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Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors.

OncoTargets and therapy

Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ.
PMID: 28919776
Onco Targets Ther. 2017 Aug 29;10:4239-4250. doi: 10.2147/OTT.S136992. eCollection 2017.

BACKGROUND: Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the appropriate dose for Phase II studies, characterize pharmacokinetic...

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Creelan BC, Gabrilovich DI, Gray JE, et al. Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. Onco Targets Ther. 2017;10:4239-4250doi: 10.2147/OTT.S136992.
Creelan, B. C., Gabrilovich, D. I., Gray, J. E., Williams, C. C., Tanvetyanon, T., Haura, E. B., Weber, J. S., Gibney, G. T., Markowitz, J., Proksch, J. W., Reisman, S. A., McKee, M. D., Chin, M. P., Meyer, C. J., & Antonia, S. J. (2017). Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. OncoTargets and therapy, 104239-4250. https://doi.org/10.2147/OTT.S136992
Creelan, Ben C, et al. "Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors." OncoTargets and therapy vol. 10 (2017): 4239-4250. doi: https://doi.org/10.2147/OTT.S136992
Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ. Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. Onco Targets Ther. 2017 Aug 29;10:4239-4250. doi: 10.2147/OTT.S136992. eCollection 2017. PMID: 28919776; PMCID: PMC5587199.
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Nonlinear Schrödinger equations with mean terms in nonresonant multidimensional quadratic materials.

Physical review. E, Statistical, nonlinear, and soft matter physics

Ablowitz MJ, Biondini G, Blair S.
PMID: 11308966
Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Apr;63(4):046605. doi: 10.1103/PhysRevE.63.046605. Epub 2001 Mar 23.

We derive the asymptotic equations governing the evolution of a quasi-monochromatic optical pulse in a nonresonant quadratic material starting from Maxwell equations. Under rather general assumptions, equations of nonlinear Schrödinger (NLS) type with coupling to mean fields result (here...

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Ablowitz MJ, Biondini G, Blair S. Nonlinear Schrödinger equations with mean terms in nonresonant multidimensional quadratic materials. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;63(4):046605doi: 10.1103/PhysRevE.63.046605.
Ablowitz, M. J., Biondini, G., & Blair, S. (2001). Nonlinear Schrödinger equations with mean terms in nonresonant multidimensional quadratic materials. Physical review. E, Statistical, nonlinear, and soft matter physics, 63(4), 046605. https://doi.org/10.1103/PhysRevE.63.046605
Ablowitz, M J, et al. "Nonlinear Schrödinger equations with mean terms in nonresonant multidimensional quadratic materials." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 63,4 (2001): 046605. doi: https://doi.org/10.1103/PhysRevE.63.046605
Ablowitz MJ, Biondini G, Blair S. Nonlinear Schrödinger equations with mean terms in nonresonant multidimensional quadratic materials. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Apr;63(4):046605. doi: 10.1103/PhysRevE.63.046605. Epub 2001 Mar 23. PMID: 11308966.
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New Insights into the Pathophysiology of Acquired Cytopenias.

Hematology. American Society of Hematology. Education Program

Young NS, Abkowitz JL, Luzzatto L.
PMID: 11701533
Hematology Am Soc Hematol Educ Program. 2000;18-38. doi: 10.1182/asheducation-2000.1.18.

This review addresses three related bone marrow failure diseases, the study of which has generated important insights in hematopoiesis, red cell biology, and immune-mediated blood cell injury. In Section I, Dr. Young summarizes the current knowledge of acquired aplastic...

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Young NS, Abkowitz JL, Luzzatto L. New Insights into the Pathophysiology of Acquired Cytopenias. Hematology Am Soc Hematol Educ Program. 2000;18-38doi: 10.1182/asheducation-2000.1.18.
Young, N. S., Abkowitz, J. L., & Luzzatto, L. (2000). New Insights into the Pathophysiology of Acquired Cytopenias. Hematology. American Society of Hematology. Education Program, 18-38. https://doi.org/10.1182/asheducation-2000.1.18
Young, Neal S., et al. "New Insights into the Pathophysiology of Acquired Cytopenias." Hematology. American Society of Hematology. Education Program vol. (2000): 18-38. doi: https://doi.org/10.1182/asheducation-2000.1.18
Young NS, Abkowitz JL, Luzzatto L. New Insights into the Pathophysiology of Acquired Cytopenias. Hematology Am Soc Hematol Educ Program. 2000;18-38. doi: 10.1182/asheducation-2000.1.18. PMID: 11701533.
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Dispersion management for randomly varying optical fibers.

