

While there is a vast array of aetiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including...

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Ingrasci G, Lipman ZM, Hawash AA, et al. The pruritogenic role of the type 2 immune response in diseases associated with chronic itch. Exp Dermatol. 2021;30(9):1208-1217doi: 10.1111/exd.14401.
Ingrasci, G., Lipman, Z. M., Hawash, A. A., Girolomoni, G., & Yosipovitch, G. (2021). The pruritogenic role of the type 2 immune response in diseases associated with chronic itch. Experimental dermatology, 30(9), 1208-1217. https://doi.org/10.1111/exd.14401
Ingrasci, Giuseppe, et al. "The pruritogenic role of the type 2 immune response in diseases associated with chronic itch." Experimental dermatology vol. 30,9 (2021): 1208-1217. doi: https://doi.org/10.1111/exd.14401
Ingrasci G, Lipman ZM, Hawash AA, Girolomoni G, Yosipovitch G. The pruritogenic role of the type 2 immune response in diseases associated with chronic itch. Exp Dermatol. 2021 Sep;30(9):1208-1217. doi: 10.1111/exd.14401. Epub 2021 Jun 05. PMID: 34033148.
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Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials.

Dermatitis : contact, atopic, occupational, drug

Silverberg JI, Simpson EL, Guttman-Yassky E, Cork MJ, de Bruin-Weller M, Yosipovitch G, Eckert L, Chen Z, Ardeleanu M, Shumel B, Hultsch T, Rossi AB, Hamilton JD, Orengo JM, Ruddy M, Graham NMH, Pirozzi G, Gadkari A.
PMID: 33165005
Dermatitis. 2021 Oct 01;32(1):S81-S91. doi: 10.1097/DER.0000000000000698.

BACKGROUND: Pain is a frequent symptom of atopic dermatitis (AD).OBJECTIVES: The aims of the study were to evaluate the effects of dupilumab on pain/discomfort in AD and to determine whether pain correlates with other outcomes.METHODS: This was a post...

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Silverberg JI, Simpson EL, Guttman-Yassky E, et al. Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials. Dermatitis. 2021;32(1):S81-S91doi: 10.1097/DER.0000000000000698.
Silverberg, J. I., Simpson, E. L., Guttman-Yassky, E., Cork, M. J., de Bruin-Weller, M., Yosipovitch, G., Eckert, L., Chen, Z., Ardeleanu, M., Shumel, B., Hultsch, T., Rossi, A. B., Hamilton, J. D., Orengo, J. M., Ruddy, M., Graham, N. M. H., Pirozzi, G., & Gadkari, A. (2021). Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials. Dermatitis : contact, atopic, occupational, drug, 32(1), S81-S91. https://doi.org/10.1097/DER.0000000000000698
Silverberg, Jonathan I, et al. "Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials." Dermatitis : contact, atopic, occupational, drug vol. 32,1 (2021): S81-S91. doi: https://doi.org/10.1097/DER.0000000000000698
Silverberg JI, Simpson EL, Guttman-Yassky E, Cork MJ, de Bruin-Weller M, Yosipovitch G, Eckert L, Chen Z, Ardeleanu M, Shumel B, Hultsch T, Rossi AB, Hamilton JD, Orengo JM, Ruddy M, Graham NMH, Pirozzi G, Gadkari A. Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials. Dermatitis. 2021 Oct 01;32(1):S81-S91. doi: 10.1097/DER.0000000000000698. PMID: 33165005; PMCID: PMC8560147.
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Reply to "Comment on: Chronic pruritus of unknown origin (CPUO): Uniform nomenclature and diagnosis as a pathway to standardized understanding and treatment".

Journal of the American Academy of Dermatology

Kim BS, Berger TG, Yosipovitch G.
PMID: 31374301
J Am Acad Dermatol. 2021 Dec;85(6):e383. doi: 10.1016/j.jaad.2019.07.080. Epub 2019 Jul 30.

No abstract available.

