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Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes.

Hormone molecular biology and clinical investigation

Tresguerres JA, Cuesta S, Kireev RA, Garcia C, Acuña-Castroviejo D, Vara E.
PMID: 25436746
Horm Mol Biol Clin Investig. 2013 Dec;16(2):47-54. doi: 10.1515/hmbci-2013-0041.

Abstract This paper will review the effect of aging on glucose metabolism and insulin resistance in pancreas and in peripheral tissues and how melatonin administration could affect these parameters. In SAMP8 mice insulin levels in plasma were found to...

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Tresguerres JA, Cuesta S, Kireev RA, et al. Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes. Horm Mol Biol Clin Investig. 2013;16(2):47-54doi: 10.1515/hmbci-2013-0041.
Tresguerres, J. A., Cuesta, S., Kireev, R. A., Garcia, C., Acuña-Castroviejo, D., & Vara, E. (2013). Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes. Hormone molecular biology and clinical investigation, 16(2), 47-54. https://doi.org/10.1515/hmbci-2013-0041
Tresguerres, Jesus A F, et al. "Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes." Hormone molecular biology and clinical investigation vol. 16,2 (2013): 47-54. doi: https://doi.org/10.1515/hmbci-2013-0041
Tresguerres JA, Cuesta S, Kireev RA, Garcia C, Acuña-Castroviejo D, Vara E. Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes. Horm Mol Biol Clin Investig. 2013 Dec;16(2):47-54. doi: 10.1515/hmbci-2013-0041. PMID: 25436746.
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The role of mitochondria in brain aging and the effects of melatonin.

Current neuropharmacology

Escames G, López A, García JA, García L, Acuña-Castroviejo D, García JJ, López LC.
PMID: 21358969
Curr Neuropharmacol. 2010 Sep;8(3):182-93. doi: 10.2174/157015910792246245.

Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative...

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Escames G, López A, García JA, et al. The role of mitochondria in brain aging and the effects of melatonin. Curr Neuropharmacol. 2010;8(3):182-93doi: 10.2174/157015910792246245.
Escames, G., López, A., García, J. A., García, L., Acuña-Castroviejo, D., García, J. J., & López, L. C. (2010). The role of mitochondria in brain aging and the effects of melatonin. Current neuropharmacology, 8(3), 182-93. https://doi.org/10.2174/157015910792246245
Escames, Germaine, et al. "The role of mitochondria in brain aging and the effects of melatonin." Current neuropharmacology vol. 8,3 (2010): 182-93. doi: https://doi.org/10.2174/157015910792246245
Escames G, López A, García JA, García L, Acuña-Castroviejo D, García JJ, López LC. The role of mitochondria in brain aging and the effects of melatonin. Curr Neuropharmacol. 2010 Sep;8(3):182-93. doi: 10.2174/157015910792246245. PMID: 21358969; PMCID: PMC3001212.
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Salivary Melatonin Rhythm and Prostate Cancer: CAPLIFE Study.

The Journal of urology

Lozano-Lorca M, Olmedo-Requena R, Rodríguez-Barranco M, Redondo-Sánchez D, Jiménez-Pacheco A, Vázquez-Alonso F, Arana-Asensio E, Sánchez MJ, Fernández-Martínez J, Acuña-Castroviejo D, Jiménez-Moleón JJ.
PMID: 34694161
J Urol. 2021 Oct 25;101097JU0000000000002294. doi: 10.1097/JU.0000000000002294. Epub 2021 Oct 25.

PURPOSE: We analyzed the association between salivary melatonin rhythm and prostate cancer (PCa).MATERIALS AND METHODS: A total of 40 PCa cases and 41 controls from the CAPLIFE study were analyzed to determine the salivary melatonin rhythm through 6 saliva...

