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Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials.

Environmental toxicology and chemistry

Salvito D, Fernandez M, Jenner K, Lyon DY, de Knecht J, Mayer P, MacLeod M, Eisenreich K, Leonards P, Cesnaitis R, León-Paumen M, Embry M, Déglin SE.
PMID: 32780492
Environ Toxicol Chem. 2020 Nov;39(11):2097-2108. doi: 10.1002/etc.4846. Epub 2020 Sep 16.

Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) pose unique risk assessment challenges to regulators and to product registrants. These substances can contain many constituents, sometimes partially unknown and/or variable, depending on fluctuations in...

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Salvito D, Fernandez M, Jenner K, et al. Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials. Environ Toxicol Chem. 2020;39(11):2097-2108doi: 10.1002/etc.4846.
Salvito, D., Fernandez, M., Jenner, K., Lyon, D. Y., de Knecht, J., Mayer, P., MacLeod, M., Eisenreich, K., Leonards, P., Cesnaitis, R., León-Paumen, M., Embry, M., & Déglin, S. E. (2020). Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials. Environmental toxicology and chemistry, 39(11), 2097-2108. https://doi.org/10.1002/etc.4846
Salvito, Daniel, et al. "Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials." Environmental toxicology and chemistry vol. 39,11 (2020): 2097-2108. doi: https://doi.org/10.1002/etc.4846
Salvito D, Fernandez M, Jenner K, Lyon DY, de Knecht J, Mayer P, MacLeod M, Eisenreich K, Leonards P, Cesnaitis R, León-Paumen M, Embry M, Déglin SE. Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials. Environ Toxicol Chem. 2020 Nov;39(11):2097-2108. doi: 10.1002/etc.4846. Epub 2020 Sep 16. PMID: 32780492; PMCID: PMC7693076.
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Metabolism, pharmacokinetics, and toxicokinetics defined.

Drug metabolism reviews

Di Carlo FJ.
PMID: 7084027
Drug Metab Rev. 1982;13(1):1-4. doi: 10.3109/03602538209002228.

No abstract available.

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Di Carlo FJ. Metabolism, pharmacokinetics, and toxicokinetics defined. Drug Metab Rev. 1982;13(1):1-4doi: 10.3109/03602538209002228.
Di Carlo, F. J. (1982). Metabolism, pharmacokinetics, and toxicokinetics defined. Drug metabolism reviews, 13(1), 1-4. https://doi.org/10.3109/03602538209002228
Di Carlo, F J. "Metabolism, pharmacokinetics, and toxicokinetics defined." Drug metabolism reviews vol. 13,1 (1982): 1-4. doi: https://doi.org/10.3109/03602538209002228
Di Carlo FJ. Metabolism, pharmacokinetics, and toxicokinetics defined. Drug Metab Rev. 1982;13(1):1-4. doi: 10.3109/03602538209002228. PMID: 7084027.
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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Hengstler J, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NP.
PMID: 32360905
Food Chem Toxicol. 2020 Aug;142:111349. doi: 10.1016/j.fct.2020.111349. Epub 2020 Apr 30.

Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities...

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Autrup H, Barile FA, Berry SC, et al. Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Food Chem Toxicol. 2020;142:111349doi: 10.1016/j.fct.2020.111349.
Autrup, H., Barile, F. A., Berry, S. C., Blaauboer, B. J., Boobis, A., Bolt, H., Hengstler, J., Borgert, C. J., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., Heslop-Harrison, P., & Vermeulen, N. P. (2020). Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 142111349. https://doi.org/10.1016/j.fct.2020.111349
Autrup, Herman, et al. "Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 142 (2020): 111349. doi: https://doi.org/10.1016/j.fct.2020.111349
Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Hengstler J, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NP. Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Food Chem Toxicol. 2020 Aug;142:111349. doi: 10.1016/j.fct.2020.111349. Epub 2020 Apr 30. PMID: 32360905.
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Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop.