Optics letters

Ablowitz MJ, Moeser JT.
PMID: 15119389
Opt Lett. 2004 Apr 15;29(8):821-3. doi: 10.1364/ol.29.000821.

An asymptotic theory for optical pulse propagation in a dispersion-managed (DM) fiber with random dispersion is presented. The validity of the theory is verified with direct numerical simulation. The equations that describe the slow evolution of initial pulses have...

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Ablowitz MJ, Moeser JT. Dispersion management for randomly varying optical fibers. Opt Lett. 2004;29(8):821-3doi: 10.1364/ol.29.000821.
Ablowitz, M. J., & Moeser, J. T. (2004). Dispersion management for randomly varying optical fibers. Optics letters, 29(8), 821-3. https://doi.org/10.1364/ol.29.000821
Ablowitz, Mark J, and Moeser, Jamison T. "Dispersion management for randomly varying optical fibers." Optics letters vol. 29,8 (2004): 821-3. doi: https://doi.org/10.1364/ol.29.000821
Ablowitz MJ, Moeser JT. Dispersion management for randomly varying optical fibers. Opt Lett. 2004 Apr 15;29(8):821-3. doi: 10.1364/ol.29.000821. PMID: 15119389.
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Carrier-envelope phase slip of ultrashort dispersion-managed solitons.

Optics letters

Ablowitz MJ, Ilan B, Cundiff ST.
PMID: 15352377
Opt Lett. 2004 Aug 01;29(15):1808-10. doi: 10.1364/ol.29.001808.

The carrier-envelope phase slip of an ultrashort pulse circulating in a mode-locked Ti:sapphire laser is analyzed. The laser cavity is modeled by a dispersion- and nonlinearity-managed nonlinear Schrödinger equation. The combined contributions to the phase slip induced by nonlinear...

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Ablowitz MJ, Ilan B, Cundiff ST. Carrier-envelope phase slip of ultrashort dispersion-managed solitons. Opt Lett. 2004;29(15):1808-10doi: 10.1364/ol.29.001808.
Ablowitz, M. J., Ilan, B., & Cundiff, S. T. (2004). Carrier-envelope phase slip of ultrashort dispersion-managed solitons. Optics letters, 29(15), 1808-10. https://doi.org/10.1364/ol.29.001808
Ablowitz, Mark J, et al. "Carrier-envelope phase slip of ultrashort dispersion-managed solitons." Optics letters vol. 29,15 (2004): 1808-10. doi: https://doi.org/10.1364/ol.29.001808
Ablowitz MJ, Ilan B, Cundiff ST. Carrier-envelope phase slip of ultrashort dispersion-managed solitons. Opt Lett. 2004 Aug 01;29(15):1808-10. doi: 10.1364/ol.29.001808. PMID: 15352377.
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The influence of various sugars on the respiratory quotient: A contribution to the significance of the R.Q.

The Journal of physiology

Cathcart EP, Markowitz J.
PMID: 16993892
J Physiol. 1927 Sep 09;63(4):309-24. doi: 10.1113/jphysiol.1927.sp002406.

No abstract available.