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Kim BS, Berger TG, Yosipovitch G. Reply to "Comment on: Chronic pruritus of unknown origin (CPUO): Uniform nomenclature and diagnosis as a pathway to standardized understanding and treatment". J Am Acad Dermatol. 2019;85(6):e383doi: 10.1016/j.jaad.2019.07.080.
Kim, B. S., Berger, T. G., & Yosipovitch, G. (2021). Reply to "Comment on: Chronic pruritus of unknown origin (CPUO): Uniform nomenclature and diagnosis as a pathway to standardized understanding and treatment". Journal of the American Academy of Dermatology, 85(6), e383. https://doi.org/10.1016/j.jaad.2019.07.080
Kim, Brian S, et al. "Reply to "Comment on: Chronic pruritus of unknown origin (CPUO): Uniform nomenclature and diagnosis as a pathway to standardized understanding and treatment"." Journal of the American Academy of Dermatology vol. 85,6 (2021): e383. doi: https://doi.org/10.1016/j.jaad.2019.07.080
Kim BS, Berger TG, Yosipovitch G. Reply to "Comment on: Chronic pruritus of unknown origin (CPUO): Uniform nomenclature and diagnosis as a pathway to standardized understanding and treatment". J Am Acad Dermatol. 2021 Dec;85(6):e383. doi: 10.1016/j.jaad.2019.07.080. Epub 2019 Jul 30. PMID: 31374301.
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When topical therapy of atopic dermatitis fails: a guide for the clinician.

Expert review of clinical immunology

Ingrasci G, Lipman ZM, Yosipovitch G.
PMID: 34720031
Expert Rev Clin Immunol. 2021 Dec;17(12):1245-1256. doi: 10.1080/1744666X.2021.2000390. Epub 2021 Nov 11.

INTRODUCTION: While topical medications are the first line of treatment for mild-to-moderate atopic dermatitis, they are ineffective in individuals with diffuse disease and moderate-to-severe atopic itch. For these individuals, as well as those who do not respond to topical...

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Ingrasci G, Lipman ZM, Yosipovitch G. When topical therapy of atopic dermatitis fails: a guide for the clinician. Expert Rev Clin Immunol. 2021;17(12):1245-1256doi: 10.1080/1744666X.2021.2000390.
Ingrasci, G., Lipman, Z. M., & Yosipovitch, G. (2021). When topical therapy of atopic dermatitis fails: a guide for the clinician. Expert review of clinical immunology, 17(12), 1245-1256. https://doi.org/10.1080/1744666X.2021.2000390
Ingrasci, Giuseppe, et al. "When topical therapy of atopic dermatitis fails: a guide for the clinician." Expert review of clinical immunology vol. 17,12 (2021): 1245-1256. doi: https://doi.org/10.1080/1744666X.2021.2000390
Ingrasci G, Lipman ZM, Yosipovitch G. When topical therapy of atopic dermatitis fails: a guide for the clinician. Expert Rev Clin Immunol. 2021 Dec;17(12):1245-1256. doi: 10.1080/1744666X.2021.2000390. Epub 2021 Nov 11. PMID: 34720031.
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Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair.

Journal of the American Academy of Dermatology

Rick JW, Alavi A, Hsiao JL, Yosipovitch G, Shi VY.
PMID: 34214619
J Am Acad Dermatol. 2021 Dec;85(6):e387-e388. doi: 10.1016/j.jaad.2021.03.126. Epub 2021 Jun 29.

No abstract available.

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Rick JW, Alavi A, Hsiao JL, et al. Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair. J Am Acad Dermatol. 2021;85(6):e387-e388doi: 10.1016/j.jaad.2021.03.126.
Rick, J. W., Alavi, A., Hsiao, J. L., Yosipovitch, G., & Shi, V. Y. (2021). Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair. Journal of the American Academy of Dermatology, 85(6), e387-e388. https://doi.org/10.1016/j.jaad.2021.03.126
Rick, Jonathan W, et al. "Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair." Journal of the American Academy of Dermatology vol. 85,6 (2021): e387-e388. doi: https://doi.org/10.1016/j.jaad.2021.03.126
Rick JW, Alavi A, Hsiao JL, Yosipovitch G, Shi VY. Atopic dermatitis and hidradenitis suppurativa: An under-recognized pair. J Am Acad Dermatol. 2021 Dec;85(6):e387-e388. doi: 10.1016/j.jaad.2021.03.126. Epub 2021 Jun 29. PMID: 34214619.
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THE SKIN MICROBIOTA AND ITCH: Is There a Link?.

The Journal of clinical and aesthetic dermatology

Sung Kim H, Yosipovitch G.
PMID: 33282109
J Clin Aesthet Dermatol. 2020 Jun;13(6):S39-S46. Epub 2020 Jun 01.

Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings, and the skin microbiota, relaying itch signals to the brain....

