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Showing 1 to 12 of 17 entries
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Is anonymous peer review the best way to review and accept manuscripts?.

Magnesium and trace elements

Altura BT.
PMID: 2248691
Magnes Trace Elem. 1990;9(3):117-8.

No abstract available.

3-Acetyl-4-benzoyl-2-methyl-5-phenyl-3,3a-dihydropyrazolo[2,3-c]pyrimidine-7(6H)-thione.

Acta crystallographica. Section C, Crystal structure communications

Akkurt M, Oztürk S, Fun HK, Onal Z, Altural B.
PMID: 15263129
Acta Crystallogr C. 2000 Jun 01;56:E276-7. doi: 10.1107/S0108270100007241. Epub 2000 Jun 01.

The molecule of the title compound, C(22)H(19)N(3)O(2)S, is not planar. The dihedral angle between the two phenyl rings is 27.46 (7) degrees and in the dihydropyrazolopyrimidine ring the total puckering amplitude Q(T) is 0.526 (3) A. The structure is...

Mg deficiency results in modulation of serum lipids, glutathione, and NO synthase isozyme activation in cardiovascular tissues: relevance to de novo synthesis of ceramide, serum Mg and atherogenesis.

International journal of clinical and experimental medicine

Shah NC, Liu JP, Iqbal J, Hussain M, Jiang XC, Li Z, Li Y, Zheng T, Li W, Sica AC, Perez-Albela JL, Altura BT, Altura BM.
PMID: 21686135
Int J Clin Exp Med. 2011;4(2):103-18. Epub 2011 Apr 05.

The present work tested the hypothesis that short-term (S-T) dietary deficiency of magnesium (Mg) (21 days) in rats would: 1) result in reduction in serum(s) sphingomyelin (SM) and changes in several blood lipids, HDL-cholesterol (HDL-C) and phosphatidylcholine (PC) concomitant...

Rapamycin induces the anti-apoptotic protein survivin in neuroblastoma.

International journal of biochemistry and molecular biology

Samkari A, Cooper ZA, Holloway MP, Liu J, Altura RA.
PMID: 22509478
Int J Biochem Mol Biol. 2012;3(1):28-35. Epub 2012 Feb 10.

Neuroblastoma is the most common solid tumor of infancy, accounting for 15% of all cancer cell deaths in children. Expression of the anti-apoptotic protein survivin in these tumors correlates with poor prognostic features and resistance to therapy. The mammalian...

Developing a Successful Master of Health Administration Student Mentor-Mentee Program.

The health care manager

Shaikh A, AlTurabi L, West DJ.
PMID: 27892913
Health Care Manag (Frederick). 2016 Jan/Mar;35(1):47-57. doi: 10.1097/HCM.0000000000000091.

A student mentoring program can impact the overall experience in an academic program and establish a strong connection between students. It creates a platform for students to ask specific questions, learn more about the curriculum and professional opportunities, and...

The CRM1 nuclear export protein in normal development and disease.

International journal of biochemistry and molecular biology

Nguyen KT, Holloway MP, Altura RA.
PMID: 22773955
Int J Biochem Mol Biol. 2012;3(2):137-51. Epub 2012 May 18.

CRM1 (Chromosomal Maintenance 1, also known as Exportin 1) is the major mammalian export protein that facilitates the transport of large macromolecules including RNA and protein across the nuclear membrane to the cytoplasm. The gene encoding CRM1 was originally...

Ambulatory abdominoplasty tailored to patients with an appropriate body mass index.

Aesthetic surgery journal

Williams TC, Hardaway M, Altuna B.
PMID: 19338803
Aesthet Surg J. 2005 Mar-Apr;25(2):132-7. doi: 10.1016/j.asj.2005.01.011.

BACKGROUND: The office-based surgery setting potentially offers advantages to both the patient and the plastic surgeon, but some patients may not be considered good candidates for abdominoplasty or combined abdominoplasty/lipoplasty performed in the ambulatory setting.OBJECTIVE: We conducted a retrospective...

HDFx: a novel biologic immunomodulator accelerates wound healing and is suggestive of unique regenerative powers: potential implications for the warfighter and disaster victims.

International journal of clinical and experimental medicine

Altura BM, Carella A, Gebrewold A.
PMID: 22993647
Int J Clin Exp Med. 2012;5(4):289-95. Epub 2012 Aug 22.

Recently, we reported on the discovery of a new, conserved biologic protein (35-40 KDa), termed HDFx, that protects rats, guinea-pigs, mice, and rabbits against lethal hemorrhage, endotoxins, intestinal ischemic-shock, and traumatic injuries. It was found to stimulate several arms...

First-in-Class Anti-immunoglobulin-like Transcript 4 Myeloid-Specific Antibody MK-4830 Abrogates a PD-1 Resistance Mechanism in Patients with Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Siu LL, Wang D, Hilton J, Geva R, Rasco D, Perets R, Abraham AK, Wilson DC, Markensohn JF, Lunceford J, Suttner L, Siddiqi S, Altura RA, Maurice-Dror C.
PMID: 34598945
Clin Cancer Res. 2021 Oct 01; doi: 10.1158/1078-0432.CCR-21-2160. Epub 2021 Oct 01.

PURPOSE: In this first-in-human study (NCT03564691) in advanced solid tumors, we investigated a novel first-in-class human IgG4 monoclonal antibody targeting the immunoglobulin-like transcript 4 (ILT4) receptor, MK-4830, as monotherapy and in combination with pembrolizumab.EXPERIMENTAL DESIGN: Patients with histologically/cytologically confirmed...

Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.

International journal of clinical and experimental medicine

Shah NC, Shah GJ, Li Z, Jiang XC, Altura BT, Altura BM.
PMID: 24753742
Int J Clin Exp Med. 2014 Mar 15;7(3):497-514. eCollection 2014.

THE PRESENT WORK TESTED THE HYPOTHESES THAT: 1) short-term dietary deficiency of magnesium (Mg; 21 days) in rats (MgD) would result in a downregulation of telomerase in cardiac and aortic smooth muscle cells, 2) low levels of Mg(2+) added...

Magnesium deficiency upregulates sphingomyelinases in cardiovascular tissues and cells: cross-talk among proto-oncogenes, Mg(2+), NF-κB and ceramide and their potential relationships to resistant hypertension, atherogenesis and cardiac failure.

International journal of clinical and experimental medicine

Altura BM, Shah NC, Shah GJ, Li W, Zhang A, Zheng T, Li Z, Jiang XC, Perez-Albela JL, Altura BT.
PMID: 24260592
Int J Clin Exp Med. 2013 Oct 25;6(10):861-79. eCollection 2013.

The present study tested the hypotheses that 1) short-term (ST) dietary deficiency of magnesium (MgD; 21 days) in rats would result in the upregulation of neutral-, acid-, and alkaline- sphingomyelinases SMases) in cardiac and vascular smooth muscles (VSMCs), 2)...

A novel biologic immunomodulator, HDFx, protects against lethal hemorrhage, endotoxins and traumatic injury: potential relevance to emerging diseases.

International journal of clinical and experimental medicine

Altura BM, Gebrewold A, Carella A.
PMID: 19918319
Int J Clin Exp Med. 2009 Sep 15;2(3):266-79.

For more than 125 years, it has been known that the RES, macrophages and the innate immune system play fundamental roles in host defense against pathogenic infections, trauma, hemorrhage, and combined injuries. Some years ago, we and others reported...

Showing 1 to 12 of 17 entries