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Showing 1 to 12 of 34 entries
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A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine library.

Organic letters

Palysaeva NV, Kumpan KP, Struchkova MI, Dalinger IL, Kormanov AV, Aleksandrova NS, Chernyshev VM, Pyreu DF, Suponitsky KY, Sheremetev AB.
PMID: 24377749
Org Lett. 2014 Jan 17;16(2):406-9. doi: 10.1021/ol403308h. Epub 2013 Dec 30.

The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded...

[Secondary prophylaxis of ischemic heart diseases].

Sovetskaia meditsina

Metelitsa VI, Tsafris TP, Kokurina EV, Sapozhnikov II, Aleksandrov AA.
PMID: 5018161
Sov Med. 1972 Mar;35(3):133-7.

No abstract available.

Synthesis and Characterization of 3-(5-(Fluorodinitromethyl)-1H-1,2,4-triazol-3-yl)-4-nitrofurazan: A Novel Promising Energetic Component of Boron-based Fuels for Rocket Ramjet Engines.

Chemistry, an Asian journal

Sheremetev AB, Aleksandrova NS, Semyakin SS, Suponitsky KY, Lempert DB.
PMID: 31608576
Chem Asian J. 2019 Dec 02;14(23):4255-4261. doi: 10.1002/asia.201901280. Epub 2019 Oct 21.

The synthesis of a new energetic 1,2,4-triazole compound bearing nitrofurazanyl and fluorodinitromethyl units, which may find use as a component for rocket ramjet engines (RRE), is described. The target product was prepared in a four-step process applying oxidation/nitration/decarboxylation/fluorination reactions...

Membrane Permeability of Modified Butyltriphenylphosphonium Cations.

The journal of physical chemistry. B

Rokitskaya TI, Aleksandrova EV, Korshunova GA, Khailova LS, Tashlitsky VN, Luzhkov VB, Antonenko YN.
PMID: 34994564
J Phys Chem B. 2022 Jan 07; doi: 10.1021/acs.jpcb.1c08135. Epub 2022 Jan 07.

The alkyltriphenylphosphonium (TPP) group is the most widely used vector targeted to mitochondria. Previously, the length of the alkyl linker was varied as well as structural modifications in the TPP phenyl rings to obtain the optimal therapeutic effect of...

[INSTRUMENTS FOR INCREASING LABOR MOTIVATION OF MEDICAL ORGANIZATIONS EMPLOYEES].

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

Aleksandrova OA, Yarasheva AV, Alikperova NV, Vinogradova KV, Aksenova EI.
PMID: 33219757
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2020 Oct;28:1049-1055. doi: 10.32687/0869-866X-2020-28-s2-1049-1055.

The article is devoted to the study of motivation of medical organization employees to work. A competent system of motivation of medical personnel, focused on building long-term goals and development conditions, supporting the organizational climate and increasing the involvement...

Gel Synthesis of Hexaferrites Pb.

Nanomaterials (Basel, Switzerland)

Lisnevskaya IV, Aleksandrova IA.
PMID: 32825193
Nanomaterials (Basel). 2020 Aug 19;10(9). doi: 10.3390/nano10091630.

We investigated the opportunities for obtaining hexaferrites Pb

[The etiology and pathogenesis of primary chronic adrenal insufficiency: Current aspects].

Problemy endokrinologii

Melnichenko GA, Maryina TL, Aleksandrova GF.
PMID: 31627670
Probl Endokrinol (Mosk). 2006 Dec 15;52(6):45-50. doi: 10.14341/probl200652645-50.

Primary chronic adrenal insufficiency is a relatively rare disease. To date, according to various authors, the prevalence of Primary chronic adrenal insufficiency in the world varies significantly.

Regenerative Effects and Development Patterns of Solid Neural Tissue Grafts Located in Gelatin Hydrogel Conduit for Treatment of Peripheral Nerve Injury.

Plastic and reconstructive surgery. Global open

Sukhinich KK, Dashinimaev EB, Vorotelyak EA, Aleksandrova MA.
PMID: 32309071
Plast Reconstr Surg Glob Open. 2020 Feb 11;8(2):e2610. doi: 10.1097/GOX.0000000000002610. eCollection 2020 Feb.

BACKGROUND: The regeneration of the peripheral nerves after injuries is still a challenging fundamental and clinical problem. The cell therapy and nerve guide conduit construction are promising modern approaches. Nowadays, different sources of cells for transplantation are available. But...

The relationship of antibodies to modified citrullinated vimentin and markers of bone and cartilage destruction in rheumatoid arthritis.

International journal of rheumatology

Avdeeva AS, Aleksandrova EN, Novikov AA, Smirnov AV, Cherkasova MV, Nasonov EL.
PMID: 24839444
Int J Rheumatol. 2014;2014:464585. doi: 10.1155/2014/464585. Epub 2014 Apr 15.

Objective. To make individualised decisions regarding treatment is one of the most important challenges in clinical practise, and identification of sensitive and specific markers of prognosis is an important research question. The main objective of this study was to...

A Comparative Assessment of Effects of Major Mediators of Acute Phase Response (IL-1, TNF-α, IL-6) on Breathing Pattern and Survival Rate in Rats with Acute Progressive Hypoxia.

Journal of evolutionary biochemistry and physiology

Donina ZA, Baranova EV, Aleksandrova NP.
PMID: 34456365
J Evol Biochem Physiol. 2021;57(4):936-944. doi: 10.1134/S0022093021040177. Epub 2021 Aug 24.

A pressing issue of the day is the identification of therapeutic targets to suppress the "cytokine storm" in COVID-19 complicated by acute respiratory distress syndrome (ARDS) with concomitant hypoxemia. However, the key cytokine and its relative contribution to the...

Machine-learning scoring functions to improve structure-based binding affinity prediction and virtual screening.

Wiley interdisciplinary reviews. Computational molecular science

Ain QU, Aleksandrova A, Roessler FD, Ballester PJ.
PMID: 27110292
Wiley Interdiscip Rev Comput Mol Sci. 2015 Nov-Dec;5(6):405-424. doi: 10.1002/wcms.1225. Epub 2015 Aug 28.

Docking tools to predict whether and how a small molecule binds to a target can be applied if a structural model of such target is available. The reliability of docking depends, however, on the accuracy of the adopted scoring...

Pseudodimeric Complexes of an (18-Crown-6)stilbene with Styryl Dyes Containing an Ammonioalkyl Group: Synthesis, Structure, and Stereospecific [2 + 2] Cross-Photocycloaddition.

The Journal of organic chemistry

Martyanov TP, Ushakov EN, Nuriev VN, Aleksandrova NA, Sazonov SK, Vedernikov AI, Kuz'mina LG, Klimenko LS, Martyanova EG, Gromov SP.
PMID: 33528258
J Org Chem. 2021 Feb 19;86(4):3164-3175. doi: 10.1021/acs.joc.0c02514. Epub 2021 Feb 02.

A new efficient method was proposed for the synthesis of (18-crown-6)stilbene; the structure of the product was confirmed by X-ray diffraction analysis. In MeCN, this compound forms pseudodimeric complexes with

Showing 1 to 12 of 34 entries