Environmental health perspectives

Taylor KW, Joubert BR, Braun JM, Dilworth C, Gennings C, Hauser R, Heindel JJ, Rider CV, Webster TF, Carlin DJ.
PMID: 27905274
Environ Health Perspect. 2016 Dec 01;124(12):A227-A229. doi: 10.1289/EHP547.

No abstract available.

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Taylor KW, Joubert BR, Braun JM, et al. Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop. Environ Health Perspect. 2016;124(12):A227-A229doi: 10.1289/EHP547.
Taylor, K. W., Joubert, B. R., Braun, J. M., Dilworth, C., Gennings, C., Hauser, R., Heindel, J. J., Rider, C. V., Webster, T. F., & Carlin, D. J. (2016). Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop. Environmental health perspectives, 124(12), A227-A229. https://doi.org/10.1289/EHP547
Taylor, Kyla W, et al. "Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop." Environmental health perspectives vol. 124,12 (2016): A227-A229. doi: https://doi.org/10.1289/EHP547
Taylor KW, Joubert BR, Braun JM, Dilworth C, Gennings C, Hauser R, Heindel JJ, Rider CV, Webster TF, Carlin DJ. Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop. Environ Health Perspect. 2016 Dec 01;124(12):A227-A229. doi: 10.1289/EHP547. PMID: 27905274; PMCID: PMC5132642.
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Ecological risk assessment in the United States environmental protection agency: a historical overview.

Integrated environmental assessment and management

Suter GW.
PMID: 18321143
Integr Environ Assess Manag. 2008 Jul;4(3):285-9. doi: 10.1897/IEAM_2007-062. Epub 2008 Mar 05.

EDITOR'S NOTE: This is 1 of 4 papers from the US Environmental Protection Agency Science Advisory Board's Ecological Processes and Effects Committee workshop on the current and future practice of ecological risk assessment. The workshop was held in Washington,...

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Suter GW. Ecological risk assessment in the United States environmental protection agency: a historical overview. Integr Environ Assess Manag. 2008;4(3):285-9doi: 10.1897/IEAM_2007-062.
Suter, G. W. (2008). Ecological risk assessment in the United States environmental protection agency: a historical overview. Integrated environmental assessment and management, 4(3), 285-9. https://doi.org/10.1897/IEAM_2007-062
Suter, Glenn W. "Ecological risk assessment in the United States environmental protection agency: a historical overview." Integrated environmental assessment and management vol. 4,3 (2008): 285-9. doi: https://doi.org/10.1897/IEAM_2007-062
Suter GW. Ecological risk assessment in the United States environmental protection agency: a historical overview. Integr Environ Assess Manag. 2008 Jul;4(3):285-9. doi: 10.1897/IEAM_2007-062. Epub 2008 Mar 05. PMID: 18321143.
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Systematic reviews: Separating fact from fiction.

Environment international

Haddaway NR, Bilotta GS.
PMID: 26371438
Environ Int. 2016 Jul-Aug;92:578-84. doi: 10.1016/j.envint.2015.07.011. Epub 2015 Sep 12.

The volume of scientific literature continues to expand and decision-makers are faced with increasingly unmanageable volumes of evidence to assess. Systematic reviews (SRs) are powerful tools that aim to provide comprehensive, transparent, reproducible and updateable summaries of evidence. SR...

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Haddaway NR, Bilotta GS. Systematic reviews: Separating fact from fiction. Environ Int. 2015;92:578-84doi: 10.1016/j.envint.2015.07.011.
Haddaway, N. R., & Bilotta, G. S. (2016). Systematic reviews: Separating fact from fiction. Environment international, 92578-84. https://doi.org/10.1016/j.envint.2015.07.011
Haddaway, Neal R, and Bilotta, Gary S. "Systematic reviews: Separating fact from fiction." Environment international vol. 92 (2016): 578-84. doi: https://doi.org/10.1016/j.envint.2015.07.011
Haddaway NR, Bilotta GS. Systematic reviews: Separating fact from fiction. Environ Int. 2016 Jul-Aug;92:578-84. doi: 10.1016/j.envint.2015.07.011. Epub 2015 Sep 12. PMID: 26371438.
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Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity.