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Sung Kim H, Yosipovitch G. THE SKIN MICROBIOTA AND ITCH: Is There a Link?. J Clin Aesthet Dermatol. 2020;13(6):S39-S46
Sung Kim, H., & Yosipovitch, G. (2020). THE SKIN MICROBIOTA AND ITCH: Is There a Link?. The Journal of clinical and aesthetic dermatology, 13(6), S39-S46.
Sung Kim, Hei, and Yosipovitch, Gil. "THE SKIN MICROBIOTA AND ITCH: Is There a Link?." The Journal of clinical and aesthetic dermatology vol. 13,6 (2020): S39-S46.
Sung Kim H, Yosipovitch G. THE SKIN MICROBIOTA AND ITCH: Is There a Link?. J Clin Aesthet Dermatol. 2020 Jun;13(6):S39-S46. Epub 2020 Jun 01. PMID: 33282109; PMCID: PMC7710288.
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The Skin Microbiota and Itch: Is There a Link?.

Journal of clinical medicine

Kim HS, Yosipovitch G.
PMID: 32331207
J Clin Med. 2020 Apr 22;9(4). doi: 10.3390/jcm9041190.

Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings and the skin microbiota, relaying itch signals to the brain....

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Kim HS, Yosipovitch G. The Skin Microbiota and Itch: Is There a Link?. J Clin Med. 2020;9(4)doi: 10.3390/jcm9041190.
Kim, H. S., & Yosipovitch, G. (2020). The Skin Microbiota and Itch: Is There a Link?. Journal of clinical medicine, 9(4), . https://doi.org/10.3390/jcm9041190
Kim, Hei Sung, and Yosipovitch, Gil. "The Skin Microbiota and Itch: Is There a Link?." Journal of clinical medicine vol. 9,4 (2020). doi: https://doi.org/10.3390/jcm9041190
Kim HS, Yosipovitch G. The Skin Microbiota and Itch: Is There a Link?. J Clin Med. 2020 Apr 22;9(4). doi: 10.3390/jcm9041190. PMID: 32331207; PMCID: PMC7230651.
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Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase.

Journal of the European Academy of Dermatology and Venereology : JEADV

Weisshaar E, Szepietowski JC, Bernhard JD, Hait H, Legat FJ, Nattkemper L, Reich A, Sadoghi B, Sciascia TR, Zeidler C, Yosipovitch G, Ständer S.
PMID: 34780095
J Eur Acad Dermatol Venereol. 2021 Nov 15; doi: 10.1111/jdv.17816. Epub 2021 Nov 15.

BACKGROUND: Treatment of prurigo nodularis (PN) is challenging and new treatment options are needed.OBJECTIVE: To evaluate the efficacy and safety of two oral doses of the kappa opioid agonist and mu opioid antagonist nalbuphine extended release (NAL-ER) tablets in...

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Weisshaar E, Szepietowski JC, Bernhard JD, et al. Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase. J Eur Acad Dermatol Venereol. 2021;doi: 10.1111/jdv.17816.
Weisshaar, E., Szepietowski, J. C., Bernhard, J. D., Hait, H., Legat, F. J., Nattkemper, L., Reich, A., Sadoghi, B., Sciascia, T. R., Zeidler, C., Yosipovitch, G., & Ständer, S. (2021). Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase. Journal of the European Academy of Dermatology and Venereology : JEADV, . https://doi.org/10.1111/jdv.17816
Weisshaar, E, et al. "Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase." Journal of the European Academy of Dermatology and Venereology : JEADV vol. (2021). doi: https://doi.org/10.1111/jdv.17816
Weisshaar E, Szepietowski JC, Bernhard JD, Hait H, Legat FJ, Nattkemper L, Reich A, Sadoghi B, Sciascia TR, Zeidler C, Yosipovitch G, Ständer S. Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase. J Eur Acad Dermatol Venereol. 2021 Nov 15; doi: 10.1111/jdv.17816. Epub 2021 Nov 15. PMID: 34780095.
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Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.

Cell reports

Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA.
PMID: 34233199
Cell Rep. 2021 Jul 06;36(1):109308. doi: 10.1016/j.celrep.2021.109308.

Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in...