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Cathcart EP, Markowitz J. The influence of various sugars on the respiratory quotient: A contribution to the significance of the R.Q. J Physiol. 1927;63(4):309-24doi: 10.1113/jphysiol.1927.sp002406.
Cathcart, E. P., & Markowitz, J. (1927). The influence of various sugars on the respiratory quotient: A contribution to the significance of the R.Q. The Journal of physiology, 63(4), 309-24. https://doi.org/10.1113/jphysiol.1927.sp002406
Cathcart, E P, and Markowitz, J. "The influence of various sugars on the respiratory quotient: A contribution to the significance of the R.Q." The Journal of physiology vol. 63,4 (1927): 309-24. doi: https://doi.org/10.1113/jphysiol.1927.sp002406
Cathcart EP, Markowitz J. The influence of various sugars on the respiratory quotient: A contribution to the significance of the R.Q. J Physiol. 1927 Sep 09;63(4):309-24. doi: 10.1113/jphysiol.1927.sp002406. PMID: 16993892; PMCID: PMC1514945.
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Piston dispersive shock wave problem.

Physical review letters

Hoefer MA, Ablowitz MJ, Engels P.
PMID: 18352629
Phys Rev Lett. 2008 Feb 29;100(8):084504. doi: 10.1103/PhysRevLett.100.084504. Epub 2008 Feb 28.

The piston shock problem is a classical result of shock wave theory. In this work, the analogous dispersive shock wave (DSW) problem for a fluid described by the nonlinear Schrödinger equation is analyzed. Asymptotic solutions are calculated for a...

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Hoefer MA, Ablowitz MJ, Engels P. Piston dispersive shock wave problem. Phys Rev Lett. 2008;100(8):084504doi: 10.1103/PhysRevLett.100.084504.
Hoefer, M. A., Ablowitz, M. J., & Engels, P. (2008). Piston dispersive shock wave problem. Physical review letters, 100(8), 084504. https://doi.org/10.1103/PhysRevLett.100.084504
Hoefer, M A, et al. "Piston dispersive shock wave problem." Physical review letters vol. 100,8 (2008): 084504. doi: https://doi.org/10.1103/PhysRevLett.100.084504
Hoefer MA, Ablowitz MJ, Engels P. Piston dispersive shock wave problem. Phys Rev Lett. 2008 Feb 29;100(8):084504. doi: 10.1103/PhysRevLett.100.084504. Epub 2008 Feb 28. PMID: 18352629.
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The Clinician's Physiologist.

Canadian Medical Association journal

Markowitz J.
PMID: 20327520
Can Med Assoc J. 1963 May 04;88(18):950.

No abstract available.

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Markowitz J. The Clinician's Physiologist. Can Med Assoc J. 1963;88(18):950
Markowitz, J. (1963). The Clinician's Physiologist. Canadian Medical Association journal, 88(18), 950.
Markowitz, J. "The Clinician's Physiologist." Canadian Medical Association journal vol. 88,18 (1963): 950.
Markowitz J. The Clinician's Physiologist. Can Med Assoc J. 1963 May 04;88(18):950. PMID: 20327520; PMCID: PMC1921262.
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Commentaries.

Canadian Medical Association journal

Markowitz J, Turner DA.
PMID: 20328822
Can Med Assoc J. 1967 Mar 25;96(12):787-8.

No abstract available.

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Markowitz J, Turner DA. Commentaries. Can Med Assoc J. 1967;96(12):787-8
Markowitz, J., & Turner, D. A. (1967). Commentaries. Canadian Medical Association journal, 96(12), 787-8.
Markowitz, J, and Turner, D A. "Commentaries." Canadian Medical Association journal vol. 96,12 (1967): 787-8.
Markowitz J, Turner DA. Commentaries. Can Med Assoc J. 1967 Mar 25;96(12):787-8. PMID: 20328822; PMCID: PMC1936169.
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Commentaries.

Canadian Medical Association journal

Turner DA, Markowitz J.
PMID: 20328823
Can Med Assoc J. 1967 Mar 25;96(12):789-90.

No abstract available.

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Turner DA, Markowitz J. Commentaries. Can Med Assoc J. 1967;96(12):789-90
Turner, D. A., & Markowitz, J. (1967). Commentaries. Canadian Medical Association journal, 96(12), 789-90.
Turner, D A, and Markowitz, J. "Commentaries." Canadian Medical Association journal vol. 96,12 (1967): 789-90.
Turner DA, Markowitz J. Commentaries. Can Med Assoc J. 1967 Mar 25;96(12):789-90. PMID: 20328823; PMCID: PMC1936108.
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rac-3-Benzoyl-2-methylpropionic acid and its organic salts: possibilities of Yang photocyclization in crystals.