The Science of the total environment

Naasz S, Altenburger R, Kühnel D.
PMID: 29710572
Sci Total Environ. 2018 Sep 01;635:1170-1181. doi: 10.1016/j.scitotenv.2018.04.180. Epub 2018 Apr 24.

The usage of engineered nanomaterials (NM) offers many novel products and applications with advanced features, but at the same time raises concerns with regard to potential adverse biological effects. Upon release and emission, NM may interact with chemicals in...

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Naasz S, Altenburger R, Kühnel D. Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity. Sci Total Environ. 2018;635:1170-1181doi: 10.1016/j.scitotenv.2018.04.180.
Naasz, S., Altenburger, R., & Kühnel, D. (2018). Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity. The Science of the total environment, 6351170-1181. https://doi.org/10.1016/j.scitotenv.2018.04.180
Naasz, Steffi, et al. "Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity." The Science of the total environment vol. 635 (2018): 1170-1181. doi: https://doi.org/10.1016/j.scitotenv.2018.04.180
Naasz S, Altenburger R, Kühnel D. Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity. Sci Total Environ. 2018 Sep 01;635:1170-1181. doi: 10.1016/j.scitotenv.2018.04.180. Epub 2018 Apr 24. PMID: 29710572.
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Environmental monitoring: a changing challenge.

Journal of environmental monitoring : JEM

Nieboer E.
PMID: 19809694
J Environ Monit. 2009 Oct;11(10):1729-30. doi: 10.1039/b918031c. Epub 2009 Sep 10.

No abstract available.

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Nieboer E. Environmental monitoring: a changing challenge. J Environ Monit. 2009;11(10):1729-30doi: 10.1039/b918031c.
Nieboer, E. (2009). Environmental monitoring: a changing challenge. Journal of environmental monitoring : JEM, 11(10), 1729-30. https://doi.org/10.1039/b918031c
Nieboer, Evert. "Environmental monitoring: a changing challenge." Journal of environmental monitoring : JEM vol. 11,10 (2009): 1729-30. doi: https://doi.org/10.1039/b918031c
Nieboer E. Environmental monitoring: a changing challenge. J Environ Monit. 2009 Oct;11(10):1729-30. doi: 10.1039/b918031c. Epub 2009 Sep 10. PMID: 19809694.
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Global climate change and environmental contaminants: a SETAC call for research.

Integrated environmental assessment and management

Wenning RJ, Finger SE, Guilhermino L, Helm RC, Hooper MJ, Landis WG, Menzie CA, Munns WR, Römbke J, Stahl RG.
PMID: 20821685
Integr Environ Assess Manag. 2010 Apr;6(2):197-8. doi: 10.1002/ieam.49.

No abstract available.

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Wenning RJ, Finger SE, Guilhermino L, et al. Global climate change and environmental contaminants: a SETAC call for research. Integr Environ Assess Manag. 2010;6(2):197-8doi: 10.1002/ieam.49.
Wenning, R. J., Finger, S. E., Guilhermino, L., Helm, R. C., Hooper, M. J., Landis, W. G., Menzie, C. A., Munns, W. R., Römbke, J., & Stahl, R. G. (2010). Global climate change and environmental contaminants: a SETAC call for research. Integrated environmental assessment and management, 6(2), 197-8. https://doi.org/10.1002/ieam.49
Wenning, Richard J, et al. "Global climate change and environmental contaminants: a SETAC call for research." Integrated environmental assessment and management vol. 6,2 (2010): 197-8. doi: https://doi.org/10.1002/ieam.49
Wenning RJ, Finger SE, Guilhermino L, Helm RC, Hooper MJ, Landis WG, Menzie CA, Munns WR, Römbke J, Stahl RG. Global climate change and environmental contaminants: a SETAC call for research. Integr Environ Assess Manag. 2010 Apr;6(2):197-8. doi: 10.1002/ieam.49. PMID: 20821685.
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Trace analysis as an aid to risk assessment.

Ecotoxicology and environmental safety

Egan H.
PMID: 7318732
Ecotoxicol Environ Saf. 1981 Dec;5(4):465-8. doi: 10.1016/0147-6513(81)90021-x.