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Lozano-Lorca M, Olmedo-Requena R, Rodríguez-Barranco M, et al. Salivary Melatonin Rhythm and Prostate Cancer: CAPLIFE Study. J Urol. 2021;101097JU0000000000002294doi: 10.1097/JU.0000000000002294.
Lozano-Lorca, M., Olmedo-Requena, R., Rodríguez-Barranco, M., Redondo-Sánchez, D., Jiménez-Pacheco, A., Vázquez-Alonso, F., Arana-Asensio, E., Sánchez, M. J., Fernández-Martínez, J., Acuña-Castroviejo, D., & Jiménez-Moleón, J. J. (2021). Salivary Melatonin Rhythm and Prostate Cancer: CAPLIFE Study. The Journal of urology, 101097JU0000000000002294. https://doi.org/10.1097/JU.0000000000002294
Lozano-Lorca, Macarena, et al. "Salivary Melatonin Rhythm and Prostate Cancer: CAPLIFE Study." The Journal of urology vol. (2021): 101097JU0000000000002294. doi: https://doi.org/10.1097/JU.0000000000002294
Lozano-Lorca M, Olmedo-Requena R, Rodríguez-Barranco M, Redondo-Sánchez D, Jiménez-Pacheco A, Vázquez-Alonso F, Arana-Asensio E, Sánchez MJ, Fernández-Martínez J, Acuña-Castroviejo D, Jiménez-Moleón JJ. Salivary Melatonin Rhythm and Prostate Cancer: CAPLIFE Study. J Urol. 2021 Oct 25;101097JU0000000000002294. doi: 10.1097/JU.0000000000002294. Epub 2021 Oct 25. PMID: 34694161.
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The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage.

Antioxidants (Basel, Switzerland)

Sayed RKA, Fernández-Ortiz M, Rahim I, Fernández-Martínez J, Aranda-Martínez P, Rusanova I, Martínez-Ruiz L, Alsaadawy RM, Escames G, Acuña-Castroviejo D.
PMID: 34439517
Antioxidants (Basel). 2021 Aug 10;10(8). doi: 10.3390/antiox10081269.

To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin therapy. The results...

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Sayed RKA, Fernández-Ortiz M, Rahim I, et al. The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage. Antioxidants (Basel). 2021;10(8)doi: 10.3390/antiox10081269.
Sayed, R. K. A., Fernández-Ortiz, M., Rahim, I., Fernández-Martínez, J., Aranda-Martínez, P., Rusanova, I., Martínez-Ruiz, L., Alsaadawy, R. M., Escames, G., & Acuña-Castroviejo, D. (2021). The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage. Antioxidants (Basel, Switzerland), 10(8), . https://doi.org/10.3390/antiox10081269
Sayed, Ramy K A, et al. "The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage." Antioxidants (Basel, Switzerland) vol. 10,8 (2021). doi: https://doi.org/10.3390/antiox10081269
Sayed RKA, Fernández-Ortiz M, Rahim I, Fernández-Martínez J, Aranda-Martínez P, Rusanova I, Martínez-Ruiz L, Alsaadawy RM, Escames G, Acuña-Castroviejo D. The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage. Antioxidants (Basel). 2021 Aug 10;10(8). doi: 10.3390/antiox10081269. PMID: 34439517; PMCID: PMC8389221.
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Melatonin in antinociception: its therapeutic applications.

Current neuropharmacology

Srinivasan V, Lauterbach EC, Ho KY, Acuña-Castroviejo D, Zakaria R, Brzezinski A.
PMID: 23204986
Curr Neuropharmacol. 2012 Jun;10(2):167-78. doi: 10.2174/157015912800604489.

The intensity of pain sensation exhibits marked day and night variations. Since the intensity of pain perception is low during dark hours of the night when melatonin levels are high, this hormone has been implicated as one of the...

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Srinivasan V, Lauterbach EC, Ho KY, et al. Melatonin in antinociception: its therapeutic applications. Curr Neuropharmacol. 2012;10(2):167-78doi: 10.2174/157015912800604489.
Srinivasan, V., Lauterbach, E. C., Ho, K. Y., Acuña-Castroviejo, D., Zakaria, R., & Brzezinski, A. (2012). Melatonin in antinociception: its therapeutic applications. Current neuropharmacology, 10(2), 167-78. https://doi.org/10.2174/157015912800604489
Srinivasan, Venkatramanujam, et al. "Melatonin in antinociception: its therapeutic applications." Current neuropharmacology vol. 10,2 (2012): 167-78. doi: https://doi.org/10.2174/157015912800604489
Srinivasan V, Lauterbach EC, Ho KY, Acuña-Castroviejo D, Zakaria R, Brzezinski A. Melatonin in antinociception: its therapeutic applications. Curr Neuropharmacol. 2012 Jun;10(2):167-78. doi: 10.2174/157015912800604489. PMID: 23204986; PMCID: PMC3386506.
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Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023.

Journal of critical care

Acuña-Castroviejo D, Bueno-Laraño P.
PMID: 26025099
J Crit Care. 2015 Oct;30(5):1133. doi: 10.1016/j.jcrc.2015.05.009. Epub 2015 May 19.