Acta crystallographica. Section C, Crystal structure communications

Bakowicz J, Turowska-Tyrk I.
PMID: 18682652
Acta Crystallogr C. 2008 Aug;64:o437-40. doi: 10.1107/S0108270108021380. Epub 2008 Jul 19.

The analysis of the crystal structures of rac-3-benzoyl-2-methylpropionic acid, C(11)H(12)O(3), (I), morpholinium rac-3-benzoyl-2-methylpropionate monohydrate, C(4)H(10)NO(+).C(11)H(11)O(3)(-).H(2)O, (II), pyridinium [hydrogen bis(rac-3-benzoyl-2-methylpropionate)], C(5)H(6)N(+).(H(+).2C(11)H(11)O(3)(-)), (III), and pyrrolidinium rac-3-benzoyl-2-methylpropionate rac-3-benzoyl-2-methylpropionic acid, C(4)H(10)N(+).C(11)H(11)O(3)(-).C(11)H(12)O(3), (IV), has enabled us to predict and understand the behaviour of these...

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Bakowicz J, Turowska-Tyrk I. rac-3-Benzoyl-2-methylpropionic acid and its organic salts: possibilities of Yang photocyclization in crystals. Acta Crystallogr C. 2008;64:o437-40doi: 10.1107/S0108270108021380.
Bakowicz, J., & Turowska-Tyrk, I. (2008). rac-3-Benzoyl-2-methylpropionic acid and its organic salts: possibilities of Yang photocyclization in crystals. Acta crystallographica. Section C, Crystal structure communications, 64o437-40. https://doi.org/10.1107/S0108270108021380
Bakowicz, Julia, and Turowska-Tyrk, Ilona. "rac-3-Benzoyl-2-methylpropionic acid and its organic salts: possibilities of Yang photocyclization in crystals." Acta crystallographica. Section C, Crystal structure communications vol. 64 (2008): o437-40. doi: https://doi.org/10.1107/S0108270108021380
Bakowicz J, Turowska-Tyrk I. rac-3-Benzoyl-2-methylpropionic acid and its organic salts: possibilities of Yang photocyclization in crystals. Acta Crystallogr C. 2008 Aug;64:o437-40. doi: 10.1107/S0108270108021380. Epub 2008 Jul 19. PMID: 18682652.
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Integrable nonlocal nonlinear Schrödinger equation.

Physical review letters

Ablowitz MJ, Musslimani ZH.
PMID: 23432249
Phys Rev Lett. 2013 Feb 08;110(6):064105. doi: 10.1103/PhysRevLett.110.064105. Epub 2013 Feb 07.

A new integrable nonlocal nonlinear Schrödinger equation is introduced. It possesses a Lax pair and an infinite number of conservation laws and is PT symmetric. The inverse scattering transform and scattering data with suitable symmetries are discussed. A method...

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Ablowitz MJ, Musslimani ZH. Integrable nonlocal nonlinear Schrödinger equation. Phys Rev Lett. 2013;110(6):064105doi: 10.1103/PhysRevLett.110.064105.
Ablowitz, M. J., & Musslimani, Z. H. (2013). Integrable nonlocal nonlinear Schrödinger equation. Physical review letters, 110(6), 064105. https://doi.org/10.1103/PhysRevLett.110.064105
Ablowitz, Mark J, and Musslimani, Ziad H. "Integrable nonlocal nonlinear Schrödinger equation." Physical review letters vol. 110,6 (2013): 064105. doi: https://doi.org/10.1103/PhysRevLett.110.064105
Ablowitz MJ, Musslimani ZH. Integrable nonlocal nonlinear Schrödinger equation. Phys Rev Lett. 2013 Feb 08;110(6):064105. doi: 10.1103/PhysRevLett.110.064105. Epub 2013 Feb 07. PMID: 23432249.
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Showing 1 to 12 of 136 entries