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Benraiss A, Mariani JN, Osipovitch M, et al. Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell Rep. 2021;36(1):109308doi: 10.1016/j.celrep.2021.109308.
Benraiss, A., Mariani, J. N., Osipovitch, M., Cornwell, A., Windrem, M. S., Villanueva, C. B., Chandler-Militello, D., & Goldman, S. A. (2021). Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell reports, 36(1), 109308. https://doi.org/10.1016/j.celrep.2021.109308
Benraiss, Abdellatif, et al. "Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease." Cell reports vol. 36,1 (2021): 109308. doi: https://doi.org/10.1016/j.celrep.2021.109308
Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA. Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell Rep. 2021 Jul 06;36(1):109308. doi: 10.1016/j.celrep.2021.109308. PMID: 34233199.
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Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.

Cell reports

Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA.
PMID: 34233199
Cell Rep. 2021 Jul 06;36(1):109308. doi: 10.1016/j.celrep.2021.109308.

Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in...

Cite
Benraiss A, Mariani JN, Osipovitch M, et al. Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell Rep. 2021;36(1):109308doi: 10.1016/j.celrep.2021.109308.
Benraiss, A., Mariani, J. N., Osipovitch, M., Cornwell, A., Windrem, M. S., Villanueva, C. B., Chandler-Militello, D., & Goldman, S. A. (2021). Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell reports, 36(1), 109308. https://doi.org/10.1016/j.celrep.2021.109308
Benraiss, Abdellatif, et al. "Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease." Cell reports vol. 36,1 (2021): 109308. doi: https://doi.org/10.1016/j.celrep.2021.109308
Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA. Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell Rep. 2021 Jul 06;36(1):109308. doi: 10.1016/j.celrep.2021.109308. PMID: 34233199.
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Autoimmune Progesterone Dermatitis: A Systematic Review.

Dermatitis : contact, atopic, occupational, drug

Lipman ZM, Labib A, Vander Does A, Yosipovitch G.
PMID: 34405830
Dermatitis. 2021 Aug 16; doi: 10.1097/DER.0000000000000779. Epub 2021 Aug 16.

ABSTRACT: Autoimmune progesterone dermatitis (AIPD) is a cyclical, cutaneous reaction to endogenous progesterone that occurs throughout the menstrual cycle. The cutaneous manifestations of AIPD vary greatly from patient to patient, ranging anywhere from urticaria to erythema multiforme to anaphylaxis....

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Lipman ZM, Labib A, Vander Does A, et al. Autoimmune Progesterone Dermatitis: A Systematic Review. Dermatitis. 2021;doi: 10.1097/DER.0000000000000779.
Lipman, Z. M., Labib, A., Vander Does, A., & Yosipovitch, G. (2021). Autoimmune Progesterone Dermatitis: A Systematic Review. Dermatitis : contact, atopic, occupational, drug, . https://doi.org/10.1097/DER.0000000000000779
Lipman, Zoe M, et al. "Autoimmune Progesterone Dermatitis: A Systematic Review." Dermatitis : contact, atopic, occupational, drug vol. (2021). doi: https://doi.org/10.1097/DER.0000000000000779
Lipman ZM, Labib A, Vander Does A, Yosipovitch G. Autoimmune Progesterone Dermatitis: A Systematic Review. Dermatitis. 2021 Aug 16; doi: 10.1097/DER.0000000000000779. Epub 2021 Aug 16. PMID: 34405830.
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Dry skin and impairment of barrier function associated with itch - new insights.

International journal of cosmetic science

Yosipovitch G.
PMID: 18494919
Int J Cosmet Sci. 2004 Feb;26(1):1-7. doi: 10.1111/j.0142-5463.2004.00199.x.

Itch is a common symptom in dry skin related to inflammatory skin diseases, normal aging, and systemic diseases such as chronic renal failure, and HIV. However, correlations between itch and objective measures of barrier function and skin dryness such...

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Yosipovitch G. Dry skin and impairment of barrier function associated with itch - new insights. Int J Cosmet Sci. 2004;26(1):1-7doi: 10.1111/j.0142-5463.2004.00199.x.
Yosipovitch, G. (2004). Dry skin and impairment of barrier function associated with itch - new insights. International journal of cosmetic science, 26(1), 1-7. https://doi.org/10.1111/j.0142-5463.2004.00199.x
Yosipovitch, G. "Dry skin and impairment of barrier function associated with itch - new insights." International journal of cosmetic science vol. 26,1 (2004): 1-7. doi: https://doi.org/10.1111/j.0142-5463.2004.00199.x
Yosipovitch G. Dry skin and impairment of barrier function associated with itch - new insights. Int J Cosmet Sci. 2004 Feb;26(1):1-7. doi: 10.1111/j.0142-5463.2004.00199.x. PMID: 18494919.
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Showing 13 to 24 of 58 entries