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Showing 1 to 12 of 278 entries
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Randomized controlled trial of the NS5A inhibitor daclatasvir plus pegylated interferon and ribavirin for HCV genotype-4 (COMMAND-4).

Antiviral therapy

Hézode C, Alric L, Brown A, Hassanein T, Rizzetto M, Buti M, Bourlière M, Thabut D, Molina E, Rustgi V, Samuel D, McPhee F, Liu Z, Yin PD, Hughes E, Treitel M.
PMID: 26313445
Antivir Ther. 2015 Aug 27;21(3):195-205. doi: 10.3851/IMP2985. Epub 2015 Aug 27.

BACKGROUND: Treatment options for HCV genotype-4 (GT4) are limited. This Phase III study (COMMAND-4; AI444-042) evaluated the efficacy and safety of daclatasvir (DCV), a pan-genotypic HCV NS5A inhibitor, with pegylated interferon-α2a/ribavirin (PEG-IFN/RBV) in treatment-naive patients with HCV GT4 infection.METHODS:...

Lung transplantation at Duke.

Journal of thoracic disease

Gray AL, Mulvihill MS, Hartwig MG.
PMID: 27076968
J Thorac Dis. 2016 Mar;8(3):E185-96. doi: 10.21037/jtd.2016.02.08.

Lung transplantation represents the gold-standard therapy for patients with end-stage lung disease. Utilization of this therapy continues to rise. The Lung Transplant Program at Duke University Medical Center was established in 1992, and since that time has grown to...

HLA-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared to HLA-Bw4-T-80 and HLA-A-Bw4 Isoforms in Rituximab or Dinutuximab-Based Cancer Immunotherapy.

Frontiers in immunology

Erbe AK, Wang W, Reville PK, Carmichael L, Kim K, Mendonca EA, Song Y, Hank JA, London WB, Naranjo A, Hong F, Hogarty MD, Maris JM, Park JR, Ozkaynak MF, Miller JS, Gilman AL, Kahl B, Yu AL, Sondel PM.
PMID: 28659916
Front Immunol. 2017 Jun 12;8:675. doi: 10.3389/fimmu.2017.00675. eCollection 2017.

Killer-cell immunoglobulin-like receptors (KIRs) are a family of glycoproteins expressed primarily on natural killer cells that can regulate their function. Inhibitory KIRs recognize MHC class I molecules (KIR-ligands) as ligands. We have reported associations of KIRs and KIR-ligands for...

Effects of repeated dosing with mechanistically distinct antinociceptive ligands in a rat model of neuropathic spinal cord injury pain.

Pharmacology research & perspectives

Hama AT, Pearson JP, Sagen J.
PMID: 25505583
Pharmacol Res Perspect. 2014 Apr;2(2):e00034. doi: 10.1002/prp2.34. Epub 2014 Mar 13.

A lack of efficacy of some analgesic drugs has been previously described in rats with neuropathic spinal cord injury (SCI) pain. It has been suggested that repeated dosing in these animals over time may eventually lead to efficacy. However,...

Comparing voice self-assessment with auditory perceptual analysis in patients with multiple sclerosis.

International archives of otorhinolaryngology

Bauer V, Aleric Z, Jancic E.
PMID: 25992162
Int Arch Otorhinolaryngol. 2015 Apr;19(2):100-5. doi: 10.1055/s-0034-1397332. Epub 2014 Dec 30.

Introduction Disordered voice quality could be a symptom of multiple sclerosis (MS). The impact of MS on voice-related quality of life is still controversial. Objectives The aim of this study was to compare the results of voice self-assessment with...

Gas-Phase Oxidation of Neutral Basic Residues in Polypeptide Cations by Periodate.

Journal of the American Society for Mass Spectrometry

Pilo AL, Bu J, McLuckey SA.
PMID: 27644939
J Am Soc Mass Spectrom. 2016 Dec;27(12):1979-1988. doi: 10.1007/s13361-016-1491-0. Epub 2016 Sep 19.

The gas-phase oxidation of doubly protonated peptides containing neutral basic residues to various products, including [M + H + O]

On the Gaussian approximation in colloidal hard sphere fluids.

Soft matter

Thorneywork AL, Aarts DG, Horbach J, Dullens RP.
PMID: 27064930
Soft Matter. 2016 May 14;12(18):4129-34. doi: 10.1039/c5sm03049h. Epub 2016 Apr 11.

We study the behaviour of the self-intermediate scattering function and self-van Hove correlation function for quasi-two-dimensional colloidal hard sphere fluids at a range of area fractions. We compute these functions first directly from the particle coordinates and secondly from...

Striga Biocontrol on a Toothpick: A Readily Deployable and Inexpensive Method for Smallholder Farmers.

Frontiers in plant science

Nzioki HS, Oyosi F, Morris CE, Kaya E, Pilgeram AL, Baker CS, Sands DC.
PMID: 27551284
Front Plant Sci. 2016 Aug 08;7:1121. doi: 10.3389/fpls.2016.01121. eCollection 2016.

Striga hermonthica (witchweed) is a parasitic weed that attacks and significantly reduces the yields of maize, sorghum, millet, and sugarcane throughout sub-Saharan Africa. Low cost management methods such as hand weeding, short crop rotations, trap cropping, or conventional biocontrol...

Antinociceptive effects of topical mepivacaine in a rat model of HIV-associated peripheral neuropathic pain.

Journal of pain research

Sagen J, Castellanos DA, Hama AT.
PMID: 27350758
J Pain Res. 2016 Jun 06;9:361-71. doi: 10.2147/JPR.S104397. eCollection 2016.

BACKGROUND: A consequence of HIV infection is sensory neuropathy, a debilitating condition that degrades the quality of life of HIV patients. Furthermore, life-extending antiretroviral treatment may exacerbate HIV sensory neuropathy. Analgesics that relieve other neuropathic pains show little or...

Boceprevir-Based Triple Antiviral Therapy for Chronic Hepatitis C Virus Infection in Kidney-Transplant Candidates.

Journal of transplantation

Mehawej M, Rostaing L, Alric L, Del Bello A, Izopet J, Kamar N.
PMID: 26257919
J Transplant. 2015;2015:159795. doi: 10.1155/2015/159795. Epub 2015 Jul 16.

Background. There are few data on the combination of (pegylated-) interferon- (Peg-IFN-) α, ribavirin, and first-generation direct-acting antiviral agents (DAAs). Our aim was to describe the efficacy and safety of Peg-IFN-α, ribavirin, and boceprevir in hemodialysis patients. Patients. Six...

Communication: radial distribution functions in a two-dimensional binary colloidal hard sphere system.

The Journal of chemical physics

Thorneywork AL, Roth R, Aarts DG, Dullens RP.
PMID: 24784245
J Chem Phys. 2014 Apr 28;140(16):161106. doi: 10.1063/1.4872365.

Two-dimensional hard disks are a fundamentally important many-body model system in classical statistical mechanics. Despite their significance, a comprehensive experimental data set for two-dimensional single component and binary hard disks is lacking. Here, we present a direct comparison between...

Erratum: renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy.

Journal of experimental & clinical cancer research : CR

Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A.
PMID: 25480670
J Exp Clin Cancer Res. 2014 Dec 05;33:95. doi: 10.1186/s13046-014-0095-4.

No abstract available.

Showing 1 to 12 of 278 entries