No abstract available.

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Acuña-Castroviejo D, Bueno-Laraño P. Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023. J Crit Care. 2015;30(5):1133doi: 10.1016/j.jcrc.2015.05.009.
Acuña-Castroviejo, D., & Bueno-Laraño, P. (2015). Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023. Journal of critical care, 30(5), 1133. https://doi.org/10.1016/j.jcrc.2015.05.009
Acuña-Castroviejo, Dario, and Bueno-Laraño, Pablo. "Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023." Journal of critical care vol. 30,5 (2015): 1133. doi: https://doi.org/10.1016/j.jcrc.2015.05.009
Acuña-Castroviejo D, Bueno-Laraño P. Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023. J Crit Care. 2015 Oct;30(5):1133. doi: 10.1016/j.jcrc.2015.05.009. Epub 2015 May 19. PMID: 26025099.
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Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

Hormone molecular biology and clinical investigation

Escames G, Díaz-Casado ME, Doerrier C, Luna-Sánchez M, López LC, Acuña-Castroviejo D.
PMID: 25436750
Horm Mol Biol Clin Investig. 2013 Dec;16(2):91-100. doi: 10.1515/hmbci-2013-0026.

Abstract Mitochondrial dysfunction and oxidative/nitrosative stress are common features of senescence, and they explain some of the pathophysiological events during aging. In different animal models of aging, the existence of oxidative stress, inflammation, and mitochondrial dysfunction has been reported....

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Escames G, Díaz-Casado ME, Doerrier C, et al. Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy. Horm Mol Biol Clin Investig. 2013;16(2):91-100doi: 10.1515/hmbci-2013-0026.
Escames, G., Díaz-Casado, M. E., Doerrier, C., Luna-Sánchez, M., López, L. C., & Acuña-Castroviejo, D. (2013). Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy. Hormone molecular biology and clinical investigation, 16(2), 91-100. https://doi.org/10.1515/hmbci-2013-0026
Escames, Germaine, et al. "Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy." Hormone molecular biology and clinical investigation vol. 16,2 (2013): 91-100. doi: https://doi.org/10.1515/hmbci-2013-0026
Escames G, Díaz-Casado ME, Doerrier C, Luna-Sánchez M, López LC, Acuña-Castroviejo D. Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy. Horm Mol Biol Clin Investig. 2013 Dec;16(2):91-100. doi: 10.1515/hmbci-2013-0026. PMID: 25436750.
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Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging.

Antioxidants (Basel, Switzerland)

Fernández-Ortiz M, Sayed RKA, Fernández-Martínez J, Cionfrini A, Aranda-Martínez P, Escames G, de Haro T, Acuña-Castroviejo D.
PMID: 33260800
Antioxidants (Basel). 2020 Nov 27;9(12). doi: 10.3390/antiox9121187.

Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate immune response pathways. Some of the molecular mechanisms underlying these processes, however, remain unclear. This study tested...

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Fernández-Ortiz M, Sayed RKA, Fernández-Martínez J, et al. Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants (Basel). 2020;9(12)doi: 10.3390/antiox9121187.
Fernández-Ortiz, M., Sayed, R. K. A., Fernández-Martínez, J., Cionfrini, A., Aranda-Martínez, P., Escames, G., de Haro, T., & Acuña-Castroviejo, D. (2020). Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants (Basel, Switzerland), 9(12), . https://doi.org/10.3390/antiox9121187
Fernández-Ortiz, Marisol, et al. "Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging." Antioxidants (Basel, Switzerland) vol. 9,12 (2020). doi: https://doi.org/10.3390/antiox9121187
Fernández-Ortiz M, Sayed RKA, Fernández-Martínez J, Cionfrini A, Aranda-Martínez P, Escames G, de Haro T, Acuña-Castroviejo D. Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants (Basel). 2020 Nov 27;9(12). doi: 10.3390/antiox9121187. PMID: 33260800; PMCID: PMC7760557.
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The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.

Antioxidants (Basel, Switzerland)

Sayed RK, Fernández-Ortiz M, Fernández-Martínez J, Aranda Martínez P, Guerra-Librero A, Rodríguez-Santana C, de Haro T, Escames G, Acuña-Castroviejo D, Rusanova I.
PMID: 33801675
Antioxidants (Basel). 2021 Mar 27;10(4). doi: 10.3390/antiox10040524.

