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Showing 25 to 36 of 646 entries
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Ion-pair reversed-phase chromatography of short double-stranded deoxyribonucleic acid in silicon micro-pillar array columns: retention model and applications.

Journal of chromatography. A

Zhang L, Majeed B, Lagae L, Peumans P, Van Hoof C, De Malsche W.
PMID: 23647613
J Chromatogr A. 2013 Jun 14;1294:1-9. doi: 10.1016/j.chroma.2013.04.002. Epub 2013 Apr 08.

Separation of double-stranded (ds) DNAs is important in numerous biochemical analyses relevant for clinical applications. A widely used separation technique is high performance liquid chromatography (HPLC), in the variant of ion-pair reversed-phase (IP-RP) chromatography. HPLC can be miniaturized by...

Synthesis of branched DNA using oxidatively cleavable tritylsulfenyl as a hydroxy protecting group.

Current protocols in nucleic acid chemistry

Seio K, Kanamori T, Sekine M.
PMID: 25199636
Curr Protoc Nucleic Acid Chem. 2014 Sep 08;58:2.18.1-19. doi: 10.1002/0471142700.nc0218s58.

The application of oxidatively cleavable tritylsulfenyl (TrS) group to the synthesis of branched DNA is described. The TrS protecting group can be removed by treatment with 1 M aqueous iodine, while it is stable toward an oxaziridine-type oxidant. At...

Models and standards of proof in cross-disciplinary science: the case of arsenic DNA.

Astrobiology

Benner SA, Bains W, Seager S.
PMID: 23634974
Astrobiology. 2013 May;13(5):510-3. doi: 10.1089/ast.2012.0954. Epub 2013 May 02.

No abstract available.

Physicists about to hi-jack DNA?.

Nature

Maddox J.
PMID: 3785362
Nature. 1986 Nov 6-12;324(6092):11. doi: 10.1038/324011a0.

No abstract available.

Bigger and cheaper.

Nature nanotechnology

[No authors listed]
PMID: 29317786
Nat Nanotechnol. 2018 Jan;13(1):1. doi: 10.1038/s41565-017-0054-2.

No abstract available.

Manipulation of the magnetoresistance effect in a double-helix DNA.

Journal of physics. Condensed matter : an Institute of Physics journal

Li YS, Wang XF.
PMID: 30272566
J Phys Condens Matter. 2018 Nov 14;30(45):455102. doi: 10.1088/1361-648X/aae567.

Magnetoresistance (R

DNA nanostructures: Through, rather than across.

Nature materials

Bruchez MP.
PMID: 29358770
Nat Mater. 2018 Jan 23;17(2):112-113. doi: 10.1038/nmat5073.

No abstract available.

DNA skybridge: 3D structure producing a light sheet for high-throughput single-molecule imaging.

Nucleic acids research

Kim D, Rashid F, Cho Y, Zaher MS, Cho IIH, Hamdan SM, Jeong C, Lee JB.
PMID: 31340015
Nucleic Acids Res. 2019 Oct 10;47(18):e107. doi: 10.1093/nar/gkz625.

Real-time visualization of single-proteins or -complexes on nucleic acid substrates is an essential tool for characterizing nucleic acid binding proteins. Here, we present a novel surface-condition independent and high-throughput single-molecule optical imaging platform called 'DNA skybridge'. The DNA skybridge...

Droplet microfluidics for synthetic biology.

Lab on a chip

Gach PC, Iwai K, Kim PW, Hillson NJ, Singh AK.
PMID: 28820204
Lab Chip. 2017 Oct 11;17(20):3388-3400. doi: 10.1039/c7lc00576h.

Synthetic biology is an interdisciplinary field that aims to engineer biological systems for useful purposes. Organism engineering often requires the optimization of individual genes and/or entire biological pathways (consisting of multiple genes). Advances in DNA sequencing and synthesis have...

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.

Journal of the American Chemical Society

Wranne MS, Füchtbauer AF, Dumat B, Bood M, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM.
PMID: 28613885
J Am Chem Soc. 2017 Jul 12;139(27):9271-9280. doi: 10.1021/jacs.7b04517. Epub 2017 Jun 27.

Förster resonance energy transfer (FRET) using fluorescent base analogues is a powerful means of obtaining high-resolution nucleic acid structure and dynamics information that favorably complements techniques such as NMR and X-ray crystallography. Here, we expand the base-base FRET repertoire...

Compound Libraries: Recent Advances and Their Applications in Drug Discovery.

Current drug discovery technologies

Gong Z, Hu G, Li Q, Liu Z, Wang F, Zhang X, Xiong J, Li P, Xu Y, Ma R, Chen S, Li J.
PMID: 28443514
Curr Drug Discov Technol. 2017;14(4):216-228. doi: 10.2174/1570163814666170425155154.

BACKGROUND: Hit identification is the starting point of small-molecule drug discovery and is therefore very important to the pharmaceutical industry. One of the most important approaches to identify a new hit is to screen a compound library using an...

Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base Pairs.

Chemphyschem : a European journal of chemical physics and physical chemistry

Liu Q, Liu G, Wang T, Fu J, Li R, Song L, Wang ZG, Ding B, Chen F.
PMID: 28856771
Chemphyschem. 2017 Nov 03;18(21):2977-2980. doi: 10.1002/cphc.201700809. Epub 2017 Sep 22.

Self-assembled DNA nanostructures hold great promise in the fields of nanofabrication, biosensing and nanomedicine. However, the inherent low stability of the DNA double helices, formed by weak interactions, largely hinders the assembly and functions of DNA nanostructures. In this...

Showing 25 to 36 of 646 entries