No abstract available.

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Egan H. Trace analysis as an aid to risk assessment. Ecotoxicol Environ Saf. 1981;5(4):465-8doi: 10.1016/0147-6513(81)90021-x.
Egan, H. (1981). Trace analysis as an aid to risk assessment. Ecotoxicology and environmental safety, 5(4), 465-8. https://doi.org/10.1016/0147-6513(81)90021-x
Egan, H. "Trace analysis as an aid to risk assessment." Ecotoxicology and environmental safety vol. 5,4 (1981): 465-8. doi: https://doi.org/10.1016/0147-6513(81)90021-x
Egan H. Trace analysis as an aid to risk assessment. Ecotoxicol Environ Saf. 1981 Dec;5(4):465-8. doi: 10.1016/0147-6513(81)90021-x. PMID: 7318732.
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Hormetic dose-responses in nanotechnology studies.

The Science of the total environment

Iavicoli I, Fontana L, Leso V, Calabrese EJ.
PMID: 24793332
Sci Total Environ. 2014 Jul 15;487:361-74. doi: 10.1016/j.scitotenv.2014.04.023. Epub 2014 May 03.

While exposure to nanoparticles is a growing concern, research into their toxicological impact and possible hazard for human health is limited. There remains a lack of information concerning the nature of the dose-response relationship especially at low level exposures....

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Iavicoli I, Fontana L, Leso V, et al. Hormetic dose-responses in nanotechnology studies. Sci Total Environ. 2014;487:361-74doi: 10.1016/j.scitotenv.2014.04.023.
Iavicoli, I., Fontana, L., Leso, V., & Calabrese, E. J. (2014). Hormetic dose-responses in nanotechnology studies. The Science of the total environment, 487361-74. https://doi.org/10.1016/j.scitotenv.2014.04.023
Iavicoli, Ivo, et al. "Hormetic dose-responses in nanotechnology studies." The Science of the total environment vol. 487 (2014): 361-74. doi: https://doi.org/10.1016/j.scitotenv.2014.04.023
Iavicoli I, Fontana L, Leso V, Calabrese EJ. Hormetic dose-responses in nanotechnology studies. Sci Total Environ. 2014 Jul 15;487:361-74. doi: 10.1016/j.scitotenv.2014.04.023. Epub 2014 May 03. PMID: 24793332.
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Bioaccumulation data from laboratory and field studies: are they comparable?.

Integrated environmental assessment and management

Burkhard LP, Cowan-Ellsberry C, Embry MR, Hoke RA, Kidd KA.
PMID: 21538830
Integr Environ Assess Manag. 2012 Jan;8(1):13-6. doi: 10.1002/ieam.196.

Once they are released into the environment, a number of chemicals are known to bioaccumulate in organisms, sometimes to concentrations that may threaten the individual or their predators. However, use of physical or chemical properties or results from laboratory...

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Burkhard LP, Cowan-Ellsberry C, Embry MR, et al. Bioaccumulation data from laboratory and field studies: are they comparable?. Integr Environ Assess Manag. 2012;8(1):13-6doi: 10.1002/ieam.196.
Burkhard, L. P., Cowan-Ellsberry, C., Embry, M. R., Hoke, R. A., & Kidd, K. A. (2012). Bioaccumulation data from laboratory and field studies: are they comparable?. Integrated environmental assessment and management, 8(1), 13-6. https://doi.org/10.1002/ieam.196
Burkhard, Lawrence P, et al. "Bioaccumulation data from laboratory and field studies: are they comparable?." Integrated environmental assessment and management vol. 8,1 (2012): 13-6. doi: https://doi.org/10.1002/ieam.196
Burkhard LP, Cowan-Ellsberry C, Embry MR, Hoke RA, Kidd KA. Bioaccumulation data from laboratory and field studies: are they comparable?. Integr Environ Assess Manag. 2012 Jan;8(1):13-6. doi: 10.1002/ieam.196. PMID: 21538830.
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Showing 25 to 36 of 40 entries