Muscular aging is a complex process and underlying physiological mechanisms are not fully clear. In recent years, the participation of the NF-kB pathway and the NLRP3 inflammasome in the chronic inflammation process that accompanies the skeletal muscle's aging has...

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Sayed RK, Fernández-Ortiz M, Fernández-Martínez J, et al. The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle. Antioxidants (Basel). 2021;10(4)doi: 10.3390/antiox10040524.
Sayed, R. K., Fernández-Ortiz, M., Fernández-Martínez, J., Aranda Martínez, P., Guerra-Librero, A., Rodríguez-Santana, C., de Haro, T., Escames, G., Acuña-Castroviejo, D., & Rusanova, I. (2021). The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle. Antioxidants (Basel, Switzerland), 10(4), . https://doi.org/10.3390/antiox10040524
Sayed, Ramy Ka, et al. "The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle." Antioxidants (Basel, Switzerland) vol. 10,4 (2021). doi: https://doi.org/10.3390/antiox10040524
Sayed RK, Fernández-Ortiz M, Fernández-Martínez J, Aranda Martínez P, Guerra-Librero A, Rodríguez-Santana C, de Haro T, Escames G, Acuña-Castroviejo D, Rusanova I. The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle. Antioxidants (Basel). 2021 Mar 27;10(4). doi: 10.3390/antiox10040524. PMID: 33801675; PMCID: PMC8066875.
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β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.

Biomedicines

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC.
PMID: 34680574
Biomedicines. 2021 Oct 13;9(10). doi: 10.3390/biomedicines9101457.

Primary mitochondrial diseases are caused by mutations in mitochondrial or nuclear genes, leading to the abnormal function of specific mitochondrial pathways. Mitochondrial dysfunction is also a secondary event in more common pathophysiological conditions, such as obesity and metabolic syndrome....

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Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, et al. β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. Biomedicines. 2021;9(10)doi: 10.3390/biomedicines9101457.
Hidalgo-Gutiérrez, A., Barriocanal-Casado, E., Díaz-Casado, M. E., González-García, P., Zenezini Chiozzi, R., Acuña-Castroviejo, D., & López, L. C. (2021). β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. Biomedicines, 9(10), . https://doi.org/10.3390/biomedicines9101457
Hidalgo-Gutiérrez, Agustín, et al. "β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight." Biomedicines vol. 9,10 (2021). doi: https://doi.org/10.3390/biomedicines9101457
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC. β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. Biomedicines. 2021 Oct 13;9(10). doi: 10.3390/biomedicines9101457. PMID: 34680574; PMCID: PMC8533582.
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Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.

Antioxidants (Basel, Switzerland)

Guerra-Librero A, Fernandez-Gil BI, Florido J, Martinez-Ruiz L, Rodríguez-Santana C, Shen YQ, García-Verdugo JM, López-Rodríguez A, Rusanova I, Quiñones-Hinojosa A, Acuña-Castroviejo D, Marruecos J, De Haro T, Escames G.
PMID: 33919790
Antioxidants (Basel). 2021 Apr 14;10(4). doi: 10.3390/antiox10040603.

Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as one of the major mechanisms underlying therapeutic resistance. Mitochondria, which are directly involved...

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Guerra-Librero A, Fernandez-Gil BI, Florido J, et al. Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function. Antioxidants (Basel). 2021;10(4)doi: 10.3390/antiox10040603.
Guerra-Librero, A., Fernandez-Gil, B. I., Florido, J., Martinez-Ruiz, L., Rodríguez-Santana, C., Shen, Y. Q., García-Verdugo, J. M., López-Rodríguez, A., Rusanova, I., Quiñones-Hinojosa, A., Acuña-Castroviejo, D., Marruecos, J., De Haro, T., & Escames, G. (2021). Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function. Antioxidants (Basel, Switzerland), 10(4), . https://doi.org/10.3390/antiox10040603
Guerra-Librero, Ana, et al. "Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function." Antioxidants (Basel, Switzerland) vol. 10,4 (2021). doi: https://doi.org/10.3390/antiox10040603
Guerra-Librero A, Fernandez-Gil BI, Florido J, Martinez-Ruiz L, Rodríguez-Santana C, Shen YQ, García-Verdugo JM, López-Rodríguez A, Rusanova I, Quiñones-Hinojosa A, Acuña-Castroviejo D, Marruecos J, De Haro T, Escames G. Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function. Antioxidants (Basel). 2021 Apr 14;10(4). doi: 10.3390/antiox10040603. PMID: 33919790; PMCID: PMC8070770.
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